lactic acid and zidovudine

lactic acid has been researched along with zidovudine in 25 studies

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (24.00)	18.2507
2000's	12 (48.00)	29.6817
2010's	7 (28.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Cheema-Dhadli, S; Gopinath, R; Halperin, M; Hutcheon, M	1
Hobbs, GA; Keilbaugh, SA; Rief, PM; Simpson, MV	1
de Martino, M; Donati, MA; Filippi, L; Galli, L; Mannelli, F; Vierucci, A; Zammarchi, E	1
Boal, JH; Miller, RK; Plessinger, MA; van den Reydt, C	1
Agarwal, RP; Olivero, OA	1
Barnett, T; Eidelberg, D; Frank, Y; Hyman, RA; Lu, D; Pavlakis, SG; Wiznia, A	1
Burlina, A; D'Elia, R; De Romeo, A; De Rossi, A; Giacomet, V; Giaquinto, C; Rampon, O; Ruga, E; Sturkenboom, M	1
Corzo, JE; Gómez-Mateos , J; Lozano, F; Ramayo, E	1
Haase, CP; Hoit, BD; Lewis, W; Raidel, SM; Russ, RB; Samarel, AM; Sutliff, RL	1
Alimenti, A; Burdge, DR; Forbes, JC; Money, DM; Ogilvie, GS	1
Biour, M; Djouadi, F; Fromenty, B; Guimont, MC; Igoudjil, A; Lettéron, P; Maisonneuve, C; Note, R; Pessayre, D; Peytavin, G	1
Koopmans, PP; ter Hofstede, HJ; Willems, HL	1
Amin, S; Civin, CI; Lewis, LD; Lietman, PS	1
Artuch, R; Fortuny, C; Jimenez, R; Muñoz-Almagro, C; Noguera, A; Pou, J; Sanchez, E; Vilaseca, MA	1
Averitt, D; Kumar, PN; Pakes, GE; Pappa, KA; Rodriguez-French, A; Shaefer, MS; Tashima, KT; Thompson, MA; Wannamaker, PG; Williams, VC	1
Bastow, B; Glesby, MJ; Gulick, RM; Kuritzkes, DR; Meyer, WA; Ribaudo, HJ; Shikuma, CM; Tashima, KT; Webb, N; Yang, Y	1
Bassit, L; Detorio, MA; Dikalov, S; Hernandez-Santiago, BI; Jones, DP; Kleinhenz, DJ; Kline, ER; Liang, B; Schinazi, RF; Sutliff, RL; Walp, ER	1
Gremião, MP; Khalil, NM; Mainardes, RM	1
Chen, H; Hu, M; Jiang, Z; Li, Z; Tao, Y; Xiong, Y; Zhang, L; Zhang, P	1
Esteban-Cruciani, N; Hoffman, RS; Lee, S; Livshits, Z; Nelson, LS	1
Ajitkumar, GN; Hariharan, S; Nareshkumar, PN; Penmetsa, SD; Sankar, V	1
Contado, C; Dalpiaz, A; Hanuskovà, M; Leo, E; Mari, L; Paganetto, G; Pavan, B; Perrone, D; Vighi, E	1
Aranha, N; Balcão, VM; Chaud, MV; Gremião, MP; Oliveira Júnior, JM; Vila, MM; Yoshida, VM	1

Trials

3 trial(s) available for lactic acid and zidovudine

Article	Year
Lactic acid levels in children perinatally treated with antiretroviral agents to prevent HIV transmission. AIDS (London, England), 2001, May-25, Volume: 15, Issue:8 Topics: Anti-HIV Agents; Cross-Sectional Studies; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Lactic Acid; Lamivudine; Male; Perinatal Care; Pregnancy; Pregnancy Complications, Infectious; Prenatal Care; Reverse Transcriptase Inhibitors; Stavudine; Zidovudine	2001
A prospective, 96-week study of the impact of Trizivir, Combivir/nelfinavir, and lamivudine/stavudine/nelfinavir on lipids, metabolic parameters and efficacy in antiretroviral-naive patients: effect of sex and ethnicity. HIV medicine, 2006, Volume: 7, Issue:2 Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Black or African American; CD4 Lymphocyte Count; Cholesterol; Dideoxynucleosides; Drug Combinations; Female; Hispanic or Latino; HIV Infections; HIV-1; Humans; Hyperlipidemias; Lactic Acid; Lamivudine; Male; Nelfinavir; Nevirapine; Prospective Studies; Sex Factors; Stavudine; Treatment Outcome; Triglycerides; Zidovudine	2006
Metabolic effects of protease inhibitor-sparing antiretroviral regimens given as initial treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095). Journal of acquired immune deficiency syndromes (1999), 2007, Apr-15, Volume: 44, Issue:5 Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Blood Glucose; Body Composition; Cyclopropanes; Dideoxynucleosides; Double-Blind Method; Female; HIV Infections; HIV-1; Humans; Insulin Resistance; Lactic Acid; Lamivudine; Lipids; Male; Reverse Transcriptase Inhibitors; Zidovudine	2007

Other Studies

22 other study(ies) available for lactic acid and zidovudine

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Chronic lactic acidosis in a patient with acquired immunodeficiency syndrome and mitochondrial myopathy: biochemical studies. Journal of the American Society of Nephrology : JASN, 1992, Volume: 3, Issue:6 Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Adult; Exercise; Humans; Kidney; Lactates; Lactic Acid; Male; Mitochondrial Myopathies; Zidovudine	1992
Cellular targets of 3'-azido-3'-deoxythymidine: an early (non-delayed) effect on oxidative phosphorylation. Biochemical pharmacology, 1995, Jul-31, Volume: 50, Issue:3 Topics: Adenosine Triphosphate; Animals; Cell Division; Cell Line; Cytosol; Dideoxynucleosides; DNA Replication; DNA, Mitochondrial; Lactates; Lactic Acid; Mice; Mitochondria; Oxidative Phosphorylation; Oxygen; Protein Biosynthesis; Time Factors; Zidovudine	1995
Redox potential status in children with perinatal HIV-1 infection treated with zidovudine. AIDS (London, England), 1995, Volume: 9, Issue:12 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Child; Child, Preschool; Female; HIV Infections; HIV-1; Humans; Hydroxybutyrates; Infant; Infectious Disease Transmission, Vertical; Lactates; Lactic Acid; Male; Mitochondria; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Zidovudine	1995
Pharmacokinetic and toxicity studies of AZT (zidovudine) following perfusion of human term placenta for 14 hours. Toxicology and applied pharmacology, 1997, Volume: 143, Issue:1 Topics: Anti-HIV Agents; Chorionic Gonadotropin; Female; Glucose; Humans; In Vitro Techniques; Lactic Acid; Maternal-Fetal Exchange; Oxygen; Perfusion; Placenta; Pregnancy; Pregnancy Trimester, Third; Tissue Distribution; Zidovudine	1997
Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3'-azido-2',3'-dideoxythymidine. Mutation research, 1997, May-23, Volume: 390, Issue:3 Topics: Anti-HIV Agents; Cell Nucleus; Cells, Cultured; Chromosome Aberrations; DNA Adducts; DNA Damage; DNA, Mitochondrial; Humans; Lactic Acid; Lipid Metabolism; Micronuclei, Chromosome-Defective; Mitochondria; Mutagenicity Tests; Radioimmunoassay; T-Lymphocytes; Zidovudine	1997
Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy. AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:2 Topics: AIDS Dementia Complex; Anti-HIV Agents; Aspartic Acid; Brain; Child; Child, Preschool; Creatine; Didanosine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurologic Examination; Zidovudine	1998
[Symptomatic hyperlactemia in patients infected with the human immunodeficiency virus treated with nucleoside analogs]. Medicina clinica, 2001, Jun-09, Volume: 117, Issue:1 Topics: Adult; Anti-HIV Agents; Didanosine; Female; HIV Infections; HIV Reverse Transcriptase; Humans; Lactic Acid; Lamivudine; Male; Reverse Transcriptase Inhibitors; Zidovudine	2001
Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice. Laboratory investigation; a journal of technical methods and pathology, 2001, Volume: 81, Issue:11 Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atrial Natriuretic Factor; Calcium-Transporting ATPases; Cardiomyopathies; Drug Therapy, Combination; Echocardiography; Gene Expression; HIV Protease Inhibitors; Indinavir; Lactic Acid; Lamivudine; Mice; Mice, Transgenic; Microscopy, Electron; Myocardium; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Zidovudine	2001
Lactic acidemia in human immunodeficiency virus-uninfected infants exposed to perinatal antiretroviral therapy. The Pediatric infectious disease journal, 2003, Volume: 22, Issue:9 Topics: Acidosis, Lactic; Adult; Antiretroviral Therapy, Highly Active; Case-Control Studies; Cohort Studies; Confidence Intervals; Female; HIV Infections; HIV Seronegativity; HIV Seropositivity; Humans; Incidence; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lactic Acid; Male; Monitoring, Physiologic; Odds Ratio; Perinatal Care; Pregnancy; Probability; Prognosis; Prospective Studies; Risk Assessment; Zidovudine	2003
Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:11 Topics: Aminoisobutyric Acids; Animals; Blotting, Northern; Cholesterol; DNA; Fatty Acids; Immunoblotting; Ketone Bodies; Lactic Acid; Lipid Metabolism; Liver; Male; Metabolism; Mice; Mitochondria; Oxidation-Reduction; Phospholipids; Pyruvic Acid; Reverse Transcriptase Inhibitors; Thymidine; Triglycerides; Zidovudine	2003
Serum L-lactate and pyruvate in HIV-infected patients with and without presumed NRTI-related adverse events compared to healthy volunteers. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2004, Volume: 29, Issue:1 Topics: Adult; Anti-HIV Agents; DNA, Mitochondrial; Female; HIV Infections; HIV-1; Humans; Lactic Acid; Male; Mitochondria; Pyruvic Acid; Reverse Transcriptase Inhibitors; Stavudine; Zidovudine	2004
Ex vivo zidovudine (AZT) treatment of CD34+ bone marrow progenitors causes decreased steady state mitochondrial DNA (mtDNA) and increased lactate production. Human & experimental toxicology, 2004, Volume: 23, Issue:4 Topics: Anti-HIV Agents; Antigens, CD34; Cell Differentiation; Cell Proliferation; Cells, Cultured; DNA, Mitochondrial; Dose-Response Relationship, Drug; Erythrocytes; Granulocytes; Hematopoietic Stem Cells; Humans; Immunoblotting; Lactic Acid; Zidovudine	2004
Hyperlactatemia in human immunodeficiency virus-uninfected infants who are exposed to antiretrovirals. Pediatrics, 2004, Volume: 114, Issue:5 Topics: Alanine; Antiretroviral Therapy, Highly Active; Didanosine; Female; HIV Infections; HIV Seronegativity; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lactic Acid; Logistic Models; Male; Mitochondria; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Reverse Transcriptase Inhibitors; Zidovudine	2004
Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction. Cardiovascular toxicology, 2009, Volume: 9, Issue:1 Topics: Biomarkers; Cell Death; Cell Line, Tumor; Cells, Cultured; DNA, Mitochondrial; Endothelial Cells; Glutathione; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Mitochondria; Mitochondria, Liver; Oxidative Stress; Phosphorylation; Reverse Transcriptase Inhibitors; Stavudine; Superoxides; Time Factors; Zidovudine	2009
Intranasal delivery of zidovudine by PLA and PLA-PEG blend nanoparticles. International journal of pharmaceutics, 2010, Aug-16, Volume: 395, Issue:1-2 Topics: Administration, Intranasal; Animals; Biological Availability; Chemistry, Pharmaceutical; Drug Carriers; Drug Compounding; Half-Life; Lactic Acid; Male; Mice; Particle Size; Polyesters; Polyethylene Glycols; Polymers; Rats; Rats, Wistar; Reverse Transcriptase Inhibitors; Surface Properties; Technology, Pharmaceutical; Zidovudine	2010
Evaluation of mitochondrial toxicity in Marmota himalayana treated with metacavir, a novel 2',3'-dideoxyguanosine prodrug for treatment of hepatitis B Virus. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:5 Topics: Acidosis, Lactic; Animals; Antiviral Agents; Dideoxynucleosides; DNA, Mitochondrial; Fatty Liver; Hepatitis B; Hepatitis B virus; Lactic Acid; Marmota; Mitochondria; Prodrugs; Purine Nucleosides; Zidovudine	2011
Zidovudine (AZT) overdose in a healthy newborn receiving postnatal prophylaxis. Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:8 Topics: Acidosis; Alanine Transaminase; Anti-HIV Agents; Drug Overdose; HIV Infections; Humans; Infant, Newborn; Lactic Acid; Male; Medication Errors; Neutropenia; Zidovudine	2011
Comparative studies of lamivudine-zidovudine nanoparticles for the selective uptake by macrophages. Current drug delivery, 2012, Volume: 9, Issue:5 Topics: Animals; Anti-HIV Agents; Drug Carriers; Drug Combinations; Lactic Acid; Lamivudine; Lipids; Macrophages; Male; Mice; Nanoparticles; Poloxamer; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polysorbates; Reverse Transcriptase Inhibitors; Surface-Active Agents; Tissue Distribution; Zidovudine	2012
Development and characterization of PLGA nanoparticles as delivery systems of a prodrug of zidovudine obtained by its conjugation with ursodeoxycholic acid. Drug delivery, 2014, Volume: 21, Issue:3 Topics: Animals; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Carriers; Drug Stability; Hydrolysis; Kinetics; Lactic Acid; Liver; Male; Microscopy, Electron, Scanning; Nanoparticles; Nanotechnology; Particle Size; Poloxamer; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prodrugs; Rats, Wistar; Reverse Transcriptase Inhibitors; Solubility; Surface Properties; Technology, Pharmaceutical; Ursodeoxycholic Acid; Zidovudine	2014
Zidovudine-poly(L-lactic acid) solid dispersions with improved intestinal permeability prepared by supercritical antisolvent process. Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:5 Topics: Animals; Chromatography, Supercritical Fluid; Intestinal Absorption; Lactic Acid; Male; Permeability; Rats; Rats, Wistar; Solvents; Zidovudine	2015