Compounds > lactic acid

lactic acid and stavudine

lactic acid has been researched along with stavudine in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's21 (80.77)29.6817
2010's5 (19.23)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Burlina, A; D'Elia, R; De Romeo, A; De Rossi, A; Giacomet, V; Giaquinto, C; Rampon, O; Ruga, E; Sturkenboom, M1
Rastegar, DA1
Huff, B1
Alberti, C; Bagnard, G; Carel, O; Erlich, D; Feugeas, JP; Hocqueloux, L; Lafaurie, M; Lukasiewicz, E; Molina, JM1
Antoniou, T; Gough, K; Weisdorf, T1
Cahn, P; Harris, M; Mittelman, G; Montaner, JS; Ochoa, C; Perez, H; Quercia, R; Tocci, M; Zala, C1
Blanco, F; de la Cruz, JJ; García-Benayas, T; González-Lahoz, J; Soriano, V1
Alvarez, M; Bonnet, E; Delobel, P; Khatibi, S; Marchou, B; Massip, P; Obadia, M1
Desai, N; Mathur, M; Weedon, J1
Datta, D; Gazzard, B; Mandalia, S; Moyle, G1
Koopmans, PP; ter Hofstede, HJ; Willems, HL1
Bäuerle, J; Gatell, JM; Laguno, M; Mallolas, J; Mauss, S; Miquel, R; Murillas, J; Schmutz, G; Setzer, B; Walker, UA1
Balestre, E; Bernardin, E; Bonnet, F; Dabis, F; Neau, D; Pellegrin, JL1
Schlesier, M; Setzer, B; Thomas, AK; Walker, UA1
Averitt, D; Kumar, PN; Pakes, GE; Pappa, KA; Rodriguez-French, A; Shaefer, MS; Tashima, KT; Thompson, MA; Wannamaker, PG; Williams, VC1
de Baar, MP; de Ronde, A; Ruiter, JP; Tebas, P; Timmermans, EC; Wanders, RJ1
Bogner, J; Claas, GJ; Goebel, FD; Jülg, B1
Castelnuovo, B; Kambugu, A; Mugasha, EB; Ocama, P; Songa, PM1
Baron, E; Frank, I; Lebrecht, D; Lo Re, V; McComsey, GA; Mounzer, K; O'Riordan, M; Walker, UA1
Bassit, L; Detorio, MA; Dikalov, S; Hernandez-Santiago, BI; Jones, DP; Kleinhenz, DJ; Kline, ER; Liang, B; Schinazi, RF; Sutliff, RL; Walp, ER1
Kamerman, PR; Mitchell, B; Mitchell, D; Veliotes, D; Weber, J1
Boulle, A; Meintjes, G; Osler, M; Rebe, K; Stead, D1
Dragovic, G; Jevtovic, D1
Chagoma, N; Heyderman, RS; Kampira, E; Kaunda, S; Mallewa, J; Mukaka, M; Njalale, Y; van Oosterhout, JJ1
Chakraborty, S; Ghosh, S; Mondal, L; Mukherjee, B1

Trials

4 trial(s) available for lactic acid and stavudine

ArticleYear
Lactic acid levels in children perinatally treated with antiretroviral agents to prevent HIV transmission.
    AIDS (London, England), 2001, May-25, Volume: 15, Issue:8

    Topics: Anti-HIV Agents; Cross-Sectional Studies; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Lactic Acid; Lamivudine; Male; Perinatal Care; Pregnancy; Pregnancy Complications, Infectious; Prenatal Care; Reverse Transcriptase Inhibitors; Stavudine; Zidovudine

2001
A prospective, 96-week study of the impact of Trizivir, Combivir/nelfinavir, and lamivudine/stavudine/nelfinavir on lipids, metabolic parameters and efficacy in antiretroviral-naive patients: effect of sex and ethnicity.
    HIV medicine, 2006, Volume: 7, Issue:2

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Black or African American; CD4 Lymphocyte Count; Cholesterol; Dideoxynucleosides; Drug Combinations; Female; Hispanic or Latino; HIV Infections; HIV-1; Humans; Hyperlipidemias; Lactic Acid; Lamivudine; Male; Nelfinavir; Nevirapine; Prospective Studies; Sex Factors; Stavudine; Treatment Outcome; Triglycerides; Zidovudine

2006
Metabolic and anthropometric changes one year after switching from didanosine/stavudine to tenofovir in HIV-infected patients.
    European journal of medical research, 2007, Feb-26, Volume: 12, Issue:2

    Topics: Adenine; Adult; Aged; Anti-HIV Agents; Body Weight; CD4 Lymphocyte Count; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Didanosine; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Hemoglobins; HIV Infections; Humans; Lactic Acid; Male; Middle Aged; Organophosphonates; Phosphates; Skinfold Thickness; Stavudine; Tenofovir; Treatment Outcome; Triglycerides; Uric Acid; Viral Load

2007
Effect of reducing the dose of stavudine on body composition, bone density, and markers of mitochondrial toxicity in HIV-infected subjects: a randomized, controlled study.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Apr-15, Volume: 46, Issue:8

    Topics: Adipose Tissue; Adult; Anti-HIV Agents; Body Composition; Bone Density; DNA, Mitochondrial; Female; Genotype; HIV Infections; Humans; Lactic Acid; Leukocytes, Mononuclear; Male; Middle Aged; Pyruvic Acid; Stavudine

2008

Other Studies

22 other study(ies) available for lactic acid and stavudine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Mitochondrial DNA and nucleoside toxicity.
    The New England journal of medicine, 2002, Jul-18, Volume: 347, Issue:3

    Topics: Anti-HIV Agents; DNA; DNA, Mitochondrial; Drug-Related Side Effects and Adverse Reactions; Genetic Markers; HIV Infections; Humans; Lactic Acid; Stavudine

2002
The case against Zerit.
    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 2002, Volume: 16, Issue:10

    Topics: HIV Infections; Humans; Insulin Resistance; Lactic Acid; Lipodystrophy; Mitochondria; Reverse Transcriptase Inhibitors; Stavudine

2002
Prevalence, risk factors and outcome of hyperlactataemia in HIV-infected patients.
    HIV medicine, 2003, Volume: 4, Issue:1

    Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Didanosine; Female; Follow-Up Studies; HIV Infections; Humans; Lactic Acid; Male; Middle Aged; Prevalence; Prognosis; Prospective Studies; Reverse Transcriptase Inhibitors; Risk Factors; Stavudine

2003
Symptomatic hyperlactatemia in an HIV-positive patient: a case report and discussion.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2003, Jan-21, Volume: 168, Issue:2

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Didanosine; HIV Infections; Humans; Lactic Acid; Male; Reverse Transcriptase Inhibitors; Stavudine

2003
Venous and arterial blood lactate in HIV-infected patients.
    Antiviral therapy, 2002, Volume: 7, Issue:4

    Topics: Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Lactic Acid; Male; Middle Aged; Stavudine

2002
Replacing stavudine by abacavir reduces lactate levels and may improve lipoatrophy.
    AIDS (London, England), 2003, Apr-11, Volume: 17, Issue:6

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Case-Control Studies; Dideoxynucleosides; Female; Follow-Up Studies; HIV Reverse Transcriptase; HIV-Associated Lipodystrophy Syndrome; Humans; Lactic Acid; Male; Middle Aged; Prospective Studies; Reverse Transcriptase Inhibitors; Stavudine

2003
Reversible nucleoside analogue-associated lactic acidosis despite a prolonged course.
    Intensive care medicine, 2003, Volume: 29, Issue:6

    Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Bicarbonates; Female; Hemodiafiltration; HIV Reverse Transcriptase; Humans; Lactic Acid; Reverse Transcriptase Inhibitors; Stavudine; Time Factors

2003
Lactate levels in children with HIV/AIDS on highly active antiretroviral therapy.
    AIDS (London, England), 2003, Jul-04, Volume: 17, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biomarkers; Child; Child, Preschool; Female; HIV Protease Inhibitors; Humans; Infant; Lactic Acid; Male; Patient Compliance; Reverse Transcriptase Inhibitors; Ritonavir; Stavudine; Viral Load

2003
Matched case-control study to evaluate risk factors for hyperlactataemia in HIV patients on antiretroviral therapy.
    HIV medicine, 2003, Volume: 4, Issue:4

    Topics: Acidosis, Lactic; Anti-HIV Agents; Case-Control Studies; Didanosine; Female; HIV Infections; Humans; Lactic Acid; Male; Multivariate Analysis; Risk Factors; Sex Factors; Stavudine

2003
Serum L-lactate and pyruvate in HIV-infected patients with and without presumed NRTI-related adverse events compared to healthy volunteers.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2004, Volume: 29, Issue:1

    Topics: Adult; Anti-HIV Agents; DNA, Mitochondrial; Female; HIV Infections; HIV-1; Humans; Lactic Acid; Male; Mitochondria; Pyruvic Acid; Reverse Transcriptase Inhibitors; Stavudine; Zidovudine

2004
Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or zalcitabine.
    Hepatology (Baltimore, Md.), 2004, Volume: 39, Issue:2

    Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Didanosine; DNA, Mitochondrial; Female; Hepatitis C, Chronic; HIV Infections; Humans; Lactic Acid; Liver; Male; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine

2004
Risk factors for hyperlactataemia in HIV-infected patients, Aquitaine Cohort, 1999--2003.
    Antiviral chemistry & chemotherapy, 2005, Volume: 16, Issue:1

    Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Adult; Age Factors; Anti-HIV Agents; CD4 Antigens; Cohort Studies; Didanosine; Drug Therapy, Combination; HIV-Associated Lipodystrophy Syndrome; Humans; Lactic Acid; Longitudinal Studies; Male; Middle Aged; Reverse Transcriptase Inhibitors; Stavudine; Triglycerides

2005
Mitochondrial toxicity of nucleoside analogues in primary human lymphocytes.
    Antiviral therapy, 2005, Volume: 10, Issue:2

    Topics: CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Didanosine; DNA, Mitochondrial; Female; Humans; Lactic Acid; Lymphocyte Activation; Male; Mitochondrial Diseases; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine

2005
Real-time nucleic acid sequence-based amplification assay to quantify changes in mitochondrial DNA concentrations in cell cultures and blood cells from HIV-infected patients receiving antiviral therapy.
    Clinical chemistry, 2006, Volume: 52, Issue:6

    Topics: Anti-HIV Agents; Base Sequence; Blood Platelets; Cell Nucleus; Cells, Cultured; Didanosine; DNA, Mitochondrial; Drug Therapy, Combination; Feasibility Studies; Fibroblasts; HIV Infections; Humans; Indinavir; Lactic Acid; Lamivudine; Leukocytes, Mononuclear; Nucleic Acid Amplification Techniques; Pyruvic Acid; Stavudine; Zalcitabine

2006
Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a resource-limited setting (Uganda).
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Aug-15, Volume: 45, Issue:4

    Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Lactic Acid; Lamivudine; Male; Middle Aged; Nevirapine; Reverse Transcriptase Inhibitors; Stavudine; Uganda

2007
Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.
    Cardiovascular toxicology, 2009, Volume: 9, Issue:1

    Topics: Biomarkers; Cell Death; Cell Line, Tumor; Cells, Cultured; DNA, Mitochondrial; Endothelial Cells; Glutathione; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Mitochondria; Mitochondria, Liver; Oxidative Stress; Phosphorylation; Reverse Transcriptase Inhibitors; Stavudine; Superoxides; Time Factors; Zidovudine

2009
Hyperalgesia induced by oral stavudine administration to rats does not depend on spinal neuronal cell death, or on spinal or systemic inflammatory cytokine secretion, or metabolic dysregulation.
    Neurotoxicology, 2009, Volume: 30, Issue:3

    Topics: Adiponectin; Administration, Oral; Animals; Apoptosis; Cytokines; Female; Hyperalgesia; Inflammation; Lactic Acid; Neurons; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Spinal Cord; Stavudine

2009
Risk factors for and clinical characteristics of severe hyperlactataemia in patients receiving antiretroviral therapy: a case-control study.
    HIV medicine, 2010, Volume: 11, Issue:2

    Topics: Acidosis, Lactic; Adult; Alanine Transaminase; Anti-HIV Agents; Developing Countries; Drug Administration Schedule; Epidemiologic Methods; Female; Humans; Lactic Acid; Male; Overweight; Peripheral Nervous System Diseases; Pregnancy; Reverse Transcriptase Inhibitors; South Africa; Stavudine; Weight Loss

2010
The role of nucleoside reverse transcriptase inhibitors usage in the incidence of hyperlactatemia and lactic acidosis in HIV/AIDS patients.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2012, Volume: 66, Issue:4

    Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Adult; CD4 Lymphocyte Count; Didanosine; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; Humans; Incidence; Lactic Acid; Male; Middle Aged; Prospective Studies; Reverse Transcriptase Inhibitors; Risk Factors; Sex Factors; Stavudine

2012
Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2013, Volume: 107, Issue:10

    Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Drug Costs; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lactic Acid; Lipodystrophy; Malawi; Male; Medically Underserved Area; Peripheral Nervous System Diseases; Point-of-Care Systems; Prospective Studies; Stavudine

2013
Early Stage HIV Management and Reduction of Stavudine-Induced Hepatotoxicity in Rats by Experimentally Developed Biodegradable Nanoparticles.
    AAPS PharmSciTech, 2017, Volume: 18, Issue:3

    Topics: Animals; Anti-HIV Agents; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Excipients; HIV Infections; Lactic Acid; Macrophages; Male; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Stavudine

2017