lactic acid has been researched along with thiophenes in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.33) | 29.6817 |
| 2010's | 25 (83.33) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Burnell, J; de Arriba, SG; Loske, C; Münch, G; Stuchbury, G; Yarin, J | 1 |
| Halestrap, AP; Manoharan, C; Murray, CM; Ovens, MJ; Wilson, MC | 1 |
| Harada, M; Itai, S; Iwao, Y; Saito, S; Sato, T; Takeda, J; Umeki, N | 1 |
| Binauld, S; Connal, LA; Damiron, D; Drockenmuller, E; Hawker, CJ | 1 |
| Chiche, J; Critchlow, SE; Ilc, K; Ilk, K; Le Floch, R; Marchiq, I; Murray, CM; Naiken, T; Pouysségur, J; Roux, D; Simon, MP | 1 |
| Krishnan, UM; Sethuraman, S; Subramanian, A | 1 |
| Bishop, PW; Blackhall, F; Critchlow, SE; Dive, C; Fusi, A; Hodgkinson, CL; Kelly, P; Morrow, CJ; Nonaka, D; Polański, R; Priest, L; Smith, PD; Trapani, F; White, A | 1 |
| Bouzin, C; Draoui, N; Feron, O; Riant, O; Schicke, O; Seront, E; Sonveaux, P | 1 |
| Murakami, M; Saito, T; Tabata, Y | 1 |
| Ahmad, FJ; Anwar, M; Garg, V; Jain, GK; Khar, RK; Talegaonkar, S; Warsi, MH | 1 |
| Blagih, J; Coelho, PP; Griss, T; Jones, RG; Vincent, EE; Viollet, B | 1 |
| Halestrap, AP; Nancolas, B; Sessions, RB | 1 |
| Gaddipati, S; Kaplan, HJ; Kasetti, RB; Li, Q; Lu, Q; Miller, MC; Trent, JO | 1 |
| Chung, FF; Hii, LW; Ho, GF; Leong, CO; Malik, RA; Ng, CH; See, MH; Soo, JS; Taib, NA; Tan, BS; Tan, SH; Teh, YC; Teo, SH; Yip, CH | 1 |
| Ahn, SM; Chang, WJ; Cho, JH; Jung, KS; Kang, WK; Kim, HS; Kim, KM; Kim, ST; Kim, SY; Lee, I; Lee, J; Lee, JY; Lee, S; Lim, HY; Lim, SH; Park, JO; Park, SH; Park, YS; Song, HN; Yoo, KH | 1 |
| Inamdar, MS; Karp, JM; Levy, O; Martyn, K; Ranganath, SH; Tong, Z | 1 |
| Fridley, C; Fu, J; Gedam, M; Hanes, J; Hu, Q; Liu, W; Liu, Y; Pitha, I; Quigley, HA; Sun, F | 1 |
| Acquaviva, C; Braendlein, M; Ferro, M; Lopresti, A; Malliaras, GG; Mamessier, E; Owens, RM; Pappa, AM | 1 |
| Choy, YB; Huh, BK; Kim, SN; Kim, YK; Lee, SH; Park, CG; Park, KH; Park, MA; Won, H | 1 |
| Bacon, CM; Bell, N; Blair, H; Bomken, S; Critchlow, SE; Crossland, R; Keun, HC; Long, A; Miwa, S; Nakjang, S; Noble, RA; Phillips, N; Rand, V; Sikka, A; Televantou, D; Thomas, H; Wedge, SR | 1 |
| Becker, HM; Deitmer, JW; Forero-Quintero, LS | 1 |
| Arunan, V; Beloueche-Babari, M; Casals Galobart, T; Chung, YL; Eykyn, TR; Koniordou, M; Leach, MO; Parkes, HG; Smith, PD; Wantuch, S | 1 |
| Bastien, E; Becker, HM; Chaltin, P; Corbet, C; Doix, B; Draoui, N; Feron, O; Jordan, BF; Marchand, A; Mignion, L; Riant, O; Schakman, O; Vanherck, JC | 1 |
| Eichner, R; Girardi, E; Hashimoto, M; Superti-Furga, G | 1 |
| Boyers, A; Chadwick, A; Critchlow, SE; Mehibel, M; Mueller-Klieser, W; Ortiz-Martinez, F; Stratford, IJ; Telfer, BA; Voelxen, N; West, CM; Williams, KJ | 1 |
| Guan, X; Morris, ME; Rodriguez-Cruz, V | 1 |
| Eliopoulos, E; Papakonstantinou, E; Thireou, T; Vlachakis, D; Vlachoyiannopoulos, PG | 1 |
| Deng, L; He, Y; Wu, B; Wu, L; Yin, Z | 1 |
| Badisa, RB; Mack, N; Mazzio, E; Soliman, KFA | 1 |
| Afonso, J; Antunes, B; Baltazar, F; Batista, A; Pinto-Ribeiro, F; Silva, A | 1 |
2 review(s) available for lactic acid and thiophenes
| Article | Year |
|---|---|
Precise synthesis of molecularly defined oligomers and polymers by orthogonal iterative divergent/convergent approaches.
Topics: Aniline Compounds; Caproates; Chemistry Techniques, Synthetic; Lactic Acid; Lactones; Molecular Structure; Molecular Weight; Nylons; Polyesters; Polyethylenes; Polymers; Thiophenes | 2011 |
In Vivo Anticancer Activity of AZD3965: A Systematic Review.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Management; Disease Progression; Drug Evaluation, Preclinical; Energy Metabolism; Glycolysis; Humans; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Pyrimidinones; Signal Transduction; Symporters; Thiophenes; Tumor Microenvironment; Warburg Effect, Oncologic; Xenograft Model Antitumor Assays | 2021 |
28 other study(ies) available for lactic acid and thiophenes
| Article | Year |
|---|---|
Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells--protection by carbonyl scavengers.
Topics: Adenosine Triphosphate; Analysis of Variance; Cell Line, Tumor; Dose-Response Relationship, Drug; Energy Metabolism; Enzyme Inhibitors; Flow Cytometry; Glucose; Guanidines; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Neurons; Piperazines; Pyruvaldehyde; Reactive Oxygen Species; Thiophenes | 2007 |
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein.
Topics: Animals; Basigin; Erythrocytes; Glycoproteins; Kinetics; Lactic Acid; Membrane Proteins; Monocarboxylic Acid Transporters; Mutant Proteins; Oocytes; Rabbits; Rats; Recombinant Proteins; Symporters; Thiophenes; Uracil; Xenopus laevis; Xenopus Proteins | 2010 |
Preparation and evaluation of biodegradable films containing the potent osteogenic compound BFB0261 for localized delivery.
Topics: Animals; Chemistry, Pharmaceutical; Drug Carriers; Drug Compounding; Drug Implants; Female; Isoxazoles; Kinetics; Lactates; Lactic Acid; Microscopy, Electron, Scanning; Osteogenesis; Polyesters; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Powder Diffraction; Rats; Rats, Wistar; Solubility; Surface Properties; Technology, Pharmaceutical; Temperature; Tensile Strength; Thiophenes; X-Ray Diffraction | 2011 |
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
Topics: Basigin; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; DNA Primers; Flow Cytometry; Fluorescent Antibody Technique; Gene Knockout Techniques; Gene Silencing; Glycolysis; Humans; Immunohistochemistry; Lactic Acid; Monocarboxylic Acid Transporters; Muscle Proteins; Oxygen Consumption; Protein Subunits; Symporters; Thiophenes; Uracil | 2011 |
In vivo biocompatibility of PLGA-polyhexylthiophene nanofiber scaffolds in a rat model.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Equipment Design; Equipment Failure Analysis; Lactic Acid; Male; Materials Testing; Nanofibers; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Thiophenes; Tissue Scaffolds | 2013 |
Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Inhibitory Concentration 50; Kaplan-Meier Estimate; Lactic Acid; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Monocarboxylic Acid Transporters; Multivariate Analysis; Muscle Proteins; Pyrimidinones; Small Cell Lung Carcinoma; Symporters; Thiophenes; Xenograft Model Antitumor Assays | 2014 |
Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.
Topics: Animals; Breast Neoplasms; Colorectal Neoplasms; Coumarins; Female; HCT116 Cells; Humans; Lactic Acid; MCF-7 Cells; Mice; Neoplasm Recurrence, Local; Prognosis; Thiophenes; Uracil | 2014 |
Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment.
Topics: Animals; Cattle; Cell Count; Cell Movement; Delayed-Action Preparations; Gelatin; Humans; Hydrogels; Lactic Acid; Lysophospholipids; Macrophages; Male; Mice, Inbred C57BL; Micelles; Oxadiazoles; Solubility; Sphingosine; Sus scrofa; Thiophenes; Time Factors; Water | 2014 |
Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits.
Topics: Animals; Carbonic Anhydrase Inhibitors; Glaucoma; Intraocular Pressure; Lactic Acid; Microscopy, Electron, Scanning; Nanoparticles; Ocular Hypertension; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Radionuclide Imaging; Sulfonamides; Thiophenes; Vitamin A; Vitamin E | 2014 |
Differential effects of AMPK agonists on cell growth and metabolism.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Glucose; HCT116 Cells; HEK293 Cells; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mice; Neoplasms; Phenformin; Pyrones; Ribonucleotides; Sodium Salicylate; Thiophenes | 2015 |
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.
Topics: Amino Acid Substitution; Amino Acids; Animals; Binding Sites; Biological Transport; Female; Gene Expression; Humans; Lactic Acid; Mice; Molecular Docking Simulation; Monocarboxylic Acid Transporters; Muscle Proteins; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Rats; Recombinant Proteins; Symporters; Thiophenes; Uracil; Xenopus laevis | 2015 |
IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment.
Topics: Amides; Animals; Choroidal Neovascularization; Disease Models, Animal; Drug Carriers; Female; I-kappa B Kinase; Lactic Acid; Macrophages; Male; Mice; Mice, Inbred C57BL; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Protein Kinase Inhibitors; Thiophenes | 2015 |
Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cyclophosphamide; DNA Damage; DNA Repair; Drug Combinations; Drug Synergism; Embryonic Stem Cells; Epirubicin; Female; Fibroblasts; Fluorouracil; Glucose; Humans; Hypoglycemic Agents; Lactic Acid; Lung; Metformin; Neoplastic Stem Cells; Pyrones; Ribonucleotides; Thiophenes | 2015 |
MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Female; Humans; Lactic Acid; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Monocarboxylic Acid Transporters; Muscle Proteins; Peritoneal Neoplasms; RNA Interference; RNA, Small Interfering; Stomach Neoplasms; Symporters; Thiophenes; Up-Regulation; Uracil; Xenograft Model Antitumor Assays | 2016 |
Controlled Inhibition of the Mesenchymal Stromal Cell Pro-inflammatory Secretome via Microparticle Engineering.
Topics: Amides; Animals; Bone Marrow Cells; Cell Differentiation; Chemical Engineering; Coculture Techniques; Culture Media, Conditioned; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Fibroblasts; Gene Expression; Humans; Inflammation; Lactic Acid; Mesenchymal Stem Cells; Mice; Models, Biological; Monocytes; NF-kappa B; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Primary Cell Culture; Thiophenes; Tumor Necrosis Factor-alpha | 2016 |
Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits.
Topics: Animals; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Ethylamines; Female; Glaucoma; Intraocular Pressure; Lactic Acid; Male; Oleic Acid; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Sodium Dodecyl Sulfate; Sulfonamides; Thiophenes | 2016 |
Lactate Detection in Tumor Cell Cultures Using Organic Transistor Circuits.
Topics: Animals; Biosensing Techniques; Calibration; Cattle; Cell Culture Techniques; Chitosan; Electric Impedance; Electrochemical Techniques; Equipment Design; Ferrous Compounds; Humans; Lactic Acid; Leukocytes, Mononuclear; Metallocenes; Mixed Function Oxygenases; Neoplasms; Polystyrenes; Sensitivity and Specificity; Serum Albumin, Bovine; Thiophenes; Transistors, Electronic | 2017 |
Enhanced ocular efficacy of topically-delivered dorzolamide with nanostructured mucoadhesive microparticles.
Topics: Adhesives; Administration, Ophthalmic; Administration, Topical; Animals; Carbonic Anhydrase Inhibitors; Drug Compounding; Intraocular Pressure; Lactic Acid; Male; Mucous Membrane; Nanofibers; Ophthalmic Solutions; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Propylene Glycol; Rabbits; Solubility; Sulfonamides; Thiophenes | 2017 |
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.
Topics: Antineoplastic Agents; Biomarkers; Burkitt Lymphoma; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; Electron Transport Complex I; Energy Metabolism; Humans; Lactic Acid; Lymphoma, Large B-Cell, Diffuse; Mitochondria; Monocarboxylic Acid Transporters; Muscle Proteins; Oxidative Phosphorylation; Pyrimidinones; Symporters; Thiophenes | 2017 |
Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters.
Topics: 3-Hydroxybutyric Acid; Animals; Astrocytes; Brain; Diet, Ketogenic; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glycolysis; Ketone Bodies; Lactic Acid; Mice; Mice, Inbred C57BL; Microtomy; Monocarboxylic Acid Transporters; Neurons; Primary Cell Culture; Seizures; Signal Transduction; Symporters; Thiophenes; Tissue Culture Techniques; Uracil | 2017 |
MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy.
Topics: Acrylates; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Energy Metabolism; Female; HT29 Cells; Humans; Lactic Acid; Lymphoma; Magnetic Resonance Spectroscopy; Metformin; Mice, SCID; Mitochondria; Monocarboxylic Acid Transporters; Muscle Proteins; Pyrimidinones; Symporters; Thiophenes; Xenograft Model Antitumor Assays | 2017 |
Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Female; Gene Silencing; Glucose; Glycolysis; Humans; Ion Transport; Lactic Acid; Male; MCF-7 Cells; Mice; Mice, Inbred C57BL; Mitochondria; Monocarboxylic Acid Transporters; Muscle Proteins; Neoplasm Transplantation; Oxygen; Pyruvic Acid; Radiation-Sensitizing Agents; Rats; RNA, Small Interfering; Symporters; Thiophenes; Uracil; Xenopus laevis | 2018 |
Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay.
Topics: Biological Assay; Excitatory Amino Acid Transporter 2; Formates; Glutamate Plasma Membrane Transport Proteins; Heating; HEK293 Cells; Humans; Lactic Acid; Ligands; Monocarboxylic Acid Transporters; Protein Binding; Protein Stability; Pyrimidinones; Thiophenes; Uracil | 2018 |
Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters.
Topics: Animals; Biomarkers; Head and Neck Neoplasms; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactic Acid; Mice; Monocarboxylic Acid Transporters; Oxidative Phosphorylation; Precision Medicine; Prognosis; Pyrimidinones; Thiophenes | 2018 |
Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Coumaric Acids; Drug Screening Assays, Antitumor; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Mice; Monocarboxylic Acid Transporters; Pyrimidinones; Symporters; Thiophenes; Uracil | 2019 |
A Holistic Evolutionary and 3D Pharmacophore Modelling Study Provides Insights into the Metabolism, Function, and Substrate Selectivity of the Human Monocarboxylate Transporter 4 (hMCT4).
Topics: Animals; Antineoplastic Agents; Binding Sites; Biological Transport; Drug Design; Glycolysis; Humans; Lactic Acid; Molecular Docking Simulation; Monocarboxylic Acid Transporters; Muscle Proteins; Phloretin; Phylogeny; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Protein Isoforms; Pyrimidinones; Quercetin; Reserpine; Structural Homology, Protein; Substrate Specificity; Thiophenes; Uracil | 2021 |
Engineered PLGA microspheres for extended release of brexpiprazole:
Topics: Animals; Lactic Acid; Microspheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Quinolones; Rats; Thiophenes | 2021 |
Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid.
Topics: Cell Cycle; Cell Line, Tumor; Cell Survival; Cytostatic Agents; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glycolysis; High-Throughput Screening Assays; Humans; Lactic Acid; Pyridones; Thiophenes; Triple Negative Breast Neoplasms; Tumor Microenvironment | 2021 |