lactic acid has been researched along with sirolimus in 95 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 33 (34.74) | 29.6817 |
| 2010's | 58 (61.05) | 24.3611 |
| 2020's | 4 (4.21) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chan, C; Fitzgerald, PJ; Gerckens, U; Grube, E; Honda, Y; Ikeno, F; Kar, S; Lansky, AJ; Sonoda, S | 1 |
| Wang, G; Yin, T | 1 |
| Rudin, CM; Vanderweele, DJ | 1 |
| Boey, FY; Loo, JS; Tan, LP; Venkatraman, SS; Wang, X | 1 |
| Engbers, GH; Feijen, J; Grijpma, DW; Zweers, ML | 1 |
| Armstrong, G; Ormiston, JA; Webster, MW | 1 |
| Hossainy, S; Prabhu, S | 1 |
| Buellesfeld, L; Grube, E | 1 |
| Chevalier, B; de Bruyne, B; Dudek, D; Ormiston, JA; Serruys, PW; Tanimoto, S; Thuesen, L | 1 |
| Huang, N; Pan, CJ; Shao, ZY; Tang, JJ; Wang, J | 1 |
| Feng, B; Huang, YY; Qi, M; Su, HY; Xia, YH; Xu, K; Yang, DZ | 1 |
| Huang, N; Pan, CJ; Tang, JJ; Wang, J; Weng, YJ | 1 |
| Das, S; Elamanchili, P; Haddadi, A; Lavasanifar, A; Samuel, J; Shapiro, J | 1 |
| Lemos, PA | 1 |
| Das, S; Haddadi, A; Samuel, J; Veniamin, S | 1 |
| Huang, DH; Jiang, W; Li, H; Liu, J; Sheng, J; Shun, HM; Tian, EJ; Yuan, XB; Yuan, XY; Yuan, YB | 1 |
| Boey, F; Loo, SC; Tan, LP; Venkatraman, S; Wang, XT | 1 |
| Belu, AM; Fahey, AJ; Mahoney, CM | 1 |
| Belu, A; Mahoney, C; Wormuth, K | 1 |
| Moussa, ID | 1 |
| Chen, X; Gao, R; Han, Y; Jing, Q; Li, Y; Liu, H; Luan, B; Ma, Y; Wang, D; Wang, G; Wang, S; Wang, Z; Xu, B | 1 |
| Chen, LF; Huang, CL; Miao, LF; Song, CX; Yang, J; Zeng, YJ; Zhu, WL | 1 |
| Bruining, N; Ligthart, JM; Radeva, P; Rotger, D; Serruys, PW; Tanimoto, S; van Domburg, RT | 1 |
| Jhunjhunwala, S; Little, SR; Raimondi, G; Thomson, AW | 1 |
| Cui, H; Fu, S; Hou, Y; Liu, H; Liu, J; Liu, P; Wu, L; Xing, L; Zhang, X | 1 |
| Davies, MC; Hossainy, S; Kleiner, L; Roberts, CJ; Tang, FW; Wu, M | 2 |
| Ako, J; Buellesfeld, L; Costa, M; Fitzgerald, P; Gerckens, U; Grube, E; Hauptmann, KE; Mueller, R; Shimohama, T; Sievert, H | 1 |
| Carter, TP; Feder, D; Hancock, L; Kamberi, M; Myo-Min, K; Nayak, S | 1 |
| Cao, G; Xi, Y; Zhang, N; Zou, W | 1 |
| Acharya, S; Dilnawaz, F; Sahoo, SK | 1 |
| Belu, AM; Fisher, GL; Mahoney, CM; Sanada, N; Wormuth, K | 1 |
| Jiang, W; Li, XR; Sun, HM; Tian, EJ; Wang, YQ; Yuan, JQ; Yuan, XB; Zhang, SX | 1 |
| Ormiston, JA; Serruys, PW | 1 |
| Brandes, AH; Chaumeil, MM; Dafni, H; Haas-Kogan, DA; James, CD; Kurhanewicz, J; Nelson, SJ; Ronen, SM; Sukumar, S; Vancriekinge, M; Venkatesh, HS; Vigneron, DB; Ward, CS | 1 |
| Chen, LF; Huang, CL; Liu, PM; Miao, LF; She, MP; Song, CX; Wang, YG; Yang, J; Zhang, H; Zhu, WL | 1 |
| Chen, L; Gao, R; Liu, J; Luo, T; Wei, Y; Xi, T; Xu, B; Zhong, S | 1 |
| Bruining, N; Cheong, WF; de Winter, S; Dudek, D; Hamers, R; Heller, I; Miquel-Hebert, K; Onuma, Y; Ormiston, JA; Regar, E; Roelandt, JR; Serruys, PW; Thuesen, L; van Domburg, RT; Veldhof, S; Webster, MW | 1 |
| Buszman, P; Corti, R; de Vries, T; Di Mario, C; Eberli, F; Eerdmans, P; Garg, S; Ischinger, T; Jüni, P; Klauss, V; Linke, A; Meier, B; Morice, MC; Sarno, G; Serruys, PW; van Es, GA; van Geuns, RJ; Wijns, W; Windecker, S | 1 |
| Abizaid, A; Costa, JR | 1 |
| Akers, LJ; Chen, Z; Fang, W; Franklin, AR; Ghisoli, ML; Graham, T; Huang, P; Kannan, S; Levy, AG; Zage, PE; Zeng, L; Zweidler-McKay, PA | 1 |
| Cao, G; Liu, K; Liu, R; Wu, S; Zhang, X; Zou, W | 1 |
| Bianchi, CF; Buchholz, B; Gao, F; Gu, Z; Laham, R; Ma, X; McCarthy, S; Oyamada, S; Robich, MP; Sellke, FW; Wang, X; Wu, H; Wu, T | 1 |
| Deng, Y; Fu, J; He, N; Jin, S; Wang, D; Wang, H; Wang, T; Yang, W | 1 |
| Ma, H; Wang, S; Yang, H; Zhang, X; Zhu, Y; Zou, J | 1 |
| Beckert, S; Coerper, S; Königsrainer, A; Königsrainer, I; Löb, S; Löffler, M; Weinreich, J; Zieker, D | 1 |
| Acharya, S; Sahoo, SK | 1 |
| Alani, AW; Bae, Y; Cho, H; Kolesar, JM; Kwon, GS; Shin, HC | 1 |
| Hong, D; Li, H; Liu, J; Tan, L; Xia, Y; Xu, K; Yang, K; Zhang, B; Zheng, F; Zhong, H | 1 |
| Fujii, K; Hayashi, Y; Ikari, Y; Inoue, N; Iwabuchi, M; Kadota, K; Kimura, T; Mitsudo, K; Muramatsu, T; Namiki, A; Nanto, S; Saito, S | 1 |
| Heo, SY; Hong, WK; Kim, CH; Kim, DH; Kim, S; Luo, LH; Oh, BR; Seo, JW | 1 |
| Choi, JW; Heo, JS; Jang, YS; Kim, JH; Kim, SJ; Kwon, IK; Lee, SJ; Park, JG; Yoon, J | 1 |
| Chaumeil, MM; Haas-Kogan, DA; James, CD; Ronen, SM; Venkatesh, HS; Ward, CS | 1 |
| Bakuzis, AF; Branquinho, LC; Cintra, ER; Ferreira, FS; Lima, EM; Oliveira, RR | 1 |
| Brugaletta, S; Chevalier, B; de Bruyne, B; Dudek, D; Gijsen, F; Gutiérrez-Chico, JL; McClean, DR; Onuma, Y; Ormiston, J; Regar, E; Serruys, PW; Thuesen, L; Wentzel, J; Whitbourn, R; Windecker, S | 1 |
| Bayer, G; Diener, T; Joner, M; Koppara, T; Steigerwald, K; Wittchow, E | 1 |
| Attizzani, G; Balvedi, JA; Centeno, PR; Kosachenco, BG; Matte, BS; Nascimento, L; Raudales, JC; Yamamoto, GI; Zago, AC; Zago, AJ | 1 |
| Delikatny, EJ; Glickson, JD; Kantekure, K; Lee, SC; Liu, X; Marzec, M; Nelson, DS; Ragunath, PN; Wasik, MA; Wehrli, S | 1 |
| Huang, WQ; Lei, WL; Li, C; Li, Y; Liu, KX; Liu, WF; Wen, SH; Xia, ZQ; Zhang, XY | 1 |
| Bailey, L; Carlyle, WC; Edelman, ER; Markham, PM; McClain, JB; Stanley, JR; Tzafriri, AR; Zani, BG | 1 |
| Hagiwara, H; Hirai, T; Hiraishi, Y; Inoue, K; Kimura, J; Murota, S; Sakaoka, A; Sasaki, M; Terao, H | 1 |
| Chen, LC; da Silva Coelho, L; de Souza, DC; Guillo, LA; Vieira, IL | 1 |
| Chu, Y; Gao, RL; Hu, X; Hu, XY; Luo, T; Mu, CW; Qiu, H; Ran, YM; Tang, Y; Wu, C; Xie, J; Xu, B; Xu, XL | 1 |
| Berdichevsky, Y; Dryer, AM; Lucini, CA; Mahoney, MM; Pimentel, CA; Saponjian, Y; Staley, KJ; Usenovic, M | 1 |
| Bingchun, Z; Ke, Y; Lili, T; Shanshan, C; Yingxue, T | 1 |
| Bureau, C; Guerin, P; Haroun, F; Langlois, V; Loirand, G; Renard, E; Seron, A; Vergnol, G | 1 |
| Chen, JJ; Fang, ZG; Lin, DJ; Liu, LL; Liu, Q; Long, ZJ; Wang, LX; Wang, SW; Xu, DF; Yan, M; Zheng, FM | 1 |
| Blagosklonny, MV; Leontieva, OV | 1 |
| Chourasia, MK; Gupta, A; Madan, J; Misra, A; Mitra, K; Pant, G | 1 |
| Guo, S; Huang, L; Lin, CM; Miao, L; Wang, Y; Xu, Z | 1 |
| Coles, A; Fok, WC; Pérez, VI; Salmon, AB; Wang, R; Yu, Z | 1 |
| Chen, J; Cui, JG; Gao, RL; Gao, Z; Mintz, GS; Qian, J; Sun, ZW; Tang, YD; Xu, B; Yan, HB; Yang, YJ; Zhang, YJ; Zhao, YL | 1 |
| Ding, T; Kou, ZZ; Li, YQ; Lu, YC; Luo, ZJ; Wang, LY; Yin, JB; Zhang, T; Zhu, C | 1 |
| Choi, J; Han, DK; Jang, BN; Joung, YK; Park, BJ | 1 |
| Ding, T; Li, YQ; Lu, YC; Ren, J; Yin, JB; Zhang, T; Zhu, C | 1 |
| Altreuter, DH; Browning, E; Farokhzad, OC; Ferrari, JD; Griset, AP; Johnston, L; Kishimoto, TK; Kolte, PN; LaMothe, RA; Langer, R; Maldonado, RA; O'Neil, C; Rossi, RJ; Scott, DW; von Andrian, UH; Zhang, AH | 1 |
| Choi, J; Goo, JH; Han, DK; Hong, YJ; Jeong, MH; Joung, YK; Kang, SN; Kim, JH; Kim, SE; Lee, J; Park, K; Sim, DS | 1 |
| Domb, AJ; Katiyar, SS; Khan, W; Muntimadugu, E; Rafeeqi, TA | 1 |
| Chen, LF; Cui, YL; Liu, PM; Miao, LF; Song, CX; Yang, J; Yin, YP; Zhang, H; Zhu, WL | 1 |
| Chen, LF; Cui, YL; Huang, CL; Miao, LF; She, MP; Song, CX; Yang, J; Yin, YP; Zeng, Y; Zhang, H; Zhu, WL | 1 |
| Gupta, A; Gupta, P; Gupta, UD; Kumar, S; Meena, J; Misra, A; Mitra, K; Panda, AK; Pandya, S; Sachan, M; Sharma, D; Sharma, S; Singh, K | 1 |
| Allen, E; Hanahan, D; Li, L; Miéville, P; Peng, MW; Saghafinia, S; Warren, CM | 1 |
| Matsui, M; Nagata, J; Tabata, Y | 1 |
| Altreuter, DH; Browning, E; Chalishazar, A; Chan, V; Ferrari, JD; Fu, FN; Griset, AP; Johnston, L; Kishimoto, TK; Kolte, PN; Kuhlman, W; LaMothe, RA; Maldonado, RA; O'Neil, C; Viseux, N | 1 |
| Aldeborgh, HN; Alvarez, JA; DiGialleonardo, V; Eskandari, R; Granlund, KL; Jeong, S; Keshari, KR; Miloushev, V; Poot, AJ; Tee, SS; Truong, S | 1 |
| Gao, R; Guan, C; Guo, Y; Li, Y; Li, Z; Qiao, S; Qin, L; Song, L; Sun, Z; Xu, B | 1 |
| Dankó, T; Drahos, L; Hujber, Z; Jeney, A; Krencz, I; Kriston, C; Nagy, N; Ozohanics, O; Paku, S; Petővári, G; Sebestyén, A; Szoboszlai, N | 1 |
| Pan, J; Sevim, K | 1 |
| Hu, W; Ji, Z; Lu, S; Zhang, T; Zhang, Z | 1 |
| Chen, W; Chen, YQ; Feng, N; He, Z; Jiang, X; Lin, G; Tong, Y; Wang, S; Yang, Q; Zhu, S | 1 |
| Cui, Z; Li, J; Liao, S; Qi, M; Sun, P; Tan, B; Tang, S; Tang, Y; Wang, Y; Yin, Y; Zha, A | 1 |
| Chen, X; Gou, H; Li, L; Luo, Y; Wang, X; Xu, Y | 1 |
| Bolognesi, G; Ekanem, EE; Nakajima, M; Vladisavljević, GT; Zhang, Z | 1 |
| Dai, J; Hu, W; Ji, Z; Ren, P; Shao, X; Xiong, B; Zhang, T; Zhang, Z; Zhu, L | 1 |
4 review(s) available for lactic acid and sirolimus
| Article | Year |
|---|---|
[Research progress of the drug-coated stents].
Topics: Angioplasty, Balloon, Coronary; Coated Materials, Biocompatible; Coronary Restenosis; Drug Delivery Systems; Humans; Lactic Acid; Paclitaxel; Pharmaceutical Preparations; Polyesters; Polymers; Sirolimus; Stents | 2005 |
BioMatrix Biolimus A9-eluting coronary stent: a next-generation drug-eluting stent for coronary artery disease.
Topics: Animals; Coated Materials, Biocompatible; Coronary Artery Disease; Coronary Restenosis; Drug Carriers; Drug Delivery Systems; Humans; Lactic Acid; Polyesters; Polymers; Randomized Controlled Trials as Topic; Sirolimus; Stents | 2006 |
Bioabsorbable coronary stents.
Topics: Absorbable Implants; Angioplasty, Balloon, Coronary; Cardiovascular Agents; Drug-Eluting Stents; Everolimus; Humans; Lactic Acid; Magnesium; Polycarboxylate Cement; Polyesters; Polymers; Prosthesis Design; Sirolimus; Stents; Thrombosis; Time Factors; Treatment Outcome | 2009 |
New drug-eluting stents: an overview on biodegradable and polymer-free next-generation stent systems.
Topics: Angioplasty; Animals; Clinical Trials as Topic; Coated Materials, Biocompatible; Constriction, Pathologic; Drug-Eluting Stents; Endothelium, Vascular; Humans; Lactic Acid; Metals; Polyesters; Polymers; Postoperative Complications; Sirolimus | 2010 |
7 trial(s) available for lactic acid and sirolimus
| Article | Year |
|---|---|
Six- and twelve-month results from first human experience using everolimus-eluting stents with bioabsorbable polymer.
Topics: Aged; Anticoagulants; Catheterization; Cineangiography; Coated Materials, Biocompatible; Comorbidity; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Drug Implants; Everolimus; Female; Follow-Up Studies; Growth Inhibitors; Humans; Hyperplasia; Immunosuppressive Agents; Lactic Acid; Male; Middle Aged; Myocardial Infarction; Polyesters; Polymers; Prospective Studies; Single-Blind Method; Sirolimus; Stainless Steel; Stents; Treatment Outcome; Tunica Intima; Ultrasonography, Interventional | 2004 |
Novel drug eluting stent system for customised treatment of coronary lesions: CUSTOM I feasibility trial 24 month results.
Topics: Aged; Angioplasty, Balloon, Coronary; Coated Materials, Biocompatible; Coronary Artery Disease; Drug Delivery Systems; Drug-Eluting Stents; Feasibility Studies; Female; Follow-Up Studies; Humans; Lactic Acid; Male; Middle Aged; Polyesters; Polymers; Prospective Studies; Sirolimus; Treatment Outcome | 2008 |
Monitoring in vivo absorption of a drug-eluting bioabsorbable stent with intravascular ultrasound-derived parameters a feasibility study.
Topics: Absorbable Implants; Angioplasty, Balloon, Coronary; Cardiovascular Agents; Coronary Artery Disease; Coronary Vessels; Drug-Eluting Stents; Europe; Everolimus; Feasibility Studies; Humans; Image Interpretation, Computer-Assisted; Lactic Acid; New Zealand; Polyesters; Polymers; Predictive Value of Tests; Prosthesis Design; Sirolimus; Solubility; Time Factors; Treatment Outcome; Ultrasonography, Interventional | 2010 |
The twelve-month outcomes of a biolimus eluting stent with a biodegradable polymer compared with a sirolimus eluting stent with a durable polymer.
Topics: Absorbable Implants; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Lactic Acid; Male; Middle Aged; Polyesters; Polymers; Prospective Studies; Sirolimus; Time Factors; Treatment Outcome | 2010 |
Randomized comparison of the Nobori biolimus A9-eluting stent with the sirolimus-eluting stent in patients with stenosis in native coronary arteries.
Topics: Aged; Cardiovascular Agents; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Coronary Thrombosis; Drug-Eluting Stents; Female; Humans; Japan; Lactic Acid; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Polyesters; Polymers; Prosthesis Design; Sirolimus; Time Factors; Treatment Outcome | 2012 |
Optical coherence tomography assessment of a PLGA-polymer with electro-grafting base layer versus a PLA-polymer sirolimus-eluting stent at three-month follow-up: the BuMA-OCT randomised trial.
Topics: Aged; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Lactic Acid; Male; Middle Aged; Percutaneous Coronary Intervention; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prospective Studies; Sirolimus; Tomography, Optical Coherence | 2014 |
Comparison of two biodegradable-polymer-based sirolimus-eluting stents with varying elution and absorption kinetics in patients with acute myocardial infarction: A subgroup analysis of the PANDA III trial.
Topics: Absorbable Implants; Adsorption; Aged; Cardiovascular Agents; China; Coronary Angiography; Coronary Thrombosis; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Kinetics; Lactic Acid; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prospective Studies; Prosthesis Design; Recurrence; Risk Factors; Sirolimus; Treatment Outcome | 2017 |
84 other study(ies) available for lactic acid and sirolimus
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mammalian target of rapamycin promotes vincristine resistance through multiple mechanisms independent of maintained glycolytic rate.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Line; Drug Resistance, Neoplasm; Glucose; Glycolysis; Hexokinase; Lactic Acid; Liver; Mice; Microtubules; Mutagenesis; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Vincristine | 2005 |
Controlled release of sirolimus from a multilayered PLGA stent matrix.
Topics: Delayed-Action Preparations; Diffusion; Kinetics; Lactic Acid; Molecular Structure; Molecular Weight; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sirolimus; Stents | 2006 |
Release of anti-restenosis drugs from poly(ethylene oxide)-poly(DL-lactic-co-glycolic acid) nanoparticles.
Topics: Coronary Restenosis; Dexamethasone; Diffusion; Drug Carriers; Epoxy Compounds; Ethylene Oxide; Lactic Acid; Nanostructures; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Proteins; Sirolimus; Solubility | 2006 |
First-in-human implantation of a fully bioabsorbable drug-eluting stent: the BVS poly-L-lactic acid everolimus-eluting coronary stent.
Topics: Absorbable Implants; Angina Pectoris; Coronary Angiography; Drug Delivery Systems; Everolimus; Humans; Immunosuppressive Agents; Lactic Acid; Male; Middle Aged; Polyesters; Polymers; Sirolimus; Stents; Ultrasonography, Interventional | 2007 |
Modeling of degradation and drug release from a biodegradable stent coating.
Topics: Coated Materials, Biocompatible; Drug Delivery Systems; Everolimus; Humans; Immunosuppressive Agents; Lactic Acid; Models, Theoretical; Polyesters; Polymers; Sirolimus; Stents | 2007 |
Comparison of in vivo acute stent recoil between the bioabsorbable everolimus-eluting coronary stent and the everolimus-eluting cobalt chromium coronary stent: insights from the ABSORB and SPIRIT trials.
Topics: Aged; Angioplasty, Balloon, Coronary; Biocompatible Materials; Biomechanical Phenomena; Cardiovascular Agents; Chromium Alloys; Clinical Trials as Topic; Coronary Angiography; Coronary Artery Disease; Drug-Eluting Stents; Everolimus; Female; Humans; Lactic Acid; Male; Middle Aged; Polyesters; Polymers; Prosthesis Design; Research Design; Sirolimus; Tomography, Optical Coherence | 2007 |
Improved blood compatibility of rapamycin-eluting stent by incorporating curcumin.
Topics: Absorbable Implants; Adsorption; Angioplasty, Balloon, Coronary; Blood; Coated Materials, Biocompatible; Coronary Restenosis; Curcumin; Fibrinogen; Humans; In Vitro Techniques; Lactic Acid; Materials Testing; Microscopy, Electron, Scanning; Platelet Adhesiveness; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sirolimus; Spectroscopy, Fourier Transform Infrared; Stents | 2007 |
[Pharmacodynamics of China-made rapamycin-polylactide-co-glycolide peripheral arterial eluting stent membrane: in vitro experiment].
Topics: Alloys; China; Drug-Eluting Stents; Lactic Acid; Microscopy, Atomic Force; Nickel; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Titanium | 2007 |
Preparation and characterization of rapamycin-loaded PLGA coating stent.
Topics: Absorbable Implants; Anti-Bacterial Agents; Catheterization; Coated Materials, Biocompatible; Drug-Eluting Stents; Humans; Lactic Acid; Materials Testing; Models, Biological; Platelet Adhesiveness; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sirolimus | 2007 |
Delivery of rapamycin by PLGA nanoparticles enhances its suppressive activity on dendritic cells.
Topics: Animals; CD40 Antigens; Cell Survival; Dendritic Cells; Immunosuppressive Agents; Interleukin-10; Interleukin-12; Lactic Acid; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; T-Lymphocytes; Transforming Growth Factor beta | 2008 |
Polymeric stents: degradable but strong.
Topics: Angioplasty, Balloon, Coronary; Biocompatible Materials; Biomechanical Phenomena; Cardiovascular Agents; Chromium Alloys; Coronary Angiography; Coronary Artery Disease; Drug-Eluting Stents; Everolimus; Humans; Lactic Acid; Polyesters; Polymers; Prosthesis Design; Sirolimus | 2007 |
Delivery of rapamycin-loaded nanoparticle down regulates ICAM-1 expression and maintains an immunosuppressive profile in human CD34+ progenitor-derived dendritic cells.
Topics: Antigens, CD34; Cytokines; Dendritic Cells; Down-Regulation; Drug Delivery Systems; Flow Cytometry; Humans; Immunosuppression Therapy; Intercellular Adhesion Molecule-1; Lactic Acid; Myeloid Cells; Nanoparticles; Phenotype; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Stem Cells; Surface Properties; Toll-Like Receptor 4; Toll-Like Receptor 9 | 2008 |
Preparation of rapamycin-loaded chitosan/PLA nanoparticles for immunosuppression in corneal transplantation.
Topics: Administration, Topical; Animals; Chemistry, Pharmaceutical; Chitosan; Cholesterol; Corneal Transplantation; Drug Carriers; Electrochemistry; Immunosuppressive Agents; Isotope Labeling; Lactic Acid; Microscopy, Electron, Scanning; Nanoparticles; Ophthalmic Solutions; Polyesters; Polymers; Rabbits; Radionuclide Imaging; Radiopharmaceuticals; Sirolimus; Solubility; Technetium Tc 99m Pentetate | 2008 |
Effects of controlled-released sirolimus from polymer matrices on human coronary artery smooth muscle cells.
Topics: Cell Adhesion; Cell Survival; Coronary Vessels; DNA; Humans; Lactic Acid; Microscopy, Electron, Scanning; Myocytes, Smooth Muscle; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sirolimus | 2007 |
Three-dimensional compositional analysis of drug eluting stent coatings using cluster secondary ion mass spectrometry.
Topics: Antibiotics, Antineoplastic; Bismuth; Coated Materials, Biocompatible; Delayed-Action Preparations; Drug Delivery Systems; Drug-Eluting Stents; Fluorides; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sirolimus; Spectrometry, Mass, Secondary Ion; Sulfur Compounds; Temperature | 2008 |
Chemical imaging of drug eluting coatings: combining surface analysis and confocal Raman microscopy.
Topics: Delayed-Action Preparations; Drug Carriers; Lactic Acid; Microscopy, Confocal; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sirolimus; Spectrum Analysis, Raman; Stents; Surface Properties | 2008 |
Biodegradable polymers--are they the answer to late stent thrombosis? Too early to tell.
Topics: Absorption; Coated Materials, Biocompatible; Drug-Eluting Stents; Humans; Lactic Acid; Polyesters; Polymers; Sirolimus; Thrombosis | 2008 |
Long-term clinical, angiographic, and intravascular ultrasound outcomes of biodegradable polymer-coated sirolimus-eluting stents.
Topics: Absorption; Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Aspirin; Coated Materials, Biocompatible; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Drug-Eluting Stents; Female; Humans; Lactic Acid; Male; Middle Aged; Platelet Aggregation Inhibitors; Polyesters; Polymers; Sirolimus; Ultrasonography, Interventional | 2008 |
[Rapamycin-loaded poly (lactic-co-glycolic) acid nanoparticles for intraarterial local drug delivery: preparation, characterization, and in vitro/in vivo release].
Topics: Animals; Aorta, Abdominal; Coronary Vessels; Drug Carriers; Drug Delivery Systems; Infusions, Intra-Arterial; Lactic Acid; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Sirolimus; Swine; Swine, Miniature | 2008 |
Late stent recoil of the bioabsorbable everolimus-eluting coronary stent and its relationship with plaque morphology.
Topics: Aged; Biocompatible Materials; Coronary Artery Disease; Coronary Vessels; Drug-Eluting Stents; Everolimus; Female; Humans; Immunosuppressive Agents; Lactic Acid; Male; Middle Aged; Polyesters; Polymers; Sirolimus; Time Factors | 2008 |
Delivery of rapamycin to dendritic cells using degradable microparticles.
Topics: Animals; Apoptosis; B7-2 Antigen; Biological Availability; CD4-Positive T-Lymphocytes; CD40 Antigens; Cell Proliferation; Cell Survival; Dendritic Cells; Drug Delivery Systems; Histocompatibility Antigens Class II; Lactic Acid; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Microspheres; Particle Size; Phagocytosis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Surface Properties | 2009 |
Polylactide-glycoli acid and rapamycin coating intraocular lens prevent posterior capsular opacification in rabbit eyes.
Topics: Animals; Aqueous Humor; Cataract; Cell Proliferation; Chromatography, High Pressure Liquid; Coated Materials, Biocompatible; Drug Carriers; Epithelial Cells; Immunosuppressive Agents; Lactic Acid; Lens Capsule, Crystalline; Lens Implantation, Intraocular; Lenses, Intraocular; Phacoemulsification; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Postoperative Complications; Rabbits; Sirolimus | 2009 |
Nanoscale mechanical measurement determination of the glass transition temperature of poly(lactic acid)/everolimus coated stents in air and dissolution media.
Topics: Everolimus; Glass; Hot Temperature; Lactic Acid; Microscopy, Atomic Force; Nanotechnology; Polyesters; Polymers; Sirolimus; Solubility; Stents | 2009 |
A novel accelerated in vitro release method for biodegradable coating of drug eluting stents: Insight to the drug release mechanisms.
Topics: Absorbable Implants; Chromatography, Gel; Drug-Eluting Stents; Electrons; Everolimus; Excipients; Immunosuppressive Agents; Lactic Acid; Microscopy, Electron, Scanning; Molecular Weight; Pharmaceutical Preparations; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Solubility; Solvents | 2009 |
New approach for local delivery of rapamycin by bioadhesive PLGA-carbopol nanoparticles.
Topics: Acrylic Resins; Adhesiveness; Animals; Cell Survival; Coronary Restenosis; Dogs; Drug Carriers; Drug Stability; Excipients; Humans; Immunosuppressive Agents; Lactic Acid; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus | 2009 |
Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy.
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carriers; ErbB Receptors; Female; Humans; Lactic Acid; Materials Testing; Nanostructures; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus | 2009 |
Three-dimensional time-of-flight secondary ion mass spectrometry imaging of a pharmaceutical in a coronary stent coating as a function of elution time.
Topics: Drug-Eluting Stents; Gold; Lactic Acid; Pharmaceutical Preparations; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Spectrometry, Mass, Secondary Ion; Surface Properties; Time Factors | 2009 |
[Combined rapamycin eye drop in nanometer vector and poly (lactic acid) wafers of cyclosporine A effectively prevents high-risk corneal allograft rejection in rabbits].
Topics: Animals; Corneal Transplantation; Cyclosporine; Drug Delivery Systems; Graft Rejection; Immunosuppressive Agents; Lactic Acid; Nanoparticles; Polyesters; Polymers; Rabbits; Sirolimus | 2009 |
Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.
Topics: Animals; Carbon Isotopes; Chromones; Drug Delivery Systems; Enzyme Inhibitors; Everolimus; Glioblastoma; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Monitoring, Physiologic; Morpholines; Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Sirolimus; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2010 |
[Effects of rapamycin-loaded poly(lactic-co-glycolic) acid nanoparticles on distribution of cell cycle, expression of p27 protein, and proliferation of human umbilical arterial vascular smooth muscle cell in vitro].
Topics: Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Drug Carriers; Humans; Lactic Acid; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Umbilical Arteries | 2010 |
Surface characterization of poly(lactic acid)/everolimus and poly(ethylene vinyl alcohol)/everolimus stents.
Topics: Biocompatible Materials; Cytostatic Agents; Diffusion; Drug Delivery Systems; Drug-Eluting Stents; Everolimus; Hydrophobic and Hydrophilic Interactions; Kinetics; Lactic Acid; Microscopy, Atomic Force; Photoelectron Spectroscopy; Polyesters; Polymers; Polyvinyls; Sirolimus; Spectrophotometry, Infrared; Surface Properties | 2010 |
In vitro and in vivo changes to PLGA/sirolimus coating on drug eluting stents.
Topics: Animals; Biocompatible Materials; Drug-Eluting Stents; Equipment Failure Analysis; Lactic Acid; Male; Materials Testing; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prosthesis Design; Rats; Rats, Sprague-Dawley; Sirolimus | 2010 |
The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma.
Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Glycolysis; HEK293 Cells; Humans; Hydrocarbons, Brominated; Lactic Acid; Mice; Mice, Inbred NOD; Mice, SCID; Neuroblastoma; Oxygen Consumption; Propionates; Protein Kinase Inhibitors; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Pretreatment with intraluminal rapamycin nanoparticle perfusion inhibits neointimal hyperplasia in a rabbit vein graft model.
Topics: Animals; Graft Occlusion, Vascular; In Vitro Techniques; Jugular Veins; Lactic Acid; Models, Animal; Nanomedicine; Nanoparticles; Neointima; Perfusion; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Sirolimus; Transplantation, Autologous | 2010 |
Paclitaxel/sirolimus combination coated drug-eluting stent: in vitro and in vivo drug release studies.
Topics: Animals; Antineoplastic Agents; Aorta, Abdominal; Calcium Phosphates; Coronary Artery Disease; Coronary Restenosis; Drug Combinations; Drug-Eluting Stents; Kinetics; Lactic Acid; Male; Microscopy, Electron, Scanning; Paclitaxel; Pilot Projects; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Sirolimus; Solubility; Surface Properties; Tubulin Modulators | 2011 |
High entrapment efficiency of chitosan/polylactic acid/tripolyphotspate nanosized microcapsules for rapamycin by an emulsion-evaporation approach.
Topics: Capsules; Chitosan; Drug Delivery Systems; Emulsions; Lactic Acid; Nanocapsules; Polyesters; Polymers; Polyphosphates; Sirolimus; Volatilization | 2010 |
Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts.
Topics: Animals; Blotting, Western; Cardiovascular Agents; Carotid Arteries; Carrier Proteins; Cell Proliferation; Cells, Cultured; Delayed-Action Preparations; Drug Carriers; Endothelial Cells; Graft Survival; Hyperplasia; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Jugular Veins; Lactic Acid; Light; Male; Microscopy, Electron, Transmission; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nanoparticles; Phosphoproteins; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Scattering, Radiation; Sirolimus; Solubility; Tunica Intima; Vascular Grafting | 2011 |
Rapamycin-induced impaired wound healing is associated with compromised tissue lactate accumulation and extracellular matrix remodeling.
Topics: Animals; Extracellular Matrix; Hydroxyproline; Immunosuppressive Agents; Lactic Acid; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Sirolimus; Tensile Strength; Tissue Distribution; Wound Healing | 2011 |
Sustained targeting of Bcr-Abl + leukemia cells by synergistic action of dual drug loaded nanoparticles and its implication for leukemia therapy.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug Synergism; Humans; Lactic Acid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Potential, Mitochondrial; Nanoparticles; Paclitaxel; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymerase Chain Reaction; Sirolimus | 2011 |
A 3-in-1 polymeric micelle nanocontainer for poorly water-soluble drugs.
Topics: Benzoquinones; Cell Line, Tumor; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Lactic Acid; Micelles; Models, Theoretical; Paclitaxel; Polyesters; Polyethylene Glycols; Polymers; Sirolimus; Solubility; TOR Serine-Threonine Kinases; Water | 2011 |
Enhanced efficacy of sirolimus-eluting bioabsorbable magnesium alloy stents in the prevention of restenosis.
Topics: Alloys; Angioplasty; Animals; Aorta, Abdominal; Aortic Diseases; Arterial Occlusive Diseases; Cardiovascular Agents; Cell Proliferation; Coated Materials, Biocompatible; Constriction, Pathologic; Dioxanes; Disease Models, Animal; Drug-Eluting Stents; Endothelial Cells; Hyperplasia; Lactic Acid; Magnesium; Male; Polyesters; Polymers; Prosthesis Design; Rabbits; Secondary Prevention; Sirolimus; Time Factors; Wound Healing | 2011 |
Production of 3-hydroxypropionic acid through propionaldehyde dehydrogenase PduP mediated biosynthetic pathway in Klebsiella pneumoniae.
Topics: Aldehydes; Amino Acid Sequence; Bacterial Proteins; Biosynthetic Pathways; Escherichia coli; Gene Deletion; Klebsiella pneumoniae; Lactic Acid; Microbial Viability; Molecular Sequence Data; Oxidoreductases; Sequence Analysis, Protein; Sirolimus; Substrate Specificity | 2012 |
Development of a biodegradable sirolimus-eluting stent coated by ultrasonic atomizing spray.
Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Coated Materials, Biocompatible; Drug Delivery Systems; Drug-Eluting Stents; Lactic Acid; Materials Testing; Microscopy, Electron, Scanning; Nebulizers and Vaporizers; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prosthesis Design; Sirolimus; Swine; Water | 2011 |
Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma.
Topics: Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Everolimus; Glioblastoma; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2012 |
Magnetic nanoparticles and rapamycin encapsulated into polymeric nanocarriers.
Topics: Drug Stability; Emulsions; Lactic Acid; Magnetite Nanoparticles; Nanocapsules; Nanospheres; Oleic Acid; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Spectroscopy, Fourier Transform Infrared | 2012 |
Differences in neointimal thickness between the adluminal and the abluminal sides of malapposed and side-branch struts in a polylactide bioresorbable scaffold: evidence in vivo about the abluminal healing process.
Topics: Absorbable Implants; Aged; Angioplasty, Balloon, Coronary; Australia; Cardiovascular Agents; Cell Proliferation; Coated Materials, Biocompatible; Coronary Artery Disease; Coronary Vessels; Europe; Everolimus; Female; Humans; Lactic Acid; Male; Middle Aged; Neointima; New Zealand; Polyesters; Polymers; Predictive Value of Tests; Prosthesis Design; Registries; Sirolimus; Time Factors; Tissue Scaffolds; Tomography, Optical Coherence; Treatment Outcome | 2012 |
Histopathological comparison of biodegradable polymer and permanent polymer based sirolimus eluting stents in a porcine model of coronary stent implantation.
Topics: Absorbable Implants; Angioplasty, Balloon, Coronary; Animals; Cardiovascular Agents; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Drug-Eluting Stents; Lactic Acid; Models, Animal; Neointima; Polyesters; Polyglactin 910; Polymers; Prosthesis Design; Sirolimus; Sus scrofa; Time Factors; Tissue Distribution | 2012 |
Local delivery of sirolimus nanoparticles for the treatment of in-stent restenosis.
Topics: Acrylic Resins; Animals; Cardiac Catheters; Cardiovascular Agents; Chemistry, Pharmaceutical; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Equipment Design; Infusions, Parenteral; Lactic Acid; Nanoparticles; Neointima; Percutaneous Coronary Intervention; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porosity; Sirolimus; Swine; Time Factors; Ultrasonography, Interventional | 2013 |
Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma.
Topics: Animals; Down-Regulation; Glycolysis; Lactic Acid; Lymphoma, B-Cell; Magnetic Resonance Spectroscopy; Mice; Mice, SCID; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation.
Topics: Amine Oxidase (Copper-Containing); Animals; Apoptosis; Caspase 3; Dinoprost; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Immunosuppressive Agents; Intestinal Mucosa; Ischemic Preconditioning; Janus Kinase 2; Lactic Acid; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; STAT3 Transcription Factor; Thromboxane B2; Tyrphostins | 2012 |
Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug.
Topics: Animals; Anti-Inflammatory Agents; Constriction, Pathologic; Coronary Vessels; Crystallization; Drug Delivery Systems; Drug-Eluting Stents; Lactic Acid; Models, Biological; Neointima; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sirolimus; Swine; Tunica Media | 2012 |
Vascular responses to a biodegradable polymer (polylactic acid) based biolimus A9-eluting stent in porcine models.
Topics: Angioplasty, Balloon; Animals; Cardiovascular Agents; Coronary Angiography; Coronary Vessels; Drug-Eluting Stents; Endothelial Cells; Granuloma; Inflammation; Lactic Acid; Lymphocytes; Metals; Microscopy, Electron, Scanning; Models, Animal; Polyesters; Polymers; Prosthesis Design; Sirolimus; Swine; Swine, Miniature; Time Factors; Ultrasonography; Vascular Patency; Wound Healing | 2012 |
In vitro mutagenicity and blood compatibility of paclitaxel and curcumin in poly (DL-lactide-co-glicolide) films.
Topics: Adsorption; Antineoplastic Agents, Phytogenic; Curcumin; Drug-Eluting Stents; Fibrinogen; Humans; Lactic Acid; Mutagenicity Tests; Mutagens; Paclitaxel; Platelet Activation; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Salmonella typhi; Sirolimus | 2013 |
Short-term safety and effects of a novel fully bioabsorable poly-L-lactic acid sirolimus-eluting stents in porcine coronary arteries.
Topics: Animals; Coronary Vessels; Drug-Eluting Stents; Lactic Acid; Polyesters; Polymers; Sirolimus; Swine | 2013 |
PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy.
Topics: Analysis of Variance; Animals; Animals, Newborn; Axons; Cell Death; Dose-Response Relationship, Drug; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Kynurenic Acid; L-Lactate Dehydrogenase (Cytochrome); Lactic Acid; Male; Microtubule-Associated Proteins; Neurons; Organ Culture Techniques; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases | 2013 |
Study of drug-eluting coating on metal coronary stent.
Topics: Coated Materials, Biocompatible; Drug-Eluting Stents; Lactic Acid; Metals; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rheology; Rotation; Sirolimus; Solutions; Solvents; Surface Properties | 2013 |
Electrografting of a biodegradable layer as a primer adhesion coating onto a metallic stent: in vitro and in vivo evaluations.
Topics: Angioplasty; Animals; Arteries; Biocompatible Materials; Cell Adhesion; Coronary Restenosis; Drug Delivery Systems; Drug-Eluting Stents; Electrochemistry; Humans; Inflammation; Lactic Acid; Male; Metals; Polyesters; Polymers; Rabbits; Sirolimus; Stents; Stress, Mechanical | 2013 |
Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Aurora Kinases; Benzamides; Cell Line, Tumor; Deoxyglucose; Gene Expression Regulation, Neoplastic; Glucose; Glycolysis; HL-60 Cells; Humans; Indoles; Lactic Acid; Leukemia, Myeloid, Acute; Piperazines; Polyploidy; Purines; Quinazolines; Sequestosome-1 Protein; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; U937 Cells | 2013 |
M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue.
Topics: Aging; Animals; Antibiotics, Antineoplastic; Cell Hypoxia; Cell Line; Cell Proliferation; Cellular Senescence; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid; Mice; Mitochondria; Oligomycins; Oxidative Phosphorylation; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
Inhalable particles containing rapamycin for induction of autophagy in macrophages infected with Mycobacterium tuberculosis.
Topics: Administration, Inhalation; Autophagy; Cell Survival; Cells, Cultured; Drug Delivery Systems; Humans; Lactic Acid; Macrophages; Microspheres; Mycobacterium tuberculosis; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Solubility | 2014 |
Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cisplatin; Dihydroxyphenylalanine; Disease Progression; Drug Carriers; Humans; In Situ Nick-End Labeling; Lactic Acid; Melanoma; Mice; Nanoparticles; Nanotechnology; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Platelet Endothelial Cell Adhesion Molecule-1; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Skin Neoplasms; Solvents; Tumor Microenvironment | 2014 |
Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver.
Topics: Animals; Antibiotics, Antineoplastic; Biomarkers; Caloric Restriction; Glucose-6-Phosphate; Lactic Acid; Liver; Longevity; Male; Mice; Mice, Inbred C57BL; Sirolimus | 2015 |
Neural tissue engineering scaffold with sustained RAPA release relieves neuropathic pain in rats.
Topics: Animals; Delayed-Action Preparations; Drug-Eluting Stents; Ganglia, Spinal; Gene Expression; Immunosuppressive Agents; Lactic Acid; Male; NAV1.3 Voltage-Gated Sodium Channel; NAV1.7 Voltage-Gated Sodium Channel; NAV1.8 Voltage-Gated Sodium Channel; Neuralgia; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sirolimus; Tissue Engineering; Tissue Scaffolds | 2014 |
Effect of solvent on drug release and a spray-coated matrix of a sirolimus-eluting stent coated with poly(lactic-co-glycolic acid).
Topics: Drug Liberation; Drug-Eluting Stents; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sirolimus; Solvents; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2014 |
Slow-releasing rapamycin-coated bionic peripheral nerve scaffold promotes the regeneration of rat sciatic nerve after injury.
Topics: Animals; Biocompatible Materials; Cells, Cultured; Delayed-Action Preparations; Immunosuppressive Agents; Lactic Acid; Male; Microspheres; Nerve Regeneration; Peripheral Nerves; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sirolimus; Tissue Engineering; Tissue Scaffolds | 2015 |
Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance.
Topics: Animals; Antigens; CD4-Positive T-Lymphocytes; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Factor VIII; Female; Hemocyanins; Hemophilia A; Humans; Hypersensitivity, Delayed; Immune Tolerance; Immunity, Humoral; Immunosuppression Therapy; Immunosuppressive Agents; Lactic Acid; Mice; Mice, Inbred BALB C; Nanocapsules; Nanoparticles; Oligodeoxyribonucleotides; Ovalbumin; Peptide Fragments; Peptides; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Proteins; Recombinant Proteins; Sirolimus | 2015 |
Comparison of phytoncide with sirolimus as a novel drug candidate for drug-eluting stent.
Topics: Adsorption; Animals; Calorimetry, Differential Scanning; Cell Death; Cell Proliferation; Cell Shape; Drug Discovery; Drug-Eluting Stents; Female; Fluorescence; Human Umbilical Vein Endothelial Cells; Humans; Lactic Acid; Microscopy, Electron, Scanning; Monoterpenes; Myocytes, Smooth Muscle; Platelet Adhesiveness; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Sus scrofa; Water; X-Ray Diffraction | 2015 |
Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment.
Topics: Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Availability; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Lactic Acid; Nanoparticles; Piperidines; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polyunsaturated Alkamides; Sirolimus | 2016 |
[Effects of Rapamycin and Rapamycin-loaded Poly(lactic-co-glycolic)Acid Nanoparticles on Apoptosis and Expression of bcl-2 and p27(kip1) Proteins of Human Umbilical Arterial Vascular Smooth Muscle Cell].
Topics: Apoptosis; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Humans; In Situ Nick-End Labeling; Lactic Acid; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Umbilical Arteries | 2015 |
[Efficacy and mechanism of local delivery of rapamycin and rapamycin-loaded poly(lactic-co-glycolic) acid nanoparticles on coronary restenosis of injury-stenosis model of minipigs].
Topics: Animals; Constriction, Pathologic; Disease Models, Animal; Lactic Acid; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus; Swine; Swine, Miniature | 2016 |
Preparation and Preclinical Evaluation of Inhalable Particles Containing Rapamycin and Anti-Tuberculosis Agents for Induction of Autophagy.
Topics: Administration, Inhalation; Animals; Antitubercular Agents; Autophagy; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Lactic Acid; Macrophages; Male; Mice; Monocytes; Mycobacterium tuberculosis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirolimus | 2016 |
Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling.
Topics: Angiogenesis Inhibitors; Animals; Axitinib; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Imidazoles; Indazoles; Indoles; Intestinal Neoplasms; Lactic Acid; Membrane Transport Proteins; Mice; Models, Biological; Neuroendocrine Tumors; Pancreatic Neoplasms; Pyrroles; Signal Transduction; Sirolimus; Stomach Neoplasms; Sunitinib; TOR Serine-Threonine Kinases; Up-Regulation | 2016 |
Intracellular release of rapamycin from poly (lactic acid) nanospheres modifies autophagy.
Topics: Antineoplastic Agents; Autophagy; Drug Carriers; Drug Liberation; Hep G2 Cells; Humans; Lactic Acid; Leupeptins; Microtubule-Associated Proteins; Nanospheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Proteasome Inhibitors; Sirolimus; Surface Properties | 2016 |
Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles.
Topics: Adalimumab; Anaphylaxis; Animals; Arthritis, Experimental; Bone Resorption; Drug Delivery Systems; Female; Hyperuricemia; Immune Tolerance; Lactic Acid; Macaca fascicularis; Mice, Transgenic; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Sprague-Dawley; Sirolimus; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha; Vaccines, Synthetic | 2016 |
Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field.
Topics: Animals; Antibiotics, Antineoplastic; Humans; Lactic Acid; Magnetic Fields; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice, Inbred NOD; Mice, SCID; Prostatic Neoplasms; Pyruvic Acid; Sarcoma; Sirolimus; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Movement; Cell Proliferation; Fibrosarcoma; Glutarates; Humans; Isocitrate Dehydrogenase; Lactic Acid; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, SCID; Mutation; Phenotype; Sirolimus; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
A model for hydrolytic degradation and erosion of biodegradable polymers.
Topics: Biocompatible Materials; Drug Liberation; Hydrolysis; Implants, Experimental; Lactic Acid; Models, Theoretical; Molecular Weight; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sirolimus; Time Factors | 2018 |
Sirolimus-coated, poly(L-lactic acid)-modified polypropylene mesh with minimal intra-peritoneal adhesion formation in a rat model.
Topics: Abdominal Wall; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Female; Lactic Acid; Laparotomy; Peritoneum; Polypropylenes; Rats; Rats, Sprague-Dawley; Sirolimus; Surgical Mesh; Surgical Wound; Tissue Adhesions | 2018 |
Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Disease Models, Animal; Fatty Acids, Omega-3; Female; Humans; Lactic Acid; Malondialdehyde; MCF-7 Cells; Metabolomics; Mice; Microtubule-Associated Proteins; Oxidative Phosphorylation; Reactive Oxygen Species; Sirolimus | 2018 |
Chloroquine Improves Deoxynivalenol-Induced Inflammatory Response and Intestinal Mucosal Damage in Piglets.
Topics: Amine Oxidase (Copper-Containing); Animals; Antioxidants; Autophagy; Cadherins; Chloroquine; Cytokines; Diet; Inflammation; Integrins; Intestinal Mucosa; Lactic Acid; Occludin; Proliferating Cell Nuclear Antigen; RNA, Messenger; Sirolimus; Swine; Trichothecenes; Zonula Occludens-1 Protein | 2020 |
Lactate inhibits osteogenic differentiation of human periodontal ligament stem cells via autophagy through the MCT1-mTOR signaling pathway.
Topics: Autophagy; Beclin-1; Cell Differentiation; Cell Proliferation; Cells, Cultured; Humans; Lactic Acid; Osteocalcin; Osteogenesis; Periodontal Ligament; Signal Transduction; Sirolimus; Stem Cells; TOR Serine-Threonine Kinases | 2022 |
Monodispersed Sirolimus-Loaded PLGA Microspheres with a Controlled Degree of Drug-Polymer Phase Separation for Drug-Coated Implantable Medical Devices and Subcutaneous Injection.
Topics: Injections, Subcutaneous; Lactic Acid; Microspheres; Particle Size; Pharmaceutical Preparations; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prostheses and Implants; Sirolimus; Solvents | 2022 |
Polypropylene mesh combined with electrospun poly (L-lactic acid) membrane in situ releasing sirolimus and its anti-adhesion efficiency in rat hernia repair.
Topics: Animals; Herniorrhaphy; Inflammation; Lactic Acid; Polyesters; Polypropylenes; Rats; Rats, Sprague-Dawley; Sirolimus; Surgical Mesh; Tissue Adhesions | 2022 |