lactoferrin and dimyristoylphosphatidylglycerol

lactoferrin has been researched along with dimyristoylphosphatidylglycerol* in 1 studies

Other Studies

1 other study(ies) available for lactoferrin and dimyristoylphosphatidylglycerol

ArticleYear
Lactoferrin-derived antimicrobial peptide induces a micellar cubic phase in a model membrane system.
    Biophysical journal, 2011, Aug-03, Volume: 101, Issue:3

    The observation of a micellar cubic phase is reported for a mixture of an antimicrobial peptide from the Lactoferrin family, LFampin 265-284, and a model membrane system of dimyristoylphosphatidylcholine/dimyristoylphosphatidylglycerol (3:1), as derived from small-angle x-ray diffraction (SAXD) measurements. The system shows remarkable thermotropic polymorphism: the peptide disrupts the lipid bilayer, forming a cubic phase of the space group Pm3n (t < 28°C), and as the temperature increases it shows a complex phase behavior (not fully clarified by SAXD). The onset, volume fraction of each phase, and phase parameters are seen to vary with peptide/lipid ratio and temperature. The obtained SAXD data represent the first experimental evidence, to our knowledge, of a micellar cubic phase in the context of antimicrobial peptide/membrane interaction. We propose that the micellization of the membrane according to the carpet model, for long proposed as a possible mechanism of action, can go through the formation of a cubic micellar phase.

    Topics: Antimicrobial Cationic Peptides; Cell Membrane; Dimyristoylphosphatidylcholine; Lactoferrin; Micelles; Phosphatidylglycerols; Scattering, Small Angle; X-Ray Diffraction

2011