lactic acid has been researched along with leuprolide in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (14.71) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 15 (44.12) | 29.6817 |
| 2010's | 8 (23.53) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Ogawa, Y; Okada, H; Toguchi, H; Yamamoto, M | 1 |
| Asano, M; Fukuzaki, H; Imai, K; Kumakura, M; Mashimo, T; Yamanaka, H; Yoshida, M; Yuasa, H | 1 |
| Heya, T; Ogawa, Y; Okada, H; Shimamoto, T | 1 |
| Ogawa, Y; Okada, H; Shimamoto, T; Yamamoto, M; Yashiki, T | 1 |
| Ogawa, Y; Okada, H; Shimamoto, T; Takada, S; Yamamoto, M | 1 |
| Ogawa, Y; Okada, H; Shimamoto, T; Yamamoto, M | 1 |
| Doken, Y; Ogawa, Y; Okada, H; Toguchi, H | 1 |
| Ogawa, Y; Takada, S | 1 |
| Dunn, RL; Moyer, KL; Ravivarapu, HB | 1 |
| DeLuca, PP; Lee, H; Ravivarapu, HB | 1 |
| Burton, K; DeLuca, PP; Ravivarapu, HB | 1 |
| Choi, SH; Park, TG | 1 |
| Burton, KW; DeLuca, PP; Shameem, M; Thanoo, BC | 1 |
| Carron, GJ; Chu, FM; Dineen, MK; Perez-Marreno, R; Sartor, O; Tyler, RC | 1 |
| DeLuca, PP; Kim, WB; Lee, KC; Lee, SD; Na, DH; Son, MW; Youn, YS | 1 |
| DeLuca, PP; Lee, KC; Na, DH | 1 |
| Domb, AJ; Slager, J | 1 |
| Bodmeier, R; Luan, X | 1 |
| Bodmeier, R; Luan, X; Siepmann, J; Skupin, M | 1 |
| Baena, V; Ferran, M; Giménez-Arnau, A; Lloreta, J; Pujol, RM; Toll, A; Yébenes, M | 1 |
| Singh, J; Singh, S | 1 |
| Bodmeier, R; Dong, WY; Körber, M; López Esguerra, V | 1 |
| Arnault, JP; Barbaud, A; Cuny, JF; Petitpain, N; Plenat, F; Schmutz, JL; Vieu, C | 1 |
| Blasi, P; Deluca, PP; Schoubben, A | 1 |
| Aguilar-Rosas, I; Alcalá-Alcalá, S; Quintanar-Guerrero, D; Urbán-Morlán, Z | 1 |
| Cheng, JX; Desai, KG; Mazzara, JM; Olsen, KF; Schwendeman, SP; Sophocleous, AM; Tong, L | 1 |
| D'Souza, S; DeLuca, PP; Dorati, R; Faraj, JA | 1 |
| Behnamghader, A; Mobedi, H; Rahimi, M | 1 |
| Ackermann, R; Choi, S; Doty, AC; Feng, MR; Hirota, K; Olsen, KF; Qu, W; Schwendeman, AS; Schwendeman, SP; Wang, Y; Zhou, J | 1 |
| Ackermann, R; Choi, S; Doty, AC; Feng, MR; Hirota, K; Olsen, KF; Qu, W; Sakamoto, N; Schwendeman, A; Schwendeman, SP; Wang, Y | 1 |
| Guo, N; Li, X; Sun, Y; Yang, H; Zhang, Q | 1 |
| Jensen, H; Li, Z; Mu, H; Weng Larsen, S; Østergaard, J | 1 |
| Dharamsi, A; Pandya, T | 1 |
| Bao, Q; Burgess, DJ; Wan, B; Wang, R | 1 |
2 review(s) available for lactic acid and leuprolide
| Article | Year |
|---|---|
[Once-a-month injectable microcapsules of leuprorelin acetate].
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Capsules; Delayed-Action Preparations; Drug Delivery Systems; Endometriosis; Glycolates; Humans; Injections; Lactates; Lactic Acid; Leuprolide; Male; Molecular Sequence Data; Polymers; Prostatic Neoplasms | 1991 |
[Design and development of controlled release of drugs from injectable microcapsules].
Topics: Animals; Antineoplastic Agents, Hormonal; Biocompatible Materials; Capsules; Delayed-Action Preparations; Dogs; Drug Delivery Systems; Drug Design; Humans; Injections; Lactic Acid; Leuprolide; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Thyrotropin-Releasing Hormone | 1998 |
1 trial(s) available for lactic acid and leuprolide
| Article | Year |
|---|---|
An eight-month clinical study of LA-2575 30.0 mg: a new 4-month, subcutaneous delivery system for leuprolide acetate in the treatment of prostate cancer.
Topics: Aged; Delayed-Action Preparations; Drug Delivery Systems; Humans; Injections, Subcutaneous; Lactic Acid; Leuprolide; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Prostatic Neoplasms; Pyrrolidinones; Testosterone | 2003 |
31 other study(ies) available for lactic acid and leuprolide
| Article | Year |
|---|---|
In vivo characteristics of low molecular weight copoly (D,L-lactic acid) formulations with controlled release of LH-RH agonist.
Topics: Animals; Biodegradation, Environmental; Chemical Phenomena; Chemistry, Physical; Crystallization; Delayed-Action Preparations; Gonadotropin-Releasing Hormone; Lactates; Lactic Acid; Leuprolide; Male; Molecular Weight; Polyesters; Polymers; Prostheses and Implants; Rats; Rats, Inbred Strains; Spectrophotometry; Time Factors | 1989 |
One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats.
Topics: Animals; Capsules; Delayed-Action Preparations; Endometriosis; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Injections; Lactic Acid; Leuprolide; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Inbred Strains | 1988 |
A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid.
Topics: Capsules; Chemistry, Pharmaceutical; Glycolates; Gonadotropin-Releasing Hormone; Lactates; Lactic Acid; Leuprolide; Polyesters; Polymers | 1988 |
Controlled-release of leuprolide acetate from polylactic acid or copoly(lactic/glycolic) acid microcapsules: influence of molecular weight and copolymer ratio of polymer.
Topics: Antineoplastic Agents; Capsules; Delayed-Action Preparations; Glycolates; Gonadotropin-Releasing Hormone; Lactates; Lactic Acid; Leuprolide; Molecular Weight; Polyesters; Polymers | 1988 |
In vivo release profiles of leuprolide acetate from microcapsules prepared with polylactic acids or copoly(lactic/glycolic) acids and in vivo degradation of these polymers.
Topics: Animals; Antineoplastic Agents; Capsules; Excipients; Gonadotropin-Releasing Hormone; Lactates; Lactic Acid; Leuprolide; Male; Molecular Weight; Polyesters; Polymers; Rats | 1988 |
Preparation of three-month depot injectable microspheres of leuprorelin acetate using biodegradable polymers.
Topics: Acids; Animals; Biocompatible Materials; Chemical Phenomena; Chemistry, Physical; Delayed-Action Preparations; Injections, Subcutaneous; Lactates; Lactic Acid; Leuprolide; Male; Microspheres; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley | 1994 |
Parameters affecting the efficacy of a sustained release polymeric implant of leuprolide.
Topics: Animals; Delayed-Action Preparations; Dogs; Drug Implants; Humans; Lactic Acid; Leuprolide; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Suspensions; Testosterone | 2000 |
Enhancing initial release of peptide from poly(d,l-lactide-co-glycolide) (PLGA) microspheres by addition of a porosigen and increasing drug load.
Topics: Animals; Antineoplastic Agents, Hormonal; Calcium Chloride; Drug Carriers; Lactic Acid; Leuprolide; Male; Microscopy, Electron, Scanning; Microspheres; Particle Size; Peptides; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porosity; Rats; Rats, Sprague-Dawley; Surface Properties | 2000 |
Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres.
Topics: Animals; Chemistry, Pharmaceutical; Lactic Acid; Leuprolide; Male; Microspheres; Molecular Weight; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Testosterone; Viscosity | 2000 |
Hydrophobic ion pair formation between leuprolide and sodium oleate for sustained release from biodegradable polymeric microspheres.
Topics: Delayed-Action Preparations; Lactic Acid; Leuprolide; Oleic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solubility | 2000 |
Extended release peptide delivery systems through the use of PLGA microsphere combinations.
Topics: Animals; Biocompatible Materials; Chromatography, High Pressure Liquid; Drug Carriers; Injections; Lactic Acid; Leuprolide; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Testosterone | 2000 |
Monitoring of peptide acylation inside degrading PLGA microspheres by capillary electrophoresis and MALDI-TOF mass spectrometry.
Topics: Acylation; Amino Acid Sequence; Animals; Calcitonin; Drug Carriers; Electrophoresis, Capillary; Glycolates; Humans; Lactic Acid; Leuprolide; Lysine; Microspheres; Molecular Sequence Data; Parathyroid Hormone; Peptide Hormones; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Salmon; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2003 |
Direct determination of the peptide content in microspheres by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Topics: Calcitonin; Lactic Acid; Leuprolide; Microspheres; Peptides; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Hetero-stereocomplexes of D-poly(lactic acid) and the LHRH analogue leuprolide. Application in controlled release.
Topics: Animals; Biopolymers; Delayed-Action Preparations; Gonadotropin-Releasing Hormone; Lactic Acid; Leuprolide; Male; Polyesters; Polymers; Rats; Rats, Wistar; Stereoisomerism | 2004 |
Influence of the poly(lactide-co-glycolide) type on the leuprolide release from in situ forming microparticle systems.
Topics: Antineoplastic Agents, Hormonal; Diffusion; Drug Implants; Lactic Acid; Leuprolide; Molecular Weight; Nanostructures; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solubility; Solvents; Viscosity | 2006 |
Key parameters affecting the initial release (burst) and encapsulation efficiency of peptide-containing poly(lactide-co-glycolide) microparticles.
Topics: Delayed-Action Preparations; Ethanol; Lactic Acid; Leuprolide; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sodium Chloride; Volatilization | 2006 |
Depot leuprorelin acetate-induced granulomas manifested as persistent suppurative nodules.
Topics: Aged; Delayed-Action Preparations; Granuloma; Humans; Injections, Subcutaneous; Lactic Acid; Leuprolide; Male; Polyesters; Polymers; Prostatic Neoplasms; Suppuration | 2006 |
Phase-sensitive polymer-based controlled delivery systems of leuprolide acetate: in vitro release, biocompatibility, and in vivo absorption in rabbits.
Topics: Animals; Antineoplastic Agents, Hormonal; Biocompatible Materials; Chemistry, Pharmaceutical; Data Interpretation, Statistical; Drug Compounding; Drug Delivery Systems; Intestinal Absorption; Lactic Acid; Leuprolide; Materials Testing; Polyesters; Polymers; Rabbits; Solubility; Testosterone; Tetrazolium Salts; Thiazoles | 2007 |
Stability of poly(D,L-lactide-co-glycolide) and leuprolide acetate in in-situ forming drug delivery systems.
Topics: Chromatography, Gel; Chromatography, High Pressure Liquid; Differential Thermal Analysis; Drug Compounding; Drug Delivery Systems; Drug Stability; Drug Storage; Freeze Drying; Humidity; Lactic Acid; Leuprolide; Nanoparticles; Oils; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solvents; Temperature; Water | 2006 |
[Granuloma at the injection site of leuprorelin acetate: foreign body reaction to polylactic acid].
Topics: Aged; Buttocks; Granuloma, Foreign-Body; Humans; Injections, Intramuscular; Lactic Acid; Leuprolide; Male; Polyesters; Polymers | 2007 |
Effect of agitation regimen on the in vitro release of leuprolide from poly(lactic-co-glycolic) acid microparticles.
Topics: Antineoplastic Agents; Drug Carriers; Lactic Acid; Leuprolide; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2012 |
A biodegradable polymeric system for peptide-protein delivery assembled with porous microspheres and nanoparticles, using an adsorption/infiltration process.
Topics: Adsorption; Chemistry, Pharmaceutical; Delayed-Action Preparations; Lactic Acid; Leuprolide; Microspheres; Models, Chemical; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity | 2013 |
The nature of peptide interactions with acid end-group PLGAs and facile aqueous-based microencapsulation of therapeutic peptides.
Topics: Adsorption; Animals; Delayed-Action Preparations; Drug Compounding; Lactic Acid; Leuprolide; Male; Octreotide; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley | 2013 |
A short term quality control tool for biodegradable microspheres.
Topics: Chemistry, Pharmaceutical; Drug Carriers; Kinetics; Lactic Acid; Leuprolide; Microspheres; Models, Chemical; Models, Statistical; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Quality Control; Reproducibility of Results; Solubility; Surface Properties; Technology, Pharmaceutical; Water | 2014 |
In situ-forming PLGA implants loaded with leuprolide acetate/β-cyclodextrin complexes: mathematical modelling and degradation.
Topics: beta-Cyclodextrins; Drug Implants; Lactic Acid; Leuprolide; Models, Chemical; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2016 |
Characterizing release mechanisms of leuprolide acetate-loaded PLGA microspheres for IVIVC development I: In vitro evaluation.
Topics: Boron Compounds; Drug Liberation; Lactic Acid; Leuprolide; Microspheres; Molecular Weight; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Transition Temperature | 2016 |
Validation of a cage implant system for assessing in vivo performance of long-acting release microspheres.
Topics: Animals; Biocompatible Materials; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Gonadotropin-Releasing Hormone; Humans; Injections, Subcutaneous; Kinetics; Lactic Acid; Leuprolide; Male; Microspheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Silicon; Solubility; Stainless Steel; Triamcinolone Acetonide; Water | 2016 |
Absolute quantification of poly(dl-lactide-co-glycolide) in microspheres using quantitative
Topics: Chromatography, High Pressure Liquid; Lactic Acid; Leuprolide; Magnetic Resonance Spectroscopy; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers | 2017 |
An in vitro gel-based system for characterizing and predicting the long-term performance of PLGA in situ forming implants.
Topics: Drug Implants; Lactic Acid; Leuprolide; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Triacetin | 2021 |
Preparation and Optimization of Leuprolide Acetate Nanoparticles Using Response Surface Methodology:
Topics: Animals; Drug Carriers; Lactic Acid; Leuprolide; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sheep | 2022 |
Polymer source affects in vitro-in vivo correlation of leuprolide acetate PLGA microspheres.
Topics: Drug Liberation; Lactic Acid; Leuprolide; Microspheres; Particle Size; Peptides; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2022 |