lactic acid and simvastatin

lactic acid has been researched along with simvastatin in 49 studies

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (20.41)	29.6817
2010's	35 (71.43)	24.3611
2020's	4 (8.16)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Al Riyami, S; Ferns, GA; Livingstone, C; Wilkins, P	1
Grageda, E; Khan, A; Lawton, M; McDonald, J; Satsangi, N; Whang, K	1
Khan, A; McDonald, J; Satsangi, N; Whang, K	1
Cullen, DM; Genrich, MA; Killpack, B; Lee, Y; Marx, DB; Narayana, N; Reinhardt, RA; Schmid, MJ; Stein, D	1
Hirano, T; Iseki, K; Itagaki, S; Kobayashi, M; Otsuka, Y	1
Liu, ST; Sun, HC; Wang, Y; Wu, Z	1
Liu, C; Sun, H; Wu, Z; Zang, G	1
Jeon, JH; Lin, YL; Piepgrass, WT; Puleo, DA; Thomas, MV	1
Hollister, SJ; La Marca, F; Lin, CY; Park, JB; Park, P; Wang, L; Yang, VC; Zhang, H	1
Tabata, Y; Takaoka, R; Tanigo, T	1
Chan, HT; Dai, YL; Fong, B; Lau, CP; Lee, SW; Li, SW; Luk, TH; Siu, CW; Tam, S; Tse, HF; Yiu, KH	1
Han, X; Liao, J; Song, C; Song, Q; Wang, J; Yang, Y; Zhu, J	1
Liu, C; Sun, HC; Wu, Z	1
Han, X; Li, X; Song, C; Song, Q; Sun, Y; Wang, L; Yang, Y; Zhu, J	1
Chang, PC; Chong, LY; Chung, MC; Lei, C; Wang, CH	1
Lee, BT; Min, YK; Nath, SD; Sadiasa, A; Son, S	1
Buttery, LD; Qutachi, O; Shakesheff, KM	1
Park, K	1
Chang, PC; Chong, LY; Dovban, AS; Kuo, MY; Lim, JC; Lim, LP; Wang, CH	1
Lee, BT; Linh, NT; Nath, SD; Sadiasa, A	1
Aguilar, MR; Bölgen, N; Fernández, Mdel M; Gonzalo-Flores, S; Pişkin, E; San Román, J; Villar-Rodil, S	1
Gao, K; Jiang, L; Li, C; Li, D; Li, X; Shi, C; Sun, H; Yang, B; Yuan, A; Zhang, K; Zheng, C	1
Chang, JK; Fu, YC; Ho, ML; Tai, IC; Wang, CK	1
Belousova, ES; Mikashinovich, ZI	2
Coelho, PG; Galli, S; Ichikawa, T; Jimbo, R; Kozai, Y; Naito, Y; Ozeki, T; Tagami, T; Terukina, T; Vandeweghe, S	1
Dong, ZH; Gu, X; Guo, CC; Han, XQ; Wu, Z; Yu, XR	1
Fisher, PD; Hilt, JZ; Milbrandt, TA; Palomino, P; Puleo, DA	1
Arana-Chavez, VE; Bradaschia-Correa, V; Ferreira, LB; Marques, ND; Moreira, MM	1
Asahi, M; Ii, M; Kanokpanont, S; Saito, T; Tabata, Y; Thitiwuthikiat, P	1
Dong, ZG; Li, L; Li, YH; Ma, ZY; Nie, L; Pan, X; Wang, X; Xiao, GY; Zhang, HX	1
Gao, Y; Huang, L; Jiang, L; Liu, G; Mei, L; Shi, X; Tao, W; Wang, X; Wang, Z; Wu, Y; Zeng, X	1
Chai, G; Hu, FQ; Liu, J; Tao, S; Wang, H; Wang, J; Yuan, H	1
Aragonez, A; Bobinski, F; Cordeiro, MM; Corrêa, M; de Freitas, SF; dos Santos, AR; Encarnação, IC; Goldfeder, EM; Xavier, CC	1
Chen, CH; Fu, YC; Ho, ML; Wang, CK; Wang, GJ; Wang, YH	1
Clemens, J; Fisher, PD; Puleo, DA; Zach Hilt, J	1
Dinarvand, R; Eslami, H; Hooshmand, B; Jafarzadeh Kashi, TS; Khoshroo, K; Masaeli, R; Mashhadi Abbas, F; Rajabnejad, A; Rakhshan, V; Raz, M; Shahoon, H; Tahriri, M; Tayebi, L	1
He, J; Jiang, C; Liu, J; Wang, Z; Yang, Y; Zhang, M; Zhang, W	1
Amani, A; Deiham, B; Doosti, M; Faramarzi, MA; Imanparast, F; Kobarfard, F; Paknejad, M; Vatannejad, A	1
Aragones, A; Barbo, MLP; Cattani, SMM; Domingues, JA; Duek, EAR; Hausen, MA; Inácio, RF; Mendes Junior, D; Oliveira, ALR	1
Aragones, A; Corrêa, LR; Corrêa, M; Magini, RS; Marodin, A; Noronha Oliveira, M; Rau, LH	1
Alvarez-Lorenzo, C; Catanzano, O; Concheiro, A; d'Angelo, I; Diaz-Gomez, L; Miro, A; Quaglia, F; Ungaro, F	1
Ong, HX; Pisano, E; Scalia, S; Traini, D; Tulbah, AS; Young, PM	1
Li, X; Lin, Q; Liu, X; Liu, Y; Ni, S; Sun, H	1
Bouitbir, J; Duthaler, U; Handschin, C; Krähenbühl, S; Panajatovic, MV; Roos, NJ; Singh, F	1
Aragones, Á; Cordeiro, MMR; da Cruz, ACC; de Souza Magini, R; Sordi, MB	1
Ai, M; Li, M; Liu, Y; Qiao, F; Sui, L; Wang, J; Yang, Y; Zhang, J; Zhou, Y; Zhou, Z	1
Chauhan, S; Dora, CP; Grewal, AK; Kaur, M; Nagpal, M; Singh, TG	1

Trials

1 trial(s) available for lactic acid and simvastatin

Article	Year
Ridge Preservation After Maxillary Third Molar Extraction Using 30% Porosity PLGA/HA/β-TCP Scaffolds With and Without Simvastatin: A Pilot Randomized Controlled Clinical Trial. Implant dentistry, 2017, Volume: 26, Issue:6 Topics: Alveolar Ridge Augmentation; Biocompatible Materials; Bone Substitutes; Calcium Phosphates; Collagen; Cone-Beam Computed Tomography; Durapatite; Female; Humans; Lactic Acid; Male; Maxilla; Minerals; Molar, Third; Pilot Projects; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Prospective Studies; Simvastatin; Tissue Scaffolds; Tooth Extraction; Young Adult	2017

Article

Year

Ridge Preservation After Maxillary Third Molar Extraction Using 30% Porosity PLGA/HA/β-TCP Scaffolds With and Without Simvastatin: A Pilot Randomized Controlled Clinical Trial.

Implant dentistry, 2017, Volume: 26, Issue:6

Topics: Alveolar Ridge Augmentation; Biocompatible Materials; Bone Substitutes; Calcium Phosphates; Collagen; Cone-Beam Computed Tomography; Durapatite; Female; Humans; Lactic Acid; Male; Maxilla; Minerals; Molar, Third; Pilot Projects; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Prospective Studies; Simvastatin; Tissue Scaffolds; Tooth Extraction; Young Adult

2017

Other Studies

48 other study(ies) available for lactic acid and simvastatin

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
McArdle's disease diagnosed following statin-induced myositis. Annals of clinical biochemistry, 2004, Volume: 41, Issue:Pt 4 Topics: Aged; Ammonia; Anticholesteremic Agents; Creatine Kinase; Glycogen Storage Disease Type V; Humans; Lactic Acid; Male; Muscle, Skeletal; Myositis; Physical Exertion; Simvastatin	2004
A novel osteotropic biomaterial OG-PLG: in vitro efficacy. Journal of biomedical materials research. Part A, 2005, Aug-01, Volume: 74, Issue:2 Topics: Alkaline Phosphatase; Animals; Bone Marrow Cells; Bone Regeneration; Culture Media; In Vitro Techniques; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Inbred Lew; Simvastatin	2005
A novel osteotropic biomaterial OG-PLG: Synthesis and in vitro release. Journal of biomedical materials research. Part A, 2005, Aug-01, Volume: 74, Issue:2 Topics: Biocompatible Materials; Bone Regeneration; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Simvastatin; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared	2005
Local simvastatin effects on mandibular bone growth and inflammation. Journal of periodontology, 2005, Volume: 76, Issue:11 Topics: Animals; Collagenases; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Fibronectins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Inflammation Mediators; Lactic Acid; Mandible; Matrix Metalloproteinase 13; Membranes, Artificial; Methylcellulose; Mice; Nitrobenzenes; Osteogenesis; Pharmaceutical Vehicles; Polyesters; Polymers; Procollagen; Rats; Simvastatin; Skull; Sulfonamides; Up-Regulation	2005
Inhibitory effects of statins on human monocarboxylate transporter 4. International journal of pharmaceutics, 2006, Jul-06, Volume: 317, Issue:1 Topics: Animals; Atorvastatin; Basigin; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lactic Acid; LLC-PK1 Cells; Lovastatin; Monocarboxylic Acid Transporters; Muscle Proteins; Pyridines; Pyrroles; Simvastatin; Swine; Transfection	2006
[Effect of simvastatin on residual ridge resorption after tooth extraction]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2006, Volume: 41, Issue:12 Topics: Alveolar Bone Loss; Alveolar Process; Animals; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Simvastatin; Tooth Extraction	2006
The effect of simvastatin on remodelling of the alveolar bone following tooth extraction. International journal of oral and maxillofacial surgery, 2008, Volume: 37, Issue:2 Topics: Alveolar Bone Loss; Alveolar Process; Animals; Biocompatible Materials; Bone Density; Bone Remodeling; Disease Models, Animal; Drug Carriers; Drug Implants; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incisor; Lactic Acid; Male; Mandible; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Random Allocation; Rats; Rats, Wistar; Simvastatin; Time Factors; Tooth Extraction; Tooth Socket	2008
Localized intermittent delivery of simvastatin hydroxyacid stimulates bone formation in rats. Journal of periodontology, 2008, Volume: 79, Issue:8 Topics: Administration, Topical; Animals; Cellulose; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Hydroxymethylglutaryl CoA Reductases; Lactic Acid; Male; Microspheres; Models, Animal; Osteogenesis; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Simvastatin; Skull; Time Factors	2008
Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury. Arthritis research & therapy, 2009, Volume: 11, Issue:6 Topics: Animals; Bone Morphogenetic Protein 2; Drug Carriers; Gels; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intervertebral Disc; Intervertebral Disc Degeneration; Lactic Acid; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin	2009
Sustained release of water-insoluble simvastatin from biodegradable hydrogel augments bone regeneration. Journal of controlled release : official journal of the Controlled Release Society, 2010, Apr-19, Volume: 143, Issue:2 Topics: Animals; Bone Regeneration; Cell Line; Gelatin; Hydrogel, Polyethylene Glycol Dimethacrylate; Hypolipidemic Agents; Lactic Acid; Micelles; Rabbits; Simvastatin; Solubility; Tooth; Water	2010
Mitochondrial dysfunction induced by statin contributes to endothelial dysfunction in patients with coronary artery disease. Cardiovascular toxicology, 2010, Volume: 10, Issue:2 Topics: Aged; Biomarkers; Brachial Artery; Coronary Artery Disease; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactic Acid; Male; Mitochondria, Heart; Mitochondrial Diseases; Pyruvic Acid; Regional Blood Flow; Simvastatin; Vasodilation	2010
[Study on local implantation of simvastatin for repairing rabbit radial critical size defects]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2010, Volume: 24, Issue:4 Topics: Animals; Bone Regeneration; Bone Substitutes; Bone Transplantation; Lactic Acid; Male; Polyesters; Polymers; Rabbits; Radius; Radius Fractures; Simvastatin	2010
The effect of simvastatin on mRNA expression of transforming growth factor-beta1, bone morphogenetic protein-2 and vascular endothelial growth factor in tooth extraction socket. International journal of oral science, 2009, Volume: 1, Issue:2 Topics: Alveolar Process; Animals; Bone Morphogenetic Protein 2; Bone Remodeling; Drug Carriers; Endothelial Cells; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Hybridization; Lactic Acid; Male; Mandible; Osteoblasts; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Simvastatin; Stromal Cells; Time Factors; Tooth Socket; Transforming Growth Factor beta1; Up-Regulation; Vascular Endothelial Growth Factor A	2009
[Effect of simvastatin on inducing endothelial progenitor cells homing and promoting bone defect repair]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2010, Volume: 24, Issue:9 Topics: Animals; Bone Regeneration; Cells, Cultured; Endothelial Cells; Female; Lactic Acid; Male; Polyesters; Polymers; Rabbits; Simvastatin; Stem Cells; Tissue Engineering	2010
Biocompatibility of PDGF-simvastatin double-walled PLGA (PDLLA) microspheres for dentoalveolar regeneration: a preliminary study. Journal of biomedical materials research. Part A, 2012, Volume: 100, Issue:11 Topics: Animals; Biocompatible Materials; Delayed-Action Preparations; Hypolipidemic Agents; Lactic Acid; Male; Materials Testing; Platelet-Derived Growth Factor; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Simvastatin	2012
Preparation and characterization of PLGA microspheres by the electrospraying method for delivering simvastatin for bone regeneration. International journal of pharmaceutics, 2013, Feb-25, Volume: 443, Issue:1-2 Topics: Bone Regeneration; Calorimetry, Differential Scanning; Cell Adhesion; Cell Line; Cell Proliferation; Cell Survival; Drug Carriers; Drug Compounding; Humans; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Osteoblasts; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin; Solubility; Spectroscopy, Fourier Transform Infrared; Surface Properties	2013
Delivery of definable number of drug or growth factor loaded poly(DL-lactic acid-co-glycolic acid) microparticles within human embryonic stem cell derived aggregates. Journal of controlled release : official journal of the Controlled Release Society, 2013, May-28, Volume: 168, Issue:1 Topics: Bone Morphogenetic Protein 2; Cell Culture Techniques; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; Drug Carriers; Embryonic Stem Cells; Humans; Lactic Acid; Osteocalcin; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin; Vascular Endothelial Growth Factor A	2013
Delivery of definable numbers of PLGA microparticles within embryoid bodies. Journal of controlled release : official journal of the Controlled Release Society, 2013, May-28, Volume: 168, Issue:1 Topics: Bone Morphogenetic Protein 2; Drug Carriers; Embryonic Stem Cells; Humans; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin; Vascular Endothelial Growth Factor A	2013
Sequential platelet-derived growth factor-simvastatin release promotes dentoalveolar regeneration. Tissue engineering. Part A, 2014, Volume: 20, Issue:1-2 Topics: Alveolar Process; Animals; Humans; Lactic Acid; Male; Microspheres; Particle Size; Platelet-Derived Growth Factor; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Regeneration; Simvastatin; X-Ray Microtomography	2014
Encapsulation of simvastatin in PLGA microspheres loaded into hydrogel loaded BCP porous spongy scaffold as a controlled drug delivery system for bone tissue regeneration. Journal of biomaterials applications, 2014, Volume: 28, Issue:8 Topics: 3T3 Cells; Animals; Bone Regeneration; Drug Carriers; Drug Compounding; Drug Delivery Systems; Gene Expression; Hydrogels; Hydroxyapatites; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactic Acid; Materials Testing; Mice; Microscopy, Electron, Scanning; Microspheres; Osteoblasts; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin; Tissue Scaffolds	2014
Thermoresponsive biodegradable HEMA-lactate-Dextran-co-NIPA cryogels for controlled release of simvastatin. Artificial cells, nanomedicine, and biotechnology, 2015, Volume: 43, Issue:1 Topics: Acrylamides; Anticholesteremic Agents; Cryogels; Delayed-Action Preparations; Dextrans; Drug Compounding; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Lactic Acid; Methacrylates; Microscopy, Electron, Scanning; Polymers; Porosity; Simvastatin; Solutions; Spectroscopy, Fourier Transform Infrared; Temperature	2015
Enhancement of osteoinduction by continual simvastatin release from poly(lactic-co-glycolic acid)-hydroxyapatite-simvastatin nano-fibrous scaffold. Journal of biomedical nanotechnology, 2013, Volume: 9, Issue:11 Topics: Animals; Delayed-Action Preparations; Durapatite; Equipment Design; Equipment Failure Analysis; Female; Lactic Acid; Materials Testing; Nanocapsules; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Simvastatin; Skull Fractures; Tissue Scaffolds; Treatment Outcome	2013
Local delivery of controlled-release simvastatin/PLGA/HAp microspheres enhances bone repair. International journal of nanomedicine, 2013, Volume: 8 Topics: Animals; Bone Regeneration; Capsules; Delayed-Action Preparations; Diffusion; Durapatite; Lactic Acid; Mice; Mice, Inbred BALB C; Osteonecrosis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin; Treatment Outcome	2013
Analysis of biochemical changes in rat erythrocytes induced by long-term simvastatin treatment. Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:5 Topics: 2,3-Diphosphoglycerate; Animals; Catalase; Erythrocytes; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glycolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactic Acid; Lipid Peroxidation; Male; Pyruvic Acid; Rats; Simvastatin; Superoxide Dismutase	2013
The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria. International journal of pharmaceutics, 2014, Jan-30, Volume: 461, Issue:1-2 Topics: Animals; Bone and Bones; Bone Cements; Capsules; Disease Models, Animal; Emulsions; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Simvastatin; Skull; Solvents; Time Factors	2014
[Experimental study of tissue-engineered bone constructed with simvastatin carried by PLGA/CPC and bone marrow stromal cells]. Shanghai kou qiang yi xue = Shanghai journal of stomatology, 2014, Volume: 23, Issue:1 Topics: Alkaline Phosphatase; Bone Marrow Cells; Calcium Phosphates; Cell Differentiation; Lactic Acid; Mesenchymal Stem Cells; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin; Tissue Engineering; Tissue Scaffolds	2014
Improved small molecule drug release from in situ forming poly(lactic-co-glycolic acid) scaffolds incorporating poly(β-amino ester) and hydroxyapatite microparticles. Journal of biomaterials science. Polymer edition, 2014, Volume: 25, Issue:11 Topics: Clodronic Acid; Drug Implants; Drug Liberation; Durapatite; Hydrogels; Kinetics; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porosity; Simvastatin	2014
Evaluation of bone repair of critical size defects treated with simvastatin-loaded poly(lactic-co-glycolic acid) microspheres in rat calvaria. Journal of biomaterials applications, 2015, Volume: 29, Issue:7 Topics: Animals; Anticholesteremic Agents; Bone Regeneration; Bone Substitutes; Extracellular Matrix Proteins; Immunohistochemistry; Integrin-Binding Sialoprotein; Lactic Acid; Male; Materials Testing; Microscopy, Electron, Scanning; Microspheres; Osteopontin; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Proteoglycans; Rats; Rats, Wistar; Simvastatin; Skull; Tissue Scaffolds	2015
A vascular patch prepared from Thai silk fibroin and gelatin hydrogel incorporating simvastatin-micelles to recruit endothelial progenitor cells. Tissue engineering. Part A, 2015, Volume: 21, Issue:7-8 Topics: Animals; Blood Vessel Prosthesis; Bone Marrow Cells; Carotid Arteries; Cell Adhesion; Cell Movement; Cell Proliferation; Endothelial Progenitor Cells; Fibroins; Fluorescent Antibody Technique; Gelatin; Hydrogel, Polyethylene Glycol Dimethacrylate; Lactic Acid; Male; Micelles; Rats, Inbred F344; Simvastatin	2015
Biocompatibility and osteogenesis of calcium phosphate composite scaffolds containing simvastatin-loaded PLGA microspheres for bone tissue engineering. Journal of biomedical materials research. Part A, 2015, Volume: 103, Issue:10 Topics: Animals; Bone Substitutes; Cells, Cultured; Lactic Acid; Materials Testing; Microspheres; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Simvastatin; Tissue Engineering; Tissue Scaffolds	2015
Novel Simvastatin-Loaded Nanoparticles Based on Cholic Acid-Core Star-Shaped PLGA for Breast Cancer Treatment. Journal of biomedical nanotechnology, 2015, Volume: 11, Issue:7 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cholic Acid; Diffusion; Female; Lactic Acid; Mice; Mice, Inbred BALB C; Nanocapsules; Neoplasms, Experimental; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin; Tissue Distribution; Treatment Outcome	2015
Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system. International journal of nanomedicine, 2015, Volume: 10 Topics: 3T3 Cells; Animals; Bone and Bones; Cell Differentiation; Chromatography, High Pressure Liquid; Drug Delivery Systems; Female; Fluorescein; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Nanoparticles; Osteogenesis; Osteoporosis; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Simvastatin; Solvents; Surface Properties; Tetracycline	2015
Analysis of Bone Repair and Inflammatory Process Caused by Simvastatin Combined With PLGA+HA+βTCP Scaffold. Implant dentistry, 2016, Volume: 25, Issue:1 Topics: Animals; Bone Regeneration; Calcium Phosphates; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Simvastatin; Skull; Tissue Scaffolds	2016
Combination of calcium sulfate and simvastatin-controlled release microspheres enhances bone repair in critical-sized rat calvarial bone defects. International journal of nanomedicine, 2015, Volume: 10 Topics: Animals; Bone Regeneration; Bone Substitutes; Calcium Sulfate; Cell Adhesion; Cell Death; Delayed-Action Preparations; Immunohistochemistry; Lactic Acid; Male; Mice; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Sprague-Dawley; Simvastatin; Skull; Staining and Labeling; Wound Healing	2015
Multifunctional poly(β-amino ester) hydrogel microparticles in periodontal in situ forming drug delivery systems. Biomedical materials (Bristol, England), 2016, Mar-07, Volume: 11, Issue:2 Topics: Biocompatible Materials; Biomechanical Phenomena; Doxycycline; Drug Delivery Systems; Drug Implants; Humans; Hydrogels; Lactic Acid; Materials Testing; Particle Size; Periodontitis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porosity; Simvastatin; X-Ray Microtomography	2016
Biochemical Changes in Erythrocytes as a Molecular Marker of Cell Damage during Long-Term Simvastatin Treatment. Bulletin of experimental biology and medicine, 2016, Volume: 161, Issue:4 Topics: 2,3-Diphosphoglycerate; Animals; Erythrocytes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactic Acid; Male; Rats; Simvastatin	2016
Efficacy of the biomaterials 3wt%-nanostrontium-hydroxyapatite-enhanced calcium phosphate cement (nanoSr-CPC) and nanoSr-CPC-incorporated simvastatin-loaded poly(lactic-co-glycolic-acid) microspheres in osteogenesis improvement: An explorative multi-phase Materials science & engineering. C, Materials for biological applications, 2016, Dec-01, Volume: 69 Topics: Animals; Biocompatible Materials; Bone and Bones; Bone Diseases; Calcium Phosphates; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Carriers; Humans; Hydroxyapatites; Lactic Acid; Male; Microspheres; Nanocomposites; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Rats; Rats, Sprague-Dawley; Simvastatin; Strontium	2016
Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy. International journal of nanomedicine, 2017, Volume: 12 Topics: Animals; Cholesterol; Coculture Techniques; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Flow Cytometry; Human Umbilical Vein Endothelial Cells; Humans; Hyaluronic Acid; Hyaluronoglucosaminidase; Lactic Acid; Lipoproteins, HDL; Macrophages; Male; Mice; Nanoparticles; Particle Size; Plaque, Atherosclerotic; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; RAW 264.7 Cells; Simvastatin; Static Electricity; Tunica Intima	2017
mZD7349 peptide-conjugated PLGA nanoparticles directed against VCAM-1 for targeted delivery of simvastatin to restore dysfunctional HUVECs. Microvascular research, 2017, Volume: 112 Topics: Anti-Inflammatory Agents; Cells, Cultured; Drug Carriers; Drug Compounding; Drug Liberation; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lactic Acid; Nanoparticles; Nitric Oxide Synthase Type III; Peptides, Cyclic; Phosphorylation; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Serine; Simvastatin; Solubility; Time Factors; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1	2017
Study of mesenchymal stem cells cultured on a poly(lactic-co-glycolic acid) scaffold containing simvastatin for bone healing. Journal of applied biomaterials & functional materials, 2017, Apr-26, Volume: 15, Issue:2 Topics: Animals; Bone Regeneration; Cells, Cultured; Glycols; Lactic Acid; Male; Mesenchymal Stem Cells; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Simvastatin; Tissue Engineering; Tissue Scaffolds	2017
Microparticle-embedded fibroin/alginate beads for prolonged local release of simvastatin hydroxyacid to mesenchymal stem cells. Carbohydrate polymers, 2017, Nov-01, Volume: 175 Topics: Alginates; Cells, Cultured; Drug Delivery Systems; Fibroins; Humans; Lactic Acid; Mesenchymal Stem Cells; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin	2017
Inhaled simvastatin nanoparticles for inflammatory lung disease. Nanomedicine (London, England), 2017, Volume: 12, Issue:20 Topics: Administration, Inhalation; Anti-Inflammatory Agents; Biological Transport; Chemistry, Pharmaceutical; Chronic Disease; Drug Carriers; Drug Liberation; Epithelial Cells; Humans; Inflammation; Lactic Acid; Lung Diseases; Mucus; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin; Surface Properties	2017
Enhanced osteogenic healing process of rat tooth sockets using a novel simvastatin-loaded injectable microsphere-hydrogel system. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2019, Volume: 47, Issue:7 Topics: Animals; Hydrogels; Lactic Acid; Microspheres; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Simvastatin; Tooth Socket	2019
PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice. Acta physiologica (Oxford, England), 2020, Volume: 228, Issue:4 Topics: Animals; Citrate (si)-Synthase; DNA, Mitochondrial; Glutathione; Glycolysis; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactic Acid; Mice; Mice, Knockout; Mitochondria, Muscle; Muscle, Skeletal; Myotoxicity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Conditioning, Animal; Simvastatin	2020
PLGA+HA/βTCP Scaffold Incorporating Simvastatin: A Promising Biomaterial for Bone Tissue Engineering. The Journal of oral implantology, 2021, Apr-01, Volume: 47, Issue:2 Topics: Biocompatible Materials; Calcium Phosphates; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Simvastatin; Tissue Engineering; Tissue Scaffolds	2021
Polymeric non-spherical coarse microparticles fabricated by double emulsion-solvent evaporation for simvastatin delivery. Colloids and surfaces. B, Biointerfaces, 2021, Volume: 199 Topics: Drug Carriers; Emulsions; Lactic Acid; Microspheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin; Solvents	2021
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis. Current drug targets, 2023, Volume: 24, Issue:13 Topics: Animals; Delayed-Action Preparations; Drug Carriers; Hydroxyapatites; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactic Acid; Nanoparticles; Osteoporosis; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Simvastatin	2023