lactic acid has been researched along with methotrexate in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.23) | 18.7374 |
| 1990's | 3 (9.68) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 21 (67.74) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bracht, A; Ishii-Iwamoto, EL; Yamamoto, NS | 1 |
| Bracht, A; Bracht, AM; Campello, Ade P; de Oliveira, MB; Ishii, EL; Kluppel, ML; Yamamoto, NS | 1 |
| Singh, UV; Udupa, N | 1 |
| Caetano, NN; Campello, AP; Carnieri, EG; Kluppel, ML; Oliveira, MB | 1 |
| Calvillo, M; Caruso, U; Dufour, C; Minniti, G; Schiaffino, MC; Svahn, J | 1 |
| Burt, HM; Jackson, J; Liang, LS; Min, W; Risovic, V; Wasan, KM | 1 |
| Abrey, LE; DeAngelis, LM; Koutcher, JA; Lis, E; Panageas, KS; Raizer, JJ; Xu, S; Zakian, KL | 1 |
| Burt, HM; Liang, LS; Wong, W | 1 |
| Celik, A; Eralp, A; Yüncü, M | 1 |
| Domb, AJ; Jain, JP; Kumar, N; Modi, S | 1 |
| Chen, D; Chen, J; Chen, X; Sun, J; Tian, H; Wu, M | 1 |
| Asmatulu, R; Gopu, JS; Man, KP; Misak, HE; Wooley, PH; Yang, SY; Zacharias, NM | 1 |
| Afshari, M; Derakhshandeh, K; Hosseinzadeh, L | 1 |
| Augsburger, JJ; Banerjee, RK; Correa, ZM; Landero, JA; Manna, S | 1 |
| Chen, Y; Ding, M; Huang, S; Jiang, W; Li, Q; Luo, X; Qi, H; Wang, Z; Xiao, X; Zhang, H; Zhang, X; Zheng, Y | 1 |
| Ashwanikumar, N; Kumar, GSV; Kumar, NA; Nair, SA | 1 |
| Moura, CC; Neves, Jd; Reis, S; Sarmento, B; Segundo, MA | 1 |
| Cui, F; Hou, Z; Jia, M; Li, Y; Lin, J; Luo, F; Wu, H; Wu, S; Xie, L; Yang, X; Ye, S; Yu, F | 1 |
| Al-Rjoub, MF; Augsburger, JJ; Banerjee, RK; Correa, ZM; Donnell, A; Manna, S | 1 |
| Du, GQ; Wang, YM | 1 |
| Akbarzadeh, A; Alizadeh, E; Azizi Jalalian, F; Davaran, S; Gorjikhah, F; Hasanzadeh, A; Panahi, Y; Salehi, R | 1 |
| Katare, OP; Kumar, R; Raza, K; Sharma, G; Singh, A; Singh, B; Thotakura, N | 1 |
| Chakraborty, J; Ray, S; Sa, B; Saha, S | 1 |
| Katare, OP; Kumar, P; Kumar, R; Raza, K; Sharma, G; Singh, B | 1 |
| Cornélio, AM; da Silva-Júnior, AA; de Almeida, YMB; de Oliveira, AR; do Egito, EST; Farias, KJS; Fernandes-Pedrosa, MF; Machado, PRL; Mesquita, PC | 1 |
| Balasubramanian, V; Correia, A; Kashif, PM; Madni, A; Mäkilä, E; Rehman, M; Salonen, J; Santos, HA; Tahir, N | 1 |
| Duan, D; Gao, L; Liu, X; Luo, L; Xia, L; Xu, J; Zhang, R | 1 |
| Al-Rjoub, MF; Augsburger, JJ; Banerjee, RK; Donnell, AM; Kaval, N; Manna, S | 1 |
| Lee, RJ; Li, Y; Sun, F; Sun, X; Teng, L; Yu, C; Zhang, X; Zhao, J; Zhao, M; Zhou, Y | 1 |
| Baek, IJ; Gao, N; Hwang, SW; Kamada, N; Kang, SW; Kim, KS; Kim, S; Kim, TY; Kim, Y; Kweon, MN; Lee, SH; Lee, YS; Liu, S; O, E; Park, YY; Sung, YH; Yang, JY | 1 |
31 other study(ies) available for lactic acid and methotrexate
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Metabolic effects of diltiazem in the perfused rat liver.
Topics: Animals; Atractyloside; Diltiazem; Glucose; In Vitro Techniques; Lactates; Lactic Acid; Liver; Male; Methotrexate; Norepinephrine; Oxygen Consumption; Perfusion; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1992 |
Methotrexate increases glycogenolysis in the intact rat liver.
Topics: Animals; Dose-Response Relationship, Drug; Glucose; Glycogen; Glycolysis; In Vitro Techniques; Lactates; Lactic Acid; Liver; Male; Methotrexate; Oxygen Consumption; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1986 |
In vitro characterization of methotrexate loaded poly(lactic-co-glycolic) acid microspheres and antitumor efficacy in Sarcoma-180 mice bearing tumor.
Topics: Animals; Antimetabolites, Antineoplastic; Capsules; Drug Carriers; Drug Compounding; Drug Screening Assays, Antitumor; Lactic Acid; Methotrexate; Mice; Mice, Inbred BALB C; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sarcoma 180; Surface Properties | 1997 |
Effect of methotrexate (MTX) on NAD(P)+ dehydrogenases of HeLa cells: malic enzyme, 2-oxoglutarate and isocitrate dehydrogenases.
Topics: Antimetabolites, Antineoplastic; HeLa Cells; Humans; Isocitrate Dehydrogenase; Ketoglutarate Dehydrogenase Complex; Lactic Acid; Malate Dehydrogenase; Methotrexate; Mitochondria; NADPH Dehydrogenase; Oxidoreductases; Oxygen Consumption; Pyruvic Acid | 1997 |
Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy.
Topics: Acidosis, Lactic; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant; Lactic Acid; Leukemia, B-Cell; Lymphoma, B-Cell; Methotrexate; Parenteral Nutrition; Pyruvate Dehydrogenase Complex; Sleep Stages; Thiamine Deficiency | 2003 |
Methotrexate loaded poly(L-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint.
Topics: Animals; Antirheumatic Agents; Calorimetry, Differential Scanning; Drug Compounding; Drug Delivery Systems; Excipients; Female; Injections, Intra-Articular; Joints; Lactic Acid; Materials Testing; Methotrexate; Microspheres; Molecular Weight; Particle Size; Polyesters; Polymers; Rabbits; Thermodynamics | 2004 |
Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Aspartic Acid; Central Nervous System Neoplasms; Choline; Creatine; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Immunocompetence; Lactic Acid; Lipid Metabolism; Lymphoma; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Protons; Survival Analysis | 2005 |
Pharmacokinetic study of methotrexate following intra-articular injection of methotrexate loaded poly(L-lactic acid) microspheres in rabbits.
Topics: Alanine Transaminase; Animals; Area Under Curve; Female; Injections, Intra-Articular; Lactic Acid; Methotrexate; Microspheres; Polyesters; Polymers; Rabbits; Synovial Membrane | 2005 |
Effect of aged garlic extract against methotrexate-induced damage to the small intestine in rats.
Topics: Animals; Diarrhea; Garlic; Intestine, Small; Lactic Acid; Male; Malondialdehyde; Methotrexate; Plant Extracts; Rats; Rats, Wistar; Weight Loss | 2006 |
Copolymers of pharmaceutical grade lactic acid and sebacic acid: drug release behavior and biocompatibility.
Topics: Animals; Biocompatible Materials; Buffers; Chemistry, Pharmaceutical; Decanoic Acids; Dicarboxylic Acids; Drug Carriers; Drug Compounding; Female; Hydrogen-Ion Concentration; Inflammation; Injections, Subcutaneous; Kinetics; Lactic Acid; Methotrexate; Microspheres; Particle Size; Polymers; Rats; Rats, Sprague-Dawley; Solubility; Time Factors | 2006 |
Robust and flexible free-standing films for unidirectional drug delivery.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Survival; Dextrans; Drug Compounding; Drug Delivery Systems; Fibroblasts; Gels; HeLa Cells; Humans; Hyaluronic Acid; Kinetics; Lactic Acid; Methotrexate; Mice; Microscopy, Electron, Scanning; Polyamines; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Surface Properties | 2013 |
Albumin-based nanocomposite spheres for advanced drug delivery systems.
Topics: Animals; Cell Line; Drug Delivery Systems; Emulsions; Humans; Lactic Acid; Magnetite Nanoparticles; Methotrexate; Mice; Models, Molecular; Nanocomposites; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Serum Albumin | 2014 |
Characterisation, cytotoxicity and apoptosis studies of methotrexate-loaded PLGA and PLGA-PEG nanoparticles.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Cell Line, Tumor; Cytotoxins; Drug Screening Assays, Antitumor; Humans; Lactic Acid; Methotrexate; Nanocapsules; Neoplasms; Particle Size; Polyethylene Glycols; Polyglactin 910; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2014 |
Development of chitosan and polylactic acid based methotrexate intravitreal micro-implants to treat primary intraocular lymphoma: an in vitro study.
Topics: Absorption, Physicochemical; Animals; Capsules; Chitosan; Diffusion; Drug Implants; Humans; In Vitro Techniques; Intraocular Lymphoma; Intravitreal Injections; Lactic Acid; Materials Testing; Methotrexate; Polyesters; Polymers; Treatment Outcome | 2014 |
Methotrexate-loaded PLGA nanobubbles for ultrasound imaging and Synergistic Targeted therapy of residual tumor during HIFU ablation.
Topics: Animals; Cell Line, Tumor; Contrast Media; Diagnostic Imaging; Female; High-Intensity Focused Ultrasound Ablation; Humans; Lactic Acid; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Microbubbles; Neoplasm, Residual; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2014 |
Dual drug delivery of 5-fluorouracil (5-FU) and methotrexate (MTX) through random copolymeric nanomicelles of PLGA and polyethylenimine demonstrating enhanced cell uptake and cytotoxicity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Calorimetry, Differential Scanning; Drug Carriers; Drug Screening Assays, Antitumor; Fluorouracil; HCT116 Cells; Humans; Lactic Acid; Methotrexate; Micelles; Microscopy, Electron, Transmission; Nanostructures; Polyethyleneimine; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2014 |
Co-association of methotrexate and SPIONs into anti-CD64 antibody-conjugated PLGA nanoparticles for theranostic application.
Topics: Animals; Antibodies; Cell Line; Cell Survival; Drug Delivery Systems; Lactic Acid; Magnetite Nanoparticles; Methotrexate; Mice; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Receptors, IgG | 2014 |
Bacillus-shape design of polymer based drug delivery systems with janus-faced function for synergistic targeted drug delivery and more effective cancer therapy.
Topics: Animals; Antineoplastic Agents; Bacillus; Drug Carriers; Drug Delivery Systems; Flow Cytometry; HeLa Cells; Humans; Lactic Acid; Methotrexate; Mice; Nanoparticles; Neoplasms; Particle Size; Polyesters; Polyethylene Glycols; Polymers | 2015 |
Biodegradable chitosan and polylactic acid-based intraocular micro-implant for sustained release of methotrexate into vitreous: analysis of pharmacokinetics and toxicity in rabbit eyes.
Topics: Absorbable Implants; Animals; Antimetabolites, Antineoplastic; Biocompatible Materials; Chitosan; Drug Delivery Systems; Drug Implants; Intravitreal Injections; Lactic Acid; Methotrexate; Models, Animal; Polyesters; Polymers; Rabbits; Retina; Vitreous Body | 2015 |
Glycyrrhizic acid prevents enteritis through reduction of NF‑κB p65 and p38MAPK expression in rat.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Caspase 3; Cyclooxygenase 2; Cytokines; Down-Regulation; Enteritis; Enzyme-Linked Immunosorbent Assay; Glycyrrhizic Acid; Intercellular Adhesion Molecule-1; Lactic Acid; Male; Methotrexate; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Transcription Factor RelA | 2016 |
Preparation and characterization of PLGA-β-CD polymeric nanoparticles containing methotrexate and evaluation of their effects on T47D cell line.
Topics: Antineoplastic Agents; beta-Cyclodextrins; Biological Transport; Cell Survival; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Liberation; Female; Humans; Kinetics; Lactic Acid; MCF-7 Cells; Methotrexate; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2017 |
PLGA-soya lecithin based micelles for enhanced delivery of methotrexate: Cellular uptake, cytotoxic and pharmacokinetic evidences.
Topics: Animals; Biological Transport; Cattle; Cell Line, Tumor; Drug Carriers; Drug Liberation; Glycine max; Humans; Lactic Acid; Lecithins; Methotrexate; Micelles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Serum Albumin, Bovine | 2017 |
In vivo pharmacological evaluation and efficacy study of methotrexate-encapsulated polymer-coated layered double hydroxide nanoparticles for possible application in the treatment of osteosarcoma.
Topics: Aluminum; Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Female; Humans; Hydroxides; Kidney; Lactic Acid; Liver; Magnesium; Male; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Osteosarcoma; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Tumor Burden | 2017 |
In vivo pharmacokinetic studies and intracellular delivery of methotrexate by means of glycine-tethered PLGA-based polymeric micelles.
Topics: Animals; Antineoplastic Agents; Biological Availability; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Drug Liberation; Glycine; Half-Life; Humans; Lactic Acid; Methotrexate; Micelles; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared | 2017 |
Monitoring structural features, biocompatibility and biological efficacy of gamma-irradiated methotrexate-loaded spray-dried microparticles.
Topics: Chemistry, Pharmaceutical; Drug Delivery Systems; Gamma Rays; Humans; Lactic Acid; Methotrexate; Microspheres; Particle Size; Polyglycolic Acid | 2017 |
Development and optimization of methotrexate-loaded lipid-polymer hybrid nanoparticles for controlled drug delivery applications.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Liberation; Humans; Lactic Acid; Methotrexate; Nanoparticles; Particle Size; Phospholipids; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2017 |
Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Calorimetry, Differential Scanning; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Implants; Drug Liberation; Female; Lactic Acid; Male; Methotrexate; Mice; Microscopy, Electron, Scanning; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Sarcoma 180 | 2017 |
Improved design and characterization of PLGA/PLA-coated Chitosan based micro-implants for controlled release of hydrophilic drugs.
Topics: Antimetabolites, Antineoplastic; Chitosan; Delayed-Action Preparations; Drug Design; Drug Implants; Drug Liberation; Hydrophobic and Hydrophilic Interactions; Lactic Acid; Methotrexate; Molecular Weight; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2018 |
Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arginine; Arthritis, Experimental; Arthritis, Rheumatoid; Cell-Penetrating Peptides; Drug Carriers; Folic Acid; Hydrogen-Ion Concentration; Lactic Acid; Lipids; Male; Methotrexate; Mice; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Stearic Acids | 2018 |
Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development.
Topics: Animals; Cell Proliferation; Goblet Cells; HEK293 Cells; Humans; L-Lactate Dehydrogenase; Lactic Acid; Lactobacillus plantarum; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Paneth Cells; Receptors, G-Protein-Coupled | 2018 |