Compounds > lactic acid

lactic acid and pyrimidinones

lactic acid has been researched along with pyrimidinones in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's8 (66.67)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Aweeka, F; Grunfeld, C; Lee, GA; Lo, JC; Mulligan, K; Rao, M; Schambelan, M; Schwarz, JM1
Belgum, T; Christensen, K; Dash, A; Destache, CJ; Sharma, A; Shibata, A1
Bishop, PW; Blackhall, F; Critchlow, SE; Dive, C; Fusi, A; Hodgkinson, CL; Kelly, P; Morrow, CJ; Nonaka, D; Polański, R; Priest, L; Smith, PD; Trapani, F; White, A1
Coviello, V; Dario, P; Filippeschi, C; La Motta, C; Menciassi, A; Piazza, V; Pingue, P; Ricotti, L; Sartini, S; Vannozzi, L1
Buckheit, RW; Ham, AS; Kelley, K; Martin, A; McNicholl, JM; Smith, JM; Srinivasan, P; Zhang, J1
Bacon, CM; Bell, N; Blair, H; Bomken, S; Critchlow, SE; Crossland, R; Keun, HC; Long, A; Miwa, S; Nakjang, S; Noble, RA; Phillips, N; Rand, V; Sikka, A; Televantou, D; Thomas, H; Wedge, SR1
Arunan, V; Beloueche-Babari, M; Casals Galobart, T; Chung, YL; Eykyn, TR; Koniordou, M; Leach, MO; Parkes, HG; Smith, PD; Wantuch, S1
Eichner, R; Girardi, E; Hashimoto, M; Superti-Furga, G1
Boyers, A; Chadwick, A; Critchlow, SE; Mehibel, M; Mueller-Klieser, W; Ortiz-Martinez, F; Stratford, IJ; Telfer, BA; Voelxen, N; West, CM; Williams, KJ1
Guan, X; Morris, ME; Rodriguez-Cruz, V1
Eliopoulos, E; Papakonstantinou, E; Thireou, T; Vlachakis, D; Vlachoyiannopoulos, PG1
Afonso, J; Antunes, B; Baltazar, F; Batista, A; Pinto-Ribeiro, F; Silva, A1

Reviews

1 review(s) available for lactic acid and pyrimidinones

ArticleYear
In Vivo Anticancer Activity of AZD3965: A Systematic Review.
    Molecules (Basel, Switzerland), 2021, Dec-29, Volume: 27, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Management; Disease Progression; Drug Evaluation, Preclinical; Energy Metabolism; Glycolysis; Humans; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Pyrimidinones; Signal Transduction; Symporters; Thiophenes; Tumor Microenvironment; Warburg Effect, Oncologic; Xenograft Model Antitumor Assays

2021

Trials

1 trial(s) available for lactic acid and pyrimidinones

ArticleYear
Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteers.
    AIDS (London, England), 2007, Oct-18, Volume: 21, Issue:16

    Topics: Adult; Aged; Blood Glucose; Carbamates; Double-Blind Method; Energy Metabolism; Furans; Glucose Clamp Technique; HIV Protease Inhibitors; Humans; Indinavir; Insulin; Insulin Resistance; Lactic Acid; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Sulfonamides

2007

Other Studies

10 other study(ies) available for lactic acid and pyrimidinones

ArticleYear
Combination antiretroviral drugs in PLGA nanoparticle for HIV-1.
    BMC infectious diseases, 2009, Dec-09, Volume: 9

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Carriers; Drug Combinations; Drug Compounding; HIV Infections; Humans; Lactic Acid; Lopinavir; Macrophages; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Pyrimidinones; Ritonavir

2009
Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Feb-15, Volume: 20, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Inhibitory Concentration 50; Kaplan-Meier Estimate; Lactic Acid; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Monocarboxylic Acid Transporters; Multivariate Analysis; Muscle Proteins; Pyrimidinones; Small Cell Lung Carcinoma; Symporters; Thiophenes; Xenograft Model Antitumor Assays

2014
Nanostructured ultra-thin patches for ultrasound-modulated delivery of anti-restenotic drug.
    International journal of nanomedicine, 2016, Volume: 11

    Topics: Barium Compounds; Cardiovascular Agents; Cell Adhesion; Cells, Cultured; Coronary Restenosis; Drug Carriers; Drug Delivery Systems; Humans; Lactic Acid; Muscle, Smooth, Vascular; Nanoparticles; Nanostructures; Polyesters; Polymers; Pyridines; Pyrimidinones; Titanium; Ultrasonics

2016
Safety and Pharmacokinetics of Quick-Dissolving Polymeric Vaginal Films Delivering the Antiretroviral IQP-0528 for Preexposure Prophylaxis.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:7

    Topics: Administration, Intravaginal; Animals; Anti-HIV Agents; Female; HIV Infections; HIV-1; Lactic Acid; Macaca nemestrina; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Pyrimidinones; Vagina

2016
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.
    Haematologica, 2017, Volume: 102, Issue:7

    Topics: Antineoplastic Agents; Biomarkers; Burkitt Lymphoma; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; Electron Transport Complex I; Energy Metabolism; Humans; Lactic Acid; Lymphoma, Large B-Cell, Diffuse; Mitochondria; Monocarboxylic Acid Transporters; Muscle Proteins; Oxidative Phosphorylation; Pyrimidinones; Symporters; Thiophenes

2017
MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy.
    Cancer research, 2017, 11-01, Volume: 77, Issue:21

    Topics: Acrylates; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Energy Metabolism; Female; HT29 Cells; Humans; Lactic Acid; Lymphoma; Magnetic Resonance Spectroscopy; Metformin; Mice, SCID; Mitochondria; Monocarboxylic Acid Transporters; Muscle Proteins; Pyrimidinones; Symporters; Thiophenes; Xenograft Model Antitumor Assays

2017
Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay.
    ACS chemical biology, 2018, 06-15, Volume: 13, Issue:6

    Topics: Biological Assay; Excitatory Amino Acid Transporter 2; Formates; Glutamate Plasma Membrane Transport Proteins; Heating; HEK293 Cells; Humans; Lactic Acid; Ligands; Monocarboxylic Acid Transporters; Protein Binding; Protein Stability; Pyrimidinones; Thiophenes; Uracil

2018
Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters.
    Scientific reports, 2018, 11-14, Volume: 8, Issue:1

    Topics: Animals; Biomarkers; Head and Neck Neoplasms; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactic Acid; Mice; Monocarboxylic Acid Transporters; Oxidative Phosphorylation; Precision Medicine; Prognosis; Pyrimidinones; Thiophenes

2018
Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells.
    The AAPS journal, 2019, 01-07, Volume: 21, Issue:2

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Coumaric Acids; Drug Screening Assays, Antitumor; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Mice; Monocarboxylic Acid Transporters; Pyrimidinones; Symporters; Thiophenes; Uracil

2019
A Holistic Evolutionary and 3D Pharmacophore Modelling Study Provides Insights into the Metabolism, Function, and Substrate Selectivity of the Human Monocarboxylate Transporter 4 (hMCT4).
    International journal of molecular sciences, 2021, Mar-13, Volume: 22, Issue:6

    Topics: Animals; Antineoplastic Agents; Binding Sites; Biological Transport; Drug Design; Glycolysis; Humans; Lactic Acid; Molecular Docking Simulation; Monocarboxylic Acid Transporters; Muscle Proteins; Phloretin; Phylogeny; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Protein Isoforms; Pyrimidinones; Quercetin; Reserpine; Structural Homology, Protein; Substrate Specificity; Thiophenes; Uracil

2021