lactic acid has been researched along with metformin in 228 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (3.07) | 18.7374 |
| 1990's | 25 (10.96) | 18.2507 |
| 2000's | 27 (11.84) | 29.6817 |
| 2010's | 117 (51.32) | 24.3611 |
| 2020's | 52 (22.81) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Caffau, C; Cernigoi, AM; Velussi, M; Viezzoli, L | 1 |
| Bailey, CJ; Day, C; Wilcock, C | 1 |
| Barzilai, N; DeFronzo, RA; Simonson, DC | 1 |
| Benzi, L; Brunetti, P; Cecchetti, P; Di Carlo, A; Di Cianni, G; Giannarelli, R; Gregorio, F; Marchetti, P; Navalesi, R; Villani, G | 1 |
| Andersen, PH; Beck-Nielsen, H; Hother-Nielsen, O; Pedersen, O; Schmitz, O | 1 |
| Disilvio, L; Featherbe, D; Hawa, MI; Jackson, RA; Jaspan, JB; Kurtz, AB; Sim, BM | 1 |
| Liang, JZ; Luo, ZT; Yang, DP | 1 |
| Bozzo, C; Carta, Q; Caselle, MT; Cocuzza, E; Pagano, G; Tagliaferro, V; Trovati, M; Vitelli, F | 1 |
| Jalling, O; Olsen, C | 1 |
| Endoh, M; Kakemi, M; Katayama, K; Koizumi, T; Saeki, K; Sasaki, H | 1 |
| Schneider, J | 1 |
| DeFronzo, RA; Goodman, AM | 1 |
| Dailey, G; Gerich, JE; Nurjhan, N; Perriello, G; Stumvoll, M | 1 |
| Belleville, I; Martinand, A; Rapin, JR; Wiernsperger, NF; Yoa, RG | 1 |
| Argaud, D; Leverve, XM; Roth, H; Wiernsperger, N | 1 |
| Bailey, CJ | 1 |
| Ambrosi, F; Filipponi, P; Gregorio, F; Manfrini, S; Testa, I | 1 |
| Consoli, A; Cusi, K; DeFronzo, RA | 1 |
| Cacáková, V; Perusicová, J; Richtrová, A | 1 |
| Pepper, GM; Schwartz, M | 1 |
| Heaney, D; Junor, B; Majid, A | 1 |
| Kliewer, SA; Lehmann, JM; Lenhard, JM; Paulik, MA; Plunket, KD; Weiel, JE | 1 |
| Elisabetta, Z; Emanuela, M; Franzetti, I; Marco, G; Paolo, D; Renato, U | 1 |
| Beck-Nielsen, H; Damsbo, P; Hermann, LS; Hother-Nielsen, O; Vaag, A | 1 |
| Bergeret, A; Lacroix, C; Lalau, JD; Mourlhon, C | 1 |
| Beisswenger, PJ; Howell, SK; Lal, S; Szwergold, BS; Touchette, AD | 1 |
| Lalau, JD; Race, JM | 2 |
| Beylot, M; Large, V | 1 |
| Dominguez, LJ; Ofenstein, JP; Sarnaik, AP; Sowers, JR | 1 |
| Adler, G; Alt, A; Ditschuneit, HH; Flechtner-Mors, M; Jenkinson, CP | 1 |
| Brindley, DN; Davidge, ST; Delrat, P; Jochemsen, R; Kelly, SE; O'Brien, SF; Pégorier, JP; Ravel, D; Russell, JC | 1 |
| Evans, JL; Gregoire, F; Havel, PJ; Mueller, WM; Stanhope, KL | 1 |
| Cherrington, AD; Chu, CA; Knauf, M; Muscato, N; Neal, DW; Wiernsperger, N | 1 |
| Bruce, DG; Chubb, P; Davis, TM; Davis, WA; Jackson, D | 1 |
| Radziuk, J; Zhang, Z | 1 |
| Hansen, SH; McCormack, JG | 1 |
| Hornick, TR; Khan, JK; Pallaki, M; Tolbert, SR | 1 |
| Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS | 1 |
| Breinholt, J; Otto, M; Westergaard, N | 1 |
| Azoulay, E; Galy-Floc'h, M; Mariot, J; Pertek, JP; Vidal, S | 1 |
| Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC | 1 |
| DEBRY, G; LAURENT, J | 1 |
| Hiraizumi, M; Seino, H | 1 |
| Brunetti, P; Gori, M; Pagano, G; Perriello, G; Turco, C | 1 |
| Holstein, A; Stumvoll, M | 1 |
| Abrahani, A; An, D; Chan, JK; Ghosh, S; Innis, SM; Kewalramani, G; Pulinilkunnil, T; Qi, D; Rodrigues, B | 1 |
| Chan, ES; Lee, YM; Lim, SC; Lim, VC; Sum, CF; Yeoh, LY | 1 |
| Habtemariam, B; Hong, Y; Mager, DE; Rohatagi, S; Schwartz, SL; Walker, JR | 1 |
| Fuller, J | 1 |
| Billis, PA; Dykens, JA; Jamieson, J; Marroquin, L; Nadanaciva, S; Will, Y | 1 |
| Byrne, CD; Cameron, IT; Coakley, S; Ingamells, S; Richardson, MC; Sellahewa, L; Simonis, CD; Sreekumar, R; Vijendren, A | 1 |
| Abramson, J; Dell'Aglio, DM; Kazzi, Z; Morgan, BW; Perino, LJ; Schwartz, MD | 1 |
| Bao, Y; Jia, W; Qiu, Y; Su, M; Wang, X; Zhao, T | 1 |
| Fujiwara, T; Hagisawa, Y; Kanda, S; Nakashima, R; Ogawa, J; Okuno, A; Takahashi, K; Tanaka, J; Yoshida, T | 1 |
| Ban, T; Kanemoto, N; Nagano, K; Niki, I; Okamoto, T; Sudo, T | 1 |
| Ernst, ME; McDanel, DL; Moores, KG; Philbrick, AM; Ross, MB | 1 |
| Hou, XH; Jia, WP; Li, L; Liu, F; Lu, HJ; Lu, JX; Tang, JL; Xiang, KS | 1 |
| Horita, S; Inoue, K; Ito, S; Kondo, T; Kuroiwa, Y; Kusuhara, H; Moriyama, Y; Nakayama, H; Sugiyama, Y; Wu, C; Yuasa, H | 1 |
| Braun, B; Chipkin, SR; Goodyear, LJ; Hagobian, TA; Hirshman, MF; Malin, SK; Sharoff, CG; Yu, H | 1 |
| Greyber, E; Pasternak, GA; Salpeter Posthumous, EE; Salpeter, SR | 1 |
| Jia, WP; Li, Q; Liu, F; Lu, HJ; Tang, JL; Zheng, TS | 1 |
| Xu, W; Yang, Y | 1 |
| Greyber, E; Pasternak, GA; Salpeter, EE; Salpeter, SR | 1 |
| Bando, K; Deguchi, J; Funabashi, H; Kimura, J; Kunimatsu, T; Ochiai, S; Seki, T | 1 |
| Djogovic, D; Kjelland, CB | 1 |
| Harvey, JN; Scale, T | 1 |
| Chen, HS | 1 |
| Lin, HD; Lin, LY; Lin, YC; Wang, HF | 1 |
| Cherrington, AD; Donahue, EP; Lacy, B; Printz, RL; Sasaki, N; Shiota, M; Torres, TP; Treadway, JL | 1 |
| Cirule, H; Dambrova, M; Liepinsh, E; Makrecka, M; Skapare, E; Svalbe, B | 1 |
| Aytemiz, E; Begenik, H; Emre, H; Erkoc, R; Ozturk, M; Soyoral, YU | 1 |
| Doorenbos, CJ; van Berlo-van de Laar, IR; Vermeij, CG | 1 |
| Brookes, P; Chang, C; Chen, LM; Chou, S; Lee, YF; Li, G; Liu, S; Massett, MP; Uno, H; Wu, Q | 1 |
| Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G | 1 |
| Dahan, E; Dichtwald, S; Ekstein, MP; Sorkine, P; Weinbroum, AA | 1 |
| Flomenberg, N; Goldberg, A; Howell, A; Ko, YH; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Pavlides, S; Pestell, RG; Sotgia, F; Wang, C | 1 |
| Chirwa, N; Choonara, YE; du Toit, LC; Kumar, P; Murphy, C; Ndesendo, VM; Pillay, V | 1 |
| Concepcion, L; Nguyen, HL | 1 |
| Fujimoto, S; Hosokawa, M; Inagaki, N; Inui, K; Katsura, T; Masuda, S; Osawa, R; Toyama, K; Yonezawa, A | 1 |
| Jia, W; Li, Q; Liu, F; Lu, F; Lu, H; Shen, Y; Tang, J; Zheng, T | 1 |
| Day, RO; Duong, JK; Furlong, TJ; Graham, GG; Greenfield, JR; Kirkpatrick, CM; Kumar, SS; Roberts, DM; Williams, KM | 1 |
| Astor, BC; Ballantyne, CM; Brancati, FL; Coresh, J; Crawford, SO; Hoogeveen, RC; Matsushita, K; Mongraw-Chaffin, ML; Schmidt, MI; Young, JH | 1 |
| Burhenne, J; Czock, D; Grün, B; Haefeli, WE; Kiessling, MK; Rauch, G; Riedel, KD; Weiss, J | 1 |
| Day, RO; Duong, JK; Furlong, TJ; Graham, GG; Greenfield, JR; Roberts, DM; Williams, KM | 1 |
| Alet, N; Bono, F; Boutzen, H; Carroll, M; Danet-Desnoyers, G; de Toni, F; Dumon, E; Junot, C; Levade, T; Manenti, S; Martineau, Y; Micklow, E; Peyraud, R; Peyriga, L; Portais, JC; Récher, C; Rocher, C; Saland, E; Sarry, JE; Scotland, S; Selak, MA; Sénégas, I; Skuli, N; Théodoro, F | 1 |
| Kitamura, A; Komuro, S; Sogame, Y; Takano, M; Yabuki, M | 1 |
| Kalantar-Zadeh, K; Lewandrowski, KB; Uppot, RN | 1 |
| Guo, FC; Wang, LQ; Wang, YS; Zhang, J | 1 |
| Kalantar-Zadeh, K | 1 |
| Goldman, M; Shtaynberg, N | 1 |
| Chagnac, A; Korzets, A; Ori, Y | 1 |
| Berend, K | 1 |
| Gattinoni, L; Protti, A | 1 |
| Alves, MG; Correia, S; Martins, AD; Moreira, PI; Oliveira, PF; Socorro, S; Vaz, CV | 1 |
| Giampreti, A; Locatelli, CA; Lonati, D; Manzo, L; Papa, P; Petrolini, VM; Protti, A; Rocchi, L; Rognoni, C; Rolandi, L; Valli, A; Vecchio, S | 1 |
| Amelio, AL; Bannister, TD; Butler, AA; Cameron, MD; Cleveland, JL; Dang, CV; Doherty, JR; Fallahi, M; Genau, HM; Hall, MA; Hooper, AT; Kumar, KG; Li, F; Li, W; Lu, Y; Mishra, JK; Rounbehler, RJ; Roush, WR; Scott, KE; Tortosa, M; Unsal-Kacmaz, K; Yang, C | 1 |
| Azzoug, ML; Briet, C; Desailloud, R; Kajbaf, F; Lalau, JD | 1 |
| Abdul-Rahman, IS; Al-Hwiesh, AK; Al-Mohanna, FA; Divino-Filho, JC; El-Deen, MA; Gupta, KL; Larbi, E | 1 |
| Ehinger, JK; Elmér, E; Hansson, MJ; Piel, S | 1 |
| De Smet, PA; de Vries, F; Derijks, HJ; Egberts, A; Eppenga, WL; Geerts, AF; Lalmohamed, A; Wensing, M | 1 |
| Albright, RA; Bhanot, S; Braddock, DT; Camporez, JP; Cline, GW; Erion, DM; Jurczak, MJ; Kibbey, RG; Lee, HY; MacDonald, MJ; Madiraju, AK; Prigaro, BJ; Rahimi, Y; Samuel, VT; Shulman, GI; Wood, JL; Zhang, XM | 1 |
| Bian, C; Han, X; Li, X; Lin, H; Ma, J; Qu, F; Wu, X; Xiang, D | 1 |
| Acharya, AP; Gardner, AB; Murthy, N; Rafi, M; Woods, EC | 1 |
| Adam, WR; O'Brien, RC | 1 |
| Kyle, G; Naunton, M; Naunton-Boom, K; Owoka, F | 1 |
| Balen, AH; Barth, JH; Campbell, BK; Harris, SE; Maruthini, D; Picton, HM | 1 |
| Blagih, J; Coelho, PP; Griss, T; Jones, RG; Vincent, EE; Viollet, B | 1 |
| Day, RO; Duong, JK; Furlong, TJ; Graham, GG; Greenfield, JR; Kirkpatrick, CM; Kumar, SS; Williams, KM | 1 |
| Ferrannini, E | 1 |
| Cetin, M; Gundogdu, N | 1 |
| Chang, SH; Chen, WJ; Hsieh, MJ; Hung, KC; Juang, JH; Lee, CH; Lin, YH; Liu, SJ; Pang, JH | 1 |
| Drzewoski, J; Sliwinska, A | 1 |
| Hanatani, T; Sai, K; Saito, Y; Segawa, K; Tohkin, M | 1 |
| Calello, DP; Ghannoum, M; Gosselin, S; Hoffman, RS; Lavergne, V; Liu, KD; Nolin, TD; Roberts, DM; Wiegand, TJ | 1 |
| Brenner, T; Decker, SO; Hofer, S; Siegler, BH; Ulrich, A; Wortmann, M | 1 |
| Baltazar, F; Granja, S; Le Floch, R; Marchiq, I; Moura, CS; Pouysségur, J | 1 |
| Archer, JR; Baker, EH; Hitchings, AW; Srivastava, SA | 1 |
| Makehei, S; Sam, R | 1 |
| Eckert, MA; Johnson, A; Lengyel, E; Litchfield, LM; Mills, KA; Mukherjee, A; Pan, S; Romero, IL; Shridhar, V | 1 |
| Bianchini, F; Calvani, M; Chiarugi, P; Comito, G; Giannoni, E; Morandi, A; Raugei, G; Richichi, B; Taddei, ML; Tang, D; Wong, N | 1 |
| Ai, Q; Ao, JE; Duan, R; Ge, P; Gong, X; Lin, L; Zhang, L | 1 |
| Chung, FF; Hii, LW; Ho, GF; Leong, CO; Malik, RA; Ng, CH; See, MH; Soo, JS; Taib, NA; Tan, BS; Tan, SH; Teh, YC; Teo, SH; Yip, CH | 1 |
| Balakrishnan, P; Beaty, TH; Boerwinkle, E; Hoogeveen, RC; Kao, WH; Tin, A; Young, JH | 1 |
| Blumrich, EM; Dringen, R; Westhaus, A | 1 |
| Keltanen, T; Ketola, RA; Lindroos, K; Nenonen, T; Ojanperä, I; Sajantila, A | 1 |
| Bhat, MK; Chaube, B; Malvi, P; Meena, AS; Mohammad, N; Singh, SV | 1 |
| Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y | 1 |
| Choi, SC; Croker, BP; Kanda, N; Morel, L; Xu, Z; Yin, Y; Zeumer, L | 1 |
| Chen, AF; Cheng, Y; Guo, P; Huang, Y; Li, L; Li, X; Liu, Z; Lv, H; Peng, M; Su, Q; Tao, T; Tao, X; Xue, L; Yang, X; Zeng, Q | 1 |
| Carvajal, K; El Hafidi, M; Moreno-Arriola, E; Ortega-Cuéllar, D | 1 |
| Altman, JJ; Boucaud-Maitre, D; Bouhanick, B; Doucet, J; Emmerich, J; Girardin, E; Kaloustian, E; Lassmann Vague, V; Porokhov, B; Ropers, J | 1 |
| Chanoine, S; Giai, J; Lepelley, M; Villier, C; Yahiaoui, N | 1 |
| Bassani, G; Ferrero, S; Gattinoni, L; Guenzani, S; Langer, T; Magnoni, S; Properzi, P; Protti, A; Santini, A; Stocchetti, N | 1 |
| Ellen, R; Omar, A; Sorisky, A | 1 |
| He, F; He, J; Huang, Y; Li, B; Li, X; Lyu, X; Ni, Z; Wang, Y; Wu, Y; Yan, X; Zeng, Y; Zhang, Y; Zheng, Y | 1 |
| Heather, LC; Lewis, AJ; McCallum, C; Miller, JJ; Neubauer, S; Rider, OJ; Tyler, DJ | 1 |
| Carriere, KC; Cha, WC; Hwang, SY; Jeon, K; Jo, IJ; Lee, TR; Park, J; Shin, TG; Sim, MS; Suh, GY; Yeon, S; Yoon, H | 1 |
| Hiraoka, S; Nishihara, M; Tsuji, H; Yokoyama, S | 1 |
| Cha, BS; Han, E; Hwang, S; Kang, ES; Kang, HP; Lee, BW; Lee, EY; Lee, HC; Lee, SH; Lee, W; Lee, YH; Lee, YM | 1 |
| Brouwers, MC; Stassen, PM; van den Nouland, DP | 1 |
| Heden, TD; Kanaley, JA; Liu, Y | 1 |
| Connelly, PJ; Donnelly, L; Lonergan, M; Pearson, ER; Soto-Pedre, E; Zhou, K | 1 |
| Aarnoutse, RE; Burger, DM; Colbers, A; de Kanter, CTMM; Drenth, JPH; Smolders, EJ; Tack, CJ; van Ewijk-Beneken Kolmer, N; Velthoven-Graafland, K; Wolberink, LT | 1 |
| Doenyas-Barak, K; Golik, A; Koren, R; Koren, S; Zilberman-Itskovich, S | 1 |
| Blumrich, EM; Dringen, R | 1 |
| Kuo, CC; Ting, IW; Tsai, CW; Wu, JY; Yeh, HC | 1 |
| Alber, J; Bultmann-Mellin, I; de Angelis, MH; Gründemann, D; Guschlbauer, M; Klatt, AR; Klingenspor, M; Rozman, J; Schommers, P; Sterner-Kock, A; Thurau, A; Wiesner, RJ | 1 |
| Wu, MC; Ye, WR; Zhang, SS; Zheng, YJ | 1 |
| Castelino, RL; Huang, W; Peterson, GM | 1 |
| Arunan, V; Beloueche-Babari, M; Casals Galobart, T; Chung, YL; Eykyn, TR; Koniordou, M; Leach, MO; Parkes, HG; Smith, PD; Wantuch, S | 1 |
| Aarts, EO; Aelfers, SCW; Berends, FJ; de Boer, H; Deden, LN; Janssen, IMC; van Borren, MMGJ | 1 |
| Geng, Y; Lv, X; Meng, S; Mina, A; Puchi, B; Ren, Q; Song, J; Yang, L; Yang, S; Zhou, L | 1 |
| Bosch, FH; Kramers, C; Manders, M; van Luin, M | 1 |
| Belpaire, F; Bennis, Y; De Broe, ME; Hurtel-Lemaire, AS; Kajbaf, F; Lalau, JD | 1 |
| Flavell, RR; Kurhanewicz, J; Marco-Rius, I; Ohliger, MA; Pearce, D; Vigneron, DB; von Morze, C; Wang, ZJ; Wilson, DM | 1 |
| Chu, X; Cook, JA; Custodio, JM; Galetin, A; Giacomini, KM; Lee, CA; Paine, MF; Ray, AS; Ware, JA; Wittwer, MB; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Mertaniasih, NM; Novita, BD; Pranoto, A; Soediono, EI | 1 |
| Dai, Y; Huo, X; Liu, K; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Yang, S | 1 |
| Chen, D; Chen, H; Li, T; Liu, J; Liu, X; Lu, C; Ning, Z; Piao, HL; Qi, H; Tekcham, DS; Wang, W; Wang, Z; Xia, T; Xu, G; Yan, M; Zhao, X | 1 |
| Benjamin, D; Colombi, M; El-Shemerly, MY; Hall, MN; Hindupur, SK; Lane, HA; Maira, SM; Moroni, C; Pohlmann, J; Robay, D | 1 |
| Agius, L; Alshawi, A | 1 |
| Young, CKJ; Young, MJ | 1 |
| Arend, C; Dringen, R; Ehrke, E | 1 |
| Abolhassani, M; da Veiga Moreira, J; Hamraz, M; Jolicœur, M; Peres, S; Schwartz, L | 1 |
| Guddattu, V; Mareddy, AS; Nagaraju, SP; Prabhu, RA; Rangaswamy, D | 1 |
| Hoffman, RS; Manini, AF; Taub, ES | 1 |
| Abu Bakar, AB; Ahmad, A; Mohamed, M; Nna, VU | 1 |
| Hastings, C; Johnson, K; Slaven, E; Zhang, QC | 1 |
| Abdessadek, M; Ajdi, F; Khabbal, Y; Magoul, R; Marmouzi, I | 1 |
| Ellinger-Ziegelbauer, H; Freyberger, A; Heinz, S; Lawrenz, B; Schladt, L; Schmuck, G | 1 |
| Abdel Shaheed, C; Carland, JE; Chowdhury, G; Day, RO; Furlong, T; Graham, GG; Greenfield, JR; Hicks, M; Macdonald, P; Smith, FC; Smith, G; Stocker, SL; Williams, KM | 1 |
| Canavan, C; Coyle, N; Nasim, S; Nestor, C | 1 |
| Gosmanov, AR; Gosmanova, EO; Kovesdy, CP; Shahzad, SR; Sumida, K | 1 |
| Park, D | 1 |
| Ahmad, A; Bakar, ABA; Mohamed, M; Nna, VU; Othman, ZA; Suleiman, JB; Umar, UZ; Zakaria, Z | 1 |
| Andersen, NR; Balendran, A; Birk, JB; Kjøbsted, R; Kristensen, JM; Lillelund, C; Mellberg, K; Nybo, L; Richter, EA; Wojtaszewski, JFP | 1 |
| Schoenrogge, M; Vollmar, B; Wendt, EHU; Zechner, D | 1 |
| Benabbas, R; Blumenberg, A; Jeng, A; Sinert, R; Wiener, SW | 2 |
| Braithwaite, HE; Carland, JE; Cheng, TS; Danta, M; Day, RO; Graham, GG; Greenfield, JR; Kumar, SS; Liu, Z; Smith, FC; Stocker, SL; Williams, KM | 1 |
| El Shamieh, S; Fakhoury, R; Naja, K | 1 |
| Gika, H; Kechagidou, A; Leondaritis, G; Mougios, V; Nikolaidis, S; Pappas, P; Skari, A; Theodoridis, G; Vekiou, M; Virgiliou, C | 1 |
| Berendsen, TA; de Meijer, VE; Fujiyoshi, M; Leuvenink, HGD; Lisman, T; Moshage, H; Nijsten, MWN; Ottens, PJ; Porte, RJ; Touw, DJ; Westerkamp, AC | 1 |
| Essop, MF; Mato Mofo, EP; Owira, PMO | 1 |
| Hoffman, RS; Wang, JJ | 1 |
| Gorbach, O; Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI | 1 |
| Duffull, SB; Kuan, IHS; Wright, DFB; Zhu, X | 1 |
| Li, P; Li, W; Li, Y; Ma, C; Ma, M; Ping, F; Sun, Q; Xu, L; Zhang, H | 1 |
| Creagh, F; Goonoo, MS; Morris, R; Raithatha, A | 1 |
| Christiansen, CF; Hulman, A; Jespersen, B; Nijsten, MW; Posma, RA; Thomsen, RW | 1 |
| Alamin, M; Elshafei, MN; Mohamed, MFH | 1 |
| Agra-Montava, I; Juanes-Borrego, A; Lozano-Polo, L; Mangues-Bafalluy, MA; Puig-Campmany, M; Ruiz-Ramos, J | 1 |
| Deng, Y; Feng, P; Gao, C; Liu, C; Liu, Q; Shuai, C; Tan, W; Wang, Z | 1 |
| Klein, J; Lau, H; Lehto, A; Piechotta, C; Thinnes, A; Westenberger, M; Wirth, F | 1 |
| Attou, R; Barreto Gutierrez, L; De Bels, D; Gallerani, A; Honore, PM; Kaefer, K; Kugener, L; Redant, S | 1 |
| Balikian, P; Bastos-Silva, VJ; Bezerra da Silva, JB; de Barros Sousa, FA; Gomes de Araujo, G; Learsi, S; Marinho, AH | 1 |
| Andrews, S; Cheatham, B; Dobbins, R; Hanmant, B; Hussey, EK; O'Connor-Semmes, R; Sagar, K; Tao, W; Wilkison, WO | 1 |
| Barry, AP; Bonglack, EN; Cable, JM; Ch'ng, J; Christofk, HR; Dave, SS; Luftig, MA; Messinger, JE; Parnell, KM; Reinoso-Vizcaíno, NM; Russell, VS | 1 |
| Aagaard, NK; Brøsen, K; Grønbaek, H; Hartmann, B; Holst, JJ; Jessen, N; Rittig, N; Sandahl, TD; Sundelin, E; Villadsen, GE | 1 |
| Alemón-Medina, R; Altamirano-Bustamante, NF; Barajas-Olmos, F; Centeno-Cruz, F; Contreras-Cubas, C; García-Álvarez, R; García-Ortiz, H; Gómez-Garduño, J; Ilizaliturri-Flores, I; Martínez-Hernández, A; Mendoza-Caamal, EC; Mirzaeicheshmeh, E; Morales-Rivera, MI; Orozco, L; Pérez-Guillé, MG; Revilla-Monsalve, C | 1 |
| Chen, G; Chen, S; Gao, Y; Hu, Z; Jiang, X; Li, S; Li, W; Ling, C; Liu, J; Shi, R; Song, N; Sui, X; Yang, X; Zhou, X | 1 |
| Cursiol, JA; De Andrade, VL; De Araujo, GG; De Arruda, TB; Norberto, MS; Papoti, M | 1 |
| Chang, MY; Chou, LF; Hsu, SH; Hung, CC; Ong, ACM; Tian, YC; Tsai, CY; Yang, CW; Yang, HY | 1 |
| Cao, W; Deng, W; Hao, Q; Huang, Z; Li, J; Li, Q; Liu, D; Liu, Z; Su, R; Vadgama, J; Wang, K; Wang, P; Wu, K; Wu, Y | 1 |
| Abiko, Y; Kobayashi, Y; Liu, S; Otani, H; Sasaki, S; Sato, S; Shinohara, Y; Takahashi, N; Wang, X; Washio, J | 1 |
| Bolze, S; Fontaine, E; Fouqueray, P; Hallakou-Bozec, S; Moller, DE; Monternier, PA; Theurey, P; Vial, G | 1 |
| Chen, W; Dai, Y; Li, H; Wu, G; Yan, Y; Zhang, H; Zheng, X | 1 |
| Huber, SM; Stransky, N | 1 |
| Hao, C; Hao, W; Jin, C; Liu, Z; Lu, X; Song, Y; Wu, S; Yang, J; Zhu, X | 1 |
| Konieczna, K; Szkudelska, K; Szkudelski, T | 1 |
| Khinast, J; Kottlan, A; Koutsamanis, I; Makert, C; Paudel, A; Piller, M; Rajkovaca, M; Spoerk, M | 1 |
| Rahman, F; Tuba, S | 1 |
| De Decker, K; De Neve, N; Tackaert, T; Van Moorter, N; Van Vlem, B | 1 |
| Wu, C; Xia, Y; Zhu, X | 1 |
| Gnirke, M; Gosselin, S; Hoffman, RS; Mohan, S; Su, MK; Trebach, J | 1 |
| Ates, G; De Bruyne, E; De Veirman, K; Faict, S; Fan, R; Maes, A; Massie, A; Menu, E; Oudaert, I; Satilmis, H; Van der Vreken, A; Vanderkerken, K; Vlummens, P | 1 |
| Korotina, MA; Pochinka, IG; Strongin, LG | 1 |
| Carland, JE; Chowdhury, G; Day, RO; Graham, G; Greenfield, JR; Hayward, CS; Kumar, S; Kumarasinghe, G; Macdonald, P; Olsen, N; Stocker, SL | 1 |
| Gayatri, MB; Gundeti, S; Kancha, RK; Patchva, D; Reddy, ABM; Velugonda, N | 1 |
| Ke, JF; Li, LX; Ma, YL; Wang, JW; Wang, YJ; Xu, MR | 1 |
| Bradberry, SM; Coulson, JM; Gray, LA; Hughes, BW; Sandilands, EA; Thanacoody, RH | 1 |
| Benjamin, D | 1 |
| Cao, JD; Koyfman, A; Long, B; Onisko, N; Rivera, D | 1 |
| Beckers, J; Birkenfeld, AL; Goj, T; Gudiksen, A; Hrabě de Angelis, M; Irmler, M; Karstoft, K; Lehmann, R; Li, Q; Maurer, J; Peter, A; Pilegaard, H; Pilmark, NS; Weigert, C; Xu, G; Zhao, X | 1 |
| Abdullin, M; Braden, GL; Hodgins, S; Landry, DL; Tiru, B; Yusim, D | 1 |
17 review(s) available for lactic acid and metformin
| Article | Year |
|---|---|
Metformin and intestinal glucose handling.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Glucose; Humans; Hypoglycemic Agents; Intestinal Absorption; Lactates; Lactic Acid; Metformin; Splanchnic Circulation | 1995 |
[Progress in diagnosis of and therapy for diabetic lactic acidosis].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Blood Gas Analysis; Consciousness Disorders; Diabetes Complications; Diagnosis, Differential; Glucose; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Metformin; Pyruvic Acid; Sodium Bicarbonate | 2004 |
Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature.
Topics: Acidosis, Lactic; Acute Disease; Adult; Drug Overdose; Female; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Survival Analysis | 2009 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Prospective Studies; Risk | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Incidence; Lactic Acid; Metformin; Prospective Studies; Risk | 2010 |
The role of serum lactate in the acute care setting.
Topics: Acidosis, Lactic; Adult; Aged; Antiretroviral Therapy, Highly Active; Biomarkers; Critical Care; Drug Overdose; Female; Humans; Hypoglycemic Agents; Lactic Acid; Liver Failure, Acute; Male; Metformin; Middle Aged; Shock, Septic | 2010 |
A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure.
Topics: Acidosis, Lactic; Diabetes Mellitus; Drug Administration Schedule; Drug Overdose; Glomerular Filtration Rate; Guideline Adherence; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Kidney Failure, Chronic; Lactic Acid; Metformin; Practice Guidelines as Topic; Treatment Outcome | 2014 |
Molecular action of metformin in hepatocytes: an updated insight.
Topics: AMP-Activated Protein Kinases; Dihydroxyacetone Phosphate; Electron Transport Complex I; Gluconeogenesis; Glycerolphosphate Dehydrogenase; Hepatocytes; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mitochondria, Liver; Pyruvic Acid | 2015 |
Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup.
Topics: Acidosis, Lactic; Consciousness; Delphi Technique; Humans; Hydrogen-Ion Concentration; Lactic Acid; Metformin; Renal Dialysis; Shock | 2015 |
Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Biomarkers; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Mortality; Renal Replacement Therapy | 2017 |
Lactate Levels with Chronic Metformin Use: A Narrative Review.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Incidence; Lactic Acid; Metformin; Renal Insufficiency | 2017 |
[Metformin-associated lactic acidosis: an insufficiently recognised problem].
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid; Metformin | 2017 |
Is the use of metformin in patients undergoing dialysis hazardous for life? A systematic review of the safety of metformin in patients undergoing dialysis.
Topics: Acidosis; Diabetes Mellitus, Type 2; Drug Monitoring; Humans; Hypoglycemic Agents; Kidney; Kidney Diseases; Lactic Acid; Metformin; Renal Dialysis | 2019 |
Do Patients Die with or from Metformin-Associated Lactic Acidosis (MALA)? Systematic Review and Meta-analysis of pH and Lactate as Predictors of Mortality in MALA.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Biomarkers; Female; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Prognosis; Risk Assessment; Risk Factors | 2020 |
Osmolar-gap in the setting of metformin-associated lactic acidosis: Case report and a literature review highlighting an apparently unusual association.
Topics: Acid-Base Imbalance; Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Osmolar Concentration | 2020 |
Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Renal Insufficiency, Chronic | 2022 |
High risk and low prevalence diseases: Metformin toxicities.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Prevalence | 2023 |
19 trial(s) available for lactic acid and metformin
| Article | Year |
|---|---|
Metformin improves peripheral but not hepatic insulin action in obese patients with type II diabetes.
Topics: Blood Glucose; C-Peptide; Circadian Rhythm; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Humans; Insulin; Lactates; Lactic Acid; Liver; Metformin; Middle Aged; Obesity | 1989 |
Metformin reduces insulin requirement in Type 1 (insulin-dependent) diabetes.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Female; Humans; Insulin; Insulin Infusion Systems; Lactates; Lactic Acid; Male; Metformin; Middle Aged | 1983 |
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group.
Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fasting; Female; Folic Acid; Glucose Tolerance Test; Glyburide; Glycated Hemoglobin; Humans; Insulin; Lactates; Lactic Acid; Male; Metformin; Middle Aged; Obesity; Treatment Failure; Vitamin B 12 | 1995 |
Is metformin safe enough for ageing type 2 diabetic patients?
Topics: Aged; Aged, 80 and over; Aging; Anthropometry; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Kidney Function Tests; Lactates; Lactic Acid; Lipids; Liver Function Tests; Male; Metformin; Sulfonylurea Compounds | 1996 |
Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Gluconeogenesis; Glucose; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lactic Acid; Lipids; Liver; Male; Metformin; Middle Aged; Oxidation-Reduction | 1996 |
Irreversibility of the defect in glycogen synthase activity in skeletal muscle from obese patients with NIDDM treated with diet and metformin.
Topics: Adult; Blood Glucose; Body Weight; Calorimetry, Indirect; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Fatty Acids, Nonesterified; Female; Glycogen Synthase; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Middle Aged; Muscle, Skeletal; Obesity | 1998 |
Metformin reduces systemic methylglyoxal levels in type 2 diabetes.
Topics: Adult; Aged; Deoxyglucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Middle Aged; Osmolar Concentration; Pyruvaldehyde; Sulfonylurea Compounds; Treatment Outcome | 1999 |
The relationship between metformin therapy and the fasting plasma lactate in type 2 diabetes: The Fremantle Diabetes Study.
Topics: Aged; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Prospective Studies | 2001 |
Effects of two different glibenclamide dose-strengths in the fixed combination with metformin in patients with poorly controlled T2DM: a double blind, prospective, randomised, cross-over clinical trial.
Topics: Adult; Blood Glucose; Body Mass Index; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fasting; Female; Food; Glyburide; Glycated Hemoglobin; History, 18th Century; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Middle Aged; Prospective Studies | 2004 |
Population exposure-response modeling of metformin in patients with type 2 diabetes mellitus.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Models, Biological; Tissue Distribution | 2008 |
Trimethoprim-metformin interaction and its genetic modulation by OCT2 and MATE1 transporters.
Topics: Adult; Anti-Infective Agents, Urinary; Area Under Curve; Creatinine; Drug Interactions; Half-Life; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Polymorphism, Single Nucleotide; Trimethoprim; Young Adult | 2013 |
Metformin and daclatasvir: absence of a pharmacokinetic-pharmacodynamic drug interaction in healthy volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Blood Glucose; Carbamates; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Interactions; Female; Glucose Tolerance Test; Healthy Volunteers; Hepatitis C, Chronic; Humans; Hypoglycemic Agents; Imidazoles; Insulin; Lactic Acid; Male; Metformin; Middle Aged; Octamer Transcription Factor-1; Organic Cation Transporter 2; Pyrrolidines; Therapeutic Equivalency; Valine; Young Adult | 2017 |
A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Risk; Treatment Outcome; Tuberculosis, Pulmonary | 2018 |
Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial.
Topics: Adipose Tissue; Adult; AMP-Activated Protein Kinase Kinases; Energy Metabolism; Epinephrine; Exercise; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Muscle, Skeletal; Protein Kinases | 2019 |
Acute metformin administration increases mean power and the early Power phase during a Wingate test in healthy male subjects.
Topics: Adult; Cross-Over Studies; Exercise Test; Healthy Volunteers; Humans; Lactic Acid; Male; Metformin; Muscle Strength; Physical Exertion; Reproducibility of Results; Young Adult | 2022 |
Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin.
Topics: Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Fasting; Female; Glucosides; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Middle Aged; Pyrazoles | 2021 |
Metformin Stimulates Intestinal Glycolysis and Lactate Release: A single-Dose Study of Metformin in Patients With Intrahepatic Portosystemic Stent.
Topics: Adolescent; Adult; Aged; Blood Glucose; Female; Glycolysis; Humans; Hypoglycemic Agents; Intestinal Mucosa; Lactic Acid; Male; Metformin; Middle Aged; Portal Vein; Portasystemic Shunt, Surgical; Young Adult | 2021 |
Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers.
Topics: Bayes Theorem; High-Intensity Interval Training; Humans; Lactic Acid; Metformin; Swimming | 2021 |
Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice.
Topics: Animals; Cysts; Disease Models, Animal; Female; Kidney; Lactic Acid; Male; Metformin; Mice; Mice, Transgenic; Polycystic Kidney Diseases; Polycystic Kidney, Autosomal Dominant; TRPP Cation Channels | 2022 |
192 other study(ies) available for lactic acid and metformin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
[Median-term (4 months) treatment with glibenclamide + metformin substituting for glibenclamide + fenformin lowers the lacticemia levels in type-2 diabetics (NIDDM)].
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Evaluation; Drug Therapy, Combination; Female; Follow-Up Studies; Glyburide; Glycated Hemoglobin; Glycosuria; Humans; Lactates; Lactic Acid; Male; Metformin; Middle Aged; Phenformin | 1992 |
Effect of metformin on glucose metabolism in the splanchnic bed.
Topics: Animals; Blood Glucose; Glucose; In Vitro Techniques; Intestinal Mucosa; Intestines; Lactates; Lactic Acid; Liver; Male; Metformin; Rats; Rats, Inbred Strains; Splanchnic Circulation | 1992 |
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects.
Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fasting; Female; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Insulin; Lactates; Lactic Acid; Lipids; Liver; Male; Metformin; Middle Aged; Obesity | 1991 |
Diurnal pattern of plasma metformin concentrations and its relation to metabolic effects in type 2 (non-insulin-dependent) diabetic patients.
Topics: Alanine; Blood Glucose; Butyrates; Butyric Acid; Circadian Rhythm; Diabetes Mellitus, Type 2; Glycerol; Humans; Lactates; Lactic Acid; Metformin; Pyruvates; Pyruvic Acid | 1990 |
Mechanism of metformin action in non-insulin-dependent diabetes.
Topics: Amino Acids; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucose; Glucose Tolerance Test; Glycerol; Humans; Insulin; Kinetics; Lactates; Lactic Acid; Liver; Male; Metformin; Middle Aged | 1987 |
[Alteration of blood lactic acid levels in biguanide therapy in diabetics].
Topics: Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Lactates; Lactic Acid; Metformin; Middle Aged; Phenformin | 1985 |
The effects of metformin compared to the effects of phenformin on the lactate production and the metabolism of isolated parenchymal rat liver cell.
Topics: Adenosine Triphosphate; Animals; Carbon Dioxide; Ethanol; Glycerol; Ketone Bodies; Kinetics; Lactates; Lactic Acid; Liver; Male; Metformin; Oxygen Consumption; Phenformin; Proteins; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1984 |
Pharmacologic effects of metformin in relation to its disposition in alloxan diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Injections, Intravenous; Intestinal Absorption; Lactates; Lactic Acid; Male; Metformin; Models, Biological; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1983 |
[Metformin in patients with coronary disease?].
Topics: Acidosis, Lactic; Contraindications; Coronary Disease; Humans; Lactates; Lactic Acid; Metformin; Risk Factors | 1995 |
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus.
Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Female; Glucose; Glycated Hemoglobin; Humans; Lactates; Lactic Acid; Male; Metformin; Middle Aged; Muscle, Skeletal; Obesity | 1995 |
Demonstration of defective glucose uptake and storage in erythrocytes from non-insulin dependent diabetic patients and effects of metformin.
Topics: Adult; Diabetes Mellitus, Type 2; Erythrocytes; Glucose; Glycogen; Humans; Hyperglycemia; Lactates; Lactic Acid; Metformin; Middle Aged | 1993 |
Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Glucagon; Gluconeogenesis; Lactates; Lactic Acid; Liver; Male; Metformin; Perfusion; Pyruvate Kinase; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar | 1993 |
[The effect of metformin on lactate levels in type II diabetes].
Topics: Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Triglycerides | 1996 |
Lactic acidosis associated with Glucophage use in a man with normal renal and hepatic function.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Middle Aged | 1997 |
Bicarbonate haemodialysis as a treatment of metformin overdose.
Topics: Acidosis, Lactic; Adult; Bicarbonates; Buffers; Drug Overdose; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Renal Dialysis; Sodium Bicarbonate | 1997 |
Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways.
Topics: Animals; Biological Transport; Chromans; Glucose; Hypoglycemic Agents; Lactic Acid; Lipid Metabolism; Metformin; Mice; Mice, Inbred C3H; Mitochondria; Palmitoyl Coenzyme A; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1997 |
Possible synergistic effect of metformin and enalapril on the development of hyperkaliemic lactic acidosis.
Topics: Acidosis; Aged; Antihypertensive Agents; Chlorides; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combination; Enalapril; Female; Humans; Hypertension; Hypoglycemic Agents; Lactic Acid; Metformin | 1997 |
Consequences of metformin intoxication.
Topics: Adolescent; Adult; Blood Glucose; Creatinine; Diabetes Complications; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged | 1998 |
Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Female; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Prognosis; Retrospective Studies | 1999 |
Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.
Topics: Animals; Citric Acid Cycle; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glutamic Acid; Hypoglycemic Agents; In Vitro Techniques; Lactic Acid; Liver; Male; Metformin; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Starvation; Streptozocin | 1999 |
Lactic acidosis in metformin therapy.
Topics: Acidosis, Lactic; Adult; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Middle Aged; Phenformin; Retrospective Studies; Risk Factors | 1999 |
Effects of insulin and metformin on glucose metabolism in rat vascular smooth muscle.
Topics: Acetyl Coenzyme A; Animals; Glucose; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Mitochondria, Muscle; Muscle, Smooth, Vascular; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 1999 |
Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study.
Topics: Adipose Tissue; Adult; Body Mass Index; Electric Impedance; Epinephrine; Female; Glycerol; Humans; Hyperinsulinism; Hypertension; Hypoglycemic Agents; Kinetics; Lactic Acid; Lipolysis; Male; Metformin; Microdialysis; Norepinephrine; Obesity | 1999 |
Beneficial insulin-sensitizing and vascular effects of S15261 in the insulin-resistant JCR:LA-cp rat.
Topics: Animals; Blood Glucose; Body Weight; Chromans; Eating; Fluorenes; Gene Expression; Glucose Tolerance Test; Glucose-6-Phosphatase; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Resistance; Lactic Acid; Lipids; Liver; Male; Mesenteric Arteries; Metformin; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphoenolpyruvate Carboxylase; Rats; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Vascular Resistance | 2000 |
Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes.
Topics: Adipocytes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Hypoglycemic Agents; Insulin; Lactic Acid; Leptin; Male; Metformin; Rats; Rats, Sprague-Dawley; Regression Analysis; Time Factors; Vanadium | 2000 |
The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Animals; Arteries; Dogs; Fatty Acids, Nonesterified; Female; Gluconeogenesis; Glucose; Glycerol; Glycogen; Hypoglycemic Agents; Kinetics; Lactic Acid; Liver; Male; Metformin; Plasma; Time Factors | 2000 |
Inverse relationship between peripheral insulin removal and action: studies with metformin.
Topics: Animals; Glucose; Glycogen; Hindlimb; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Perfusion; Rats; Rats, Sprague-Dawley; Signal Transduction | 2001 |
Application of (13)C-filtered (1)H NMR to evaluate drug action on gluconeogenesis and glycogenolysis simultaneously in isolated rat hepatocytes.
Topics: Aminoimidazole Carboxamide; Animals; Carbon Isotopes; Cells, Cultured; Gluconeogenesis; Glucose; Glycerol; Glycolysis; Hepatocytes; Lactic Acid; Metformin; Nuclear Magnetic Resonance, Biomolecular; Protons; Rats; Rats, Wistar; Reference Values; Ribonucleotides | 2002 |
Lactic acidemia associated with metformin.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin | 2003 |
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.
Topics: Acidosis, Lactic; Animals; Biguanides; Disease Models, Animal; DNA-Binding Proteins; Hepatocytes; Host Cell Factor C1; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Mice; Octamer Transcription Factor-1; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Transcription Factors | 2003 |
Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes.
Topics: Animals; Cells, Cultured; Gluconeogenesis; Hepatocytes; Hypoglycemic Agents; Lactic Acid; Liver Glycogen; Magnetic Resonance Spectroscopy; Male; Metformin; Rats; Rats, Wistar | 2003 |
[Metformin-associated lactic acidosis precipitated by acute renal failure].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Blood Gas Analysis; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid; Metformin | 2003 |
[Metformin-associated lactic acidosis remains a serious complication of metformin therapy].
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Diabetes Complications; Diabetes Mellitus, Type 2; Dyspnea; Erythrocytes; Fatal Outcome; Female; Gastrointestinal Diseases; Heart Arrest; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Obesity | 2003 |
[STUDY OF FASTING BLOOD LACTIC ACID IN DIABETICS TREATED WITH N-N-DIMETHYLBIGUANIDE].
Topics: Adolescent; Biomedical Research; Blood; Child; Diabetes Mellitus; Drug Therapy; Fasting; Geriatrics; Humans; Lactates; Lactic Acid; Metformin | 1964 |
Contraindications can damage your health--is metformin a case in point?
Topics: Acidosis, Lactic; Aging; Contraindications; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypoglycemic Agents; Incidence; Lactic Acid; Metformin; Practice Guidelines as Topic; Renal Insufficiency; Risk Factors | 2005 |
Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3.
Topics: Acetyl-CoA Carboxylase; Animals; Apoptosis; Blotting, Western; Caspase 3; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Fatty Acids; Glycolysis; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Lactic Acid; Male; Metformin; Models, Biological; Myocytes, Cardiac; Palmitic Acid; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors | 2006 |
Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function.
Topics: Acidosis, Lactic; Asia; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged | 2007 |
A 39-year-old man with HIV-associated lipodystrophy.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biocompatible Materials; Body Image; Cosmetic Techniques; Diet; Exercise; Face; Growth Hormone-Releasing Hormone; HIV-Associated Lipodystrophy Syndrome; Humans; Hypoglycemic Agents; Lactic Acid; Lipectomy; Male; Metformin; Patient Acceptance of Health Care; Patient Compliance; Polyesters; Polymers; Self Concept; Thiazolidinediones | 2008 |
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Buformin; Cell Line; Cell Respiration; Cell Survival; Culture Media; Glutathione; Glycolysis; Hepatocytes; Humans; Hypoglycemic Agents; Lactic Acid; Male; Membrane Potential, Mitochondrial; Metformin; Mitochondria, Liver; Oxidation-Reduction; Phenformin; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2008 |
Stimulation of lactate production in human granulosa cells by metformin and potential involvement of adenosine 5' monophosphate-activated protein kinase.
Topics: Adiponectin; AMP-Activated Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Female; Granulosa Cells; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Metformin; Models, Biological; Time Factors; Up-Regulation | 2009 |
Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers.
Topics: Carbamates; Diabetes Mellitus, Type 2; Gas Chromatography-Mass Spectrometry; Humans; Hypoglycemic Agents; Lactic Acid; Lysine; Metabolomics; Metformin; Piperidines; Rosiglitazone; Thiazolidinediones; Uric Acid; Valine | 2009 |
Metformin primarily decreases plasma glucose not by gluconeogenesis suppression but by activating glucose utilization in a non-obese type 2 diabetes Goto-Kakizaki rats.
Topics: Alanine; Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Hepatocytes; Hypoglycemic Agents; Inhibitory Concentration 50; Insulin; Lactic Acid; Male; Metformin; Organophosphonates; Organophosphorus Compounds; Radioisotope Dilution Technique; Rats; Rats, Mutant Strains; Rats, Wistar | 2009 |
Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG2.
Topics: Animals; Cell Culture Techniques; Cell Line, Tumor; Fluorometry; Gluconeogenesis; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Metformin; Pyruvic Acid; Rats; Up-Regulation | 2009 |
Metformin use in renal dysfunction: is a serum creatinine threshold appropriate?
Topics: Acidosis, Lactic; Creatinine; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Kidney Diseases; Lactic Acid; Metformin; Risk Factors | 2009 |
Relationship of plasma creatinine and lactic acid in type 2 diabetic patients without renal dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Creatinine; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Radioimmunoassay; Young Adult | 2009 |
Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine.
Topics: Animals; Bile Canaliculi; Biological Transport; Cell Line; Humans; In Vitro Techniques; Kidney; Lactic Acid; Liver; Male; Metformin; Mice; Microvilli; Organic Cation Transport Proteins; Pyrimethamine; Tetraethylammonium | 2010 |
Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals.
Topics: Adult; AMP-Activated Protein Kinases; Blotting, Western; Exercise; Female; Glucose Clamp Technique; Heart Rate; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lactic Acid; Male; Metformin; Middle Aged; Muscle, Skeletal; Oxygen Consumption; Phosphorylation | 2010 |
SLC22A2 gene 808 G/T variant is related to plasma lactate concentration in Chinese type 2 diabetics treated with metformin.
Topics: Base Sequence; China; Diabetes Mellitus, Type 2; DNA Primers; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Polymorphism, Single Nucleotide | 2010 |
Relationship between drug release and some physical parameters of drug sorption onto PLA fibers.
Topics: Diclofenac; Diffusion; Fluorouracil; Lactic Acid; Metformin; Models, Chemical; Pharmaceutical Preparations; Polyesters; Polymers; Solvents; Temperature; Thermodynamics | 2010 |
Comparison of potential risks of lactic acidosis induction by biguanides in rats.
Topics: Acidosis, Lactic; Animals; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Phenformin; Rats; Rats, Inbred F344 | 2010 |
Diabetes, metformin and lactic acidosis.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus; Female; Humans; Lactic Acid; Male; Metformin; Middle Aged | 2011 |
Old age may not be a contraindication to the use of metformin.
Topics: Age Factors; Aged; Aged, 80 and over; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Metformin | 2010 |
Fasting plasma lactate concentrations in ambulatory elderly patients with type 2 diabetes receiving metformin therapy: a retrospective cross-sectional study.
Topics: Adult; Aged; Aged, 80 and over; Creatinine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Hypoglycemic Agents; Lactic Acid; Logistic Models; Male; Metformin; Middle Aged; Retrospective Studies | 2010 |
Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs.
Topics: Animals; Blood Glucose; Dogs; Enzyme Inhibitors; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Glycerol; Glycogen Phosphorylase, Liver Form; Hematocrit; Hypoglycemic Agents; Indoles; Insulin; Lactic Acid; Liver; Liver Glycogen; Male; Metformin; Phenylbutyrates | 2011 |
Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats.
Topics: Animals; Blood Glucose; Body Weight; Cell Nucleus; Drug Combinations; Eating; Gene Expression Regulation; Hypoglycemic Agents; Insulin; Lactic Acid; Lipid Metabolism; Male; Metformin; Methylhydrazines; Myocardium; Obesity; PPAR alpha; PPAR gamma; Rats; Rats, Zucker; RNA, Messenger | 2011 |
Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases.
Topics: Acidosis, Lactic; Adolescent; Bicarbonates; Diabetes Mellitus, Type 2; Dialysis Solutions; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Renal Dialysis; Suicide, Attempted; Treatment Outcome | 2011 |
Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Early Diagnosis; Female; Humans; Hypoglycemic Agents; Incidence; Lactic Acid; Male; Medical Records; Metformin; Middle Aged; Netherlands; Renal Insufficiency; Risk Factors; Severity of Illness Index; Treatment Outcome | 2011 |
Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Cells, Cultured; Electron Transport Complex I; Gene Expression Regulation; Humans; Lactic Acid; Metformin; Mice; Mitochondria; Mitochondrial Myopathies; Muscle Weakness; Muscle, Skeletal; Myoblasts; NADH Dehydrogenase; Physical Conditioning, Animal; Receptors, Steroid; Receptors, Thyroid Hormone; Ribonucleotides | 2011 |
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.
Topics: Adenosine Triphosphate; Carcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Deoxyglucose; Disease Progression; Genes, p53; Glucose; Glutamine; Head and Neck Neoplasms; Humans; Lactic Acid; Mass Spectrometry; Metabolomics; Metformin; Neoplasms, Squamous Cell; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome; Tumor Suppressor Protein p53 | 2011 |
Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Biomarkers; Creatinine; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Medical Records; Metformin; Middle Aged; Renal Dialysis; Retrospective Studies; Treatment Outcome | 2012 |
Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Breast Neoplasms; Cell Line, Tumor; Coculture Techniques; Doxorubicin; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor Modulators; Female; Fibroblasts; Fulvestrant; Humans; Hypoglycemic Agents; Intracellular Signaling Peptides and Proteins; Ketone Bodies; Lactic Acid; Metformin; Mitochondria; Oxides; Phosphoric Monoester Hydrolases; Poly(ADP-ribose) Polymerase Inhibitors; Tamoxifen; Tumor Microenvironment | 2011 |
Optimization of a dual mechanism gastrofloatable and gastroadhesive delivery system for narrow absorption window drugs.
Topics: Acrylic Resins; Adhesives; Chemistry, Pharmaceutical; Drug Delivery Systems; Gastric Mucosa; Intestinal Absorption; Lactic Acid; Metformin; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Stomach | 2012 |
Metformin intoxication requiring dialysis.
Topics: Acidosis, Lactic; Diabetes Mellitus; Female; Humans; Lactic Acid; Male; Metformin; Middle Aged; Renal Dialysis | 2011 |
Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus; Dose-Response Relationship, Drug; HEK293 Cells; Homozygote; Humans; Hypoglycemic Agents; Kidney; Kidney Function Tests; Lactic Acid; Liver; Liver Function Tests; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Organic Cation Transport Proteins; Species Specificity; Transfection | 2012 |
The gonadal hormone regulates the plasma lactate levels in type 2 diabetes treated with and without metformin.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Estrogens; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lactic Acid; Logistic Models; Male; Metformin; Middle Aged; Sex Factors; Testosterone | 2012 |
Metformin therapy in patients with chronic kidney disease.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors | 2012 |
Diabetes medication use and blood lactate level among participants with type 2 diabetes: the atherosclerosis risk in communities carotid MRI study.
Topics: Aged; Aged, 80 and over; Atherosclerosis; Blood Glucose; Cohort Studies; Cross-Sectional Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Middle Aged; Risk Factors; Thiazolidinediones | 2012 |
The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis.
Topics: Acidosis, Lactic; Aged; Creatinine; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Male; Metformin | 2013 |
Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Apoptosis; Blotting, Western; Cell Proliferation; Chromatography, Liquid; Glucose; Glycolysis; Humans; Hypoglycemic Agents; Immunoenzyme Techniques; Lactic Acid; Leukemia; Metformin; Mice; Mice, Nude; Mitochondria; Oxygen Consumption; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Spectrometry, Mass, Electrospray Ionization; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2013 |
Transport of biguanides by human organic cation transporter OCT2.
Topics: Biological Transport; Female; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 2; Phenformin | 2013 |
Case records of the Massachusetts General Hospital. Case 23-2013. A 54-year-old woman with abdominal pain, vomiting, and confusion.
Topics: Abdominal Pain; Acidosis, Lactic; Confusion; Diabetes Mellitus, Type 2; Diagnosis, Differential; Female; Humans; Hydrogen-Ion Concentration; Kidney; Lactic Acid; Metformin; Middle Aged; Pancreas; Pancreatitis; Renal Insufficiency, Chronic; Tomography, X-Ray Computed; Ultrasonography; Vomiting | 2013 |
[Study on the anti-Lewis lung carcinoma effect of metformin combined with MCT1 inhibitor CHC].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Lewis Lung; Coumaric Acids; Female; Lactic Acid; Lung Neoplasms; Metformin; Mice; Mice, Inbred C57BL; Monocarboxylic Acid Transporters; Symporters; Tumor Cells, Cultured | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Metformin and male reproduction: effects on Sertoli cell metabolism.
Topics: Alanine; Animals; Cells, Cultured; Glucose Transporter Type 1; Glucose Transporter Type 3; Hypoglycemic Agents; L-Lactate Dehydrogenase; Lactic Acid; Male; Metformin; Monocarboxylic Acid Transporters; Muscle Proteins; Phosphofructokinase-1; Rats; Rats, Wistar; Reproduction; RNA, Messenger; Sertoli Cells | 2014 |
Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Chronic Disease; Creatinine; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Male; Metformin; Middle Aged; Renal Dialysis; Retrospective Studies | 2014 |
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.
Topics: Animals; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutathione; Glycolysis; Homeostasis; Humans; Hydrogen Peroxide; Lactic Acid; Metformin; Mice; Monocarboxylic Acid Transporters; Oxidation-Reduction; Oxidative Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-myc; Symporters; Transcription, Genetic | 2014 |
Metformin accumulation without hyperlactataemia and metformin-induced hyperlactataemia without metformin accumulation.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Hypersensitivity; Drug Resistance; Female; Humans; Hyperlactatemia; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Treatment Outcome | 2014 |
Metformin in peritoneal dialysis: a pilot experience.
Topics: Acidosis, Lactic; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; Lactic Acid; Male; Metformin; Middle Aged; Peritoneal Dialysis; Pilot Projects; Prospective Studies | 2014 |
Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.
Topics: Blood Platelets; Female; Humans; Hypoglycemic Agents; Lactic Acid; Leukocytes, Mononuclear; Male; Metformin; Mitochondria; Oxygen Consumption | 2015 |
Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study.
Topics: Acidosis, Lactic; Adult; Aged; Cohort Studies; Comorbidity; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Incidence; Lactic Acid; Male; Metformin; Middle Aged; Renal Insufficiency; Research Design; Risk Assessment; Risk Factors | 2014 |
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Topics: Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Gluconeogenesis; Glycerolphosphate Dehydrogenase; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lactic Acid; Liver; Male; Metformin; Mice, Knockout; Mitochondria; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2014 |
Hierarchical porous bioactive glasses/PLGA-magnetic SBA-15 for dual-drug release.
Topics: Ceramics; Drug Delivery Systems; Drug Liberation; Durapatite; HeLa Cells; Humans; Hydrogen Bonding; Ibuprofen; Lactic Acid; Magnetics; Metformin; Microscopy, Electron, Scanning; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Silicon Dioxide | 2014 |
Metabolic engineering of lactate dehydrogenase rescues mice from acidosis.
Topics: Acidosis; Animals; Boronic Acids; Cells, Cultured; Female; Hypoglycemic Agents; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Metabolic Engineering; Metabolic Networks and Pathways; Metformin; Mice; Mice, Inbred C57BL; Pyruvic Acid | 2014 |
Pharmacist review prevents evolving metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Community Pharmacy Services; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin | 2014 |
The effect of metformin treatment in vivo on acute and long-term energy metabolism and progesterone production in vitro by granulosa cells from women with polycystic ovary syndrome.
Topics: Adult; Case-Control Studies; Cell Proliferation; Cells, Cultured; Female; Follicular Fluid; Glucose; Granulosa Cells; Humans; Insulin; Lactic Acid; Metformin; Ovarian Follicle; Polycystic Ovary Syndrome; Progesterone; Pyruvic Acid | 2014 |
Differential effects of AMPK agonists on cell growth and metabolism.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Glucose; HCT116 Cells; HEK293 Cells; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mice; Neoplasms; Phenformin; Pyrones; Ribonucleotides; Sodium Salicylate; Thiophenes | 2015 |
The pharmacokinetics of metformin and concentrations of haemoglobin A1C and lactate in Indigenous and non-Indigenous Australians with type 2 diabetes mellitus.
Topics: Aged; Australia; Creatinine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lactic Acid; Metabolic Clearance Rate; Metformin; Middle Aged; Native Hawaiian or Other Pacific Islander; Population Groups | 2015 |
The target of metformin in type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Dihydroxyacetone Phosphate; Gluconeogenesis; Glycerolphosphate Dehydrogenase; Humans; Hypoglycemic Agents; Lactic Acid; Liver; Metformin; Mitochondria; Rats | 2014 |
Chitosan-poly (lactide-co-glycolide) (CS-PLGA) nanoparticles containing metformin HCl: preparation and in vitro evaluation.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chitosan; Lactic Acid; Metformin; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Spectroscopy, Fourier Transform Infrared | 2014 |
Augmentation of diabetic wound healing and enhancement of collagen content using nanofibrous glucophage-loaded collagen/PLGA scaffold membranes.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Drug Administration Routes; Hypoglycemic Agents; Lactic Acid; Male; Membranes, Artificial; Metformin; Nanofibers; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Tissue Scaffolds; Wound Healing | 2015 |
Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients.
Topics: Acidosis, Lactic; Adult; Aged; Cohort Studies; Data Collection; Databases, Factual; Diabetes Mellitus, Type 2; Drug and Narcotic Control; Female; Humans; Hypoglycemic Agents; Japan; Lactic Acid; Male; Metformin; Middle Aged; Practice Patterns, Physicians'; Retrospective Studies; Young Adult | 2015 |
[Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics].
Topics: Acidosis, Lactic; Acute Kidney Injury; Carbon Dioxide; Diabetes Mellitus, Type 2; Epinephrine; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Norepinephrine; Perioperative Care; Renal Dialysis | 2015 |
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents; Basigin; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Down-Regulation; Female; Gene Knockdown Techniques; Glycolysis; Humans; Lactic Acid; Lung Neoplasms; Metformin; Mice, Nude; Monocarboxylic Acid Transporters; Muscle Proteins; Phenformin; Protein Serine-Threonine Kinases; Protein Transport; Symporters; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Safety of metformin in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Pulmonary Disease, Chronic Obstructive; Retrospective Studies; Survival Analysis; Treatment Outcome | 2015 |
Does lactate account for all of the increase in anion gap in cases of metformin-induced lactic acidosis?
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Shock, Septic | 2015 |
Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.
Topics: Animals; Antineoplastic Agents; Ascites; Cell Line, Tumor; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Glucose; Glycolysis; Humans; Hyperglycemia; Hypoglycemic Agents; Lactic Acid; MAP Kinase Signaling System; Metformin; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; Pentose Phosphate Pathway; Phenformin; Proto-Oncogene Proteins c-myc | 2015 |
Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.
Topics: Active Transport, Cell Nucleus; Animals; Binding Sites; Carcinoma; Carrier Proteins; Cell Line, Tumor; Cell Nucleus; Cohort Studies; Cysteine; Fibroblasts; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Lactic Acid; Male; Membrane Proteins; Metformin; Mice; Mice, SCID; MicroRNAs; Neoplasm Metastasis; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen; Prostatic Neoplasms; Pyruvate Kinase; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Tumor Suppressor Proteins | 2015 |
Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D‑galactosamine‑induced fulminant hepatitis.
Topics: Animals; Anti-Inflammatory Agents; Blood Coagulation; Disease Models, Animal; Erythropoietin; Galactosamine; Hepatitis; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Interleukin-6; Lactic Acid; Lipopolysaccharides; Liver; Matrix Metalloproteinase 3; Metformin; Mice; NF-kappa B; Plasminogen Activator Inhibitor 1; RNA, Messenger; Thromboplastin; Up-Regulation; Vascular Endothelial Growth Factor A | 2015 |
Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cyclophosphamide; DNA Damage; DNA Repair; Drug Combinations; Drug Synergism; Embryonic Stem Cells; Epirubicin; Female; Fibroblasts; Fluorouracil; Glucose; Humans; Hypoglycemic Agents; Lactic Acid; Lung; Metformin; Neoplastic Stem Cells; Pyrones; Ribonucleotides; Thiophenes | 2015 |
GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study.
Topics: Adaptor Proteins, Signal Transducing; Alleles; Black or African American; Cohort Studies; Diabetes Mellitus, Type 2; Female; Genome-Wide Association Study; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Protein Phosphatase 1; White People | 2016 |
The Antidiabetic Drug Metformin Stimulates Glycolytic Lactate Production in Cultured Primary Rat Astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Glycolysis; Hypoglycemic Agents; Lactic Acid; Metformin; Rats; Rats, Wistar | 2017 |
Post-mortem analysis of lactate concentration in diabetics and metformin poisonings.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Ketone Bodies; Lactic Acid; Metformin; Postmortem Changes | 2015 |
Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Progression; Electron Transport Complex I; Energy Metabolism; Enzyme Inhibitors; Glycolysis; Humans; Hydrogen-Ion Concentration; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Male; Melanoma; Melanoma, Experimental; Metformin; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Oxamic Acid; RNA Interference; Skin Neoplasms; Time Factors; Transfection; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2015 |
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Disease Susceptibility; DNA Damage; Electron Transport Complex IV; Female; Glycolysis; Humans; Lactic Acid; Lung; Lung Neoplasms; Metformin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Monocarboxylic Acid Transporters; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Pyruvic Acid; Reactive Oxygen Species; Stress, Physiological; Symporters; Urethane | 2016 |
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Glucose; Interferon-gamma; Interleukin-17; Lactic Acid; Lupus Erythematosus, Systemic; Lymphocyte Activation; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Pyruvic Acid | 2016 |
High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model.
Topics: Administration, Intravesical; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Hypoglycemic Agents; Kaplan-Meier Estimate; Lactic Acid; Metformin; Mice; Mice, Inbred C57BL; Phosphorylation; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Urinary Bladder; Urinary Bladder Neoplasms | 2016 |
AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Respiration; Energy Metabolism; Fatty Acids; Gene Expression Regulation; Glucose; Humans; Lactic Acid; Longevity; Metformin; Mitochondria; Oxygen; Oxygen Consumption; Protein Serine-Threonine Kinases; Protein Subunits; Receptors, Cytoplasmic and Nuclear; Ribonucleotides; Signal Transduction; Transcription Factors; Transcription, Genetic | 2016 |
Lactic acidosis: relationship between metformin levels, lactate concentration and mortality.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Male; Metformin; Middle Aged; Pharmacovigilance; Prognosis; Survival Analysis; Young Adult | 2016 |
Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Female; France; Hospitals, University; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Risk Assessment; Risk Factors; Treatment Outcome | 2016 |
Skeletal muscle lactate overproduction during metformin intoxication: An animal study with reverse microdialysis.
Topics: Acidosis, Lactic; Animals; Glycolysis; Hypoglycemic Agents; Infusions, Parenteral; Lactic Acid; Metformin; Microdialysis; Mitochondria, Muscle; Muscle, Skeletal; Pyruvic Acid; Swine; Time Factors | 2016 |
Metformin-Associated Lactic Acidosis in a Patient with Normal Renal Function.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Humans; Kidney Function Tests; Lactic Acid; Metformin | 2016 |
Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Dichloroacetic Acid; Drug Synergism; Drug Therapy, Combination; Female; Growth Inhibitors; Humans; Lactic Acid; Metformin; Mice; Mice, Nude; Ovarian Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.
Topics: Animals; Bicarbonates; Carbon Isotopes; Heart; Lactic Acid; Liver; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Metformin; Myocardium; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Wistar | 2016 |
Impact of Metformin Use on Lactate Kinetics in Patients with Severe Sepsis and Septic Shock.
Topics: Aged; Emergency Service, Hospital; Female; Hospital Mortality; Humans; Lactic Acid; Male; Metformin; Middle Aged; Retrospective Studies; Sepsis; Shock, Septic | 2017 |
Investigation of Risk Factors Affecting Lactate Levels in Japanese Patients Treated with Metformin.
Topics: Adult; Aged; Asian People; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hyperlactatemia; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Renal Insufficiency; Risk Factors; Uric Acid | 2016 |
Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes.
Topics: Acidosis, Lactic; Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hyperlactatemia; Hypoglycemic Agents; Incidence; Lactic Acid; Male; Metformin; Middle Aged; Prevalence; Regression Analysis; Renal Insufficiency; Risk Factors | 2017 |
Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department.
Topics: Aged; Aged, 80 and over; Comorbidity; Diabetes Mellitus; Emergency Service, Hospital; Female; Hospitals, University; Humans; Hyperlactatemia; Hypoglycemic Agents; Hypoxia; Lactic Acid; Length of Stay; Male; Metformin; Middle Aged; Netherlands; Predictive Value of Tests; Retrospective Studies; Sepsis; Shock | 2017 |
Exercise timing and blood lactate concentrations in individuals with type 2 diabetes.
Topics: Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Diet; Female; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Meals; Metformin; Middle Aged; Obesity; Postprandial Period; Resistance Training; Time Factors; Triglycerides | 2017 |
Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Incidence; Lactic Acid; Male; Metformin; Middle Aged | 2017 |
Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward.
Topics: Acidosis, Lactic; Contraindications, Drug; Diabetes Mellitus; Hospitalization; Humans; Hyperlactatemia; Hypoglycemic Agents; Internal Medicine; Lactic Acid; Metformin | 2017 |
Metformin Accelerates Glycolytic Lactate Production in Cultured Primary Cerebellar Granule Neurons.
Topics: Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Glycolysis; Hypoglycemic Agents; L-Lactate Dehydrogenase; Lactic Acid; Metformin; Neurons; Rats; Rats, Wistar | 2019 |
Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Energy Metabolism; Glucose; Hypoglycemic Agents; Intestinal Mucosa; Intestines; Lactic Acid; Liver; Male; Metformin; Mice; Mice, Inbred C57BL | 2017 |
Oxamate Enhances the Anti-Inflammatory and Insulin-Sensitizing Effects of Metformin in Diabetic Mice.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Insulin; Insulin Resistance; L-Lactate Dehydrogenase; Lactic Acid; Male; Metformin; Mice; Oxamic Acid | 2017 |
MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy.
Topics: Acrylates; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Energy Metabolism; Female; HT29 Cells; Humans; Lactic Acid; Lymphoma; Magnetic Resonance Spectroscopy; Metformin; Mice, SCID; Mitochondria; Monocarboxylic Acid Transporters; Muscle Proteins; Pyrimidinones; Symporters; Thiophenes; Xenograft Model Antitumor Assays | 2017 |
Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Obesity, Morbid; Retrospective Studies; Treatment Outcome | 2018 |
Safety of Metformin Therapy in Patients with Type 2 Diabetes Living on an Oxygen-Deficient Plateau, Tibet, China.
Topics: Acidosis, Lactic; Adult; Altitude; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Oxygen; Tibet | 2018 |
Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4.
Topics: Creatinine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Renal Insufficiency, Chronic | 2018 |
Direct assessment of renal mitochondrial redox state using hyperpolarized
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Catalysis; Ketones; Kidney; Lactic Acid; Liver; Magnetic Resonance Imaging; Metformin; Mitochondria; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2018 |
ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.
Topics: Animals; Biomarkers; Blood Glucose; Computer Simulation; Dose-Response Relationship, Drug; Drug Development; Drug Dosage Calculations; Drug Interactions; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Models, Biological; Pharmacogenetics; Polypharmacy; Renal Elimination; Research Design; Risk Assessment | 2018 |
Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Animals; Cell Line; Contrast Media; Disease Models, Animal; Hypoglycemic Agents; In Vitro Techniques; Iohexol; Kidney Tubules, Proximal; Lactic Acid; Male; Metformin; Organic Cation Transporter 2; Rats, Wistar; Up-Regulation | 2018 |
Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Citric Acid Cycle; Energy Metabolism; Enzyme Inhibitors; Fibroblasts; Humans; Hypoglycemic Agents; Lactic Acid; Metabolic Networks and Pathways; Metabolomics; Metformin; Mice; Mice, Knockout; Ribonucleotides | 2019 |
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.
Topics: Acids; Animals; Cell Line, Tumor; Energy Metabolism; Humans; Intracellular Space; Lactic Acid; Male; Metformin; Mice, Inbred C57BL; Monocarboxylic Acid Transporters; Muscle Proteins; NAD; Neoplasms; Reserpine; Symporters; Synthetic Lethal Mutations | 2018 |
Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.
Topics: Animals; Aspartic Acid; Cells, Cultured; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Glycolysis; Hepatocytes; Hypoglycemic Agents; Lactic Acid; Malates; Male; Metformin; Mice; Mice, Inbred C57BL; Mitochondria, Liver; NAD; Oxidation-Reduction; Phosphofructokinase-1; Rats; Rats, Wistar | 2019 |
Comparison of HepaRG cells following growth in proliferative and differentiated culture conditions reveals distinct bioenergetic profiles.
Topics: Acetaminophen; Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Culture Media; Energy Metabolism; Glycolysis; Hepatocytes; Humans; L-Lactate Dehydrogenase; Lactic Acid; Liver Neoplasms; Metformin; Oxidative Phosphorylation | 2019 |
Consequences of a Metabolic Glucose-Depletion on the Survival and the Metabolism of Cultured Rat Astrocytes.
Topics: Animals; Astrocytes; Cell Survival; Cells, Cultured; Glucose; Glycolysis; Lactic Acid; Metformin; Mitochondria; Rats, Wistar | 2019 |
Metabolic therapies inhibit tumor growth in vivo and in silico.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon; Carcinogenesis; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Proliferation; Citrates; Diclofenac; Energy Metabolism; Glucose; Heterografts; Humans; Lactic Acid; Metformin; Mice; Thioctic Acid | 2019 |
Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant?
Topics: Acidosis, Lactic; Creatinine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Monitoring; Female; Glomerular Filtration Rate; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Outcome Assessment, Health Care; Renal Insufficiency, Chronic; Severity of Illness Index | 2019 |
Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Case-Control Studies; Drug Overdose; Emergency Service, Hospital; Female; Humans; Hyperlactatemia; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Prospective Studies; Retrospective Studies; Risk Factors | 2019 |
Metformin mitigates impaired testicular lactate transport/utilisation and improves sexual behaviour in streptozotocin-induced diabetic rats.
Topics: Animals; Biological Transport; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucose Tolerance Test; Glucose Transporter Type 1; Glucose Transporter Type 3; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Nitric Oxide; Penis; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Streptozocin; Testis | 2021 |
Metformin-Associated Lactic Acidosis Presenting Like Acute Mesenteric Ischemia.
Topics: Acidosis, Lactic; Creatinine; Diabetes Mellitus, Type 2; Emergency Service, Hospital; Female; Humans; Hypoglycemic Agents; Lactic Acid; Laparotomy; Mesenteric Ischemia; Metformin; Middle Aged | 2019 |
Follow-up of glycemic index before and after Ramadan fasting in type 2 diabetes patients under antidiabetic medications.
Topics: Acidosis, Lactic; Adult; Aged; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Fasting; Female; Follow-Up Studies; Glycated Hemoglobin; Glycemic Index; Humans; Hypoglycemic Agents; Islam; Lactic Acid; Male; Metformin; Middle Aged; Prospective Studies; Uric Acid; Young Adult | 2019 |
Energy metabolism modulation by biguanides in comparison with rotenone in rat liver and heart.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Energy Metabolism; Gluconeogenesis; Heart; Lactic Acid; Liver; Male; Metformin; Mitochondria; Oxidative Phosphorylation; Phenformin; Rats, Wistar; Rotenone; Transcriptome | 2019 |
Laboratory-Confirmed Metformin-Associated Lactic Acidosis
Topics: Acidosis, Lactic; Aged; Alcohol Drinking; Continuous Renal Replacement Therapy; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Lactic Acid; Metformin; Middle Aged | 2019 |
Metformin is associated with increase in lactate level in elderly patients with type 2 diabetes and CKD stage 3: A case-control study.
Topics: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Humans; Hyperlactatemia; Lactic Acid; Male; Metformin; Renal Insufficiency, Chronic; United States; Veterans | 2020 |
Metformin Induces Oxidative Stress-Mediated Apoptosis without the Blockade of Glycolysis in H4IIE Hepatocellular Carcinoma Cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Glucose; Glycolysis; Humans; Hypoglycemic Agents; Lactic Acid; Liver Neoplasms; Metformin; Oxidative Stress; Reactive Oxygen Species | 2019 |
Malaysian propolis and metformin mitigate subfertility in streptozotocin-induced diabetic male rats by targeting steroidogenesis, testicular lactate transport, spermatogenesis and mating behaviour.
Topics: Animals; Diabetes Mellitus, Experimental; Fertility; Infertility, Male; Lactic Acid; Male; Metformin; Propolis; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Spermatogenesis; Steroids; Testis | 2020 |
Galloflavin Plus Metformin Treatment Impairs Pancreatic Cancer Cells.
Topics: Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Isocoumarins; Lactic Acid; Metformin; Pancreatic Neoplasms | 2020 |
The safety and pharmacokinetics of metformin in patients with chronic liver disease.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Chronic Disease; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid; Liver Diseases; Male; Metformin; Middle Aged; Prospective Studies; Severity of Illness Index | 2020 |
rs622342A>C in SLC22A1 is associated with metformin pharmacokinetics and glycemic response.
Topics: Adult; Aged; Creatinine; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Organic Cation Transporter 1; Polymorphism, Genetic | 2020 |
Effect of exercise on key pharmacokinetic parameters related to metformin absorption in healthy humans: A pilot study.
Topics: Adult; Blood Glucose; Healthy Volunteers; High-Intensity Interval Training; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Pilot Projects | 2020 |
Metformin Preconditioning Improves Hepatobiliary Function and Reduces Injury in a Rat Model of Normothermic Machine Perfusion and Orthotopic Transplantation.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bicarbonates; Biliary Tract; Cholesterol 7-alpha-Hydroxylase; Lactic Acid; Liver Transplantation; Male; Metformin; Models, Animal; Organ Preservation; Perfusion; Rats; Rats, Inbred Lew; Transplantation Conditioning | 2020 |
Citrus fruit-derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin.
Topics: Animals; Blood Glucose; Citrus; Diabetes Mellitus, Experimental; Flavanones; Flavonoids; Hypoglycemic Agents; Lactic Acid; Liver; Male; Metformin; Organic Cation Transporter 1; Rats; Rats, Sprague-Dawley; Streptozocin | 2020 |
The Effect of Residual Confoundingon Mortality in Metformin-Associated Lactic Acidosis.
Topics: Acidosis, Lactic; Humans; Hydrogen-Ion Concentration; Lactic Acid; Metformin; Risk Factors | 2020 |
Metformin enhances cytotoxic action of dichloroacetate against Lewis lung carcinoma cells in vitro.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Synergism; Glucose; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Metformin | 2020 |
In Reply: More Questions than Answers in Metformin-Associated Lactic Acidosis (MALA).
Topics: Acidosis, Lactic; Humans; Hydrogen-Ion Concentration; Lactic Acid; Metformin; Risk Factors | 2020 |
Understanding the association between metformin plasma concentrations and lactate.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Metformin | 2021 |
Low glucose enhanced metformin's inhibitory effect on pancreatic cancer cells by suppressing glycolysis and inducing energy stress via up-regulation of miR-210-5p.
Topics: Anaerobiosis; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Energy Metabolism; Gene Expression Regulation, Neoplastic; Glucose; Glycolysis; Humans; L-Lactate Dehydrogenase; Lactic Acid; Metformin; MicroRNAs; Models, Biological; Pancreatic Neoplasms; Phosphofructokinase-2; Phosphorylation; Up-Regulation | 2020 |
Metformin-associated lactic acidosis: reinforcing learning points.
Topics: Acidosis, Lactic; Acute Kidney Injury; Bicarbonates; Continuous Renal Replacement Therapy; Diabetes Mellitus, Type 2; Drug Overdose; Glomerular Filtration Rate; Humans; Hypoglycemic Agents; Hypothyroidism; Lactic Acid; Male; Metformin; Renal Dialysis; Thyroxine; Young Adult | 2020 |
Metformin use and early lactate levels in critically ill patients according to chronic and acute renal impairment.
Topics: Aged; Critical Illness; Denmark; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Renal Insufficiency; Time Factors | 2020 |
The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Aged, 80 and over; Anions; Cations; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged | 2021 |
Dual-functional scaffolds of poly(L-lactic acid)/nanohydroxyapatite encapsulated with metformin: Simultaneous enhancement of bone repair and bone tumor inhibition.
Topics: Bone Neoplasms; Durapatite; Humans; Lactic Acid; Metformin; Osteogenesis; Polyesters; Tissue Engineering; Tissue Scaffolds | 2021 |
Cholinergic and metabolic effects of metformin in mouse brain.
Topics: Acetylcholine; Acidosis, Lactic; Animals; Choline; Glucose; Hypoglycemic Agents; Hypothalamus; Lactic Acid; Metformin; Mice; Mitochondria; Neurons; Oxygen Consumption | 2021 |
Plasma Metformin Levels at Almost 24 Hours Would Help With the Delicate Decision to Start Renal Replacement Therapy: We Disagree as Lactate That Is More Widely and Early Available Should Be a Much Better Trigger to Start Renal Replacement Therapy!
Topics: Acidosis, Lactic; Humans; Lactic Acid; Metformin; Renal Replacement Therapy | 2021 |
Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.
Topics: B-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Epstein-Barr Virus Infections; Glucose; Glutathione; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; Lactic Acid; Lymphoma; Metformin; Monocarboxylic Acid Transporters; NAD; Oxygen Consumption; Phenformin; Reactive Oxygen Species; Up-Regulation | 2021 |
The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate.
Topics: Adolescent; Adult; Child; Cohort Studies; Female; Genetic Variation; Genotype; Humans; Hypoglycemic Agents; Indians, North American; Lactic Acid; Male; Metformin; Mexico; Molecular Dynamics Simulation; Organic Cation Transport Proteins; Pharmacogenetics | 2021 |
Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin.
Topics: 3-Hydroxybutyric Acid; Animals; Antineoplastic Agents; B7-H1 Antigen; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Female; Humans; Lactic Acid; Lymphocyte Activation; Metformin; Mice, Inbred BALB C; Mice, Nude; Programmed Cell Death 1 Receptor; Receptors, G-Protein-Coupled; Signal Transduction; T-Lymphocytes | 2021 |
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer.
Topics: Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucose; Glycolysis; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mice; Monocarboxylic Acid Transporters; Muscle Proteins; Prognosis; Trabectedin | 2022 |
Rewired Cellular Metabolic Profiles in Response to Metformin under Different Oxygen and Nutrient Conditions.
Topics: Cell Line, Tumor; Cell Proliferation; Culture Media; Glucose; Glutamine; HeLa Cells; Humans; Lactic Acid; Metabolomics; Metformin; NAD; Oxygen; Pyruvic Acid; Tumor Hypoxia | 2022 |
Reduced lactic acidosis risk with Imeglimin: Comparison with Metformin.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Dogs; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mice; Rats; Renal Insufficiency; Triazines | 2022 |
The lactate receptor GPR81 mediates hepatic lipid metabolism and the therapeutic effect of metformin on experimental NAFLDs.
Topics: Animals; Carnitine O-Palmitoyltransferase; Fatty Acids; Lactic Acid; Lipid Metabolism; Liver; Metformin; Mice; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, G-Protein-Coupled | 2022 |
Comment on Chen et al. Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin.
Topics: B7-H1 Antigen; Humans; Lactic Acid; Metformin; Neoplasms; Programmed Cell Death 1 Receptor | 2022 |
Metformin alleviates the cognitive impairment caused by aluminum by improving energy metabolism disorders in mice.
Topics: Aluminum; AMP-Activated Protein Kinases; Animals; Cognitive Dysfunction; Energy Metabolism; Glucose; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid; Metformin; Mice | 2022 |
Regulatory Effects of Metformin, an Antidiabetic Biguanide Drug, on the Metabolism of Primary Rat Adipocytes.
Topics: Adipocytes; Animals; Diabetes Mellitus, Type 2; Epinephrine; Glucose; Hypoglycemic Agents; Insulin; Lactic Acid; Lipolysis; Metformin; Rats; Rats, Wistar | 2022 |
Continuous Processing of Micropellets via Hot-Melt Extrusion.
Topics: Drug Compounding; Hot Temperature; Lactic Acid; Metformin; Polyesters; Solubility; Suspensions | 2022 |
New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.
Topics: Acute Kidney Injury; Humans; Kidney; Lactic Acid; Metformin; Retrospective Studies; Sepsis; Shock, Septic | 2023 |
Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report.
Topics: Acidosis, Lactic; Aeromonas veronii; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Renal Insufficiency, Chronic | 2023 |
Retrospective evaluation of management guidelines for extracorporeal treatment of metformin poisoning.
Topics: Drug Overdose; Humans; Lactic Acid; Metformin; Renal Dialysis; Retrospective Studies | 2023 |
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Lactic Acid; Metformin; Monocarboxylic Acid Transporters; Multiple Myeloma | 2023 |
[Use of metformin in patients with type 2 diabetes and acute myocardial infarction: safety and impact on glycemic control].
Topics: Acute Kidney Injury; Diabetes Mellitus, Type 2; Glycemic Control; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Myocardial Infarction; Percutaneous Coronary Intervention | 2023 |
The safe use of metformin in heart failure patients both with and without T2DM: A cross-sectional and longitudinal study.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Heart Failure; Humans; Hypoglycemic Agents; Lactic Acid; Longitudinal Studies; Male; Metformin; Prospective Studies | 2023 |
Metformin exerts antileukemic effects by modulating lactate metabolism and overcomes imatinib resistance in chronic myelogenous leukemia.
Topics: Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Glucose; Humans; Imatinib Mesylate; Lactic Acid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocytes, Mononuclear; Metformin | 2023 |
Blood lactate levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease in type 2 diabetes: a real-world study.
Topics: Asian People; Diabetes Mellitus, Type 2; Humans; Lactic Acid; Metformin; Non-alcoholic Fatty Liver Disease | 2023 |
Metformin-associated lactic acidosis reported to the United Kingdom National Poisons Information Service (NPIS) between 2010 and 2019: a ten-year retrospective analysis.
Topics: Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Poisons; Retrospective Studies | 2023 |
An acid test for metformin
Topics: Animals; Carrier Proteins; Cell Line, Tumor; Glycolysis; Hypoglycemic Agents; Lactic Acid; Metformin; Mice; Monocarboxylic Acid Transporters; Multiple Myeloma | 2023 |
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes.
Topics: Humans; Lactate Dehydrogenases; Lactic Acid; Metformin; Muscle Fibers, Skeletal; NAD; Oxidation-Reduction; Oxidoreductases; Pyruvates | 2023 |
Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report.
Topics: Acidosis, Lactic; Adult; Carbon Dioxide; Continuous Renal Replacement Therapy; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin | 2023 |