lactic acid has been researched along with transforming growth factor beta in 189 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 29 (15.34) | 18.2507 |
| 2000's | 101 (53.44) | 29.6817 |
| 2010's | 49 (25.93) | 24.3611 |
| 2020's | 10 (5.29) | 2.80 |
| Authors | Studies |
|---|---|
| Rosenthal, AK; Ryan, LM | 1 |
| Hill, PA; Meikle, MC; Papaioannou, S; Ratledge, TJ; Reynolds, JJ; Speight, PM; Watt-Smith, SR | 1 |
| Easley, K; Hyodo, A; Kambic, H; Manning, T; Muschler, GF | 1 |
| Evans, CH; Georgescu, HI; Stadler, J; Stefanovic-Racic, M | 1 |
| Bouchard, LS; Gombotz, WR; Pankey, SC; Puolakkainen, P; Ranchalis, J | 1 |
| Dawson, EG; Delamarter, RB; Kabo, JM; Kanim, LE; Liu, D; Sandhu, HS; Toth, JM; Zeegen, EN | 1 |
| Alpaslan, C; Irie, K; Nakajima, T; Ohashi, N; Ozawa, H; Sakai, H; Takahashi, K | 1 |
| Ishikawa, I; Kinoshita, A; Oda, S; Takahashi, K; Yokota, S | 1 |
| Brekke, J; Buck, DC; Hollinger, JO; Wozney, JM; Zegzula, HD | 1 |
| Chabot, MC; Fischgrund, JS; Hankin, R; Herkowitz, HN; James, SB; Shirkhoda, A; Wozney, JM | 1 |
| DeLuca, PP; Duggirala, SS; Mehta, RC | 1 |
| DeLuca, PP; Duggirala, SS; Rodgers, JB | 1 |
| DeLuca, PP; Faugere, MC; Fink, BF; Hamilton, D; Rodgers, JB; Vasconez, HC; Wells, MD | 1 |
| Itoh, T; Kadosawa, T; Kokubo, S; Matsunaga, S; Mochizuki, M; Nishimura, R; Sasaki, N; Yokota, S | 1 |
| Nugent, MA; Trinkaus-Randall, V | 1 |
| Feldmann, CP; Illi, OE | 1 |
| Brekke, JH; Buck, DC; Chamberland, DL; Hollinger, JO; Joh, SP; Schmitt, JM; Suh, KW; Wheeler, DL | 1 |
| Adashi, EY; Ben-Shlomo, I; Derman, SG; Kol, S; Resnick, CE; Rohan, RM | 1 |
| Baldo, G; Basso, D; Brigato, L; Ceolotto, G; Plebani, M; Tiengo, A; Valerio, A | 1 |
| Browne, M; Cole, BJ; Gross, J; Lane, JM; Tomin, E; Turek, T; Waller, S; Yasko, AW | 1 |
| Boyan, BD; Carnes, DL; Dean, DD; Lohmann, CH; Niederauer, GG; Schwartz, Z; Somers, A; Wozney, JM | 1 |
| Amagasa, T; Isobe, M; Mori, M; Yamazaki, Y | 1 |
| Amagasa, T; Ishihara, K; Isobe, M; Mori, M; Nakabayashi, N; Yamazaki, Y | 1 |
| Higuchi, T; Ishikawa, I; Kinoshita, A; Oda, S; Takahashi, K | 1 |
| David, SM; Gruber, HE; Hanley, EN; Howard, BA; Meyer, RA; Murakami, T; Tabor, OB; Wozney, JM | 1 |
| DeLuca, PP; Schrier, JA | 2 |
| Aufdemorte, TB; Boyan, BD; Brooks, BP; Ehler, W; Heckman, JD; Lohmann, CH; Morgan, T | 1 |
| Manninen, M; Pätiälä, H; Pohjonen, T; Puolakkainen, P; Rautavuori, J; Rokkanen, P; Tielinen, L | 1 |
| Lu, L; Mikos, AG; Stamatas, GN | 1 |
| Kim, DJ; Lu, L; Mikos, AG; Miller, MJ; Peter, SJ; Stamatas, GN; Yaszemski, MJ | 1 |
| Currier, BL; Hefferan, TE; Larson, DR; Lu, L; Mikos, AG; Oldham, JB; Porter, BD; Yaszemski, MJ; Zhu, X | 1 |
| Asahina, I; Enomoto, S; Oda, M; Seto, I | 1 |
| Brodbeck, K; Häring, HU; Lehmann, R; Schleicher, ED; Weigert, C | 1 |
| Boyadjieva, N; De, A; Hentges, S; Sarkar, DK | 1 |
| Bulliard, C; Schiffrin, EJ; von der Weid, T | 1 |
| Fujimoto, R; Fukushima, S; Kokubo, S; Murai, M; Nozaki, K; Shimokawa, S; Sonobe, T; Sonohara, S; Takahashi, K; Uchida, T; Yokohama, S; Yokota, S; Yoshida, M | 1 |
| Enomoto, S; Imai, Y; Masaka, K; Miki, T | 1 |
| Aversa, P; Barra, G; Leo, G; Milella, E; Ramires, PA; Romito, A | 1 |
| Bhatnagar, RS; Nicoll, SB; Smith, NR; Wedrychowska, A | 1 |
| Meng, Z; Xu, J; Yang, Z | 1 |
| Blunk, BT; Elisseeff, J; Fu, K; Langer, R; McIntosh, W | 1 |
| DeLuca, M; DeLuca, PP; Fink, BF; Jiang, G; Jo, YW; Page, R; Schrier, JA; Vasconez, HC; Woo, BH | 1 |
| Baker, JM; Brekke, JH; Jones, NF; Lieberman, JR; Tsingotjidou, AS; Vögelin M D, E | 1 |
| Bessho, K; Clarke, NM; Howdle, SM; Okubo, Y; Oreffo, RO; Partridge, K; Sebald, W; Shakesheff, KM; Yang, X | 1 |
| Enomoto, S; Miki, T; Mori, M; Nagao, H; Oda, M; Tachikawa, N; Takahashi, K | 1 |
| Bae, EY; Cho, CS; Hwang, SY; Kim, HY; Kim, J; Kim, SH; Kim, WU; Lee, WK; Min, SY; Park, JS; Park, SH; Ryoo, JW; Youn, J | 1 |
| Baba, Y; Kawamoto, T; Kitamura, A; Kuroda, T; Motohashi, N; Suzuki, S; Takahashi, K | 1 |
| Baba, Y; Kawamoto, T; Kitamura, A; Kuroda, T; Motohashi, N; Suzuki, S | 1 |
| Pohjonen, T; Puolakkainen, P; Rautavuori, J; Rokkanen, P; Tieline, L; Törmälä, P | 1 |
| Alam, M; Asahina, I; Enomoto, S; Marukawa, E; Oda, M; Seto, I | 1 |
| Bessho, K; Clarke, NM; Howard, D; Howdle, SM; Okubo, Y; Oreffo, RO; Partridge, K; Shakesheff, KM; Yang, X | 1 |
| Asahina, I; Enomoto, S; Hoshino, S; Marukawa, E; Mori, M; Seto, I; Tachikawa, N | 1 |
| Brunner, G; Jansen, JA; Maltha, JC; Parker, JA; Von den Hoff, JW; Walboomers, XF | 1 |
| Fujimoto, R; Fukushima, S; Kokubo, S; Miyata, K; Nozaki, K; Takahashi, K; Yokota, S | 1 |
| Besnard, M; Bochot, A; De Rosa, G; Fattal, E; Quaglia, F | 1 |
| Jansen, JA; Maltha, JC; Parker, JA; Von Den Hoff, JW; Walboomers, XF | 1 |
| Marukawa, K; Nakagawa, K; Shimada, M; Takatsuka, S; Takazakura, D; Ueki, K; Yamamoto, E | 1 |
| Attawia, MA; El-Amin, SF; Kofron, MD; Laurencin, CT; Lu, HH | 1 |
| Li, XQ; Li, YB; Liu, J; Qin, TW; Xie, HQ; Yang, ZM; Zhao, JM | 1 |
| Hedberg, EL; Jansen, JA; Mikos, AG; Padron, NT; Ruhe, PQ; Spauwen, PH | 1 |
| Du, JY; Duan, DY; Guo, XD; Liu, Y; Lu, ZJ; Quan, DP; Zheng, QX | 1 |
| Bird, RP; Raju, J | 1 |
| Huang, L; Lee, PY; Li, Z | 1 |
| DeLuca, PP; Fink, BF; Rodgers, JB; Schrier, JA; Vasconez, HC | 1 |
| Luo, E; Wei, S; Zhou, L | 1 |
| Chen, X; Dai, Y; Mao, T | 1 |
| Fukushima, S; Ito, T; Iwai, T; Kokubo, S; Miyata, K; Mochizuki, M; Nozaki, K; Sasaki, N; Takahashi, K; Yokota, S | 1 |
| Chang, J; Klein, MB; Longaker, MT; Pham, HM; Yalamanchi, N | 1 |
| Fukushima, S; Kokubo, S; Miyata, K; Nozaki, K; Saitoh, M; Sasamata, M; Suga, K; Yasuda, S | 1 |
| Ahmed, S; Tsuchiya, T | 1 |
| Inoue, H; Matsushita, N; Miyamoto, S; Nozaki, K; Okada, T; Takaoka, K; Terai, H | 1 |
| Carlsen, B; Huang, W; Ishida, K; Miller, TA; Rudkin, G; Wu, B; Wulur, I; Yamaguchi, DT | 1 |
| Bao, C; Li, S; Liu, L; Tang, W; Tian, W; Xiong, C; Zheng, X | 1 |
| Hasirci, V; Keskin, DS; Korkusuz, F; Korkusuz, P; Tezcaner, A | 1 |
| Cui, F; Hu, Y; Xiong, Z; Yan, Y; Zhang, C; Zhang, S | 1 |
| Brekke, JH; Huang, JI; Jones, NF; Lieberman, JR; Vögelin, E | 1 |
| Kato, H; Kawanami, M; Morita, M; Odajima, T; Takahashi, D | 1 |
| Boerman, OC; Jansen, JA; Mikos, AG; Ruhé, PQ; Russel, FG; Spauwen, PH | 1 |
| Ishii, N; Kawada, S | 1 |
| Gamradt, S; McAllister, DR; Miller, DJ; Puk, CK; Wu, BM | 1 |
| Cheng, X; Lan, J; Wang, J; Wang, Y; Wang, Z | 1 |
| Clark, PA; Guardado, J; Hong, L; Mao, JJ; Moioli, EK | 1 |
| Antoon, M; De Schrijver, E; Eckstein, R; Haager, B; Krex, D; Ringwald, J; Strasser, E; Zimmermann, R | 1 |
| Chen, CH; Hsiue, GH; Liu, HW; Tsai, CL | 1 |
| Buser, D; Cochran, DL; Jones, AA; Schenk, R; Wozney, J | 1 |
| Hartmann, G | 1 |
| Hanada, S; Hara, T; Kinuta, Y; Maruo, Y; Minagi, S; Moriya, K; Shimazu, C | 1 |
| Gu, JJ; Huang, DP; Jing, XB; Qin, QL; Tian, N; Zhao, HY; Zheng, YX | 1 |
| Hu, Y; Li, D; Lü, R; Ma, X; Wang, J; Xiong, Z; Xu, X; Yan, Y | 1 |
| Chan, EC; Chen, JK; Chi, PS; Lin, SS; Liu, SJ; Ueng, SW | 1 |
| Furusawa, K; Hasegawa, H; Kawai, T; Kawakami, T; Kimura, A; Mori, R; Okafuji, N; Shimizu, T; Watanabe, T | 1 |
| Furusawa, K; Hasegawa, H; Kawakami, T; Kimura, A; Kurihara, S; Okafuji, N; Shimizu, T; Watanabe, T | 1 |
| Alam, S; Hase, T; Marukawa, K; Nakagawa, K; Ohara, T; Takazakura, D; Ueki, K | 1 |
| Chang, PC; Chou, HH; Ho, MH; Hou, LT; Liu, BY; Liu, CM; Liu, HC; Wang, DM | 1 |
| Cheng, XR; Lan, J; Shi, B; Wang, ZF; Xia, HB | 1 |
| Fushiki, T; Inoue, K; Iwaki, Y; Matsumura, S; Mizunoya, W; Okabe, Y; Okuno, A; Shibakusa, T; Shibata, K | 1 |
| Jeon, O; Kang, SW; Kim, BS; Putnam, AJ; Song, SJ | 1 |
| Dupont, KM; Guldberg, RE; Kong, HJ; Mooney, DJ; Oest, ME | 1 |
| Gruber, R; Schliephake, H; Schulz, J; Weich, HA | 1 |
| Chen, S; Duan, Z; Guo, X; Yuan, Q; Zheng, Q | 1 |
| Nie, H; Wang, CH | 1 |
| Creemers, LB; Dhert, WJ; Jenner, JM; Saris, DB; van Eijk, F; Willems, WJ | 1 |
| Fu, YC; Nie, H; Soh, BW; Wang, CH | 1 |
| Guo, S; Jin, Y; Liu, P; Nie, X; Shen, N; Wang, Y; Zhang, Y | 1 |
| Ahn, KM; Chung, YI; Jeon, SH; Lee, JH; Lee, SY; Tae, G | 1 |
| Das, S; Elamanchili, P; Haddadi, A; Lavasanifar, A; Samuel, J; Shapiro, J | 1 |
| Bai, J; Fei, Z; Hu, Y; Lu, R; Song, H; Wu, D; Wu, H | 1 |
| Fu, YC; Ho, ML; Nie, H; Wang, CH; Wang, CK | 1 |
| Dullin, C; Frahse, S; Gruber, R; Schliephake, H; Weich, HA | 1 |
| Chung, HM; Eun Ahn, S; Gwak, SJ; Kim, BS; Kim, S; Kim, SS; Lee, SH; Song, JH | 1 |
| Gwak, SJ; Kim, BS; Kim, SS | 1 |
| Ishikawa, O; Negishi, I; Shibusawa, Y; Tabata, Y | 1 |
| Kang, JM; Kang, SW; Kim, BS; La, WG; Park, JH | 1 |
| Barceló, CR; Elsalanty, ME; Gendler, E; Genecov, DG; Opperman, LA; Por, YC; Salyer, KE; Troxel, K | 1 |
| Cui, Y; Hu, Y; Wu, J | 1 |
| Fan, C; Guo, S; Li, X; Ni, W; Wang, J; Zeng, B | 1 |
| Garcia-Godoy, F; Gotlieb, EL; Kuttler, S; Murray, PE; Namerow, KN | 1 |
| Cui, FZ; Hu, YY; Ruan, DK; Zhang, C; Zhang, SM | 1 |
| Classic, KL; Creemers, LB; Dhert, WJ; Hefferan, TE; Kempen, DH; Lu, L; Maran, A; Yaszemski, MJ | 1 |
| Akizuki, T; Hayashi, C; Ishikawa, I; Izumi, Y; Kawakatsu, N; Kikuchi, S; Kinoshita, A; Kokubo, S; Oda, S; Tsuchioka, H | 1 |
| Anchordoquy, TJ; Ehrhart, N; Nicholas, RW; Santoni, BG; Simon Turner, A; Wheeler, DL | 1 |
| Jeon, O; Kim, BS; Kim, JH; Kwon, IK; Lee, SH; Rhie, JW | 1 |
| Chang, T; Li, Q; Mu, X; Xiong, Z; Yu, D | 1 |
| Chung, HM; Park, JS; Park, K; Park, KH; Woo, DG; Yang, HN | 1 |
| Dullin, C; Gruber, R; Schliephake, H; Weich, HA | 1 |
| Chen, F; Cheng, X; Feng, X; Gao, Z; Li, L; Liu, L; Ma, Q; Mao, T; Wu, W; Zhang, J | 1 |
| Chang, JK; Chen, CH; Fu, HH; Fu, YC; Ho, ML; Wang, CK; Wang, GJ | 1 |
| Li, HY; Lin, CT; Yan, JQ | 1 |
| Liang, Y; Tang, P; Wang, Y; Yao, Q; Zhang, L; Zhang, W | 1 |
| Aghaloo, T; Cowan, CM; Freymiller, E; Soo, C; Ting, K; Wu, B; Zhang, X; Zhang, Z | 1 |
| Brown, KV; Guda, T; Guelcher, SA; Li, B; Perrien, DS; Wenke, JC | 1 |
| Basu, J; Bruce, AT; Genheimer, CW; Guthrie, K; Halberstadt, C; Ilagan, R; Jain, D; Jayo, MJ; Knight, T; Ludlow, JW; McCoy, D; Mihalko, K; Payne, R; Rivera, EA; Robbins, N; Sangha, N; Spencer, T; Wagner, BJ | 1 |
| Chen, C; Cui, F; Guo, X; Hong, J; Lan, S; Li, J; Pan, H; Zheng, Q; Zou, Z | 1 |
| Bharti, AC; Kumar, A; Singh, SM; Tyagi, A; Vishvakarma, NK | 1 |
| Bongiovanni, AM; Ledger, WJ; Linhares, IM; Mossop, H; Witkin, SS | 1 |
| Liu, C; Wang, C; Wang, G; Wang, Z; Yao, Y; Zhang, H | 1 |
| Gao, C; Gou, Z; Li, D; Ye, C; Zhu, Y | 1 |
| Chen, SH; Leng, Y; Qin, L; Wang, DP; Wang, XL; Xie, XH; Yao, D; Zhang, G; Zheng, LZ | 1 |
| Igwe, JC; Mikael, PE; Nukavarapu, SP | 1 |
| Anderson, JM; Chen, Z; Hennink, WE; Jansen, JA; Ji, W; Seyednejad, H; van den Beucken, JJ; Yang, F | 1 |
| Fujikawa, T; Fujitani, M; Fushiki, T; Inoue, K; Iwaki, Y; Kitaoka, R; Matsumura, S; Shibakusa, T; Yamada, H | 1 |
| Andò, S; Aquila, S; Balliet, R; Capparelli, C; Guido, C; Howell, A; Lin, Z; Lisanti, MP; Martinez-Outschoorn, U; Pestell, RG; Sotgia, F; Whitaker-Menezes, D | 1 |
| Bonuccelli, G; Carito, V; Caroleo, MC; Cione, E; Howell, A; Lisanti, MP; Martinez-Outschoorn, UE; Pestell, RG; Sotgia, F; Whitaker-Menezes, D | 1 |
| Dahanayake, T; Grant, G; Honnons, S; Hu, JZ; Isern, NG; Jones, C; Kottmann, RM; Kulkarni, AA; Lyda, E; Nathan, SD; Phipps, RP; Salibi, R; Sime, PJ; Smolnycki, KA | 1 |
| Chang, S; Huang, H; Wang, C; Wang, G; Yao, Y | 1 |
| Lara, AR; Thannickal, VJ; Tuder, RM | 1 |
| Khan, HY; Orimo, A | 1 |
| Cao, Y; Fan, Z; Lu, G; Lu, W; Tang, L; Yao, Q; Zhang, M; Zhang, Z | 1 |
| Cooper-White, JJ; Fitzpatrick, J; Little, DG; Mikulec, K; Peacock, L; Ruys, AJ; Schindeler, A; Yu, NY | 1 |
| Binjawadagi, B; Dwivedi, V; Manickam, C; Renukaradhya, GJ | 1 |
| Kottmann, R; Phipps, R; Sime, P | 1 |
| Döring, G; Meyer, KC; Worlitzsch, D | 1 |
| Beazley, KE; Niger, C; Nurminskaya, M | 1 |
| Hara, ES; Hirota, K; Kuboki, T; Nema, K; Oida, Y; Ono, M; Pham, HT; Sebald, W; Sonoyama, W; Sugama, K; Yamamoto, K | 1 |
| Bai, L; Chen, KF; Da, LC; Fan, MR; Gong, M; Li, XQ; Li-Ling, J; Xie, HQ; Yang, ZM | 1 |
| Cho, DW; Kang, SS; Kim, SE; Kim, SW; Kundu, J; Park, JY; Shim, JH | 1 |
| del Rosario, C; Delgado, A; Évora, C; García-Pizarro, E; Pérez-López, J; Reyes, R; Rodríguez-Évora, M; Rodríguez-Rey, JC | 1 |
| Clarke, NA; Gerety, PA; Lim, Y; Nah, HD; Rajapakse, CS; Sherif, RD; Taylor, JA; Wink, JD | 1 |
| Blattner, CN; da Silva, GV; de Oliveira, JR; Dias, FS; Donadio, MV; dos Santos, RS; Gadegast, I; Melo, DA; Nunes, FB; Pedrazza, L; Squizani, ED | 1 |
| Arantes, EC; da Silva Bitencourt, C; de Assis, PA; Faccioli, LH; Gelfuso, GM; Pereira, PA; Ramos, SG; Tefé-Silva, C | 1 |
| Cai, J; Singh, SR; Wei, Y; Yin, F; Yuan, F; Zen, W; Zhou, W | 1 |
| Asara, JM; Karamichos, D; Lyon, D; McKay, TB; Priyadarsini, S; Sarker-Nag, A | 1 |
| Detamore, MS; Sutherland, AJ | 1 |
| Barbieri, D; de Boer, J; Groen, N; Habibovic, P; Kanda, T; Sano, Y; Shimizu, F; Tahmasebi, N; van Blitterswijk, CA; Yuan, H | 1 |
| Bitencourt, Cda S; dos Santos, DF; Faccioli, LH; Gelfuso, GM; Nicolete, R; Pereira, PA | 1 |
| Alhadlaq, A; Alyamani, A; Hassan, AH; Hosny, KM; Murshid, ZA; Naguib, G | 1 |
| Judge, JL; Kottmann, RM; Owens, KM; Phipps, RP; Pollock, SJ; Sime, PJ; Thatcher, TH; Williams, JP; Woeller, CF | 1 |
| Epa, AP; Judge, JL; Kottmann, RM; Owens, KM; Phipps, RP; Sime, PJ; Thatcher, TH; Trawick, E; Wahl, LA | 1 |
| Berkland, CJ; Detamore, MS; Easley, JT; Galbraith, RA; Gupta, V; Key, VH; Mellott, AJ; Mohan, N; Palmer, RH; Sridharan, BP | 1 |
| Aragonês, Á; Boabaid, F; Caon, T; Cruz, AC; Granato, R; Menin, Á; Simões, CM | 1 |
| Carvalho-Cruz, P; Costello, CE; de Paula, IF; de Queiroz, RM; Dias, WB; Donadio, JL; Gondim, KC; Lucena, MC; Marinho-Carvalho, MM; McComb, ME; Oliveira, IA; Sola-Penna, M; Todeschini, AR; Whelan, SA | 1 |
| Chen, C; Cui, W; Feng, Q; Guo, X; Ji, Y; Liu, W; Sun, T; Wang, M | 1 |
| Lin, W; Liu, L; Liu, Q; Liu, X; Liu, Y; Ma, G; Ma, J; Ma, P; Zhu, Y | 1 |
| Dadsetan, M; Kakar, S; Olthof, MG; Parry, JA; Shogren, KL; Van Wijnen, A; Yaszemski, M | 1 |
| Choi, SY; Choy, YB; Han, SM; Heo, CY; Kim, BH; Lee, SH; Park, CG; Park, HJ; Park, M | 1 |
| Caetano, GF; Faccioli, LH; Frade, MAC; Galvão, AF; Leite, MN; Paula-Silva, FWG; Pereira, PAT; Reis, MB | 1 |
| Li, R; Li, Z; Ma, Y; Sun, D; Tang, Y; Zeng, J; Zhang, M | 1 |
| Beelen, RHJ; Ferrantelli, E; Keuning, ED; Paauw, NJ; Talhout, W; Ter Wee, PM; van Ittersum, FJ; Vervloet, MG; Vila Cuenca, M | 1 |
| Gu, C; Guo, X; Hu, Y; Li, A; Liu, S; Tu, CE; Zhang, Y; Zhou, P | 1 |
| Luo, T; Niu, D; Wang, H; Xia, Y; Xie, Z | 1 |
| Cai, X; Cimino, FV; King, B; Pavlova, NN; Schwörer, S; Sizemore, GM; Thompson, CB | 1 |
| Bao, T; Gan, D; Liu, P; Peng, W; Shen, J; Sun, J; Sun, L; Wang, Z; Yin, G; Zhang, WB | 1 |
| Agrawal, A; Agrawal, S; Baca, CF; de Melo Bento, CA; Mohammadi, R; Monteiro, C; Subramanian, V | 1 |
| Chen, Q; Gao, J; Gu, J; Li, X; Liang, Y; Lu, L; Shao, Q; Wang, Q; Wei, S; Xu, X; Zhou, B; Zhou, H; Zhou, J | 1 |
| Chen, ZP; Fang, HH; Li, WD; Wu, L; Xing, ML; Zhang, YT | 1 |
| Chen, L; Fan, M; Gill, PS; Ha, T; Lewis, NH; Li, C; Liu, L; Wang, X; Williams, DL; Yang, K | 1 |
| Deng, J; Huang, SQ; Li, W; Liu, JT; Shi, HQ; Sun, HY; Zeng, JR | 1 |
| Arora, MK; Banerjee, S; Kaithwas, G; Mishra, SS; Rastogi, S; Ravichandiran, V; Roy, S; Singh, L | 1 |
2 review(s) available for lactic acid and transforming growth factor beta
| Article | Year |
|---|---|
Lactic acid in tumor invasion.
Topics: Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Humans; Lactic Acid; Neoplasm Invasiveness; Signal Transduction; Transforming Growth Factor beta | 2021 |
Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment.
Topics: Acidosis; Humans; Hypoxia; Lactic Acid; Neoplasms; Transforming Growth Factor beta; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2023 |
1 trial(s) available for lactic acid and transforming growth factor beta
| Article | Year |
|---|---|
Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine. A comparison of three dosages and two carriers.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Transplantation; Cattle; Collagen; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Humans; Lactic Acid; Lumbar Vertebrae; Polyesters; Polymers; Prospective Studies; Recombinant Proteins; Spinal Fusion; Tomography, X-Ray Computed; Transforming Growth Factor beta; Treatment Outcome | 1999 |
186 other study(ies) available for lactic acid and transforming growth factor beta
| Article | Year |
|---|---|
Probenecid inhibits transforming growth factor-beta 1 induced pyrophosphate elaboration by chondrocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cartilage, Articular; Chondrocalcinosis; Diphosphates; Knee Joint; Lactates; Lactic Acid; Probenecid; Pyrophosphatases; Swine; Transforming Growth Factor beta | 1994 |
Effect of poly DL-lactide--co-glycolide implants and xenogeneic bone matrix-derived growth factors on calvarial bone repair in the rabbit.
Topics: Animals; Biocompatible Materials; Bone and Bones; Bone Matrix; Bone Morphogenetic Proteins; Bone Regeneration; Connective Tissue; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Giant Cells; Growth Substances; Immunoblotting; Immunohistochemistry; Lactic Acid; Macrophages; Major Histocompatibility Complex; Mice; Mice, Inbred BALB C; Molecular Weight; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Prostheses and Implants; Proteins; Rabbits; Skull; Transforming Growth Factor beta | 1994 |
Evaluation of human bone morphogenetic protein 2 in a canine spinal fusion model.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Proteins; Disease Models, Animal; Dogs; Growth Substances; Humans; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Proteins; Recombinant Proteins; Spinal Fusion; Tensile Strength; Transforming Growth Factor beta; Wound Healing | 1994 |
Nitric oxide and energy production in articular chondrocytes.
Topics: Animals; Arginine; Cartilage, Articular; Cells, Cultured; Cytokines; Energy Metabolism; Humans; Interleukin-1; Lactates; Lactic Acid; Nitric Oxide; omega-N-Methylarginine; Penicillamine; Rabbits; Recombinant Proteins; S-Nitroso-N-Acetylpenicillamine; Transforming Growth Factor beta | 1994 |
Controlled release of TGF-beta 1 from a biodegradable matrix for bone regeneration.
Topics: Animals; Biocompatible Materials; Bone and Bones; Bone Matrix; Delayed-Action Preparations; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Regeneration; Transforming Growth Factor beta | 1993 |
Effective doses of recombinant human bone morphogenetic protein-2 in experimental spinal fusion.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cross-Sectional Studies; Dogs; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Lactic Acid; Lumbar Vertebrae; Osteogenesis; Polyesters; Polymers; Recombinant Proteins; Spinal Fusion; Tomography, X-Ray Computed; Transforming Growth Factor beta | 1996 |
Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Drug Delivery Systems; Evaluation Studies as Topic; Humans; Lactic Acid; Male; Microspheres; Osteogenesis; Pectoralis Muscles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Inbred Strains; Recombinant Proteins; Transforming Growth Factor beta | 1996 |
Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs.
Topics: Alveolar Bone Loss; Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Dental Cementum; Dogs; Drug Carriers; Guided Tissue Regeneration, Periodontal; Humans; Lactic Acid; Periodontal Ligament; Periodontitis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Regeneration; Transforming Growth Factor beta | 1997 |
Bone formation with use of rhBMP-2 (recombinant human bone morphogenetic protein-2).
Topics: Animals; Bone and Bones; Bone Development; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Drug Delivery Systems; Humans; Lactic Acid; Polyesters; Polymers; Prostheses and Implants; Rabbits; Recombinant Proteins; Transforming Growth Factor beta | 1997 |
Augmentation of autograft using rhBMP-2 and different carrier media in the canine spinal fusion model.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Transplantation; Cell Differentiation; Collagen; Dogs; Drug Carriers; Ilium; Lactic Acid; Mesoderm; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Spinal Fusion; Surgical Sponges; Transforming Growth Factor beta | 1997 |
Interaction of recombinant human bone morphogenetic protein-2 with poly(d,l lactide-co-glycolide) microspheres.
Topics: Adsorption; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Buffers; Glutamic Acid; Humans; Kinetics; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Transforming Growth Factor beta | 1996 |
The evaluation of lyophilized polymer matrices for administering recombinant human bone morphogenetic protein-2.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Buffers; Carboxymethylcellulose Sodium; Chromatography, High Pressure Liquid; Excipients; Freeze Drying; Humans; Lactic Acid; Methylcellulose; Molecular Weight; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Recombinant Proteins; Transforming Growth Factor beta | 1996 |
Two lyophilized polymer matrix recombinant human bone morphogenetic protein-2 carriers in rabbit calvarial defects.
Topics: Animals; Biocompatible Materials; Bone Development; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Carboxymethylcellulose Sodium; Delayed-Action Preparations; Drug Delivery Systems; Drug Implants; Freeze Drying; Humans; Lactic Acid; Male; Methylcellulose; Pharmaceutic Aids; Pilot Projects; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Random Allocation; Recombinant Proteins; Skull; Time Factors; Transforming Growth Factor beta | 1998 |
Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs.
Topics: Animals; Biocompatible Materials; Bone Density; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Substitutes; Dog Diseases; Dogs; Female; Gelatin; Humans; Lactic Acid; Male; Orthopedic Procedures; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Radiography; Recombinant Proteins; Transforming Growth Factor beta; Ulna Fractures; Wound Healing | 1998 |
Biological response to a synthetic cornea.
Topics: Animals; Cell Division; Cornea; Extracellular Matrix; Fibroblasts; Glycosaminoglycans; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Prostheses and Implants; Rabbits; Transforming Growth Factor beta | 1998 |
Stimulation of fracture healing by local application of humoral factors integrated in biodegradable implants.
Topics: Absorbable Implants; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Plates; Bone Screws; Cattle; Child; Drug Delivery Systems; Finger Injuries; Fracture Fixation, Internal; Fracture Healing; Fractures, Bone; Humans; Insulin-Like Growth Factor I; Lactic Acid; Metacarpus; Osteotomy; Polyesters; Polymers; Skull Fractures; Swine; Swine, Miniature; Transforming Growth Factor beta | 1998 |
Radiomorphometry and biomechanical assessment of recombinant human bone morphogenetic protein 2 and polymer in rabbit radius ostectomy model.
Topics: Animals; Biocompatible Materials; Biomechanical Phenomena; Bone and Bones; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Transplantation; Humans; Lactic Acid; Polyesters; Polymers; Rabbits; Radiography; Radius; Recombinant Proteins; Time Factors; Transforming Growth Factor beta | 1998 |
Transforming growth factor-beta1 is a potent inhibitor of interleukin-1beta action in whole ovarian dispersates.
Topics: Animals; Culture Techniques; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Female; Glucose; Interleukin-1; Lactic Acid; Nitrites; Ovary; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Transforming Growth Factor beta | 1999 |
Glucose metabolic alterations in isolated and perfused rat hepatocytes induced by pancreatic cancer conditioned medium: a low molecular weight factor possibly involved.
Topics: Animals; Biological Factors; Cell Membrane; Cells, Cultured; Culture Media, Conditioned; Cytosol; Diglycerides; Epidermal Growth Factor; Glucose; Humans; Insulin Resistance; Interleukins; Lactic Acid; Liver; Male; Molecular Weight; Pancreatic Neoplasms; Perfusion; Protein Kinase C; Rats; Rats, Wistar; Transforming Growth Factor beta; Tumor Cells, Cultured | 1999 |
Bone marrow and recombinant human bone morphogenetic protein-2 in osseous repair.
Topics: Animals; Biocompatible Materials; Bone Diseases; Bone Marrow Transplantation; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Transplantation; Drug Carriers; Femur; Follow-Up Studies; Humans; Lactic Acid; Male; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Radiography; Rats; Rats, Inbred Lew; Recombinant Proteins; Torque; Transforming Growth Factor beta; Transplantation, Autologous; Transplantation, Isogeneic; Wound Healing | 1999 |
Potential of porous poly-D,L-lactide-co-glycolide particles as a carrier for recombinant human bone morphogenetic protein-2 during osteoinduction in vivo.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Humans; Implants, Experimental; Lactic Acid; Male; Materials Testing; Mice; Mice, Nude; Muscle, Skeletal; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Transforming Growth Factor beta | 1999 |
Bone regeneration produced in rat femur defects by polymer capsules containing recombinant human bone morphogenetic protein-2.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Capsules; Delayed-Action Preparations; Drug Delivery Systems; Femur; Humans; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Wistar; Recombinant Proteins; Transforming Growth Factor beta | 1999 |
The role of recombinant human bone morphogenetic protein-2 in PLGA capsules at an extraskeletal site of the rat.
Topics: Alkaline Phosphatase; Animals; Bone Development; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Capsules; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Histocytochemistry; Humans; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Prostheses and Implants; Rats; Rats, Wistar; Recombinant Proteins; Transforming Growth Factor beta | 1999 |
Bone regeneration by recombinant human bone morphogenetic protein-2 in rat mandibular defects. An experimental model of defect filling.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Coloring Agents; Drug Carriers; Eosine Yellowish-(YS); Fluorescent Dyes; Gelatin; Hematoxylin; Humans; Lactic Acid; Male; Mandible; Mandibular Diseases; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Long-Evans; Recombinant Proteins; Transforming Growth Factor beta | 1999 |
Recombinant human bone morphogenetic protein-2 binding and incorporation in PLGA microsphere delivery systems.
Topics: Adsorption; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Chromatography, Gel; Drug Delivery Systems; Excipients; Freeze Drying; Humans; Kinetics; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porosity; Protein Binding; Recombinant Proteins; Transforming Growth Factor beta | 1999 |
Bone morphogenetic protein but not transforming growth factor-beta enhances bone formation in canine diaphyseal nonunions implanted with a biodegradable composite polymer.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Diaphyses; Dogs; Drug Implants; Drug Therapy, Combination; Fracture Healing; Lactic Acid; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Radiography; Radius Fractures; Transforming Growth Factor beta | 1999 |
Combining transforming growth factor-beta(1) to a bioabsorbable self-reinforced polylactide pin for osteotomy healing: an experimental study on rats.
Topics: Absorbable Implants; Animals; Bone Nails; Caproates; Chi-Square Distribution; Coated Materials, Biocompatible; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Femoral Fractures; Fracture Fixation, Internal; Fracture Healing; Lactic Acid; Lactones; Male; Microradiography; Osteotomy; Polyesters; Polymers; Rats; Rats, Wistar; Statistics, Nonparametric; Transforming Growth Factor beta | 1999 |
Controlled release of transforming growth factor beta1 from biodegradable polymer microparticles.
Topics: Animals; Capsules; Cattle; Drug Delivery Systems; Drug Implants; Humans; Lactic Acid; Microscopy, Electron, Scanning; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Transforming Growth Factor beta | 2000 |
Effects of transforming growth factor beta1 released from biodegradable polymer microparticles on marrow stromal osteoblasts cultured on poly(propylene fumarate) substrates.
Topics: Animals; Biocompatible Materials; Capsules; Cells, Cultured; Drug Delivery Systems; Drug Implants; Fumarates; Humans; Lactic Acid; Osteoblasts; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Polypropylenes; Rats; Transforming Growth Factor beta | 2000 |
Biological activity of rhBMP-2 released from PLGA microspheres.
Topics: Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Remodeling; Cells, Cultured; Drug Carriers; Drug Evaluation, Preclinical; Fetus; Humans; Lactic Acid; Microspheres; Osteoblasts; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Transforming Growth Factor beta | 2000 |
Reconstruction of the primate mandible with a combination graft of recombinant human bone morphogenetic protein-2 and bone marrow.
Topics: Animals; Biocompatible Materials; Bone Marrow Transplantation; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Drug Carriers; Humans; Lactic Acid; Macaca; Mandible; Osteogenesis; Osteotomy; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Radiography; Rats; Recombinant Proteins; Skin; Time Factors; Transforming Growth Factor beta; Transplantation, Autologous; Treatment Outcome | 2001 |
Overexpression of glutamine:fructose-6-phosphate-amidotransferase induces transforming growth factor-beta1 synthesis in NIH-3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Blotting, Western; Cell Division; Enzyme-Linked Immunosorbent Assay; Fibronectins; Fibrosis; Genes, Reporter; Glucose; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Lactic Acid; Mice; Promoter Regions, Genetic; RNA, Messenger; Transcriptional Activation; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta2 | 2001 |
Effect of antisense suppression of transforming growth factor-beta3 gene on lactotropic cell proliferation.
Topics: Animals; Cell Division; Cell Membrane Permeability; Cells, Cultured; Dose-Response Relationship, Drug; Estrogens; Female; Lactic Acid; Oligonucleotides, Antisense; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred F344; Transforming Growth Factor beta; Transforming Growth Factor beta3 | 2001 |
Induction by a lactic acid bacterium of a population of CD4(+) T cells with low proliferative capacity that produce transforming growth factor beta and interleukin-10.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Division; Cells, Cultured; Coculture Techniques; Female; Interferon-gamma; Interleukin-10; Interleukin-12; Interleukin-4; Interleukin-5; Lactic Acid; Lactobacillus; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Spleen; Th1 Cells; Th2 Cells; Transforming Growth Factor beta | 2001 |
A new recombinant human bone morphogenetic protein-2 carrier for bone regeneration.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Drug Carriers; Gelatin; Humans; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porifera; Rats; Rats, Inbred F344; Recombinant Proteins; Transforming Growth Factor beta | 2001 |
Experience with freeze-dried PGLA/HA/rhBMP-2 as a bone graft substitute.
Topics: Absorbable Implants; Analysis of Variance; Animals; Biocompatible Materials; Bone Diseases; Bone Marrow; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Substitutes; Bone Transplantation; Connective Tissue; Durapatite; Follow-Up Studies; Freeze Drying; Humans; Lactic Acid; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Radiography; Rats; Recombinant Proteins; Skull; Statistics as Topic; Transforming Growth Factor beta | 2000 |
Poly(L-lactide)acid/alginate composite membranes for guided tissue regeneration.
Topics: Alginates; Alkaline Phosphatase; Biocompatible Materials; Calorimetry; Cell Adhesion; Guided Tissue Regeneration; Lactic Acid; Membranes, Artificial; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Osteoblasts; Polyesters; Polymers; Streptococcus mutans; Temperature; Transforming Growth Factor beta; X-Ray Diffraction | 2001 |
Modulation of proteoglycan and collagen profiles in human dermal fibroblasts by high density micromass culture and treatment with lactic acid suggests change to a chondrogenic phenotype.
Topics: Aggrecans; Cell Count; Cell Differentiation; Cells, Cultured; Collagen Type I; Collagen Type II; Dermis; Extracellular Matrix Proteins; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Humans; Lactic Acid; Lectins, C-Type; Phenotype; Proteoglycans; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
[Polylactic acid combined with recombinant human bone morphogenetic protein and basic fibroblast growth factor to repair the mandibular defects in rabbits].
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Drug Synergism; Female; Fibroblast Growth Factor 2; Humans; Lactic Acid; Male; Mandible; Polyesters; Polymers; Rabbits; Recombinant Proteins; Time Factors; Transforming Growth Factor beta | 1999 |
Controlled-release of IGF-I and TGF-beta1 in a photopolymerizing hydrogel for cartilage tissue engineering.
Topics: Animals; Cartilage; Cattle; Chondrocytes; Hydrogel, Polyethylene Glycol Dimethacrylate; Insulin-Like Growth Factor I; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Tissue Engineering; Transforming Growth Factor beta | 2001 |
Enhancement of bone growth by sustained delivery of recombinant human bone morphogenetic protein-2 in a polymeric matrix.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Delayed-Action Preparations; Lactic Acid; Male; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Skull; Time Factors; Transforming Growth Factor beta | 2001 |
Prefabrication of bone by use of a vascularized periosteal flap and bone morphogenetic protein.
Topics: Alginates; Animals; Biocompatible Materials; Bone and Bones; Bone Demineralization Technique; Bone Matrix; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Glucuronic Acid; Groin; Hexuronic Acids; Lactic Acid; Male; Microspheres; Osteogenesis; Periosteum; Pilot Projects; Polyesters; Polymers; Radiography; Rats; Rats, Inbred Lew; Recombinant Proteins; Surgical Flaps; Tibia; Transforming Growth Factor beta | 2002 |
Adenoviral BMP-2 gene transfer in mesenchymal stem cells: in vitro and in vivo bone formation on biodegradable polymer scaffolds.
Topics: Absorbable Implants; Adenoviridae; Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Feasibility Studies; Genetic Vectors; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Lactic Acid; Mesoderm; Mice; Mice, Nude; Osteoblasts; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Tissue Engineering; Transduction, Genetic; Transforming Growth Factor beta | 2002 |
Effect of recombinant human bone morphogenetic protein-2 on bone formation in alveolar ridge defects in dogs.
Topics: Absorbable Implants; Alveolar Ridge Augmentation; Animals; Biocompatible Materials; Bone Density; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Dogs; Gelatin; Humans; Lactic Acid; Mandible; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Radiography; Recombinant Proteins; Transforming Growth Factor beta | 2002 |
Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) nanoparticles entrapping type II collagen: a novel treatment strategy for induction of oral tolerance.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmunity; Biocompatible Materials; Cattle; Collagen Type II; Disease Models, Animal; Disease Progression; Gene Expression; In Vitro Techniques; Lactic Acid; Male; Mice; Mice, Inbred DBA; Microscopy, Electron; Particle Size; Peyer's Patches; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; RNA, Messenger; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2002 |
A histological study on experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2 in beagle dogs.
Topics: Absorbable Implants; Alveolar Bone Loss; Alveolar Process; Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Transplantation; Dogs; Female; Humans; Implants, Experimental; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Root Resorption; Tooth Movement Techniques; Transforming Growth Factor beta | 2002 |
Tooth eruption into the newly generated bone induced by recombinant human bone morphogenetic protein-2.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Bone Density; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Dogs; Dose-Response Relationship, Drug; Humans; Implants, Experimental; Incisor; Lactic Acid; Maxilla; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Tooth Eruption; Tooth Eruption, Ectopic; Transforming Growth Factor beta | 2002 |
The effect of transforming growth factor-beta1, released from a bioabsorbable self-reinforced polylactide pin, on a bone defect.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Bone and Bones; Bone Nails; Cellulose; Coated Materials, Biocompatible; Femoral Fractures; Fracture Fixation, Internal; Fracture Healing; Lactic Acid; Male; Polyesters; Polymers; Radiography; Rats; Rats, Wistar; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Functional reconstruction of the non-human primate mandible using recombinant human bone morphogenetic protein-2.
Topics: Absorbable Implants; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Plates; Bone Regeneration; Dental Implants; Dental Prosthesis, Implant-Supported; Dental Stress Analysis; Implants, Experimental; Lactic Acid; Macaca mulatta; Male; Mandible; Mandibular Prosthesis; Mastication; Oral Surgical Procedures, Preprosthetic; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Transforming Growth Factor beta | 2002 |
Immunoselection and adenoviral genetic modulation of human osteoprogenitors: in vivo bone formation on PLA scaffold.
Topics: Absorbable Implants; Adenoviridae; Aged; Alkaline Phosphatase; Animals; Antibodies, Monoclonal; Bone Marrow Cells; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Female; Genetic Vectors; Humans; Immunomagnetic Separation; Lactic Acid; Male; Mice; Mice, Nude; Osteoblasts; Osteogenesis; Polyesters; Polymers; Stem Cells; Transduction, Genetic; Transforming Growth Factor beta | 2002 |
Restoration of occlusal function using osseointegrated implants in the canine mandible reconstructed by rhBMP-2.
Topics: Analysis of Variance; Animals; Bite Force; Bone Density; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Remodeling; Dental Implantation, Endosseous; Dental Implants; Dental Occlusion; Dental Prosthesis, Implant-Supported; Denture, Partial; Dogs; Drug Carriers; Gelatin Sponge, Absorbable; Humans; Lactic Acid; Male; Mandible; Mandibular Diseases; Osseointegration; Osteogenesis; Osteotomy; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Time Factors; Transforming Growth Factor beta | 2002 |
Release of bioactive transforming growth factor beta(3) from microtextured polymer surfaces in vitro and in vivo.
Topics: Animals; Biocompatible Materials; Epithelium; In Vitro Techniques; Kinetics; Lactic Acid; Lung; Mink; Polyesters; Polymers; Silicones; Transforming Growth Factor beta; Transforming Growth Factor beta3 | 2002 |
Bone regeneration by recombinant human bone morphogenetic protein-2 and a novel biodegradable carrier in a rabbit ulnar defect model.
Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Gelatin; Humans; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Recombinant Proteins; Transforming Growth Factor beta; Ulna | 2003 |
A new delivery system for antisense therapy: PLGA microspheres encapsulating oligonucleotide/polyethyleneimine solid complexes.
Topics: Antibodies; Biocompatible Materials; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Delivery Systems; In Vitro Techniques; Lactic Acid; Microscopy, Confocal; Microscopy, Electron, Scanning; Microspheres; Nitrogen; Oligonucleotides, Antisense; Particle Size; Phosphates; Polyethyleneimine; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Surface-Active Agents; Time Factors; Transforming Growth Factor beta | 2003 |
Soft tissue reaction to microgrooved poly-L-lactic acid implants loaded with transforming growth factor beta(3).
Topics: Actins; Animals; Collagen; Lactic Acid; Macrophages; Male; Polyesters; Polymers; Prostheses and Implants; Rats; Rats, Wistar; Transforming Growth Factor beta; Transforming Growth Factor beta3; Wound Healing | 2003 |
The use of polylactic acid/polyglycolic acid copolymer and gelatin sponge complex containing human recombinant bone morphogenetic protein-2 following condylectomy in rabbits.
Topics: Animals; Biocompatible Materials; Bone Marrow; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Cartilage; Cartilage, Articular; Chondrocytes; Drug Carriers; Fibroblasts; Gelatin Sponge, Absorbable; Humans; Lactic Acid; Male; Mandibular Condyle; Osteoblasts; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Recombinant Proteins; Statistics, Nonparametric; Temporomandibular Joint; Time Factors; Transforming Growth Factor beta | 2003 |
In vitro bone formation using muscle-derived cells: a new paradigm for bone tissue engineering using polymer-bone morphogenetic protein matrices.
Topics: Absorbable Implants; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Calcification, Physiologic; Cell Adhesion; Cell Differentiation; Cell Division; Lactic Acid; Muscle, Skeletal; Osteoblasts; Osteogenesis; Phenotype; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Tissue Engineering; Transforming Growth Factor beta | 2003 |
[Ectopic osteogenesis of tissue engineered bone with slow-released bioactive factors].
Topics: Animals; Bone Morphogenetic Proteins; Bone Substitutes; Child; Drug Synergism; Female; Humans; Lactic Acid; Osteogenesis; Polyesters; Polymers; Rabbits; Recombinant Proteins; Swine; Tissue Engineering; Transforming Growth Factor beta | 2003 |
rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium-phosphate cement composites.
Topics: Bone Cements; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcium Phosphates; Drug Carriers; Glycolates; Humans; Injections; Lactic Acid; Microscopy, Electron, Scanning; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Recombinant Proteins; Transforming Growth Factor beta | 2003 |
[Neocartilage formation in vitro using transduced mesenchymal stem cells cultured on biomimetic biodegradable polymer scaffolds].
Topics: Animals; Biocompatible Materials; Cell Adhesion; Cell Culture Techniques; Cell Differentiation; Cell Division; Lactic Acid; Mesoderm; Polymers; Rabbits; Stem Cells; Tissue Engineering; Transfection; Transforming Growth Factor beta | 2001 |
Energy restriction reduces the number of advanced aberrant crypt foci and attenuates the expression of colonic transforming growth factor beta and cyclooxygenase isoforms in Zucker obese (fa/fa) rats.
Topics: Animals; Azoxymethane; Blood Glucose; Body Weight; Caloric Restriction; Carcinogens; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Eating; Female; Insulin; Isoenzymes; Lactic Acid; Membrane Proteins; Obesity; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Zucker; RNA, Messenger; Transforming Growth Factor beta; Triglycerides | 2003 |
Thermosensitive hydrogel as a Tgf-beta1 gene delivery vehicle enhances diabetic wound healing.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cell Division; Diabetes Complications; Diabetes Mellitus; DNA; Female; Gene Transfer Techniques; Hot Temperature; Humans; Hydrogels; Insulin; Lactic Acid; Mice; Mice, Inbred C57BL; Mice, Obese; Pharmaceutical Vehicles; Plasmids; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Skin; Transforming Growth Factor beta; Wound Healing | 2003 |
Porous bone morphogenetic protein-2 microspheres: polymer binding and in vitro release.
Topics: Adsorption; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Drug Carriers; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Transforming Growth Factor beta | 2001 |
Effect of a freeze-dried CMC/PLGA microsphere matrix of rhBMP-2 on bone healing.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Carboxymethylcellulose Sodium; Drug Carriers; Drug Implants; Freeze Drying; Humans; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Recombinant Proteins; Transforming Growth Factor beta | 2001 |
[The experimental study of PDLLA/rhBMP-2 compound screws for internal fixation of mandibular fracture].
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Screws; Dogs; Fracture Fixation, Internal; Fracture Healing; Lactic Acid; Male; Mandibular Fractures; Polyesters; Polymers; Recombinant Proteins; Transforming Growth Factor beta | 2003 |
[Experimental study of artificial bone composite of bicoral, rhBMP-2 and PLA in repairing calvarial defects].
Topics: Animals; Anthozoa; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Implants, Experimental; Lactic Acid; Polyesters; Polymers; Rabbits; Recombinant Proteins; Skull; Transforming Growth Factor beta | 2003 |
Long-term stability of bone tissues induced by an osteoinductive biomaterial, recombinant human bone morphogenetic protein-2 and a biodegradable carrier.
Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Transplantation; Dogs; Drug Carriers; Follow-Up Studies; Fracture Healing; Lactic Acid; Male; Materials Testing; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Tensile Strength; Tibial Fractures; Transforming Growth Factor beta | 2004 |
Flexor tendon wound healing in vitro: lactate up-regulation of TGF-beta expression and functional activity.
Topics: Animals; Biological Assay; Cell Line; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Forelimb; Lactic Acid; Male; Rabbits; Receptors, Transforming Growth Factor beta; Tendon Injuries; Tendons; Transforming Growth Factor beta; Up-Regulation; Wound Healing | 2004 |
Synergism between interleukin-11 and bone morphogenetic protein-2 in the healing of segmental bone defects in a rabbit model.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Drug Carriers; Drug Synergism; Fracture Healing; Humans; Interleukin-11; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Radiography; Recombinant Proteins; Transforming Growth Factor beta; Ulna | 2004 |
Novel mechanism of tumorigenesis: increased transforming growth factor-beta 1 suppresses the expression of connexin 43 in BALB/cJ mice after implantation of poly-L-lactic acid.
Topics: Animals; Base Sequence; Biocompatible Materials; Cell Communication; Connexin 43; Female; Gap Junctions; Gene Expression; Lactic Acid; Materials Testing; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Polyesters; Polymers; RNA, Messenger; Species Specificity; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
A new bone-inducing biodegradable porous beta-tricalcium phosphate.
Topics: Absorbable Implants; Acid Phosphatase; Animals; Bone and Bones; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Calcium Phosphates; Coated Materials, Biocompatible; Dioxanes; Drug Delivery Systems; Humans; Isoenzymes; Lactic Acid; Male; Mice; Mice, Inbred Strains; Microscopy, Electron, Scanning; Polyesters; Polyethylene Glycols; Polymers; Radiography; Recombinant Proteins; Surface Properties; Tartrate-Resistant Acid Phosphatase; Time Factors; Transforming Growth Factor beta | 2004 |
BMP-2 exerts differential effects on differentiation of rabbit bone marrow stromal cells grown in two-dimensional and three-dimensional systems and is required for in vitro bone formation in a PLGA scaffold.
Topics: Animals; Bone and Bones; Bone Development; Bone Marrow; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Collagen Type I; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Stromal Cells; Tissue Engineering; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2004 |
[Experimental study on the fabrication of bioactive membrane for inducing bone regeneration].
Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Collagen; Guided Tissue Regeneration; Lactic Acid; Male; Membranes, Artificial; Polyesters; Polymers; Rabbits; Transforming Growth Factor beta | 2004 |
Collagen-chondroitin sulfate-based PLLA-SAIB-coated rhBMP-2 delivery system for bone repair.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Chondroitin Sulfates; Coated Materials, Biocompatible; Collagen Type I; Delayed-Action Preparations; Diffusion; Elasticity; Femoral Fractures; Fracture Healing; Hardness; Lactic Acid; Male; Materials Testing; Polyesters; Polymers; Rats; Rats, Sprague-Dawley; Sucrose; Tensile Strength; Transforming Growth Factor beta; Treatment Outcome | 2005 |
[Tissue engineered bone regeneration of periosteal cells using recombinant human bone morphogenetic protein 2 induce].
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Cells, Cultured; Collagen; Durapatite; Humans; Lactic Acid; Mice; Mice, Nude; Periosteum; Polymers; Rabbits; Recombinant Proteins; Tissue Engineering; Transforming Growth Factor beta | 2005 |
Healing of a critical-sized defect in the rat femur with use of a vascularized periosteal flap, a biodegradable matrix, and bone morphogenetic protein.
Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Disease Models, Animal; Hyaluronic Acid; Lactic Acid; Male; Models, Animal; Osteogenesis; Periosteum; Polyesters; Polymers; Prostheses and Implants; Rats; Rats, Inbred Lew; Surgical Flaps; Tissue Engineering; Transforming Growth Factor beta; Wound Healing | 2005 |
Formation and resolution of ankylosis under application of recombinant human bone morphogenetic protein-2 (rhBMP-2) to class III furcation defects in cats.
Topics: Absorbable Implants; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Cats; Dental Cementum; Drug Carriers; Furcation Defects; Gelatin; Humans; Implants, Experimental; Lactic Acid; Male; Osteoclasts; Periodontal Ligament; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Regeneration; Tooth Ankylosis; Transforming Growth Factor beta | 2005 |
Controlled release of rhBMP-2 loaded poly(dl-lactic-co-glycolic acid)/calcium phosphate cement composites in vivo.
Topics: Adsorption; Animals; Biocompatible Materials; Bone Cements; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcium Phosphates; Delayed-Action Preparations; Drug Carriers; Glycolates; Lactic Acid; Male; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Transforming Growth Factor beta | 2005 |
Skeletal muscle hypertrophy after chronic restriction of venous blood flow in rats.
Topics: Animals; Base Sequence; Constriction, Pathologic; DNA Primers; Glycogen; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Hypertrophy; Japan; Lactic Acid; Male; Muscle, Skeletal; Myostatin; Nitric Oxide Synthase; Rats; Rats, Wistar; Transforming Growth Factor beta | 2005 |
The effects of short-term stimulation on fibroblast spreading in an in vitro 3D system.
Topics: Animals; Bioreactors; Cell Movement; Embryo, Mammalian; Fibroblasts; Lactic Acid; Mice; Microscopy, Electron, Scanning; Models, Biological; Polyesters; Polymers; Transforming Growth Factor beta | 2006 |
The effect of combination of recombinant human bone morphogenetic protein-2 and basic fibroblast growth factor or insulin-like growth factor-I on dental implant osseointegration by confocal laser scanning microscopy.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Coated Materials, Biocompatible; Dental Implantation, Endosseous; Dental Implants; Drug Combinations; Drug Synergism; Femur; Fibroblast Growth Factor 2; Humans; Implants, Experimental; Insulin-Like Growth Factor I; Lactic Acid; Male; Microscopy, Confocal; Osseointegration; Polyesters; Polymers; Rabbits; Recombinant Proteins; Statistics, Nonparametric; Transforming Growth Factor beta | 2006 |
Sustained release of TGFbeta3 from PLGA microspheres and its effect on early osteogenic differentiation of human mesenchymal stem cells.
Topics: Alkaline Phosphatase; Cell Differentiation; Cells, Cultured; Delayed-Action Preparations; Humans; Kinetics; Lactic Acid; Mesenchymal Stem Cells; Microscopy, Electron, Scanning; Microspheres; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Tissue Engineering; Transforming Growth Factor beta; Transforming Growth Factor beta3 | 2006 |
Impact of different hold time before addition of platelet additive solution on the in vitro quality of apheresis platelets.
Topics: Blood Platelets; Blood Preservation; Glucose; Humans; Hydrogen-Ion Concentration; Lactic Acid; Osmotic Pressure; P-Selectin; Plateletpheresis; Solutions; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation.
Topics: Alkaline Phosphatase; Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Collagen; Drug Delivery Systems; Enzyme Activation; Immunohistochemistry; Implants, Experimental; Lactic Acid; Microscopy, Electron, Scanning; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porosity; Rabbits; Recombinant Proteins; Transforming Growth Factor beta | 2006 |
The effect of rhBMP-2 around endosseous implants with and without membranes in the canine model.
Topics: Absorbable Implants; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Collagen; Dental Implantation, Endosseous; Dental Implants; Dogs; Drug Carriers; Guided Tissue Regeneration, Periodontal; Humans; Implants, Experimental; Lactic Acid; Male; Membranes, Artificial; Models, Animal; Osseointegration; Periodontitis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Polytetrafluoroethylene; Recombinant Proteins; Statistics, Nonparametric; Transforming Growth Factor beta | 2006 |
TIDES 2006--IBC conference. Oligonucleotide and peptide technology and product development. 1-3 May 2006, Carlsbad, CA, USA.
Topics: Antiviral Agents; California; Drug Delivery Systems; Drug Design; Humans; Lactic Acid; Liposomes; Microspheres; Oligonucleotides; Peptides; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Retinal Diseases; RNA, Small Interfering; Toll-Like Receptor 9; Transforming Growth Factor beta; Transforming Growth Factor beta2 | 2006 |
Enhanced vertical alveolar bone augmentation by recombinant human bone morphogenetic protein-2 with a carrier in rats.
Topics: Alveolar Process; Alveolar Ridge Augmentation; Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Gelatin Sponge, Absorbable; Jaw, Edentulous; Lactic Acid; Male; Microscopy, Electron; Osteoblasts; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Wistar; Recombinant Proteins; Transforming Growth Factor beta | 2006 |
[Reconstruction of orbital floor defect with polylacticglycolide acid/recombinant human bone morphogenetic protein 2 compound implanted material in sheep].
Topics: Absorbable Implants; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Substitutes; Female; Lactic Acid; Orbit; Orbital Fractures; Plastic Surgery Procedures; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Sheep; Transforming Growth Factor beta | 2006 |
[The experimental study of biomimetic artificial cartilage fabrication in vitro and ectopic chondrogenesis in vivo].
Topics: Animals; Biocompatible Materials; Bone Marrow Cells; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Chondrogenesis; Guided Tissue Regeneration; Humans; Implants, Experimental; Lactic Acid; Male; Mice; Mice, Nude; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Stromal Cells; Tissue Engineering; Transfection; Transforming Growth Factor beta | 2006 |
Novel solvent-free fabrication of biodegradable poly-lactic-glycolic acid (PLGA) capsules for antibiotics and rhBMP-2 delivery.
Topics: Animals; Anti-Bacterial Agents; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Capsules; Delayed-Action Preparations; Enzyme-Linked Immunosorbent Assay; Glycolates; Humans; Lactic Acid; Microbial Sensitivity Tests; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Recombinant Proteins; Staphylococcus aureus; Technology, Pharmaceutical; Transforming Growth Factor beta; Vancomycin | 2007 |
Bone repair of rabbit mandibular transsection using rhBMP-2 and atelocollagen gel.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Collagen; Drug Carriers; Gels; Humans; Lactic Acid; Mandible; Models, Biological; Osteogenesis; Polyesters; Polyglycolic Acid; Polymers; Rabbits; Recombinant Proteins; Time Factors; Titanium; Transforming Growth Factor beta; Treatment Outcome | 2006 |
Tissue reaction to poly (lactic-co-glycolic acid) copolymer membrane in rhBMP used rabbit experimental mandibular reconstruction.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Substitutes; Drug Delivery Systems; Gels; Implants, Experimental; Lactic Acid; Male; Mandible; Membranes, Artificial; Plastic Surgery Procedures; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Recombinant Proteins; Tissue Engineering; Transforming Growth Factor beta | 2006 |
Expression of bone morphogenetic protein 2 and fibroblast growth factor 2 during bone regeneration using different implant materials as an onlay bone graft in rabbit mandibles.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Bone Transplantation; Calcium Phosphates; Fibroblast Growth Factor 2; Lactic Acid; Male; Mandible; Models, Animal; Polyesters; Polymers; Rabbits; Radius; Recombinant Proteins; Transforming Growth Factor beta | 2007 |
Bone tissue engineering with novel rhBMP2-PLLA composite scaffolds.
Topics: Animals; Biocompatible Materials; Bone and Bones; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcification, Physiologic; Collagen; Connective Tissue Cells; Gene Expression Regulation; Integrin-Binding Sialoprotein; Lactic Acid; Muscles; Osteogenesis; Osteopontin; Polyesters; Polymers; Rats; Rats, Wistar; Recombinant Proteins; Sialoglycoproteins; Tissue Engineering; Transforming Growth Factor beta | 2007 |
The influence of recombinant human BMP-2 on bone-implant osseointegration: biomechanical testing and histomorphometric analysis.
Topics: Animals; Anthraquinones; Biomechanical Phenomena; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Coated Materials, Biocompatible; Femur; Fluoresceins; Fluorescent Dyes; Humans; Implants, Experimental; Lactic Acid; Male; Microscopy, Confocal; Microscopy, Electron, Scanning; Osseointegration; Polyesters; Polymers; Rabbits; Random Allocation; Recombinant Proteins; Stress, Mechanical; Surface Properties; Time Factors; Titanium; Transforming Growth Factor beta; Wound Healing | 2007 |
Transforming growth factor-beta in the brain is activated by exercise and increases mobilization of fat-related energy substrates in rats.
Topics: Adipose Tissue; Animals; Brain; Catecholamines; Energy Metabolism; Fatty Acids, Nonesterified; Glucose; Ketone Bodies; Lactic Acid; Male; Motor Activity; Rats; Rats, Wistar; Time Factors; Transforming Growth Factor beta | 2007 |
Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(L-lactic-co-glycolic acid) scaffold.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcium; CHO Cells; Cricetinae; Cricetulus; Female; Heparin; Humans; Hydrolysis; Kinetics; Lactic Acid; Muscle, Skeletal; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porosity; Prostheses and Implants; Rats; Rats, Wistar; Tissue Engineering; Transforming Growth Factor beta | 2007 |
Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Compressive Strength; Female; Femur; Lactic Acid; Osteogenesis; Osteotomy; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Tissue Engineering; Tomography, X-Ray Computed; Transforming Growth Factor beta; Transforming Growth Factor beta3 | 2007 |
In vitro characterization of a slow release system of polylactic acid and rhBMP2.
Topics: Absorbable Implants; Alkaline Phosphatase; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Line; Delayed-Action Preparations; Enzyme Induction; Gases; Humans; Hydrogen-Ion Concentration; Intercellular Signaling Peptides and Proteins; Lactic Acid; Mice; Microscopy, Electron, Scanning; Polyesters; Polymers; Recombinant Proteins; Transforming Growth Factor beta | 2007 |
Experimental research on ectopic osteogenesis of BMP2-derived peptide P24 combined with PLGA copolymers.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Guided Tissue Regeneration; Implants, Experimental; Lactic Acid; Osteogenesis; Peptides; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Random Allocation; Rats; Rats, Wistar; Tissue Engineering; Transforming Growth Factor beta | 2007 |
Fabrication and characterization of PLGA/HAp composite scaffolds for delivery of BMP-2 plasmid DNA.
Topics: Biocompatible Materials; Bone Marrow Cells; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Cell Adhesion; Cell Survival; Cells, Cultured; Chitosan; DNA; Durapatite; Humans; Lactic Acid; Nanostructures; Nucleic Acid Conformation; Plasmids; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solubility; Stem Cells; Surface Properties; Time Factors; Tissue Engineering; Transfection; Transforming Growth Factor beta | 2007 |
Effect of transforming growth factor-beta and growth differentiation factor-5 on proliferation and matrix production by human bone marrow stromal cells cultured on braided poly lactic-co-glycolic acid scaffolds for ligament tissue engineering.
Topics: Bone Marrow Cells; Bone Morphogenetic Proteins; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Extracellular Matrix; Growth Differentiation Factor 5; Humans; Lactic Acid; Ligaments; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Stromal Cells; Tissue Engineering; Transforming Growth Factor beta | 2007 |
Three-dimensional fibrous PLGA/HAp composite scaffold for BMP-2 delivery.
Topics: Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Adhesion; Cells, Cultured; Drug Carriers; Durapatite; Humans; Lactic Acid; Materials Testing; Mesenchymal Stem Cells; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Transforming Growth Factor beta | 2008 |
[Tissue engineering peripheral nerve with TGF-beta repair sciatic nerve defect].
Topics: Animals; Cell Proliferation; Cells, Cultured; Culture Media; Female; Guided Tissue Regeneration; Lactic Acid; Nerve Growth Factor; Nerve Regeneration; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Tissue Engineering; Transforming Growth Factor beta | 2007 |
Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex.
Topics: Alkaline Phosphatase; Animals; Bone Density; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Calcium; Delayed-Action Preparations; Fibrin; Heparin; Hydrogels; Immunohistochemistry; Lactic Acid; Nanoparticles; Osteocalcin; Particle Size; Phosphates; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Skull; Transforming Growth Factor beta | 2007 |
Delivery of rapamycin by PLGA nanoparticles enhances its suppressive activity on dendritic cells.
Topics: Animals; CD40 Antigens; Cell Survival; Dendritic Cells; Immunosuppressive Agents; Interleukin-10; Interleukin-12; Lactic Acid; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; T-Lymphocytes; Transforming Growth Factor beta | 2008 |
Preparation and property of a novel bone graft composite consisting of rhBMP-2 loaded PLGA microspheres and calcium phosphate cement.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Substitutes; Calcium Phosphates; Cells, Cultured; Compressive Strength; Drug-Eluting Stents; Femur; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Recombinant Proteins; Resin Cements; Transforming Growth Factor beta; X-Ray Diffraction | 2008 |
Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Delayed-Action Preparations; Drug Carriers; Durapatite; Lactic Acid; Mice; Mice, Nude; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Tibial Fractures; Transforming Growth Factor beta; Treatment Outcome | 2008 |
Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid--an experimental study in rats.
Topics: Animals; Bone and Bones; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Drug Carriers; Humans; Implants, Experimental; Lactic Acid; Male; Mandible; Polyesters; Polymers; Rats; Rats, Wistar; Recombinant Proteins; Tomography Scanners, X-Ray Computed; Transforming Growth Factor beta | 2008 |
In vivo bone formation from human embryonic stem cell-derived osteogenic cells in poly(d,l-lactic-co-glycolic acid)/hydroxyapatite composite scaffolds.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Calcification, Physiologic; Cell Differentiation; Cell Line; Cells, Cultured; Coculture Techniques; Collagen Type I; Durapatite; Embryonic Stem Cells; Female; Gene Expression; Glycolates; Humans; Integrin-Binding Sialoprotein; Lactic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Osteoblasts; Osteocalcin; Osteopontin; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sialoglycoproteins; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta | 2008 |
Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite particulates and bone morphogenetic protein-2.
Topics: Animals; Body Fluids; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcification, Physiologic; Coated Materials, Biocompatible; Drug Carriers; Drug Implants; Durapatite; Fibrin; Gels; Lactic Acid; Male; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Radiography; Rats; Rats, Sprague-Dawley; Skull; Transforming Growth Factor beta | 2008 |
Mouse model of dermal fibrosis induced by one-time injection of bleomycin-poly(L-lactic acid) microspheres.
Topics: Animals; Bleomycin; Chemokine CCL2; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Connective Tissue Growth Factor; Delayed-Action Preparations; Disease Models, Animal; Female; Fibrosis; Gene Expression; Immediate-Early Proteins; Injections, Subcutaneous; Intercellular Signaling Peptides and Proteins; Lactic Acid; Mice; Mice, Inbred C3H; Microspheres; Polymerase Chain Reaction; RNA, Messenger; Scleroderma, Systemic; Skin; Transforming Growth Factor beta | 2008 |
Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells.
Topics: Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Cell Differentiation; Cells, Cultured; Fibrinolytic Agents; Heparin; Humans; Lactic Acid; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Middle Aged; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Transforming Growth Factor beta | 2008 |
Bone generation in the reconstruction of a critical size calvarial defect in an experimental model.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Bone Diseases; Bone Matrix; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Plates; Bone Regeneration; Chromium Alloys; Coloring Agents; Cranial Sutures; Disease Models, Animal; Dogs; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Lactic Acid; Male; Osteogenesis; Plastic Surgery Procedures; Platelet-Rich Plasma; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Recombinant Proteins; Skull; Tomography, X-Ray Computed; Transforming Growth Factor beta | 2008 |
[The comparative study on the reparative effect of PLGA and collagen sponge combined with BMP on the articular cartilage defect of rabbits].
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cartilage, Articular; Chondrogenesis; Collagen; Female; Knee Joint; Lactic Acid; Male; Polyglycolic Acid; Polymers; Rabbits; Random Allocation; Recombinant Proteins; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta | 2008 |
[Manufacture and biocompatibility study of poly-D,L-lactic acid plate containing rhBMP-2].
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Plates; Female; Fracture Fixation, Internal; Fracture Healing; Lactic Acid; Male; Osteogenesis; Polyesters; Polymers; Rabbits; Recombinant Proteins; Tissue Engineering; Transforming Growth Factor beta; Ulna Fractures | 2008 |
An ultrastructural investigation of tissue-engineered pulp constructs implanted within endodontically treated teeth.
Topics: Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Adhesion; Collagen; Dental Pulp; Dental Pulp Cavity; Dentin; Glycerophosphates; Humans; Lactic Acid; Microscopy, Electron, Scanning; Polyesters; Polymers; Root Canal Preparation; Stem Cell Transplantation; Stem Cells; Time Factors; Tissue Culture Techniques; Tissue Engineering; Tissue Scaffolds; Tooth, Nonvital; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2008 |
A study on a tissue-engineered bone using rhBMP-2 induced periosteal cells with a porous nano-hydroxyapatite/collagen/poly(L-lactic acid) scaffold.
Topics: Animals; Biocompatible Materials; Bone Development; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cells, Cultured; Collagen; Drug Carriers; Durapatite; Lactic Acid; Materials Testing; Mice; Mice, Nude; Nanostructures; Osteogenesis; Periosteum; Polyesters; Polymers; Porosity; Rabbits; Recombinant Proteins; Tissue Engineering; Transforming Growth Factor beta | 2006 |
Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering.
Topics: Animals; Bone and Bones; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Line; Fumarates; Gelatin; Hydrogels; Lactic Acid; Male; Mice; Microspheres; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polypropylenes; Rats; Rats, Sprague-Dawley; Tissue Engineering; Transforming Growth Factor beta | 2008 |
Effect of rhBMP-2 with PLGA/gelatin sponge type (PGS) carrier on alveolar ridge augmentation in dogs.
Topics: Alveolar Ridge Augmentation; Animals; Biocompatible Materials; Biomechanical Phenomena; Bone Density; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Dogs; Drug Carriers; Gelatin; Lactic Acid; Male; Mandible; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Recombinant Proteins; Tomography, X-Ray Computed; Transforming Growth Factor beta; Wound Healing | 2008 |
Gene therapy to enhance allograft incorporation after host tissue irradiation.
Topics: Animals; Bone and Bones; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Transplantation; Drug Carriers; Drug Delivery Systems; Female; Genetic Therapy; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Radiotherapy Dosage; Recombinant Proteins; Sheep; Tibia; Transforming Growth Factor beta; Transplantation, Homologous | 2008 |
In vivo bone formation following transplantation of human adipose-derived stromal cells that are not differentiated osteogenically.
Topics: Adipose Tissue; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcium; Cell Differentiation; Cell Transplantation; CHO Cells; Cricetinae; Cricetulus; Durapatite; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Glycolates; Humans; Kinetics; Lactic Acid; Mice; Mice, Nude; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prosthesis Implantation; Stromal Cells; Tissue Scaffolds; Transforming Growth Factor beta | 2008 |
Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology.
Topics: Animals; Biocompatible Materials; Biomedical Engineering; Bone Diseases; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Calcium Phosphates; Cold Temperature; Disease Models, Animal; Female; Goats; Guided Tissue Regeneration; Humans; Imaging, Three-Dimensional; Lactic Acid; Male; Microscopy, Electron, Scanning; Osteogenesis; Pliability; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Random Allocation; Recombinant Proteins; Skull; Stress, Mechanical; Surface Properties; Time Factors; Tissue Scaffolds; Tomography, X-Ray Computed; Transforming Growth Factor beta | 2008 |
Triple constructs consisting of nanoparticles and microspheres for bone-marrow-derived stromal-cell-delivery microscaffolds.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Dehydroepiandrosterone; Dexamethasone; Heparin; Humans; Lactic Acid; Microspheres; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polylysine; Stromal Cells; Transforming Growth Factor beta | 2008 |
Ectopic bone formation after implantation of a slow release system of polylactic acid and rhBMP-2.
Topics: Absorbable Implants; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Buttocks; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Carriers; Humans; Lactic Acid; Male; Ossification, Heterotopic; Osteogenesis; Polyesters; Polymers; Rats; Rats, Wistar; Recombinant Proteins; Transforming Growth Factor beta | 2009 |
Novel approach to engineer implantable nasal alar cartilage employing marrow precursor cell sheet and biodegradable scaffold.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Bone Marrow Cells; Cell Culture Techniques; Cells, Cultured; Chondrocytes; Chondrogenesis; Lactic Acid; Mesenchymal Stem Cells; Mice; Mice, Nude; Nasal Cartilages; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Regeneration; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta | 2009 |
Controlled-release of rhBMP-2 carriers in the regeneration of osteonecrotic bone.
Topics: Adult; Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Cell Line; Drug Carriers; Humans; Implants, Experimental; Lactic Acid; Materials Testing; Mice; Mice, Inbred BALB C; Microspheres; Osteogenesis; Osteonecrosis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Radiography; Recombinant Proteins; Tibia; Transforming Growth Factor beta; Young Adult | 2009 |
[Heterotopic complex membrane induces bone formation].
Topics: Animals; Bone Morphogenetic Protein 2; Collagen; Glycolates; Lactic Acid; Male; Mice; Osteogenesis; Polyesters; Polyglycolic Acid; Polymers; Recombinant Proteins; Transforming Growth Factor beta | 2009 |
A study of femoral neck fracture repair using a recombinant human bone morphogenetic protein-2 directional release system.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Screws; Dogs; Eosine Yellowish-(YS); Femoral Neck Fractures; Fracture Healing; Glycolates; Hematoxylin; Humans; Kinetics; Lactic Acid; Male; Microscopy, Electron, Scanning; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Radiography; Radionuclide Imaging; Recombinant Proteins; Staining and Labeling; Transforming Growth Factor beta | 2009 |
The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Dose-Response Relationship, Drug; Drug Carriers; Drug Synergism; Humans; Lactic Acid; Male; Nerve Tissue Proteins; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Skull; Transforming Growth Factor beta; X-Ray Microtomography | 2010 |
Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Cattle; Collagen; Femur; Humans; Implants, Experimental; Kinetics; Lactic Acid; Microspheres; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polyurethanes; Rats; Recombinant Proteins; Tissue Scaffolds; Tomography, X-Ray Computed; Transforming Growth Factor beta | 2011 |
Functional evaluation of primary renal cell/biomaterial neo-kidney augment prototypes for renal tissue engineering.
Topics: Animals; Cell Adhesion; Cell Survival; Cells, Cultured; Dogs; Epithelial-Mesenchymal Transition; Gelatin; Gene Expression Profiling; Humans; Hydrogels; Kidney; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Proteome; Rats; Rats, Inbred Lew; Tissue Engineering; Transforming Growth Factor beta | 2011 |
Repair of rat cranial bone defects with nHAC/PLLA and BMP-2-related peptide or rhBMP-2.
Topics: Animals; Bone Diseases; Bone Morphogenetic Protein 2; Bone Regeneration; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Durapatite; Humans; Lactic Acid; Male; Peptides; Polyesters; Polymers; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Skull; Tissue Scaffolds; Tomography, X-Ray Computed; Transforming Growth Factor beta | 2011 |
Anti-neoplastic action of aspirin against a T-cell lymphoma involves an alteration in the tumour microenvironment and regulation of tumour cell survival.
Topics: Administration, Oral; Animals; Apoptosis; Aspirin; Cell Cycle; Cell Death; Cell Survival; Cyclin B1; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucose; Hydrogen-Ion Concentration; Injections, Intralesional; Interferon-gamma; Interleukin-10; Interleukin-4; Interleukin-6; Lactic Acid; Lymphoma, T-Cell; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Transforming Growth Factor beta; Tumor Microenvironment | 2012 |
Influence of lactic acid on endogenous and viral RNA-induced immune mediator production by vaginal epithelial cells.
Topics: Cell Line; Epithelial Cells; Female; Humans; Interleukin-1beta; Interleukin-6; Interleukin-8; Lactic Acid; Poly I-C; RNA, Viral; Secretory Leukocyte Peptidase Inhibitor; Toll-Like Receptor 3; Transforming Growth Factor beta; Vagina | 2011 |
Synergistic enhancement of new bone formation by recombinant human bone morphogenetic protein-2 and osteoprotegerin in trans-sutural distraction osteogenesis: a pilot study in dogs.
Topics: Alkaline Phosphatase; Animals; Bone Density; Bone Morphogenetic Protein 2; Bone Regeneration; Bone Remodeling; Cell Count; Cranial Sutures; Dogs; Drug Carriers; Drug Synergism; Fibrin Tissue Adhesive; Fibroblasts; Humans; Immunohistochemistry; Lactic Acid; Maxilla; Microscopy, Electron, Transmission; Osteoblasts; Osteocytes; Osteogenesis; Osteogenesis, Distraction; Osteoprotegerin; Palate, Hard; Pilot Projects; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Recombinant Proteins; Time Factors; Transforming Growth Factor beta | 2011 |
Enhancement of osteogenesis by poly(lactide-co-glycolide) sponges loaded with surface-embedded hydroxyapatite particles and rhBMP-2.
Topics: Alkaline Phosphatase; Animals; Bone Marrow Cells; Bone Morphogenetic Protein 2; Collagen; Durapatite; Gene Expression Regulation; Humans; Lactic Acid; Male; Osteocalcin; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Time Factors; Transforming Growth Factor beta; X-Ray Microtomography | 2012 |
Comparative study of osteogenic potential of a composite scaffold incorporating either endogenous bone morphogenetic protein-2 or exogenous phytomolecule icaritin: an in vitro efficacy study.
Topics: Alkaline Phosphatase; Animals; Bone Marrow Cells; Bone Morphogenetic Protein 2; Calcification, Physiologic; Calcium; Calcium Phosphates; Cell Differentiation; Cells, Cultured; Flavonoids; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Kinetics; Lactic Acid; Male; Materials Testing; Microscopy, Electron, Scanning; Molecular Weight; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Rabbits; Recombinant Proteins; Stem Cells; Tissue Scaffolds; Transforming Growth Factor beta | 2012 |
Design, fabrication and in vitro evaluation of a novel polymer-hydrogel hybrid scaffold for bone tissue engineering.
Topics: Animals; Biotinylation; Bone and Bones; Bone Morphogenetic Protein 2; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Gene Expression Profiling; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Lactic Acid; Mechanical Phenomena; Mesenchymal Stem Cells; Mice; Osteoblasts; Osteogenesis; Peptides; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Recombinant Proteins; Staining and Labeling; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta | 2014 |
Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation.
Topics: Animals; Apatites; Biocompatible Materials; Chemokine CXCL1; Cytokines; Exudates and Transudates; Giant Cells, Foreign-Body; Hydrogen-Ion Concentration; Lactic Acid; Macrophages; Male; Materials Testing; Nanofibers; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Tissue Scaffolds; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2012 |
Blood lactate functions as a signal for enhancing fatty acid metabolism during exercise via TGF-β in the brain.
Topics: Animals; Brain; Energy Metabolism; Fatty Acids; Lactic Acid; Male; Physical Exertion; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor beta | 2012 |
Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.
Topics: Animals; Autocrine Communication; Autophagy; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cell Transformation, Neoplastic; Cellular Reprogramming; Coculture Techniques; Female; Fibroblasts; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Immunohistochemistry; Lactic Acid; Ligands; Mice; Mice, Nude; Mitochondria; Neovascularization, Pathologic; Oxidative Phosphorylation; Oxidative Stress; Paracrine Communication; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Stromal Cells; Transforming Growth Factor beta; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2012 |
Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth.
Topics: Actins; Animals; Autophagy; Biomarkers, Tumor; cdc42 GTP-Binding Protein; Cell Cycle Checkpoints; Cell Hypoxia; Cell Movement; Cell Proliferation; Chemotactic Factors; Cytokines; Fibronectins; Glycolysis; Humans; Lactic Acid; Mice; Mitochondria; Models, Biological; Myofibroblasts; Neoplasms; Neovascularization, Pathologic; NF-kappa B; Phenotype; rac1 GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta; Tumor Microenvironment | 2012 |
Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.
Topics: Case-Control Studies; Cell Differentiation; Gene Expression Regulation, Enzymologic; Humans; Hydrogen-Ion Concentration; Hypoxia-Inducible Factor 1, alpha Subunit; Idiopathic Pulmonary Fibrosis; In Vitro Techniques; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Magnetic Resonance Spectroscopy; Myofibroblasts; Transforming Growth Factor beta; Up-Regulation | 2012 |
[The effect of bone morphogenetic protein-2 and osteoprotegerin in trans-sutural distraction osteogenesis].
Topics: Animals; Bone Density; Bone Morphogenetic Protein 2; Dogs; Humans; Lactic Acid; Maxilla; Osteoblasts; Osteogenesis; Osteogenesis, Distraction; Osteoprotegerin; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Recombinant Proteins; Transforming Growth Factor beta | 2012 |
Lactate, a novel trigger of transforming growth factor-β activation in idiopathic pulmonary fibrosis.
Topics: Cell Differentiation; Humans; Idiopathic Pulmonary Fibrosis; Lactic Acid; Myofibroblasts; Transforming Growth Factor beta | 2012 |
Transforming growth factor-β: guardian of catabolic metabolism in carcinoma-associated fibroblasts.
Topics: Animals; Breast Neoplasms; Female; Fibroblasts; Humans; Lactic Acid; Paracrine Communication; Transforming Growth Factor beta | 2012 |
[Experimental study on application recombinant human bone morphogenetic protein 2(rhBMP-2)/poly-lactide-co-glycolic acid (PLGA)/fibrin sealant(FS) on repair of rabbit radial bone defect].
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Bone Substitutes; Female; Fibrin Tissue Adhesive; Lactic Acid; Male; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Radius Fractures; Recombinant Proteins; Transforming Growth Factor beta | 2012 |
Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation.
Topics: Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Morphogenetic Protein 2; Bone Regeneration; Bone Substitutes; Compressive Strength; Diphosphonates; Durapatite; Female; Imidazoles; Implants, Experimental; Lactic Acid; Mice; Mice, Inbred C57BL; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porosity; Radiography; Recombinant Proteins; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta; Zoledronic Acid | 2013 |
PLGA nanoparticle entrapped killed porcine reproductive and respiratory syndrome virus vaccine helps in viral clearance in pigs.
Topics: Administration, Intranasal; Animals; Antibodies, Viral; CD8-Positive T-Lymphocytes; Cytokines; Lactic Acid; Lung; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porcine Reproductive and Respiratory Syndrome; Porcine respiratory and reproductive syndrome virus; Sus scrofa; Swine; Transforming Growth Factor beta; Vaccines, Inactivated; Viral Vaccines | 2013 |
Reply: from idiopathic pulmonary fibrosis to cystic fibrosis: got lactate?
Topics: Cell Differentiation; Humans; Idiopathic Pulmonary Fibrosis; Lactic Acid; Myofibroblasts; Transforming Growth Factor beta | 2013 |
Lactate levels in airways of patients with cystic fibrosis and idiopathic pulmonary fibrosis.
Topics: Cell Differentiation; Humans; Idiopathic Pulmonary Fibrosis; Lactic Acid; Myofibroblasts; Transforming Growth Factor beta | 2013 |
Induction of chondrogenic differentiation in mesenchymal stem cells by TGF-beta cross-linked to collagen-PLLA [poly(L-lactic acid)] scaffold by transglutaminase 2.
Topics: Cell Adhesion; Cell Differentiation; Chondrogenesis; Collagen; GTP-Binding Proteins; Humans; Immobilized Proteins; Lactic Acid; Mesenchymal Stem Cells; Polyesters; Polymers; Protein Glutamine gamma Glutamyltransferase 2; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta; Transglutaminases | 2013 |
Regeneration of calvarial defects with Escherichia coli -derived rhBMP-2 adsorbed in PLGA membrane.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Escherichia coli; Female; Humans; Lactic Acid; Membranes, Artificial; Mice; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Recombinant Proteins; Skull; Transforming Growth Factor beta | 2013 |
Tissue engineered esophagus scaffold constructed with porcine small intestinal submucosa and synthetic polymers.
Topics: 3-Hydroxybutyric Acid; Actins; Animals; Biocompatible Materials; Bone Marrow Cells; Caproates; Cell Survival; Enzyme-Linked Immunosorbent Assay; Esophagus; Inflammation; Intestinal Mucosa; Lactic Acid; Male; Mesenchymal Stem Cells; Microscopy, Electron, Scanning; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Swine; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2014 |
Three-dimensional printing of rhBMP-2-loaded scaffolds with long-term delivery for enhanced bone regeneration in a rabbit diaphyseal defect.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Cattle; Cell Differentiation; Collagen; Diaphyses; Disease Models, Animal; Gelatin; Humans; Imaging, Three-Dimensional; Immunohistochemistry; Lactic Acid; Male; Mesenchymal Stem Cells; Osteogenesis; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Printing, Three-Dimensional; Rabbits; Radius; Recombinant Proteins; Time Factors; Tissue Scaffolds; Transforming Growth Factor beta; X-Ray Microtomography | 2014 |
Smurf1 knocked-down, mesenchymal stem cells and BMP-2 in an electrospun system for bone regeneration.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Electrochemical Techniques; Gene Knockdown Techniques; Humans; Lactic Acid; Male; Membranes, Artificial; Mesenchymal Stem Cells; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Sprague-Dawley; Recombinant Proteins; Tissue Scaffolds; Transforming Growth Factor beta; Ubiquitin-Protein Ligases | 2014 |
Sustained delivery of rhBMP-2 by means of poly(lactic-co-glycolic acid) microspheres: cranial bone regeneration without heterotopic ossification or craniosynostosis.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Craniosynostoses; Drug Delivery Systems; Female; Lactic Acid; Male; Microspheres; Ossification, Heterotopic; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Recombinant Proteins; Skull; Transforming Growth Factor beta | 2014 |
Immediate effects of chest physiotherapy on hemodynamic, metabolic, and oxidative stress parameters in subjects with septic shock.
Topics: Aged; Blood Pressure; Carbon Dioxide; Female; Heart Rate; Humans; Hydrogen-Ion Concentration; Lactic Acid; Male; Middle Aged; Nitric Oxide; Oxygen; Partial Pressure; Physical Therapy Modalities; Respiratory Rate; Shock, Septic; Suction; Thiobarbituric Acid Reactive Substances; Thorax; Time Factors; Transforming Growth Factor beta; Vibration | 2014 |
Hyaluronidase-loaded PLGA microparticles as a new strategy for the treatment of pulmonary fibrosis.
Topics: Animals; Cattle; Cell Count; Cell Line; Collagen; Cytoskeleton; Hyaluronoglucosaminidase; Lactic Acid; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Microspheres; Particle Size; Phagocytes; Pneumonia; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Pulmonary Fibrosis; RNA, Messenger; Solubility; Static Electricity; Transforming Growth Factor beta | 2015 |
Cartilage Regeneration of Adipose-Derived Stem Cells in the TGF-β1-Immobilized PLGA-Gelatin Scaffold.
Topics: Adipose Tissue; Animals; Cartilage, Articular; Cell Differentiation; Gelatin; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Regeneration; Stem Cells; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta | 2015 |
Quercetin attenuates lactate production and extracellular matrix secretion in keratoconus.
Topics: Cells, Cultured; Collagen; Extracellular Matrix; Fibrosis; Humans; Keratoconus; Lactic Acid; Metabolome; Metabolomics; Quercetin; Signal Transduction; Transforming Growth Factor beta | 2015 |
Bioactive Microsphere-Based Scaffolds Containing Decellularized Cartilage.
Topics: Animals; Bone Marrow Cells; Cartilage, Articular; Chondrogenesis; Gene Expression; Lactic Acid; Male; Mesenchymal Stem Cells; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Sus scrofa; Tissue Scaffolds; Transforming Growth Factor beta | 2015 |
Exploring the Material-Induced Transcriptional Landscape of Osteoblasts on Bone Graft Materials.
Topics: Bone Morphogenetic Protein 2; Bone Regeneration; Bone Substitutes; Cell Line, Tumor; Durapatite; Humans; Lactic Acid; Nanostructures; Osteoblasts; Polyesters; Polymers; Principal Component Analysis; Signal Transduction; Tissue Engineering; Tissue Scaffolds; Transcriptome; Transforming Growth Factor beta; Wnt Proteins | 2015 |
Prostaglandin D2-loaded microspheres effectively activate macrophage effector functions.
Topics: Animals; Cell Line; Cells, Cultured; Drug Liberation; Emulsions; Interleukin-1beta; Lactic Acid; Lipopolysaccharides; Macrophages, Alveolar; Mice; Microspheres; NF-kappa B; Nitric Oxide; Particle Size; Phagocytosis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prostaglandin D2; Rats, Wistar; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2015 |
Depot injectable biodegradable nanoparticles loaded with recombinant human bone morphogenetic protein-2: preparation, characterization, and in vivo evaluation.
Topics: Alveolar Bone Loss; Animals; Bone Morphogenetic Protein 2; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Liberation; Humans; Injections; Lactic Acid; Male; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Recombinant Proteins; Transforming Growth Factor beta | 2015 |
Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase.
Topics: Animals; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Gossypol; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Lung; Mice; Mice, Inbred C57BL; Models, Biological; Myofibroblasts; Pulmonary Fibrosis; Radiation Injuries; Transforming Growth Factor beta | 2015 |
Pharmacologic inhibition of lactate production prevents myofibroblast differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Enzyme Inhibitors; Extracellular Matrix; Gene Knockdown Techniques; Gossypol; Humans; L-Lactate Dehydrogenase; Lactic Acid; Lung; Mink; Myofibroblasts; Pulmonary Fibrosis; Tissue Donors; Transforming Growth Factor beta | 2015 |
Microsphere-based gradient implants for osteochondral regeneration: a long-term study in sheep.
Topics: Animals; Bone and Bones; Calcium Phosphates; Cartilage, Articular; Chondrocytes; Chondroitin Sulfates; Female; Femur; Finite Element Analysis; Humans; Hyaline Cartilage; Inflammation; Knee Joint; Lactic Acid; Magnetic Resonance Imaging; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Regeneration; Sheep; Stress, Mechanical; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta | 2015 |
Adipose-Derived Stem Cells Decrease Bone Morphogenetic Protein Type 2-Induced Inflammation In Vivo.
Topics: Absorbable Implants; Adipose Tissue; Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Cell Culture Techniques; Cell Survival; Dogs; Giant Cells; Humans; Inflammation; Lactic Acid; Mesenchymal Stem Cells; Muscle, Skeletal; Neovascularization, Physiologic; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Recombinant Proteins; Time Factors; Tissue Scaffolds; Transforming Growth Factor beta; Young Adult | 2016 |
Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation.
Topics: Adenosine Triphosphate; Biosynthetic Pathways; Cell Line, Tumor; Enzyme Induction; Epithelial-Mesenchymal Transition; Glucose; Glycogen; Glycosylation; Hexosamines; Humans; Lactic Acid; N-Acetylglucosaminyltransferases; Protein Processing, Post-Translational; Pyruvic Acid; Transforming Growth Factor beta | 2016 |
Chitosan/nHAC/PLGA microsphere vehicle for sustained release of rhBMP-2 and its derived synthetic oligopeptide for bone regeneration.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Cell Line; Chitosan; Collagen; Delayed-Action Preparations; Durapatite; Humans; Lactic Acid; Male; Mice; Microspheres; Osteoblasts; Osteogenesis; Peptides; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Skull; Transforming Growth Factor beta | 2017 |
Evaluation of PLGA containing anti-CTLA4 inhibited endometriosis progression by regulating CD4+CD25+Treg cells in peritoneal fluid of mouse endometriosis model.
Topics: Animals; Antibodies; Ascitic Fluid; Cell Culture Techniques; Cell Proliferation; CTLA-4 Antigen; Drug Carriers; Endometriosis; Female; Humans; Interleukin-10; Lactic Acid; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; T-Lymphocytes, Regulatory; Transforming Growth Factor beta | 2017 |
Three-Dimension-Printed Porous Poly(Propylene Fumarate) Scaffolds with Delayed rhBMP-2 Release for Anterior Cruciate Ligament Graft Fixation.
Topics: Animals; Anterior Cruciate Ligament; Bone Morphogenetic Protein 2; Bone Regeneration; Fumarates; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polypropylenes; Rabbits; Recombinant Proteins; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta | 2017 |
Prolonged, acute suppression of cysteinyl leukotriene to reduce capsular contracture around silicone implants.
Topics: Adipose Tissue; Animals; Collagen; Cysteine; Female; Fibroblasts; Implants, Experimental; Inflammation; Lactic Acid; Leukotrienes; Macrophages; Microscopy, Electron, Scanning; Myofibroblasts; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Silicones; Transforming Growth Factor beta | 2017 |
Lipoxin A4 encapsulated in PLGA microparticles accelerates wound healing of skin ulcers.
Topics: Animals; Cytokines; Interleukin-1beta; Interleukin-6; Lactic Acid; Lipoxins; Male; Neutrophils; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Skin Ulcer; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Wound Healing | 2017 |
RhBMP-2-loaded Poly(lactic-co-glycolic acid) microspheres fabricated by coaxial electrospraying for protein delivery.
Topics: Bone Morphogenetic Protein 2; Cell Proliferation; Drug Carriers; Drug Liberation; Electricity; Humans; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Recombinant Proteins; Serum Albumin, Bovine; Transforming Growth Factor beta | 2017 |
Differences in peritoneal response after exposure to low-GDP bicarbonate/lactate-buffered dialysis solution compared to conventional dialysis solution in a uremic mouse model.
Topics: Actins; Animals; Bicarbonates; Buffers; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Chemokine CCL4; Collagen; Dialysis Solutions; Disease Models, Animal; Female; Interferon-gamma; Interleukin-17; Lactic Acid; Macrophages; Macrophages, Peritoneal; Mice; Peritoneal Dialysis; Peritoneum; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Uremia | 2018 |
Lactate and TGF-β antagonistically regulate inflammasome activation in the tumor microenvironment.
Topics: Colorectal Neoplasms; Culture Media, Conditioned; HCT116 Cells; Humans; Immunity, Innate; Inflammasomes; Interleukin-1beta; Lactic Acid; Macrophages; NLR Family, Pyrin Domain-Containing 3 Protein; Paracrine Communication; Reactive Oxygen Species; Signal Transduction; THP-1 Cells; Transforming Growth Factor beta; Tumor Escape; Tumor Microenvironment | 2021 |
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment.
Topics: Animals; Cancer-Associated Fibroblasts; Cell Line; Citric Acid Cycle; Collagen; Disease Susceptibility; Enzyme Activation; Fibrosis; Gene Expression Regulation, Enzymologic; Glutamine; Humans; Lactic Acid; Mice; Neoplasms; Protein Biosynthesis; Pyruvate Carboxylase; Transforming Growth Factor beta; Tumor Microenvironment | 2021 |
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Hydrogels; Lactic Acid; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Recombinant Proteins; Tissue Scaffolds; Transforming Growth Factor beta | 2022 |
Metabolites and growth factors produced by airway epithelial cells induce tolerance in macrophages.
Topics: Epithelial Cells; Granulocyte Colony-Stimulating Factor; Humans; Inflammation; Interleukin-10; Kynurenine; Lactic Acid; Lipopolysaccharides; Macrophages; Respiratory Mucosa; Transforming Growth Factor beta | 2022 |
Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Lactic Acid; Liver Neoplasms; Mice; Mice, Knockout; Microfilament Proteins; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Tumor Microenvironment | 2022 |
Effects of lactate on metabolism and differentiation of CD4
Topics: Cell Differentiation; Cytokines; Forkhead Transcription Factors; Lactic Acid; NAD; T-Lymphocytes, Regulatory; Transforming Growth Factor beta | 2023 |
Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction.
Topics: Endothelial Cells; Fibrosis; Humans; Hypoxia; Lactic Acid; Myocardial Infarction; Transforming Growth Factor beta | 2023 |
[Protective Effect of Mesenchymal Stem Cell Transplantation on Intestinal Injury in Septic Mice and Its Mechanism].
Topics: Animals; Interleukin-10; Interleukin-6; Lactic Acid; Mesenchymal Stem Cell Transplantation; Mice; Occludin; Sepsis; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2023 |