Compounds > lactic acid

lactic acid and phenformin

lactic acid has been researched along with phenformin in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199011 (42.31)18.7374
1990's4 (15.38)18.2507
2000's3 (11.54)29.6817
2010's7 (26.92)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Caffau, C; Cernigoi, AM; Velussi, M; Viezzoli, L1
Chandalia, HB; Rangnath, M1
Chew, SK; Lim, HS; Sin, FL; Tan, YT1
Liang, JZ; Luo, ZT; Yang, DP1
Arieff, AI; Park, R1
Jalling, O; Olsen, C1
Garabadu, NK; Samal, KC; Tripathy, BB1
Evans, PF; Jones, WE; King, LJ; Margetts, G; Parke, DV1
Leese, HJ; Nicholls, TJ1
Carrasco Prieto, AL; Fernández González, MJ; Jimeno Carruez, A; Largo Cabrerizo, E; Ortiz Manchado, O; Usategui Echeverría, R1
Halestrap, AP; Owen, MR1
Lalau, JD; Race, JM1
Amin, BM; Patel, JC; Sawant, MS1
EWY, GA; MAHER, JF; MINTZ, DH; PABICO, RC1
MENGIS, CL1
PHILLIPSON, EA; SPROULE, BJ1
Ogihara, T; Tanaka, Y1
Billis, PA; Dykens, JA; Jamieson, J; Marroquin, L; Nadanaciva, S; Will, Y1
Bando, K; Deguchi, J; Funabashi, H; Kimura, J; Kunimatsu, T; Ochiai, S; Seki, T1
Kitamura, A; Komuro, S; Sogame, Y; Takano, M; Yabuki, M1
Blagih, J; Coelho, PP; Griss, T; Jones, RG; Vincent, EE; Viollet, B1
Baltazar, F; Granja, S; Le Floch, R; Marchiq, I; Moura, CS; Pouysségur, J1
Eckert, MA; Johnson, A; Lengyel, E; Litchfield, LM; Mills, KA; Mukherjee, A; Pan, S; Romero, IL; Shridhar, V1
Ellinger-Ziegelbauer, H; Freyberger, A; Heinz, S; Lawrenz, B; Schladt, L; Schmuck, G1
Barry, AP; Bonglack, EN; Cable, JM; Ch'ng, J; Christofk, HR; Dave, SS; Luftig, MA; Messinger, JE; Parnell, KM; Reinoso-Vizcaíno, NM; Russell, VS1

Reviews

1 review(s) available for lactic acid and phenformin

ArticleYear
[Diabetic lactic acidosis].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Sep-28, Volume: Suppl 3

    Topics: Acidosis, Lactic; Contraindications; Diabetic Ketoacidosis; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Phenformin; Sodium Bicarbonate

2006

Trials

1 trial(s) available for lactic acid and phenformin

ArticleYear
Levels of lactic acid, normal level & its relation to food, glucose, cholesterol, raised blood urea and phenformin therapy.
    Indian journal of medical sciences, 2000, Volume: 54, Issue:1

    Topics: Diabetes Mellitus, Type 2; Diet; Female; Humans; Hypercholesterolemia; Hyperglycemia; India; Lactic Acid; Male; Phenformin; Reference Values; Urea

2000

Other Studies

24 other study(ies) available for lactic acid and phenformin

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
[Median-term (4 months) treatment with glibenclamide + metformin substituting for glibenclamide + fenformin lowers the lacticemia levels in type-2 diabetics (NIDDM)].
    La Clinica terapeutica, 1992, Volume: 141, Issue:12

    Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Evaluation; Drug Therapy, Combination; Female; Follow-Up Studies; Glyburide; Glycated Hemoglobin; Glycosuria; Humans; Lactates; Lactic Acid; Male; Metformin; Middle Aged; Phenformin

1992
Biguanide-induced lactic acidosis.
    The Journal of the Association of Physicians of India, 1990, Volume: 38, Issue:9

    Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Follow-Up Studies; Humans; Lactates; Lactic Acid; Male; Phenformin; Prospective Studies

1990
Lactic acidosis from phenformin overdose--a case report.
    Singapore medical journal, 1986, Volume: 27, Issue:4

    Topics: Acidosis; Adult; Female; Humans; Lactates; Lactic Acid; Phenformin; Suicide, Attempted

1986
[Alteration of blood lactic acid levels in biguanide therapy in diabetics].
    Sichuan yi xue yuan xue bao = Acta Academiae Medicinae Sichuan, 1985, Volume: 16, Issue:2

    Topics: Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Lactates; Lactic Acid; Metformin; Middle Aged; Phenformin

1985
Treatment of lactic acidosis with dichloroacetate in dogs.
    The Journal of clinical investigation, 1982, Volume: 70, Issue:4

    Topics: Acetates; Acidosis; Animals; Bicarbonates; Cardiac Output; Dichloroacetic Acid; Dogs; Female; Hepatectomy; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Male; Phenformin; Sodium Bicarbonate; Sodium Chloride

1982
The effects of metformin compared to the effects of phenformin on the lactate production and the metabolism of isolated parenchymal rat liver cell.
    Acta pharmacologica et toxicologica, 1984, Volume: 54, Issue:5

    Topics: Adenosine Triphosphate; Animals; Carbon Dioxide; Ethanol; Glycerol; Ketone Bodies; Kinetics; Lactates; Lactic Acid; Liver; Male; Metformin; Oxygen Consumption; Phenformin; Proteins; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains

1984
Phenformin and other antidiabetic drugs on blood lactic acid.
    The Journal of the Association of Physicians of India, 1984, Volume: 32, Issue:11

    Topics: Adolescent; Adult; Aged; Child; Diabetic Ketoacidosis; Female; Humans; Hypoglycemic Agents; India; Lactates; Lactic Acid; Male; Middle Aged; Phenformin; Prospective Studies

1984
The mechanism of action of phenformin in starved rats.
    Biochemical pharmacology, 1983, Nov-15, Volume: 32, Issue:22

    Topics: Animals; Blood Glucose; Gluconeogenesis; Glucose; Kinetics; Lactates; Lactic Acid; Male; Phenformin; Rats; Rats, Inbred Strains; Sodium Fluoride; Starvation; Succinates; Succinic Acid

1983
The effects of phenformin on the transport and metabolism of sugars by the rat small intestine.
    Biochemical pharmacology, 1984, Mar-01, Volume: 33, Issue:5

    Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Carbohydrate Metabolism; Galactose; Glucose; Intestinal Mucosa; Intestine, Small; Lactates; Lactic Acid; Male; Oxidative Phosphorylation; Phenformin; Rats; Rats, Inbred Strains

1984
[Effect of hydrocortisone on experimental hyperlactacidemia induced by fenformin in rabbits].
    Archivos de farmacologia y toxicologia, 1981, Volume: 7, Issue:2

    Topics: Animals; Drug Evaluation, Preclinical; Hydrocortisone; Lactates; Lactic Acid; Male; Phenformin; Rabbits; Time Factors

1981
The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesis.
    Biochimica et biophysica acta, 1993, Apr-05, Volume: 1142, Issue:1-2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cells, Cultured; Diuron; Glucagon; Gluconeogenesis; Lactates; Lactic Acid; Liver; Mitochondria, Liver; Phenformin; Pyruvate Carboxylase; Pyruvate Kinase; Pyruvates; Pyruvic Acid; Rats; Starvation

1993
Lactic acidosis in metformin therapy.
    Drugs, 1999, Volume: 58 Suppl 1

    Topics: Acidosis, Lactic; Adult; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Middle Aged; Phenformin; Retrospective Studies; Risk Factors

1999
LACTATE ACIDOSIS ASSOCIATED WITH PHENFORMIN THERAPY AND LOCALIZED TISSUE HYPOXIA. REPORT OF A CASE TREATED BY HEMODIALYSIS.
    Annals of internal medicine, 1963, Volume: 59

    Topics: Acidosis; Black People; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Ischemia; Kidney; Kidneys, Artificial; Lactates; Lactic Acid; Phenformin; Renal Dialysis; Toxicology

1963
LACTIC ACID ACIDEMIA AND PHENFORMIN.
    Rocky Mountain medical journal, 1964, Volume: 61

    Topics: Acidosis; Acidosis, Lactic; Blood; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Lactates; Lactic Acid; Phenformin; Toxicology

1964
THE CLINICAL SIGNIFICANCE OF ELEVATED BLOOD LACTATE.
    Canadian Medical Association journal, 1965, Jun-26, Volume: 92

    Topics: Acidosis; Acidosis, Lactic; Blood; Chemical Phenomena; Chemistry; Geriatrics; Humans; Hypertension; Hypertension, Pulmonary; Hypoxia; Lactates; Lactic Acid; Phenformin; Prognosis; Shock

1965
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.
    Toxicology and applied pharmacology, 2008, Dec-01, Volume: 233, Issue:2

    Topics: Acidosis, Lactic; Animals; Blood Glucose; Buformin; Cell Line; Cell Respiration; Cell Survival; Culture Media; Glutathione; Glycolysis; Hepatocytes; Humans; Hypoglycemic Agents; Lactic Acid; Male; Membrane Potential, Mitochondrial; Metformin; Mitochondria, Liver; Oxidation-Reduction; Phenformin; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2008
Comparison of potential risks of lactic acidosis induction by biguanides in rats.
    Regulatory toxicology and pharmacology : RTP, 2010, Volume: 58, Issue:1

    Topics: Acidosis, Lactic; Animals; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Phenformin; Rats; Rats, Inbred F344

2010
Transport of biguanides by human organic cation transporter OCT2.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2013, Volume: 67, Issue:5

    Topics: Biological Transport; Female; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 2; Phenformin

2013
Differential effects of AMPK agonists on cell growth and metabolism.
    Oncogene, 2015, Volume: 34, Issue:28

    Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Glucose; HCT116 Cells; HEK293 Cells; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mice; Neoplasms; Phenformin; Pyrones; Ribonucleotides; Sodium Salicylate; Thiophenes

2015
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.
    Oncotarget, 2015, Mar-30, Volume: 6, Issue:9

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents; Basigin; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Down-Regulation; Female; Gene Knockdown Techniques; Glycolysis; Humans; Lactic Acid; Lung Neoplasms; Metformin; Mice, Nude; Monocarboxylic Acid Transporters; Muscle Proteins; Phenformin; Protein Serine-Threonine Kinases; Protein Transport; Symporters; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays

2015
Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.
    Oncotarget, 2015, Sep-15, Volume: 6, Issue:27

    Topics: Animals; Antineoplastic Agents; Ascites; Cell Line, Tumor; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Glucose; Glycolysis; Humans; Hyperglycemia; Hypoglycemic Agents; Lactic Acid; MAP Kinase Signaling System; Metformin; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; Pentose Phosphate Pathway; Phenformin; Proto-Oncogene Proteins c-myc

2015
Energy metabolism modulation by biguanides in comparison with rotenone in rat liver and heart.
    Archives of toxicology, 2019, Volume: 93, Issue:9

    Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Energy Metabolism; Gluconeogenesis; Heart; Lactic Acid; Liver; Male; Metformin; Mitochondria; Oxidative Phosphorylation; Phenformin; Rats, Wistar; Rotenone; Transcriptome

2019
Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.
    Proceedings of the National Academy of Sciences of the United States of America, 2021, 06-22, Volume: 118, Issue:25

    Topics: B-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Epstein-Barr Virus Infections; Glucose; Glutathione; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; Lactic Acid; Lymphoma; Metformin; Monocarboxylic Acid Transporters; NAD; Oxygen Consumption; Phenformin; Reactive Oxygen Species; Up-Regulation

2021