lactoferrin has been researched along with 2-amino-1-methyl-6-phenylimidazo(4-5-b)pyridine* in 1 studies
1 other study(ies) available for lactoferrin and 2-amino-1-methyl-6-phenylimidazo(4-5-b)pyridine
Article | Year |
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Effects of lactoferrin, soya germ and polyamine on 2-amino-1-methyl-6- phenylimidazo[4,5-b]-pyridine(PhIP)- induced breast carcinogenesis in rats.
The cancer-preventive effects of food-derived bovine lactoferrin(bLF), isoflavone-rich soya germ(SG), and spermidine(SPD) on mammary gland carcinogenesis induced by 2-amino-1- methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP), were investigated in female Sprague-Dawley(SD) rats. Two hundred and six female SD rats were divided into 8 groups. Cumulative breast cancer incidence at 43 weeks was 65.4% in the PhIP group; 80.0% and 76.0% in the 0.2% and 2.0% bLF groups, respectively; 58.3% and 20.0% in the 2% and 10% SG groups, respectively; and 80.0% and 76.9% in the 0.035% and 0.175% SPD groups, respectively. Isoflavone-rich SG significantly suppressed breast cancer, and the tumors showed fibrous or less malignant features upon histological examination. Topics: Animals; Carcinogens; Cell Division; Disease Models, Animal; Female; Glycine max; Imidazoles; Lactoferrin; Mammary Neoplasms, Experimental; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Seeds | 2004 |