lactic acid and fluorouracil

lactic acid has been researched along with fluorouracil in 97 studies

Research

Studies (97)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.03)	18.7374
1990's	14 (14.43)	18.2507
2000's	33 (34.02)	29.6817
2010's	47 (48.45)	24.3611
2020's	2 (2.06)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Conway, M; Khoobehi, B; Peyman, GA; Soike, K	1
Kanda, T; Kubo, T; Maruyama, Y; Sakamoto, M	1
Bouffard, P; Caty, A; Fournier, C; Hecquet, B; Krikorian, A; Lefebvre, JL; Merle, S; Vanseymortier, L; Vert, M; Vilain, MO	1
Honda, Y; Hyon, SH; Ikada, Y; Moritera, T; Ogura, Y; Wada, R	1
Yamashita, R	1
Benoit, JP; Boisdron-Celle, M; Menei, P	1
Cheng, YL; Chiu, WJ; Gould, L; Heathcote, JG; Liu, GS; Menon, IA; Rootman, DS; Sheardown, H; Trope, GE	1
Cockerell, CJ; Cox, SE; Cruz, PD; Freeman, RG; Lawrence, N	1
Cheng, YL; Gould, L; Heathcote, JG; Liu, GS; Menon, IA; Rootman, D; Sheardown, H; Trope, G	1
Hirst, LW; Roberts, MS; Tucker, IG; Wang, G	1
Cockerell, CJ; Cox, SE; Cruz, C; Freemen, RG; Lawrence, N; Witheiler, DD	1
Arellano, M; Malet-Martino, M; Martino, R; Spector, T	1
Aboagye, EO; Bhujwalla, ZM; Glickson, JD; Shungu, DC	1
Ciftci, K; Ercan, TM; Guven, O; Hincal, AA; Kas, HS; Ruacan, S; Sungur, A	1
Hagiwara, A; Hyon, S; Ikada, Y; Muranishi, S; Sakakura, C; Shirasu, M; Takahashi, T; Togawa, T; Yamasaki, J	1
Chang, CJ; Chiang, CH; Chou, PI; Lu, DW; Yeh, MK	1
Chiang, CH; Lu, DW; Tung, SM; Yeh, MK	1
Akhtar, S; Beale, G; Hughes, M; Hussain, M	1
Benoit, JP; Deverre, JR; Hindré, F; Lemaire, L; Roullin, VG; Venier-Julienne, MC; Vienet, R	1
Gao, J; Nasongkla, N; Qian, F	1
Benoit, J; Bruna, E; Faisant, N; Haffner, J; Laffineur, V; Oury, P; Siepmann, J	1
Hwang, YH; Park, SP; Suh, CK	1
Jonnalagadda, S; Robinson, DH	1
Ciftci, K; Gupte, A	1
Chae, GS; Cho, SH; Khang, G; Kim, MS; Lee, HB; Lee, JS	1
Aksungur, P; Iskit, AB; Senel, S; Squier, CA; Sungur, A; Unal, S	1
Akhtar, S; Beck, G; Benboubetra, M; Benter, IF; Fox, S; Khan, A; Ng, KW; Sayyed, PZ	1
Hayasaka, K; Kato, M; Shiihara, T	1
Dai, H; Elmquist, WF; Hitzman, CJ; Wiedmann, TS	1
Chang, J; Chen, QK; Huang, KH; Liu, JH; Liu, XY; Zhu, ZH	1
Bozkir, A; Saka, OM	1
Hai, BL; Jeong, YK; Khang, G; Kim, JM; Kim, YS; Seo, KS	1
Akiki, J; Benoit, JP; Faisant, N; Siepmann, F; Siepmann, J	1
Copoví, A; Díez-Sales, O; Herráez-Domínguez, JV; Herráez-Domínguez, M	1
Domb, AJ; Ezra, A; Slivniak, R	1
Gao, H; Gu, Y; Ping, Q	1
Blanco, MD; Muñíz, E; Olmo, R; Sastre, RL; Teijón, C; Teijón, JM	1
Huang, KH; Li, XX; Liu, JH; Lu, XP; Zhou, SY; Zhu, ZH	1
Chen, QK; Chen, RF; Huang, KH; Liu, JH; Min, J; Wang, LY; Zhu, ZH	1
Kim, JS; Son, HJ	1
Chen, G; Li, X; Ping, Q; Wei, P; Xu, Y	1
Ahn, SH; Chi, SC; Chu, WS; Ha, WS; Lee, JH; Park, CW	1
Cui, LJ; Huang, J; Li, XH; Sun, NX; Yang, JG	1
Deng, L; Dong, A; Liu, Y; Xing, J; Zhai, Y; Zhang, Q	1
Guo, H; Huang, KH; Lan, YQ; Song, X; Xiao, JH; Zhang, C; Zhuo, YH	1
Bagatin, E; Hassun, KM; Michalany, NS; Pereira, T; Talarico, S; Teixeira, SP	1
Miyazaki, N; Tabata, Y	1
Xu, W; Yang, Y	1
Ahn, SH; Chi, SC; Danh, SD; Park, CW; Park, ES; Park, SH; Rhee, YS	1
Artemov, D; Jacobs, I; Kato, Y; Onuki, Y	1
Agarwal, A; Agrawal, GP; Agrawal, H; Jain, S; Mishra, AK; Mishra, P; Rai, G; Yadav, AK	1
He, G; He, ZY; Hou, SX; Li, JM; Li, SZ; Luo, X; Luo, YF; Song, XR; Wei, YQ; Yang, L; Yu, S; Zheng, Y	1
Berenberg, JL; Christian, D; Delaune, R; Loprinzi, CL; Menon, SP; Pajon, ER; Qin, R; Rowland, KM; Satele, DV; Thomas, S; Wolf, SL	1
Hasbak, P; Jensen, SA; Mortensen, J; Sørensen, JB	1
Agarwal, A; Agrawal, GP; Agrawal, H; Bid, H; Jain, S; Mishra, AK; Rai, G; Yadav, AK	1
Dhanawat, M; Kumar, R; Nagarwal, RC; Pandit, JK	1
Faroun, M; Husseini, GA; Karmi, A; Sowwan, M	1
Jagadeeshan, S; Kumar, GS; Nair K, L; Nair, SA	1
Asmatulu, R; Chen, YY; Chu, HY; Ho, JC; Misak, HE; Song, Z; Wamocha, HL; Yang, SY	1
Chen, T; Gao, Y; Lu, W; Ren, X; Zheng, N	1
Li, Y; Lin, Y; Ooi, CP	1
Chen, D; Ding, M; Li, J; Pu, Y; Wang, S; Zhu, M	1
Ham, IH; Han, SU; Hur, H; Kim, YB; Lee, G; Shim, W; Xuan, Y; Yun, J	1
Lu, W; Zheng, N; Zhou, M	1
Kong, L; Li, P; Wang, Y	1
Arica-Yegin, B; Caliş, S; Goracinova, K; Ocal, H; Vural, I	1
Chen, Y; Sun, W; Yuan, W	1
Chen, Y; Hu, J; Liu, W; Wei, J	1
Du, C; Lu, W; Wang, S; Zheng, N; Zhou, M	1
Fu, T; Gu, J; Guo, Y; Jin, H; Lai, Y; Wang, L; Wang, X; Wang, Y; Yao, Q; Ye, X	1
Agostino, G; Cutrignelli, A; Denora, N; Franco, M; Laquintana, V; Lasorsa, FM; Lopalco, A; Lopedota, A	1
Cheng, Z; Dai, Z; Jin, Y; Liang, X; Ma, X; Tian, J; Yang, X	1
Chen, L; Gao, W; Kong, LX; Li, P; Wang, Y; Zeng, F	1
Balasubramanian, S; Girija, AR; Iwai, S; Kizhikkilot, V; Maekawa, T; Nagaoka, Y; Nair, SD; Suzuki, M; Yoshida, Y	1
Dangi, R; Gulbake, A; Hurkat, P; Jain, A; Jain, SK; Shilpi, S	1
Bao, R; Ding, Q; Gu, J; Li, M; Liu, Y; Shu, Y; Weng, H; Wu, W; Wu, X; Yang, J; Zhang, L	1
Ghaznavi, H; Khoee, S; Khoei, S; Shakeri-Zadeh, A; Sharifi, AM; Shiran, MB	1
Çakmak, AS; Gümüşderelioğlu, M; Kutlu, C	1
Hajikarimi, Z; Khoee, S; Khoei, S; Mahdavi, SR	1
Ashwanikumar, N; Kumar, GSV; Kumar, NA; Nair, SA	1
Asha Nair, S; Ashwanikumar, N; Kumar, NA; Vinod Kumar, GS	1
Chen, F; Chen, Z; Huang, Y; Li, J; Peng, J; Wang, X; Zhong, C; Zhuang, M	1
Cortés, ME; de Castro Rodrigues, G; Denadai, ÂM; Gontijo, SM; Guimarães, PP; Lula, IS; Oliveira, SR; Sinisterra, RD	1
Amorim, R; Baltazar, F; Miranda-Gonçalves, V; Moyer, MP; Pereira, H; Pinheiro, C; Preto, A	1
Chung, FF; Hii, LW; Ho, GF; Leong, CO; Malik, RA; Ng, CH; See, MH; Soo, JS; Taib, NA; Tan, BS; Tan, SH; Teh, YC; Teo, SH; Yip, CH	1
Ahmed, SH; Elmalahy, MH; Masloub, SM; Mohamed, WS; Sabry, D	1
Azadbakht, M; Jahani, M; Mansouri, K; Norooznezhad, F	1
Iyer, AK; Jain, S; Kashaw, SK; Sahu, P; Sau, S	1
Arias, JL; Cabeza, L; Clares, B; Mallandrich, M; Melguizo, C; Prados, J; Pretel, E; Suñer, J	1
Gao, Z; Li, Z; Wang, P; Yan, J	1
Geary, SM; Leelakanok, N; Salem, AK	1
Geary, S; Leelakanok, N; Salem, A	1
Kamiki, Y; Makino, K; Takeuchi, I	1
Fu, X; Mao, L; Qiu, YD; Tang, N; Xie, WQ	1
Bae, J; Hee Lee, E; Kim, H; Kim, J; Kim, MS; Kwak, D; Lee, J; Phyu Hlaing, S; Ryong Moon, H; Saparbayeva, A; Yoo, JW; Yoon, IS	1

Reviews

1 review(s) available for lactic acid and fluorouracil

Article	Year
Fabrication and Use of Poly(d,l-lactide-co-glycolide)-Based Formulations Designed for Modified Release of 5-Fluorouracil. Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Fluorouracil; Humans; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2018

Trials

5 trial(s) available for lactic acid and fluorouracil

Article	Year
Experimental studies and preliminary clinical trial of vinorelbine-loaded polymeric bioresorbable implants for the local treatment of solid tumors. Cancer research, 1991, Oct-01, Volume: 51, Issue:19 Topics: Adult; Animals; Antineoplastic Agents; Delayed-Action Preparations; Dogs; Dose-Response Relationship, Drug; Drug Implants; Fluorouracil; Head and Neck Neoplasms; Humans; Injections, Intravenous; Injections, Subcutaneous; Lactic Acid; Leukemia P388; Male; Mice; Middle Aged; Necrosis; Neoplasms; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Inbred Strains; Skin; Vinblastine; Vinorelbine	1991
A comparison of the efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses. Archives of dermatology, 1995, Volume: 131, Issue:2 Topics: Drug Combinations; Ethanol; Facial Dermatoses; Fluorouracil; Follow-Up Studies; Humans; Keratosis; Lactates; Lactic Acid; Male; Resorcinols; Salicylates; Sunlight; Trichloroacetic Acid	1995
Chitosan delivery systems for the treatment of oral mucositis: in vitro and in vivo studies. Journal of controlled release : official journal of the Controlled Release Society, 2004, Aug-11, Volume: 98, Issue:2 Topics: Adult; Animals; Antifungal Agents; Biological Availability; Body Weight; Chitosan; Cricetinae; Cross-Over Studies; Drug Delivery Systems; Drug Therapy, Combination; Fluorouracil; Gels; Histocytochemistry; Humans; Lactic Acid; Male; Mesocricetus; Mouth Mucosa; Nystatin; Polyphosphates; Saliva; Stomatitis; Survival Rate; Treatment Outcome; Water	2004
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35 Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind Method; Drug Combinations; Female; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Keratolytic Agents; Lactic Acid; Male; Middle Aged; Neoplasms; Syndrome; Urea	2010
Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-20, Volume: 28, Issue:36 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Colorectal Neoplasms; Female; Fluorouracil; Humans; Lactic Acid; Leucovorin; Male; Middle Aged; Myocardial Ischemia; Natriuretic Peptide, Brain; Organoplatinum Compounds; Prospective Studies; Risk Factors; Ventricular Dysfunction, Left	2010

Other Studies

91 other study(ies) available for lactic acid and fluorouracil

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates. International ophthalmology, 1992, Volume: 16, Issue:2 Topics: Animals; Biocompatible Materials; Chlorocebus aethiops; Cytarabine; Drug Carriers; Fluorouracil; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Vitreous Body	1992
[Studies on a slow releasing anticancer agent for prevention of peritoneal recurrence of advanced gastrointestinal carcinomas (clinical study)]. Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:2 Topics: Delayed-Action Preparations; Duodenal Neoplasms; Fluorouracil; Humans; Infusions, Parenteral; Lactates; Lactic Acid; Peritoneal Neoplasms; Polyesters; Polymers; Rectal Neoplasms; Stomach Neoplasms	1992
[Intravitreal drug delivery by microspheres of biodegradable polymers]. Nippon Ganka Gakkai zasshi, 1990, Volume: 94, Issue:5 Topics: Animals; Biodegradation, Environmental; Delayed-Action Preparations; Drug Carriers; Fluorouracil; Lactates; Lactic Acid; Microspheres; Polyesters; Polymers; Rabbits; Vitreous Body	1990
[Experimental study of an anticancer drug delivery system using polylactic acid]. Nihon Geka Gakkai zasshi, 1987, Volume: 88, Issue:4 Topics: Animals; Antineoplastic Agents; Delayed-Action Preparations; Fluorouracil; Infusion Pumps; Lactates; Lactic Acid; Liver Neoplasms, Experimental; Male; Needles; Polyesters; Polymers; Rats; Rats, Inbred Strains	1987
Preparation and characterization of 5-fluorouracil-loaded microparticles as biodegradable anticancer drug carriers. The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:2 Topics: Biocompatible Materials; Biodegradation, Environmental; Brain Neoplasms; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Fluorouracil; In Vitro Techniques; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Molecular Weight; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Polyvinyl Alcohol; Reproducibility of Results	1995
Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1994, Volume: 29, Issue:6 Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Conjunctiva; Drug Delivery Systems; Filtering Surgery; Fluorouracil; Glaucoma; Glycolates; Lactates; Lactic Acid; Polymers; Rabbits; Random Allocation	1994
Fifty:fifty poly (DL glycolic acid-lactic acid) copolymer as a drug delivery system for 5-fluorouracil: a histopathological evaluation. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1994, Volume: 29, Issue:4 Topics: Animals; Biocompatible Materials; Conjunctiva; Drug Delivery Systems; Fibrosis; Fluorouracil; Glycolates; Granuloma, Foreign-Body; Guinea Pigs; Lactates; Lactic Acid; Polymers; Rabbits; Sclera	1994
In vitro and in vivo evaluation in rabbits of a controlled release 5-fluorouracil subconjunctival implant based on poly(D,L-lactide-co-glycolide). Pharmaceutical research, 1996, Volume: 13, Issue:7 Topics: Animals; Biocompatible Materials; Conjunctiva; Delayed-Action Preparations; Drug Implants; Fluorouracil; Glaucoma; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Prostheses and Implants; Rabbits; Sclera; Tissue Distribution	1996
Long-term efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1997, Volume: 23, Issue:3 Topics: Administration, Topical; Chemexfoliation; Drug Combinations; Ethanol; Facial Dermatoses; Fluorouracil; Follow-Up Studies; Humans; Keratosis; Lactic Acid; Male; Resorcinols; Salicylates; Sunlight; Trichloroacetic Acid	1997
5-Ethynyluracil (GW776): effects on the formation of the toxic catabolites of 5-fluorouracil, fluoroacetate and fluorohydroxypropionic acid in the isolated perfused rat liver model. British journal of cancer, 1997, Volume: 76, Issue:9 Topics: Animals; Bile; Enzyme Inhibitors; Fluoroacetates; Fluorouracil; In Vitro Techniques; Lactic Acid; Liver; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Uracil	1997
Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors. Cancer research, 1998, Mar-01, Volume: 58, Issue:5 Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Fibrosarcoma; Fluorouracil; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Radiography; Treatment Outcome	1998
Solid tumor chemotherapy and in vivo distribution of fluorouracil following administration in poly(L-lactic acid) microspheres. Pharmaceutical development and technology, 1997, Volume: 2, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Biodegradation, Environmental; Chemistry, Pharmaceutical; Drug Delivery Systems; Female; Fluorouracil; Humans; Lactic Acid; Liver Neoplasms, Experimental; Microspheres; Molecular Weight; Particle Size; Polyesters; Polymers; Rats; Rats, Wistar; Technetium; Tissue Distribution; Viscosity	1997
Therapeutic effects of 5-fluorouracil microspheres on peritoneal carcinomatosis induced by Colon 26 or B-16 melanoma in mice. Anti-cancer drugs, 1998, Volume: 9, Issue:3 Topics: Animals; Biocompatible Materials; Colonic Neoplasms; Fluorouracil; Injections, Intraperitoneal; Lactic Acid; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Microspheres; Peritoneal Neoplasms; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solutions	1998
Wound modulation after trabeculectomy by different formulations of antimetabolites in rabbits. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:6 Topics: Animals; Antimetabolites; Biocompatible Materials; Conjunctiva; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Therapy, Combination; Emulsions; Female; Fluorouracil; Intraocular Pressure; Lactic Acid; Male; Microspheres; Mitomycin; Pharmaceutical Preparations; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Prospective Studies; Rabbits; Random Allocation; Trabeculectomy; Wound Healing	2000
In vitro and in vivo evaluation of an ocular delivery system of 5-fluorouracil microspheres. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2001, Volume: 17, Issue:6 Topics: Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Drug Carriers; Drug Implants; Female; Filtering Surgery; Fluorouracil; In Vitro Techniques; Lactic Acid; Male; Microspheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rabbits; Sclera	2001
Co-delivery of an antisense oligonucleotide and 5-fluorouracil using sustained release poly (lactide-co-glycolide) microsphere formulations for potential combination therapy in cancer. International journal of pharmaceutics, 2002, Mar-02, Volume: 234, Issue:1-2 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Drug Interactions; Electrophoresis; Fluorouracil; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Oligonucleotides, Antisense; Particle Size; Phosphorus Radioisotopes; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers	2002
Anti-cancer drug diffusion within living rat brain tissue: an experimental study using [3H](6)-5-fluorouracil-loaded PLGA microspheres. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2002, Volume: 53, Issue:3 Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Brain; Brain Neoplasms; Contrast Media; Diffusion; Drug Carriers; Female; Ferrosoferric Oxide; Fluorouracil; Glioma; Injections; Iron; Lactic Acid; Microspheres; Neoplasm Transplantation; Oxides; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Tritium	2002
Membrane-encased polymer millirods for sustained release of 5-fluorouracil. Journal of biomedical materials research, 2002, Volume: 61, Issue:2 Topics: Antineoplastic Agents; Delayed-Action Preparations; Fluorouracil; Kinetics; Lactic Acid; Membranes, Artificial; Microscopy, Electron, Scanning; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sodium Chloride; Time Factors	2002
The effect of gamma-irradiation on drug release from bioerodible microparticles: a quantitative treatment. International journal of pharmaceutics, 2002, Aug-21, Volume: 242, Issue:1-2 Topics: Antimetabolites, Antineoplastic; Diffusion; Excipients; Fluorouracil; Gamma Rays; Kinetics; Lactic Acid; Microspheres; Pharmaceutical Preparations; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers	2002
Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS. Journal of Korean medical science, 2003, Volume: 18, Issue:4 Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Aspartic Acid; Axons; Biopsy; Brain; Brain Neoplasms; Choline; Colorectal Neoplasms; Diagnosis, Differential; Fluorouracil; Humans; Lactic Acid; Leukoencephalopathy, Progressive Multifocal; Levamisole; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Metastasis; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon	2003
A bioresorbable, polylactide reservoir for diffusional and osmotically controlled drug delivery. AAPS PharmSciTech, 2000, Oct-03, Volume: 1, Issue:4 Topics: Calorimetry, Differential Scanning; Delayed-Action Preparations; Diffusion; Drug Carriers; Drug Delivery Systems; Fluorouracil; Hot Temperature; Hydrophobic and Hydrophilic Interactions; Lactic Acid; Membranes, Artificial; Models, Chemical; Osmotic Pressure; Polyesters; Polyethylene Glycols; Polymers	2000
Formulation and characterization of Paclitaxel, 5-FU and Paclitaxel + 5-FU microspheres. International journal of pharmaceutics, 2004, May-19, Volume: 276, Issue:1-2 Topics: Antineoplastic Agents; Breast Neoplasms; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Combinations; Female; Fluorouracil; Humans; Lactic Acid; Microspheres; Paclitaxel; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Tumor Cells, Cultured	2004
Degradation behaviour in vitro for poly(D,L-lactide-co-glycolide) as drug carrier. Bio-medical materials and engineering, 2004, Volume: 14, Issue:2 Topics: Contraceptive Agents; Diffusion; Drug Carriers; Fluorouracil; Hydrogen-Ion Concentration; Lactic Acid; Materials Testing; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Water	2004
Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies. Journal of drug targeting, 2004, Volume: 12, Issue:6 Topics: Animals; Autoradiography; DNA, Catalytic; Drug Delivery Systems; Fluorouracil; Gene Silencing; In Vitro Techniques; Kidney; Lactic Acid; Liver; Mice; Mice, Inbred BALB C; Microspheres; Oligonucleotides, Antisense; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; RNA, Catalytic; RNA, Small Interfering; Spleen; Time Factors	2004
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology, 2005, Apr-26, Volume: 64, Issue:8 Topics: Adolescent; Brain Diseases, Metabolic; Corpus Callosum; Diagnosis, Differential; DNA, Mitochondrial; Female; Fluorouracil; Humans; Immunosuppressive Agents; Interleukin-6; Lactic Acid; Magnetic Resonance Imaging; Mitochondrial Diseases; Mitochondrial Proton-Translocating ATPases; Mutation	2005
Measurement of drug release from microcarriers by microdialysis. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: 1,2-Dipalmitoylphosphatidylcholine; Algorithms; Calibration; Chromatography, High Pressure Liquid; Drug Carriers; Drug Delivery Systems; Fluorouracil; Kinetics; Lactic Acid; Liposomes; Microdialysis; Microsomes; Particle Size; Pharmaceutical Preparations; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Reproducibility of Results	2005
[Preparation and release efficiency of polylactic acid nanoparticle]. Ai zheng = Aizheng = Chinese journal of cancer, 2005, Volume: 24, Issue:8 Topics: Antimetabolites, Antineoplastic; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Fluorouracil; Lactic Acid; Nanoparticles; Particle Size; Polyesters; Polymers	2005
Formulation and investigation of 5-FU nanoparticles with factorial design-based studies. Farmaco (Societa chimica italiana : 1989), 2005, Volume: 60, Issue:10 Topics: Anti-Infective Agents; Antimetabolites, Antineoplastic; Drug Delivery Systems; Drug Design; Fluorouracil; Glycolates; Kinetics; Lactic Acid; Models, Chemical; Nanostructures; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility	2005
Co-effect of aqueous solubility of drugs and glycolide monomer on in vitro release rates from poly(D,L-lactide-co-glycolide) discs and polymer degradation. Journal of biomaterials science. Polymer edition, 2005, Volume: 16, Issue:8 Topics: Dexamethasone; Drug Delivery Systems; Fluorouracil; Glycolates; Hydrogen-Ion Concentration; Lactic Acid; Magnetic Resonance Spectroscopy; Microscopy, Electron, Scanning; Molecular Structure; Molecular Weight; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solubility; Time Factors; Water	2005
Effects of the type of release medium on drug release from PLGA-based microparticles: experiment and theory. International journal of pharmaceutics, 2006, May-18, Volume: 314, Issue:2 Topics: Antimetabolites, Antineoplastic; Buffers; Delayed-Action Preparations; Diffusion; Drug Carriers; Fluorouracil; Hydrogen-Ion Concentration; Kinetics; Lactic Acid; Microspheres; Models, Chemical; Osmolar Concentration; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solubility; Technology, Pharmaceutical; Temperature	2006
Enhancing effect of alpha-hydroxyacids on "in vitro" permeation across the human skin of compounds with different lipophilicity. International journal of pharmaceutics, 2006, May-11, Volume: 314, Issue:1 Topics: Adult; Alcohols; Butanols; Epidermis; Female; Fluorouracil; Glycolates; Humans; Hydroxy Acids; In Vitro Techniques; Lactic Acid; Pentanols; Permeability; Phenylethyl Alcohol; Skin; Skin Absorption; Sodium Dodecyl Sulfate	2006
Hydrolytic degradation and drug release of ricinoleic acid-lactic acid copolyesters. Pharmaceutical research, 2006, Volume: 23, Issue:6 Topics: Antimetabolites, Antineoplastic; Drug Carriers; Fluorouracil; Glucocorticoids; Hydrolysis; Kinetics; Lactic Acid; Molecular Weight; Polyesters; Ricinoleic Acids; Solubility; Transition Temperature; Triamcinolone	2006
The implantable 5-fluorouracil-loaded poly(l-lactic acid) fibers prepared by wet-spinning from suspension. Journal of controlled release : official journal of the Controlled Release Society, 2007, Apr-23, Volume: 118, Issue:3 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Implants; Fluorouracil; Humans; Lactic Acid; Microspheres; Polyesters; Polymers; Technology, Pharmaceutical	2007
5-Fluorouracil plasma levels and biodegradation of subcutaneously injected drug-loaded microspheres prepared by spray-drying poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) polymers. International journal of pharmaceutics, 2007, Jun-29, Volume: 338, Issue:1-2 Topics: Animals; Drug Delivery Systems; Fluorouracil; Injections, Subcutaneous; Lactic Acid; Macrophages; Male; Microspheres; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Wistar; Technology, Pharmaceutical	2007
[Biodistribution of (99m)Tc-labeled anti-VEGF mAb 5-FU loaded polylactic acid nanoparticles in human gastric carcinoma xenografts]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2007, Volume: 27, Issue:8 Topics: Animals; Antibodies, Monoclonal; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Fluorouracil; Humans; Lactic Acid; Male; Mice; Mice, SCID; Nanoparticles; Polyesters; Polymers; Radioimmunotherapy; Stomach Neoplasms; Technetium; Vascular Endothelial Growth Factor A	2007
[Study of the anti-tumor effect of anti-vascular endothelial growth factor McAb 5-fluorouracil loaded polylactic acid nanoparticles]. Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2007, Volume: 10, Issue:5 Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Cell Line, Tumor; Drug Carriers; Fluorouracil; Humans; Lactic Acid; Mice; Mice, Nude; Nanoparticles; Neovascularization, Pathologic; Polyesters; Polymers; Stomach Neoplasms; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2007
Therapeutic efficacy of DNA-loaded PLGA microspheres in tumor-bearing mice. Archives of pharmacal research, 2007, Volume: 30, Issue:8 Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Combined Modality Therapy; DNA; Drug Carriers; Fluorouracil; Gene Transfer Techniques; Genetic Therapy; Interleukin-12; Lactic Acid; Mice; Mice, Inbred BALB C; Microspheres; Neoplasm Transplantation; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Treatment Outcome	2007
PLGA nanoparticles for the oral delivery of 5-Fluorouracil using high pressure homogenization-emulsification as the preparation method and in vitro/in vivo studies. Drug development and industrial pharmacy, 2008, Volume: 34, Issue:1 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Biological Availability; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Carriers; Emulsions; Fluorouracil; Half-Life; Lactic Acid; Male; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Solubility; Technology, Pharmaceutical	2008
Preparation of micro-fabricated biodegradable polymeric structures using NCDS. Archives of pharmacal research, 2008, Volume: 31, Issue:1 Topics: Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Drug Carriers; Drug Delivery Systems; Durapatite; Elasticity; Fluorouracil; Hardness; Lactic Acid; Microscopy, Electron, Scanning; Nanotechnology; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction	2008
Subconjunctival sustained release 5-fluorouracil for glaucoma filtration surgery. Acta pharmacologica Sinica, 2008, Volume: 29, Issue:9 Topics: Animals; Antimetabolites; Aqueous Humor; Chromatography, High Pressure Liquid; Conjunctiva; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Female; Fluorouracil; Glaucoma Drainage Implants; Indicators and Reagents; Intraocular Pressure; Lactic Acid; Microspheres; Ophthalmologic Surgical Procedures; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prosthesis Implantation; Rabbits; Spectrophotometry, Ultraviolet; Survival Analysis	2008
A new injectable thermogelling material: methoxy poly(ethylene glycol)-poly(sebacic acid-D,L-lactic acid)-methoxy poly(ethylene glycol) triblock co-polymer. Journal of biomaterials science. Polymer edition, 2009, Volume: 20, Issue:7-8 Topics: Animals; Decanoic Acids; Dicarboxylic Acids; Drug Carriers; Fluorouracil; Gels; Injections; Lactic Acid; Phase Transition; Polyethylene Glycols; Rats; Temperature	2009
[The inhibitive effects of 5-fluorouracil-loaded polylactic acid nanoparticles on human Tenon's capsule fibroblast in vitro]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2009, Volume: 45, Issue:1 Topics: Cell Proliferation; Cells, Cultured; Eye; Fascia; Fibroblasts; Fluorouracil; Humans; Lactic Acid; Nanoparticles; Polyesters; Polymers	2009
5-Fluorouracil superficial peel for multiple actinic keratoses. International journal of dermatology, 2009, Volume: 48, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biopsy; Chemexfoliation; Drug Combinations; Drug Therapy, Combination; Ethanol; Female; Fluorouracil; Glycolates; Humans; Keratolytic Agents; Keratosis, Actinic; Lactic Acid; Male; Middle Aged; Resorcinols; Retrospective Studies; Salicylates; Treatment Outcome	2009
Anti-tumor activity of carmofur water-solubilized by lactic acid oligomer-grafted pullulan nanogels. Journal of nanoscience and nanotechnology, 2009, Volume: 9, Issue:8 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dimethyl Sulfoxide; Drug Screening Assays, Antitumor; Fluorouracil; Glucans; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Nanostructures; Solubility	2009
Relationship between drug release and some physical parameters of drug sorption onto PLA fibers. Journal of biomaterials science. Polymer edition, 2010, Volume: 21, Issue:4 Topics: Diclofenac; Diffusion; Fluorouracil; Lactic Acid; Metformin; Models, Chemical; Pharmaceutical Preparations; Polyesters; Polymers; Solvents; Temperature; Thermodynamics	2010
In vitro / in vivo evaluation of NCDS-micro-fabricated biodegradable implant. Archives of pharmacal research, 2010, Volume: 33, Issue:3 Topics: Absorbable Implants; Animals; Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Compounding; Durapatite; Fluorouracil; Foreign-Body Reaction; Inflammation; Kinetics; Lactic Acid; Male; Materials Testing; Nanocomposites; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Rats; Rats, Sprague-Dawley; Solubility; Technology, Pharmaceutical; Tissue Scaffolds	2010
Noninvasive visualization of in vivo release and intratumoral distribution of surrogate MR contrast agent using the dual MR contrast technique. Biomaterials, 2010, Volume: 31, Issue:27 Topics: Animals; Cell Line, Tumor; Contrast Media; Ferric Compounds; Fluorouracil; Humans; Lactic Acid; Magnetic Resonance Imaging; Mice; Mice, SCID; Microspheres; Nanoparticles; Nanospheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2010
Development and characterization of hyaluronic acid decorated PLGA nanoparticles for delivery of 5-fluorouracil. Drug delivery, 2010, Volume: 17, Issue:8 Topics: Animals; Biocompatible Materials; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Fluorouracil; Hyaluronic Acid; Lactic Acid; Magnetic Resonance Imaging; Mice; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Spectroscopy, Fourier Transform Infrared; Toxicity Tests; X-Ray Diffraction	2010
Development of PLGA nanoparticles simultaneously loaded with vincristine and verapamil for treatment of hepatocellular carcinoma. Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:12 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Interactions; Drug Resistance, Multiple; Drug Therapy, Combination; Fluorouracil; Humans; Lactic Acid; Liver Neoplasms; Nanoparticles; Pharmaceutical Preparations; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Tetrazolium Salts; Thiazoles; Verapamil; Vincristine	2010
Chondroitin sulphate decorated nanoparticulate carriers of 5-fluorouracil: development and in vitro characterization. Journal of biomedical nanotechnology, 2010, Volume: 6, Issue:4 Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Chondroitin Sulfates; Drug Carriers; Female; Fluorouracil; Humans; Lactic Acid; Molecular Structure; Nanoparticles; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; X-Ray Diffraction	2010
Modified PLA nano in situ gel: a potential ophthalmic drug delivery system. Colloids and surfaces. B, Biointerfaces, 2011, Aug-01, Volume: 86, Issue:1 Topics: Animals; Aqueous Humor; Drug Delivery Systems; Female; Fluorouracil; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Nanoparticles; Polyesters; Polymers; Rabbits; Spectroscopy, Fourier Transform Infrared	2011
Multifunctional nanovehicles for combined 5-fluorouracil and gold nanoparticles based on the nanoprecipitation method. Journal of nanoscience and nanotechnology, 2011, Volume: 11, Issue:6 Topics: Chemical Precipitation; Drug Delivery Systems; Fluorouracil; Gold; Lactic Acid; Metal Nanoparticles; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Nanotechnology; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity	2011
Biological evaluation of 5-fluorouracil nanoparticles for cancer chemotherapy and its dependence on the carrier, PLGA. International journal of nanomedicine, 2011, Volume: 6 Topics: Acridine Orange; Antineoplastic Agents; Apoptosis; Calorimetry, Differential Scanning; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Delayed-Action Preparations; Drug Carriers; Ethidium; Flow Cytometry; Fluorouracil; Humans; Lactic Acid; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2011
Cytotoxicity of release products from magnetic nanocomposites in targeted drug delivery. Journal of biomaterials applications, 2013, Volume: 27, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Line; Cell Proliferation; Drug Delivery Systems; Fluorouracil; Lactic Acid; Macrophages; Magnetite Nanoparticles; Materials Testing; Mice; Nanocomposites; Nanotechnology; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2013
Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice. Drug delivery, 2012, Volume: 19, Issue:1 Topics: Absorbable Implants; Animals; Drug Delivery Systems; Fluorouracil; Lactic Acid; Male; Mice; Mice, Inbred ICR; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Random Allocation; Sarcoma, Experimental; Xenograft Model Antitumor Assays	2012
5-Fluorouracil encapsulated HA/PLGA composite microspheres for cancer therapy. Journal of materials science. Materials in medicine, 2012, Volume: 23, Issue:10 Topics: Antimetabolites, Antineoplastic; Durapatite; Fluorouracil; Lactic Acid; Microscopy, Electron, Scanning; Neoplasms; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Viscosity	2012
Pharmacokinetic study and effectiveness evaluation of slow-release PLGA-5-fluorouracil microsphere. Cancer chemotherapy and pharmacology, 2013, Volume: 71, Issue:2 Topics: Animals; Delayed-Action Preparations; Female; Fluorouracil; HCT116 Cells; Humans; Immunohistochemistry; Lactic Acid; Mice; Mice, Inbred BALB C; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Vascular Endothelial Growth Factor A	2013
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target. International journal of oncology, 2013, Volume: 42, Issue:1 Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Antimetabolites, Antineoplastic; Blotting, Western; Carcinoma, Signet Ring Cell; Cell Survival; Dichloroacetic Acid; Female; Fluorouracil; Glucose; Glucose Transporter Type 1; Glycolysis; Hexokinase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoenzyme Techniques; Lactic Acid; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Stomach Neoplasms; Survival Rate; Tissue Array Analysis; Tumor Cells, Cultured	2013
In vivo distribution of 5-Fluorouracil after peritumoral implantation using a biodegradable micro-device in tumor-bearing mice. European journal of drug metabolism and pharmacokinetics, 2013, Volume: 38, Issue:3 Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Chromatography, High Pressure Liquid; Drug Delivery Systems; Fluorouracil; Injections, Intraperitoneal; Lactic Acid; Male; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Tissue Distribution	2013
Chitosan-modified PLGA nanoparticles with versatile surface for improved drug delivery. AAPS PharmSciTech, 2013, Volume: 14, Issue:2 Topics: Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparations; Drug Carriers; Fluorouracil; Hydrogen-Ion Concentration; Kinetics; Lactic Acid; Nanoparticles; Nanotechnology; Photoelectron Spectroscopy; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Spectroscopy, Fourier Transform Infrared; Surface Properties; Technology, Pharmaceutical	2013
5-Fluorouracil-loaded PLA/PLGA PEG-PPG-PEG polymeric nanoparticles: formulation, in vitro characterization and cell culture studies. Drug development and industrial pharmacy, 2014, Volume: 40, Issue:4 Topics: Antimetabolites, Antineoplastic; Caco-2 Cells; Cell Survival; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Fluorouracil; Humans; Lactic Acid; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Polyesters; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Propylene Glycols	2014
Hemostatic absorbable gelatin sponge loaded with 5-fluorouracil for treatment of tumors. International journal of nanomedicine, 2013, Volume: 8 Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Delayed-Action Preparations; Fluorouracil; Gelatin Sponge, Absorbable; Lactic Acid; Male; Mice; Mice, Inbred BALB C; Neoplasm Recurrence, Local; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Random Allocation; Rats; Rats, Sprague-Dawley; Survival Analysis; Xenograft Model Antitumor Assays	2013
Preparation and characterization of electrospun PLGA/gelatin nanofibers as a drug delivery system by emulsion electrospinning. Journal of biomaterials science. Polymer edition, 2013, Volume: 24, Issue:8 Topics: Animals; Biocompatible Materials; Cells, Cultured; Cephradine; Drug Delivery Systems; Emulsions; Fluorouracil; Gelatin; Hydrophobic and Hydrophilic Interactions; Lactic Acid; Mice; Nanofibers; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2013
5-Fluorouracil delivery from a novel three-dimensional micro-device: in vitro and in vivo evaluation. Archives of pharmacal research, 2013, Volume: 36, Issue:12 Topics: Animals; Antimetabolites, Antineoplastic; Drug Carriers; Drug Delivery Systems; Drug Evaluation, Preclinical; Fluorouracil; Lactic Acid; Male; Mice; Mice, Inbred ICR; Micro-Electrical-Mechanical Systems; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Xenograft Model Antitumor Assays	2013
Protective effect of curcumin on chemotherapy-induced intestinal dysfunction. International journal of clinical and experimental pathology, 2013, Volume: 6, Issue:11 Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Biomarkers; Caspase 3; Curcumin; Cytoprotection; D-Amino-Acid Oxidase; Endotoxins; Fluorouracil; Ileum; Intestinal Mucosa; Lactic Acid; Protective Agents; Rats; Rats, Wistar; Time Factors; Weight Loss	2013
Translocator protein ligand-PLGA conjugated nanoparticles for 5-fluorouracil delivery to glioma cancer cells. Molecular pharmaceutics, 2014, Mar-03, Volume: 11, Issue:3 Topics: Antimetabolites, Antineoplastic; Apoptosis; Calorimetry, Differential Scanning; Carrier Proteins; Cell Proliferation; Drug Carriers; Drug Delivery Systems; Fluorouracil; Glioma; Humans; Lactic Acid; Microscopy, Fluorescence; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Receptors, GABA-A; Tissue Distribution; Tumor Cells, Cultured	2014
SM5-1-conjugated PLA nanoparticles loaded with 5-fluorouracil for targeted hepatocellular carcinoma imaging and therapy. Biomaterials, 2014, Volume: 35, Issue:9 Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diagnostic Imaging; Drug Delivery Systems; Female; Fluorouracil; Humans; Image Processing, Computer-Assisted; Lactic Acid; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Polyesters; Polymers; Subcutaneous Tissue; Tumor Burden	2014
Targeted delivery of 5-fluorouracil to HT-29 cells using high efficient folic acid-conjugated nanoparticles. Drug delivery, 2015, Volume: 22, Issue:2 Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Biological Transport; Cell Survival; Colonic Neoplasms; Cross-Linking Reagents; Diamines; Drug Carriers; Drug Compounding; Drug Delivery Systems; Fluorouracil; Folic Acid; HT29 Cells; Humans; Inhibitory Concentration 50; Kinetics; Lactic Acid; Microscopy, Fluorescence; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Surface Properties	2015
Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia. International journal of nanomedicine, 2014, Volume: 9 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Combined Modality Therapy; Curcumin; Drug Carriers; Fluorouracil; Folic Acid; Humans; Hyperthermia, Induced; Lactic Acid; Magnetite Nanoparticles; MCF-7 Cells; Mice; Nanoconjugates; Nanomedicine; Nanotechnology; Neoplasms; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Transferrin	2014
Targeting liver cancer via ASGP receptor using 5-FU-loaded surface-modified PLGA nanoparticles. Journal of microencapsulation, 2014, Volume: 31, Issue:5 Topics: Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Drug Delivery Systems; Fluorouracil; Hep G2 Cells; Humans; Lactic Acid; Liver Neoplasms; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2014
[Anti-tumor effect of 5-FU-PLLA-CNTs on human gastric carcinoma cell lines in vitro]. Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2014, Volume: 17, Issue:4 Topics: Cell Line, Tumor; Cell Proliferation; Delayed-Action Preparations; Fluorouracil; Humans; Lactic Acid; Nanotubes, Carbon; Polyesters; Polymers; Stomach Neoplasms	2014
A new magnetic nanocapsule containing 5-fluorouracil: in vivo drug release, anti-tumor, and pro-apoptotic effects on CT26 cells allograft model. Journal of biomaterials applications, 2014, Volume: 29, Issue:4 Topics: Allografts; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Fluorouracil; Lactic Acid; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Materials Testing; Mice; Mice, Inbred BALB C; Nanocapsules; Nanotechnology; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits	2014
Double-effective chitosan scaffold-PLGA nanoparticle system for brain tumour therapy: in vitro study. Journal of microencapsulation, 2014, Volume: 31, Issue:7 Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Chitosan; Drug Carriers; Fluorouracil; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Lactic Acid; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2014
Evaluation of the cytotoxic effects of PLGA coated iron oxide nanoparticles as a carrier of 5- fluorouracil and mega-voltage X-ray radiation in DU145 prostate cancer cell line. IEEE transactions on nanobioscience, 2014, Volume: 13, Issue:4 Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Chemoradiotherapy; Coated Materials, Biocompatible; Dextrans; Fluorouracil; Humans; Lactic Acid; Magnetite Nanoparticles; Male; Nanocapsules; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prostatic Neoplasms; Treatment Outcome	2014
Dual drug delivery of 5-fluorouracil (5-FU) and methotrexate (MTX) through random copolymeric nanomicelles of PLGA and polyethylenimine demonstrating enhanced cell uptake and cytotoxicity. Colloids and surfaces. B, Biointerfaces, 2014, Oct-01, Volume: 122 Topics: Antineoplastic Combined Chemotherapy Protocols; Calorimetry, Differential Scanning; Drug Carriers; Drug Screening Assays, Antitumor; Fluorouracil; HCT116 Cells; Humans; Lactic Acid; Methotrexate; Micelles; Microscopy, Electron, Transmission; Nanostructures; Polyethyleneimine; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction	2014
5-Fluorouracil-lipid conjugate: potential candidate for drug delivery through encapsulation in hydrophobic polyester-based nanoparticles. Acta biomaterialia, 2014, Volume: 10, Issue:11 Topics: Calorimetry, Differential Scanning; Cell Death; Chemistry, Pharmaceutical; Drug Delivery Systems; Fluorouracil; HCT116 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Lactic Acid; Lipids; Nanoparticles; Palmitic Acid; Particle Size; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction	2014
Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway. Oncology reports, 2015, Volume: 33, Issue:1 Topics: Cell Hypoxia; Cell Line, Tumor; Drug Resistance, Neoplasm; Flavanones; Fluorouracil; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid; PTEN Phosphohydrolase; Signal Transduction; Stomach Neoplasms	2015
Development of sulfadiazine-decorated PLGA nanoparticles loaded with 5-fluorouracil and cell viability. Molecules (Basel, Switzerland), 2015, Jan-08, Volume: 20, Issue:1 Topics: Calorimetry, Differential Scanning; Carbon-13 Magnetic Resonance Spectroscopy; Cell Death; Cell Line, Tumor; Cell Survival; Fluorouracil; Humans; Kinetics; Lactic Acid; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; Static Electricity; Sulfadiazine	2015
Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells. Cancer letters, 2015, Aug-28, Volume: 365, Issue:1 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; Glycolysis; Humans; Lactic Acid; Membrane Transport Modulators; Monocarboxylic Acid Transporters; Muscle Proteins; RNA Interference; Symporters; Time Factors; Transfection	2015
Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells. Apoptosis : an international journal on programmed cell death, 2015, Volume: 20, Issue:10 Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cyclophosphamide; DNA Damage; DNA Repair; Drug Combinations; Drug Synergism; Embryonic Stem Cells; Epirubicin; Female; Fibroblasts; Fluorouracil; Glucose; Humans; Hypoglycemic Agents; Lactic Acid; Lung; Metformin; Neoplastic Stem Cells; Pyrones; Ribonucleotides; Thiophenes	2015
Comparative evaluation of PLGA nanoparticle delivery system for 5-fluorouracil and curcumin on squamous cell carcinoma. Archives of oral biology, 2016, Volume: 64 Topics: Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug Delivery Systems; Drug Screening Assays, Antitumor; Fluorouracil; Head and Neck Neoplasms; Humans; Lactic Acid; Laryngeal Neoplasms; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Squamous Cell Carcinoma of Head and Neck	2016
l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88 Topics: Apoptosis; Arginine; Breast Neoplasms; Cell Movement; Cell Survival; Chemokine CXCL12; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Glucosephosphate Dehydrogenase; Humans; Lactic Acid; MCF-7 Cells; Models, Biological; Neoplasm Invasiveness; Nitric Oxide; Receptors, CXCR4; RNA, Messenger	2017
Assessment of penetration potential of pH responsive double walled biodegradable nanogels coated with eucalyptus oil for the controlled delivery of 5-fluorouracil: In vitro and ex vivo studies. Journal of controlled release : official journal of the Controlled Release Society, 2017, 05-10, Volume: 253 Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Liberation; Eucalyptus; Fluorouracil; Gels; Hemolysis; Humans; Hydrogen-Ion Concentration; Lactic Acid; Nanostructures; Plant Oils; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Skin; Skin Absorption; Swine	2017
Development of biomedical 5-fluorouracil nanoplatforms for colon cancer chemotherapy: Influence of process and formulation parameters. International journal of pharmaceutics, 2017, Sep-15, Volume: 530, Issue:1-2 Topics: Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Fluorouracil; Humans; Lactic Acid; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2017
Irinotecan and 5-fluorouracil-co-loaded, hyaluronic acid-modified layer-by-layer nanoparticles for targeted gastric carcinoma therapy. Drug design, development and therapy, 2017, Volume: 11 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Drug Delivery Systems; Fluorouracil; Humans; Hyaluronic Acid; Irinotecan; Lactic Acid; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Stomach Neoplasms	2017
Antitumor Efficacy and Toxicity of 5-Fluorouracil-Loaded Poly(Lactide Co-glycolide) Pellets. Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Implants; Female; Fluorouracil; Lactic Acid; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Thymoma	2018
Therapeutic efficacy of rebamipide-loaded PLGA nanoparticles coated with chitosan in a mouse model for oral mucositis induced by cancer chemotherapy. Colloids and surfaces. B, Biointerfaces, 2018, Jul-01, Volume: 167 Topics: Alanine; Animals; Anti-Ulcer Agents; Chitosan; Coated Materials, Biocompatible; Drug Liberation; Fluorouracil; Lactic Acid; Male; Mice, Inbred ICR; Microscopy, Electron, Scanning; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Quinolones; Stomatitis; Treatment Outcome	2018
MUC1 promotes glycolysis through inhibiting BRCA1 expression in pancreatic cancer. Chinese journal of natural medicines, 2020, Volume: 18, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Fluorouracil; Gemcitabine; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Glucose; Glycolysis; Humans; Irinotecan; Lactic Acid; Leucovorin; Male; Mice, Nude; Mucin-1; Neoplasm Transplantation; Oxaliplatin; Pancreatic Neoplasms	2020
5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid microparticles for local colorectal cancer-targeted chemotherapy. International journal of pharmaceutics, 2023, Jan-05, Volume: 630 Topics: Animals; Colorectal Neoplasms; Drug Carriers; Drug Delivery Systems; Fluorouracil; Hydrogen-Ion Concentration; Lactic Acid; Mice; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2023