lactic acid and dichloroacetic acid

lactic acid has been researched along with dichloroacetic acid in 151 studies

Research

Studies (151)

Timeframe	Studies, this research(%)	All Research%
pre-1990	32 (21.19)	18.7374
1990's	44 (29.14)	18.2507
2000's	30 (19.87)	29.6817
2010's	38 (25.17)	24.3611
2020's	7 (4.64)	2.80

Authors

Authors	Studies
Cheema-Dhadli, S; Halperin, ML; Kamel, KS	1
Abiko, H; Chang, LH; Faden, AI; James, TL; Shimizu, H; Swanson, RA; Weinstein, PR	1
Delehanty, JM; Imai, N; Liang, CS	1
Edelman, NH; Petrozzino, JJ; Santiago, TV; Scardella, AT	1
Bagby, GJ; Burns, A; deBoisblanc, BP; Meszaros, K; Nelson, S; Summer, WR	1
Dimlich, RV; Nielsen, MM	1
Ishida, T; Kawanishi, K	1
Herndon, DN; Jahoor, F; Miyoshi, H; Wolfe, RR	1
Curry, SH; Henderson, GN; Lorenz, A; Mars, DR; Stacpoole, PW	1
Hashimoto, T; Ito, M; Kuroda, Y; Naito, E; Saijo, T; Takeda, E	1
Buckley, BJ; Gootman, N; Kaplan, NA; Nudel, DB; Peterson, BJ; Weinhaouse, E	1
Anthonisen, NR; Berezanski, D; Georgopoulos, D	1
Stacpoole, PW	1
Placko, R; Siegel, JH; Vary, TC	1
Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF	1
Carraro, F; Klein, S; Rosenblatt, JI; Wolfe, RR	1
Cammenga, R; Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF	1
Kemmotsu, O; Nakata, F; Tanaka, R	2
Caputo, G; Delgado Paredes, C; Egler, J; Fleisher, G; Schaible, D; Sheikh, A; Swedlow, D	1
Hashimoto, T; Hwang, TJ; Ito, M; Kuroda, Y; Masuda, M; Miyao, M; Naito, E; Takeda, E; Toshima, K; Yamashita, K	1
Edelman, NH; Melton, JE; Neubauer, JA	1
Edelman, NH; Neubauer, JA; Simone, A	1
Egler, J; Ferraro, N; Mancini, DM; Wilson, JR	1
Barsan, WG; Dimlich, RV; Dronen, SC; Hedges, JR; Syverud, SA	1
Bodor, N; Gonzalez, MG; Oshiro, Y; Stacpoole, PW; Vlasak, J	1
Kuroda, Y; Matsuoka, S; Miyao, M; Miyauchi, Y; Naito, E; Nakatsu, T; Toshima, K	1
Kamoshita, S; Kodama, H; Kodama, M; Okabe, I; Orii, T; Yamaguchi, S	1
Davis, ME	1
Chitra, CI; Cuezva, JM; Patel, MS	1
Piper, HM; Probst, I; Spahr, R	1
Baumgartner, TG; Chu, PI; Curry, SH; Stacpoole, PW	1
Arieff, AI; Park, R	1
Enser, M; Whittington, FM	1
Casanello-Ertl, D; Duducgian-Vartavarian, L; Pardridge, WM	1
Hellige, G; Hunnemann, DH; Junggeburth, J; Kahles, H; Kochsiek, K	1
Ito, M; Kobashi, H; Kuroda, Y; Miyao, M; Takeda, E; Toshima, K; Watanabe, T	1
Agius, L; Sugden, MC; Watts, DI	1
Baumgartner, TG; Curry, SH; Harman, EM; Misbin, RI; Stacpoole, PW	1
Bretschneider, HJ; Hellige, G; Hunneman, DH; Kahles, H; Mezger, VA	1
Evans, OB; Stacpoole, PW	1
Campo, P; Dalstein, JM; Loubatières-Mariani, MM; Ribes, G	1
Goodman, MN; Komanicky, PM; Ruderman, NB; Schneider, SH	1
Cherrington, AD; Diamond, MP; Lacy, WW; Williams, PE	1
Dimlich, RV; Marangos, PJ	1
Arnold, DL; De Stefano, N; Ford, B; Genge, A; Karpati, G; Matthews, PM	1
Agbenyega, T; Angus, BJ; Bedu-Addo, G; Henderson, G; Krishna, S; O'Brien, R; Ofori-Amanfo, G; Stacpoole, PW; Szwandt, IS	1
Barron, JT; Parrillo, JE	1
Gallaher, EJ; Hromco, J; Robinson, ST; Shangraw, RE; Winter, R	1
Barnas, U; Graf, H; Ludvik, B; Mayer, G; Putz, D; Stifter, S	1
Huang, L; Itoi, T; Lopaschuk, GD	1
Ayuso, MS; Ciprés, G; González-Manchón, C; Martín-Requero, A; Parrilla, R	1
Hill, JM; Kaufman, MP; Pickar, JG; Sinoway, LI	1
Fujita, M; Konishi, J; Nohara, R; Okuda, K; Sasayama, S; Tamaki, N	1
Constantin-Teodosiu, D; Greenhaff, PL; Macdonald, IA; Poucher, SM; Timmons, JA; Worrall, V	1
Craigen, WJ	1
Brown, JA; Gore, DC	1
Arai, K; Harada, M; Hashimoto, T; Miyoshi, H; Nishitani, H; Tanouchi, M	1
Davis, RF; Haessler, R; Kozume, K; Shangraw, R; Van Winkle, DM; Wolff, RA	1
Itoi, T; Lopaschuk, GD	1
Buffini, JD; Fox, AW; Hoehler, FK; Neichin, ML; Nicora, R; O'Rourke, R; Stoltz, RR; Sullivan, BW	1
Beylot, M; Brunengraber, H; Large, V; Odeon, M	1
Huang, H; Peng, J; Wang, F	1
Grattan, RM; Kline, JA; Maiorano, PC; Schroeder, JD; Vary, TC; Watts, JA	1
Robinson, ST; Shangraw, RE	1
Hamlin, RL; Jiang, Z; Rath, DP; Robitaille, PM; Tong, X; Zhu, H	1
Chwalbinska-Moneta, J; Constantin-Teodosiu, D; Greenhaff, PL; Gustafsson, T; Hultman, E; Jansson, E; Kaijser, L; Macdonald, IA; Sundberg, CJ; Timmons, JA	1
Henderson, GN; James, MO; Stacpoole, PW; Yan, Z	1
Greenhaff, PL; Gustafsson, T; Jansson, E; Sundberg, CJ; Timmons, JA	1
Buxton, DB; Knight, RJ; Kofoed, KF; Schelbert, HR; Schöder, H	1
Kaplan, GP; Kingsley, PB; Lustbader, D; O'Shea, M; Pavlakis, SG; Stacpoole, PW	1
Corbett, R; Garcia, D; Gee, J; Laptook, A; Silmon, S; Tollefsbol, G	1
Bernard, M; Cozzone, P; El Banani, H; Feuvray, D; James, F	1
Darques, JL; Decherchi, P; Jammes, Y	1
Fisher, DM; Shangraw, RE	1
Chen, S; Ito, M; Kuroda, Y; Maehara, M; Naito, E; Saijo, T; Yokota, I	1
Agbenyega, T; Angus, BJ; Baffoe-Bonnie, B; Bedu-Addo, G; Guyton, T; Krishna, S; Stacpoole, PW	1
Barbee, RW; Kline, JA; Watts, JA	1
Heigenhauser, GJ; Hollidge-Horvat, MG; Hultman, E; Jones, NL; Matsos, MP; Parolin, ML; Spriet, LL	1
Capparelli, EV; Dziewanowska, Z; Fox, AW; Lane, JR; Turkel, CC; Williams, PJ	1
Ciufo, R; Dimarco, A; Nethery, D; Stofan, D; Supinski, G	1
Bangsbo, J; Gibala, MJ; González-Alonso, J; Krustrup, P; Saltin, B	1
Aschenbach, WG; Constantin-Teodosiu, D; Gladden, LB; Grassi, B; Greenhaff, PL; Hamann, JJ; Hogan, MC; Kelley, KM	1
George, JC; Hutson, AD; Neiberger, RE; Perkins, LA; Stacpoole, PW; Theriaque, DW	1
Bagger, JP; Frøbert, O; Gravholt, CH; Mikkelsen, EO	1
Evans, MK; Heigenhauser, GJ; Savasi, I; Spriet, LL	1
Bicego, KC; Branco, LG; Gargaglioni, LH; Steiner, AA	2
Fukumizu, M; Hanaoka, S; Hirayama, Y; Izumi, M; Kaga, M; Murayama, K; Sasaki, M; Sugai, K	1
Cook, M; Esaki, T; Itoh, Y; Kaufman, E; Law, MJ; Shimoji, K; Sokoloff, L	1
Griffiths, JR; Howe, FA; Kowalchuk, JM; Rossiter, HB; Ward, SA; Whipp, BJ; Wood, DM	1
Brocks, C; Chatham, JC; Lloyd, S	1
Back, MR; Bandyk, DF; Bowser, A; Johnson, BL; Kline, JA; Parker, JL; Rushing, G; Wilson, JS	1
Duncan, GE; Neiberger, RE; Perkins, LA; Stacpoole, PW; Theriaque, DW	1
L'Her, E; Sebert, P	1
Goto, T; Momoi, MY; Mori, M; Saito, S; Yamagata, T	1
Chiu, J; Fonarow, GC; Hage, A; Hamilton, MA; Maclellan, WR; Middlekauff, HR; Moriguchi, J; Patel, J	1
Timmons, JA	1
Curtò, N; Ferrarese, C; Grassi, MG; Guerra, L; Marzorati, L; Mattavelli, L; Piatti, ML; Tremolizzo, L	1
Savolainen, H	1
Ellsworth, ML; Rozier, MD; Zata, VJ	1
Bankart, J; Calvert, LD; Greenhaff, PL; Morgan, MD; Shelley, R; Singh, SJ; Steiner, MC	1
Carney, PR; Gilbert, LR; Neiberger, RE; Shuster, JJ; Stacpoole, PW; Theriaque, DW; Valenstein, E	1
Polakof, S; Soengas, JL	1
Barrientos, A; Bayona-Bafaluy, MP; Enriquez, JA; Fernández-Silva, P; Perales-Clemente, E; Pérez-Martos, A	1
Berger, NJ; Blackwell, JR; Campbell, IT; Jones, AM; Wilkerson, DP	1
Boobis, L; Bowtell, J; Casey, E; Constantin-Teodosiu, D; Marwood, S; Whyte, M	1
Hughes, TA; Jayne, DG; Madhok, BM; Perry, SL; Yeluri, S	1
Hayashi, J; Nakada, K; Ogasawara, E	1
Goodyear, A; Hare, JT; Logan, TM; Ni, D; Rolle, M; Skelton, D; Walton, WJ	1
Bennett, AJ; Macdonald, IA; Seevaratnam, N; Tisdale, PB; Tsintzas, K	1
Kakimoto, N; Katayama, K; Koga, Y; Matsuishi, T; Naito, E; Povalko, N; Tanaka, M	1
Alam, R; Goplen, N; Guo, L; Karim, MZ; Liang, Q; Michalec, L; Ostroukhova, M	1
Hurd, RE; Josan, S; Mayer, D; Park, JM; Pfefferbaum, A; Spielman, DM; Yen, YF	1
Baumann, M; Fabian, C; Kunz-Schughart, LA; Meyer, S; Mueller-Klieser, W; Sattler, UG; Yaromina, A; Zaleska, K; Zips, D	1
Bruchelt, G; Deubzer, B; Handgretinger, R; Krampen, L; Kuçi, Z; Niewisch, MR; Sautter, M; Wolburg, H	1
Kant, S; Kumar, A; Singh, SM	1
Beltran, JA; Charney, R; Chomicova, O; Cirillo, K; El-Khodor, BF; Marino, T; Mushlin, R; Ramboz, S; Winberg, ML	1
Ham, IH; Han, SU; Hur, H; Kim, YB; Lee, G; Shim, W; Xuan, Y; Yun, J	1
Fujiwara, S; Hata, H; Kawano, Y; Mitsuya, H; Nosaka, K; Okuno, Y; Yuki, H	1
Akazawa, T; Aoki, M; Inoue, N; Ito, Y; Kuze, B; Mizuta, K; Ohashi, T	1
Abdelmalak, M; Coats, BS; Langaee, T; Lew, A; Neiberger, RE; Ramezani, R; Shankar, MN; Shroads, AL; Stacpoole, PW; Subramony, SH	1
Kobzar, G; Mardla, V; Samel, N	1
Berger, R; Hanberry, BS; Zastre, JA	1
Dhar, S; Harn, DA; Marrache, S; Pathak, RK	1
Andrejeva, G; Boult, JK; Chung, YL; Eykyn, TR; Fong, AC; Griffiths, JR; Hill, DK; Jafar, M; Judson, IR; Koh, DM; Leach, MO; Lin, G; Orton, MR; Panek, R; Parkes, HG; Robinson, SP; Troy, H	1
Bosoi, CR; Rose, CF	1
Battiprolu, PK; Rodnick, KJ	1
Karagiannis, TC; Ngo, H; Tortorella, SM; Ververis, K	1
Agostinelli, E; Canettieri, G; Coni, S; D'Amico, D; De Smaele, E; Di Magno, L; Di Marcotullio, L; Ferretti, E; Gulino, A; Infante, P; Macone, A; Manzi, D; Screpanti, I	1
Coomber, BL; Ho, N	1
Boichuk, IV; Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI	1
Asta, J; Azam, MA; Farid, T; Jaimes, R; Kay, MW; Kusha, M; Kuzmiak-Glancy, S; Lai, PF; Lopaschuk, GD; Massé, S; Nanthakumar, K; Wagg, CS	1
Bendahan, D; Chung, Y; Hurd, RE; Josan, S; Jue, T; Mayer, D; Park, JM; Spielman, DM	1
Fang, JY; Han, B; Hoang, BX; Nimni, M; Shaw, DG	1
Boychuk, IV; Dasyukevich, OI; Fedorchuk, AG; Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI	1
Choi, SC; Croker, BP; Kanda, N; Morel, L; Xu, Z; Yin, Y; Zeumer, L	1
He, F; He, J; Huang, Y; Li, B; Li, X; Lyu, X; Ni, Z; Wang, Y; Wu, Y; Yan, X; Zeng, Y; Zhang, Y; Zheng, Y	1
Bol, A; Brender, JR; De Preter, G; Feron, O; Gallez, B; Grégoire, V; Jordan, BF; Joudiou, N; Kishimoto, S; Krishna, MC; Neveu, MA; Saito, K	1
Mittal, R; Rath, S; Reddy, MM; Sradhanjali, S; Tripathy, D	1
Hammer, SC; Harting, TP; Murua Escobar, H; Ngezahayo, A; Nolte, I; Schadzek, P; Stubbendorff, M	1
Hu, X; Tam, KY; Zhang, W; Zhou, W	1
Abdel-Aziz, W; Abdel-Latif, HM; Aboonq, MS; Ahmed, NS; Almaramhy, HH; Ayat, M; Baghdadi, H; El Sayed, SM; El-Sawy, SA; Elshazley, M; Ibrahim, W; Mahmoud, AA	1
Du, J; Huang, J; Huang, X; Lin, W; Liu, L; Long, Z; Ma, W; Xie, Y; Zhang, N	1
Gorbach, O; Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI	1
Ishihara, N; Nakada, K; Ogasawara, E	1
Angus, DC; Bakalov, V; Chang, CH; Deshpande, R; Kaynar, AM; Le Moyec, L; Maloy, AL; Reyes-Uribe, L; Shapiro, SD; Wendell, SG	1
Chen, G; Chen, Y; He, B; Ren, L; Sun, X; Xin, Y; Zhang, Y	1
Fallah-Mehrjardi, K; Hadjati, J; Jafarzadeh, L; Khakpoor-Koosheh, M; M Pawelek, J; Masoumi, E; Mirzaei, HR; Rostamian, H; Tavassolifar, MJ	1
Dai, Z; Li, H; Qu, R; Tang, J; Wang, Q; Wu, M; Yang, Y; Yu, C; Zhen, X	1
Fosam, A; Gaspar, RC; Halberstam, AA; Lee, WD; Leitner, BP; Li, Z; Perry, RJ; Rabinowitz, JD; Robles, B; Zhang, X; Zhu, W	1

Reviews

5 review(s) available for lactic acid and dichloroacetic acid

Article	Year
The pharmacology of dichloroacetate. Metabolism: clinical and experimental, 1989, Volume: 38, Issue:11 Topics: Acetates; Amino Acids; Animals; Carbohydrate Metabolism; Chemical Phenomena; Chemistry, Physical; Dichloroacetic Acid; Hemodynamics; Humans; Kidney; Lactates; Lactic Acid; Lipid Metabolism; Lipoproteins; Neurons; Peripheral Nervous System Diseases; Proteins	1989
Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats. Annals of emergency medicine, 1989, Volume: 18, Issue:11 Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Food; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains	1989
Concomitant administration of sodium dichloroacetate and thiamine in west syndrome caused by thiamine-responsive pyruvate dehydrogenase complex deficiency. Journal of the neurological sciences, 1999, Dec-01, Volume: 171, Issue:1 Topics: Amino Acid Substitution; Dichloroacetic Acid; DNA Mutational Analysis; Drug Therapy, Combination; Female; Humans; Infant; Lactic Acid; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease; Sex Factors; Spasms, Infantile; Thiamine	1999
Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy. Metabolic brain disease, 2014, Volume: 29, Issue:4 Topics: Ammonia; Animals; Brain; Brain Edema; Citric Acid Cycle; Dichloroacetic Acid; Drug Evaluation, Preclinical; Hepatic Encephalopathy; Homeostasis; Humans; L-Lactate Dehydrogenase; Lactic Acid; Liver Diseases; Pyruvate Dehydrogenase Complex	2014
The Warburg effect: molecular aspects and therapeutic possibilities. Molecular biology reports, 2015, Volume: 42, Issue:4 Topics: Antineoplastic Agents; Dichloroacetic Acid; Epigenesis, Genetic; Genes; Glycolysis; Humans; Lactic Acid; Neoplasms; Pyruvates	2015

Trials

20 trial(s) available for lactic acid and dichloroacetic acid

Article	Year
Effect of dichloroacetate on ventilatory response to sustained hypoxia in normal adults. Respiration physiology, 1990, Volume: 82, Issue:1 Topics: Adult; Brain; Dichloroacetic Acid; Female; Humans; Hypoxia; Lactates; Lactic Acid; Male; Respiration; Tidal Volume	1990
Effect of dichloroacetate on lactate concentration in exercising humans. Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 66, Issue:2 Topics: Acetates; Adult; Dichloroacetic Acid; Humans; Lactates; Lactic Acid; Male; Models, Biological; Models, Theoretical; Oxygen Consumption; Physical Exertion; Pyruvate Dehydrogenase Complex	1989
Effect of dichloroacetate on the exercise performance of patients with heart failure. Journal of the American College of Cardiology, 1988, Volume: 12, Issue:6 Topics: Acetates; Acidosis, Lactic; Adult; Aged; Dichloroacetic Acid; Exercise; Fatigue; Heart Failure; Humans; Lactates; Lactic Acid; Leg; Male; Middle Aged; Muscles; Oxygen Consumption; Regional Blood Flow	1988
Short-term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders. Neurology, 1995, Volume: 45, Issue:6 Topics: Acetylcysteine; Adenosine Diphosphate; Adolescent; Adult; Aged; Alanine; Brain; Child; Creatine; Cross-Over Studies; Dichloroacetic Acid; Double-Blind Method; Female; Humans; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondrial Myopathies; Placebos; Pyruvate Dehydrogenase Complex	1995
Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria. QJM : monthly journal of the Association of Physicians, 1995, Volume: 88, Issue:5 Topics: Acidosis, Lactic; Child; Child, Preschool; Dichloroacetic Acid; Drug Therapy, Combination; Female; Humans; Infant; Lactates; Lactic Acid; Malaria; Male; Quinine	1995
Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans. Anesthesiology, 1994, Volume: 81, Issue:5 Topics: Acidosis, Lactic; Adult; Blood Glucose; Dichloroacetic Acid; Female; Humans; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Liver Transplantation; Male; Middle Aged; Sodium Bicarbonate	1994
Reduction of serum lactate by sodium dichloroacetate, and human pharmacokinetic-pharmacodynamic relationships. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:2 Topics: Aged; Dichloroacetic Acid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Models, Biological	1996
Oxygen metabolism during liver transplantation: the effect of dichloroacetate. Anesthesia and analgesia, 1997, Volume: 85, Issue:4 Topics: Acid-Base Equilibrium; Adult; Body Temperature; Dichloroacetic Acid; Fatty Acids, Nonesterified; Female; Humans; Lactic Acid; Liver Transplantation; Male; Middle Aged; Oxygen; Oxygen Consumption	1997
Determination of dichloroacetate and its metabolites in human plasma by gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications, 1997, Dec-05, Volume: 703, Issue:1-2 Topics: Administration, Oral; Adult; Carbon Isotopes; Circadian Rhythm; Cross-Over Studies; Dichloroacetic Acid; Esters; Female; Gas Chromatography-Mass Spectrometry; Humans; Injections, Intravenous; Lactic Acid; Linear Models; Male; Reproducibility of Results; Sensitivity and Specificity	1997
Glucose and lactate kinetics in children with severe malaria. The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:4 Topics: Acidosis, Lactic; Antimalarials; Artemisinins; Artesunate; Blood Glucose; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; Infant; Insulin; Kinetics; Lactic Acid; Malaria, Falciparum; Male; Quinine; Sesquiterpenes	2000
Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia. American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:4 Topics: Acetyl Coenzyme A; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Blood Glucose; Blood Pressure; Dichloroacetic Acid; Glycogen; Glycolysis; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Phosphocreatine; Phosphorylases; Physical Exertion; Pyruvate Dehydrogenase Complex; Respiratory Function Tests	2000
Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model. Journal of clinical pharmacology, 2001, Volume: 41, Issue:3 Topics: Adult; Aged; Bayes Theorem; Brain Injuries; Chromatography, High Pressure Liquid; Computer Simulation; Dichloroacetic Acid; Humans; Infusion Pumps; Lactic Acid; Middle Aged; Models, Biological; Models, Statistical; Monte Carlo Method; Reference Values; Time Factors	2001
Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise. American journal of physiology. Endocrinology and metabolism, 2002, Volume: 283, Issue:1 Topics: Adult; Biopsy, Needle; Dichloroacetic Acid; Enzyme Activation; Exercise; Humans; Hyperoxia; Infusions, Intravenous; Lactic Acid; Male; Muscle, Skeletal; Oxidative Phosphorylation; Phosphocreatine; Phosphorylation; Physical Exertion; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Reference Values	2002
Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism. The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:4 Topics: Adult; Child; Child, Preschool; Dichloroacetic Acid; Energy Metabolism; Exercise; Female; Humans; Lactic Acid; Male; Middle Aged; Mitochondria; Mitochondrial Diseases; Oxygen Consumption	2004
Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS. Brain & development, 2004, Volume: 26, Issue:7 Topics: Abdominal Pain; Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dichloroacetic Acid; Female; Headache; Humans; Hypocalcemia; Lactic Acid; MELAS Syndrome; Mitochondria; Muscle Weakness; Peripheral Nervous System Diseases; Pyruvic Acid; Stroke; Time Factors; Treatment Outcome	2004
Muscle mechanoreceptor sensitivity in heart failure. American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:5 Topics: Arm; Cardiac Output, Low; Constriction; Dichloroacetic Acid; Double-Blind Method; Exercise; Female; Hand Strength; Humans; Lactic Acid; Male; Mechanoreceptors; Middle Aged; Motion; Muscle, Skeletal; Periodicity; Sympathetic Nervous System	2004
Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology, 2006, Jul-11, Volume: 67, Issue:1 Topics: Acidosis; Adolescent; Adult; Child; Cross-Over Studies; Dichloroacetic Acid; Double-Blind Method; Humans; Lactic Acid; MELAS Syndrome; Middle Aged; Polyneuropathies	2006
Dichloroacetate enhances performance and reduces blood lactate during maximal cycle exercise in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine, 2008, May-15, Volume: 177, Issue:10 Topics: Aged; Aged, 80 and over; Ammonia; Cross-Over Studies; Dichloroacetic Acid; Double-Blind Method; Enzyme Activators; Exercise Test; Exercise Tolerance; Female; Humans; Lactic Acid; Male; Middle Aged; Muscle, Skeletal; Pulmonary Disease, Chronic Obstructive; Pyruvate Dehydrogenase Complex	2008
Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate. Pediatrics, 2008, Volume: 121, Issue:5 Topics: Acidosis, Lactic; Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Double-Blind Method; Female; Humans; Infant; Kaplan-Meier Estimate; Lactic Acid; Male; Mitochondrial Encephalomyopathies; Neural Conduction; Pyruvate Dehydrogenase Complex Deficiency Disease	2008
Influence of dichloroacetate on pulmonary gas exchange and ventilation during incremental exercise in healthy humans. Respiratory physiology & neurobiology, 2009, Sep-30, Volume: 168, Issue:3 Topics: Adult; Bicarbonates; Dichloroacetic Acid; Energy Metabolism; Exercise; Exercise Tolerance; Heart Rate; Humans; Lactic Acid; Male; Oxygen Consumption; Physical Exertion; Pulmonary Gas Exchange; Pulmonary Ventilation; Young Adult	2009

Other Studies

126 other study(ies) available for lactic acid and dichloroacetic acid

Article	Year
Is accelerated oxidation of lactate required for dichloroacetate to lower the level of lactate in blood? Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:11 Topics: Animals; Cardiac Output; Dichloroacetic Acid; Insulin; Kidney; Lactates; Lactic Acid; Liver; Male; Muscles; Oxidation-Reduction; Oxygen Consumption; Pyruvate Dehydrogenase Complex; Rabbits	1992
Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1992, Volume: 12, Issue:6 Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cations; Dichloroacetic Acid; Disease Models, Animal; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Water	1992
Effects of dichloroacetate on hemodynamic responses to dynamic exercise in dogs. Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 72, Issue:2 Topics: Adaptation, Physiological; Animals; Cardiac Output; Dichloroacetic Acid; Dogs; Epinephrine; Hemodynamics; Lactates; Lactic Acid; Male; Norepinephrine; Oxygen Consumption; Physical Exertion; Pyruvates; Pyruvic Acid	1992
Dichloroacetate blocks endogenous opioid effects during inspiratory flow-resistive loading. Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 72, Issue:2 Topics: Afferent Pathways; Airway Resistance; Animals; Carbon Dioxide; Dichloroacetic Acid; Endorphins; Goats; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Male; Models, Biological; Muscle Contraction; Naloxone; Respiratory Mechanics; Respiratory Muscles	1992
Effect of dichloroacetate on mechanical performance and metabolism of compromised diaphragm muscle. Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 72, Issue:3 Topics: Animals; Diaphragm; Dichloroacetic Acid; Electric Stimulation; Glucose; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Toxemia	1992
Facilitating postischemic reduction of cerebral lactate in rats. Stroke, 1992, Volume: 23, Issue:8 Topics: Animals; Blood Glucose; Blood Pressure; Brain; Brain Ischemia; Dichloroacetic Acid; Lactates; Lactic Acid; Male; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains	1992
[Lactic acidosis inpatients with diabetes mellitus]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49 Suppl Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Bicarbonates; Blood Glucose; Diabetic Ketoacidosis; Dichloroacetic Acid; Female; Humans; Insulin; Lactates; Lactic Acid; Male; Middle Aged; Sodium; Sodium Bicarbonate; Tromethamine	1991
Isotopic evaluation of the metabolism of pyruvate and related substrates in normal adult volunteers and severely burned children: effect of dichloroacetate and glucose infusion. Surgery, 1991, Volume: 110, Issue:1 Topics: Absorption; Adult; Alanine; Burns; Carbon Isotopes; Child; Child, Preschool; Dichloroacetic Acid; Energy Metabolism; Glucose; Humans; Infusions, Intravenous; Lactates; Lactic Acid; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Reference Values	1991
Haemodialysis studies with dichloroacetate. European journal of clinical pharmacology, 1991, Volume: 40, Issue:6 Topics: Adult; Blood Glucose; Dichloroacetic Acid; Drug Administration Schedule; Female; Humans; Kidney Failure, Chronic; Lactates; Lactic Acid; Male; Middle Aged; Renal Dialysis	1991
Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS. Neuropediatrics, 1991, Volume: 22, Issue:3 Topics: Acidosis, Lactic; Administration, Oral; Adult; Auditory Perception; Dichloroacetic Acid; Hallucinations; Humans; Lactates; Lactic Acid; Male; Mitochondria, Muscle; Neurocognitive Disorders; Neuromuscular Diseases; Pyruvates; Pyruvic Acid; Syndrome; Visual Perception	1991
Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis. Developmental pharmacology and therapeutics, 1990, Volume: 15, Issue:2 Topics: Acidosis, Lactic; Animals; Animals, Newborn; Bicarbonates; Blood Pressure; Cardiac Output; Dichloroacetic Acid; Heart Rate; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Pulmonary Gas Exchange; Sodium; Sodium Bicarbonate; Swine	1990
Pharmacologic modulation of increased release of gluconeogenic precursors from extra-splanchnic organs in sepsis. Circulatory shock, 1989, Volume: 29, Issue:1 Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Cycloserine; Dichloroacetic Acid; Gluconeogenesis; Glutamate-Ammonia Ligase; Glutamine; Hepatectomy; Intestine, Small; Lactates; Lactic Acid; Liver; Male; Methionine Sulfoximine; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Sepsis	1989
Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia. Annals of emergency medicine, 1989, Volume: 18, Issue:11 Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Fasting; Humans; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains	1989
[Comparative effects of dichloroacetate and sodium bicarbonate on plasma lactic acid levels in experimentally produced hypoxia]. Masui. The Japanese journal of anesthesiology, 1987, Volume: 36, Issue:7 Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lactic Acid; Sodium; Sodium Bicarbonate	1987
Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs. Critical care medicine, 1986, Volume: 14, Issue:11 Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Carbon Dioxide; Dichloroacetic Acid; Dogs; Heart Arrest; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Models, Biological; Oxygen; Resuscitation; Sodium; Sodium Bicarbonate	1986
Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetate. Journal of inherited metabolic disease, 1986, Volume: 9, Issue:3 Topics: Acetates; Acidosis; Adolescent; Brain; Dichloroacetic Acid; Humans; Infant, Newborn; Kidney; Lactates; Lactic Acid; Liver; Male; Muscles; Neuromuscular Diseases	1986
CO2 sensitivity of cat phrenic neurogram during hypoxic respiratory depression. Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:2 Topics: Animals; Carbon Dioxide; Cats; Dichloroacetic Acid; Hypoxia; Lactates; Lactic Acid; Male; Phrenic Nerve; Respiration	1988
Role of brain lactic acidosis in hypoxic depression of respiration. Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:3 Topics: Acidosis, Lactic; Animals; Brain; Carbon Monoxide; Cats; Chemoreceptor Cells; Denervation; Dichloroacetic Acid; Hypoxia; Lactates; Lactic Acid; Male; Oxygen; Phrenic Nerve; Respiration	1988
[Effect of dichloroacetate on plasma lactic acid in experimentally produced hypoxia]. Masui. The Japanese journal of anesthesiology, 1986, Volume: 35, Issue:12 Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lactic Acid	1986
Effects of dichloroacetate in spinal stroke in the rabbit. Life sciences, 1987, Aug-31, Volume: 41, Issue:9 Topics: Acetates; Animals; Blood Glucose; Cerebrovascular Disorders; Dichloroacetic Acid; Lactates; Lactic Acid; Male; Movement; Rabbits; Spinal Cord; Spinal Cord Diseases; Time Factors	1987
Dichloroacetate derivatives. Metabolic effects and pharmacodynamics in normal rats. Life sciences, 1987, Nov-02, Volume: 41, Issue:18 Topics: Acetates; Animals; Biological Availability; Blood Glucose; Chloroacetates; Cholesterol; Dichloroacetic Acid; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triglycerides; Tritium; Water	1987
Effects of dichloroacetate on the mechanical function of the isolated ischemic heart. Japanese heart journal, 1987, Volume: 28, Issue:4 Topics: Acetates; Animals; Dichloroacetic Acid; Enzyme Activation; Heart; Lactates; Lactic Acid; Male; Myocardial Contraction; Myocardium; Perfusion; Pyruvate Dehydrogenase Complex; Rats	1987
Renal effects of dichloroacetate in vivo. Clinica chimica acta; international journal of clinical chemistry, 1986, Nov-15, Volume: 160, Issue:3 Topics: Acetates; Acidosis, Lactic; Administration, Oral; Child, Preschool; Dichloroacetic Acid; Gas Chromatography-Mass Spectrometry; Humans; Kidney; Lactates; Lactic Acid; Male; Pyruvates; Pyruvic Acid	1986
Effect of chloroacetic acids on the kidneys. Environmental health perspectives, 1986, Volume: 69 Topics: Acetates; Acidosis; Animals; Dichloroacetic Acid; Disinfectants; Female; Glucose; Kidney; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains; Trichloroacetic Acid; Water Supply	1986
Changes in the activity of 'active' pyruvate dehydrogenase complex in the newborn of normal and diabetic rats. Diabetologia, 1985, Volume: 28, Issue:3 Topics: Animals; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Enzyme Activation; Female; Glucose; Insulin; Lactates; Lactic Acid; Liver; Pregnancy; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains	1985
Substrate utilization of adult cardiac myocytes. Basic research in cardiology, 1985, Volume: 80 Suppl 1 Topics: Animals; Blood Glucose; Calcium; Carbon Dioxide; Cells, Cultured; Dichloroacetic Acid; Energy Metabolism; Female; Glycolysis; Heart Ventricles; Insulin; Lactates; Lactic Acid; Myocardial Contraction; Myocardium; Palmitic Acid; Palmitic Acids; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains	1985
Plasma concentrations and metabolic effects of intravenous sodium dichloroacetate. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:1 Topics: Acetates; Adult; Animals; Dichloroacetic Acid; Dose-Response Relationship, Drug; Female; Humans; Infusions, Parenteral; Kinetics; Lactates; Lactic Acid; Male; Middle Aged; Oxalates; Oxalic Acid; Rats	1985
Treatment of lactic acidosis with dichloroacetate in dogs. The Journal of clinical investigation, 1982, Volume: 70, Issue:4 Topics: Acetates; Acidosis; Animals; Bicarbonates; Cardiac Output; Dichloroacetic Acid; Dogs; Female; Hepatectomy; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Male; Phenformin; Sodium Bicarbonate; Sodium Chloride	1982
The actions of dichloroacetic acid on blood glucose, liver glycogen and fatty acid synthesis in obese-hyperglycaemic (ob/ob) and lean mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1983, Volume: 15, Issue:5 Topics: Acetates; Adipose Tissue; Animals; Blood Glucose; Dichloroacetic Acid; Fatty Acids; Female; Hyperglycemia; Insulin; Lactates; Lactic Acid; Liver Glycogen; Mice; Obesity	1983
Effects of dichloroacetate on the lactate/pyruvate ratio and on aspartate and leucine metabolism in cultured rat skeletal muscle cells. Biochemical pharmacology, 1983, Jan-01, Volume: 32, Issue:1 Topics: Acetates; Animals; Aspartic Acid; Carbon Dioxide; Cells, Cultured; Culture Media; Dichloroacetic Acid; Lactates; Lactic Acid; Leucine; Male; Muscles; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Time Factors	1983
Different effects of interventions suppressing free fatty acid metabolism on myocardial ischemia. Clinical cardiology, 1984, Volume: 7, Issue:6 Topics: Animals; Coronary Disease; Dichloroacetic Acid; Dogs; Fatty Acids, Nonesterified; Glucose; Hemodynamics; Infusions, Parenteral; Insulin; Lactates; Lactic Acid; Mannitol; Myocardium; Potassium; Pyruvates; Pyruvic Acid	1984
Effects of dichloroacetate on pyruvate metabolism in rat brain in vivo. Pediatric research, 1984, Volume: 18, Issue:10 Topics: Acetates; Animals; Blood Glucose; Brain; Dichloroacetic Acid; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Lactates; Lactic Acid; Liver; Male; Muscles; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains	1984
Effects of dichloroacetate on fatty acid synthesis in interscapular brown adipose tissue of the rat in vivo and in vitro. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1983, Volume: 15, Issue:10 Topics: Acetates; Adipose Tissue, Brown; Animals; Dichloroacetic Acid; Fatty Acids; Female; Glucose; Lactates; Lactic Acid; Lipids; Rats; Rats, Inbred Strains; Starvation	1983
Treatment of lactic acidosis with dichloroacetate. The New England journal of medicine, 1983, Aug-18, Volume: 309, Issue:7 Topics: 3-Hydroxybutyric Acid; Acetates; Acidosis; Adolescent; Adult; Aged; Alanine; Bicarbonates; Blood Pressure; Dichloroacetic Acid; Female; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Lactates; Lactic Acid; Male; Middle Aged	1983
Influence of myocardial substrate utilization on the oxygen consumption of the heart. Clinical cardiology, 1982, Volume: 5, Issue:4 Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Dichloroacetic Acid; Dogs; Fatty Acids, Nonesterified; Hemodynamics; Lactates; Lactic Acid; Myocardium; Nicotinyl Alcohol; Oxygen Consumption; Pyruvate Dehydrogenase Complex; Substrate Specificity	1982
Prolonged hypolactatemia and increased total pyruvate dehydrogenase activity by dichloroacetate. Biochemical pharmacology, 1982, Apr-01, Volume: 31, Issue:7 Topics: Acetates; Animals; Blood Glucose; Dichloroacetic Acid; Glyoxylates; In Vitro Techniques; Lactates; Lactic Acid; Liver; Male; Oxalates; Oxalic Acid; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Time Factors	1982
Effect of sodium dichloroacetate on dental caries in diabetic rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1982, Volume: 14, Issue:8 Topics: Acetates; Animals; Dental Caries; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains; Time Factors	1982
Dichloroacetate: effects on exercise endurance in untrained rats. Metabolism: clinical and experimental, 1981, Volume: 30, Issue:6 Topics: 3-Hydroxybutyric Acid; Acetates; Adenosine Triphosphate; Animals; Dichloroacetic Acid; Glycogen; Hydroxybutyrates; Lactates; Lactic Acid; Male; Muscles; Phosphocreatine; Physical Exertion; Pyruvates; Pyruvic Acid; Rats; Time Factors	1981
Effect of dichloroacetate on gluconeogenesis in vivo in the presence of a fixed gluconeogenic substrate supply to the liver. Metabolism: clinical and experimental, 1981, Volume: 30, Issue:9 Topics: Acetates; Alanine; Animals; Dichloroacetic Acid; Dogs; Female; Gluconeogenesis; Kinetics; Lactates; Lactic Acid; Liver; Male	1981
Dichloroacetate attenuates neuronal damage in a gerbil model of brain ischemia. Journal of molecular neuroscience : MN, 1994,Summer, Volume: 5, Issue:2 Topics: Animals; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Gerbillinae; Hippocampus; Lactates; Lactic Acid; Male; Motor Activity; Neurons; Pyramidal Cells	1994
Production of lactic acid and energy metabolism in vascular smooth muscle: effect of dichloroacetate. The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 2 Topics: Animals; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Glucose; Glycogen; Lactates; Lactic Acid; Muscle, Smooth, Vascular; Oxidation-Reduction; Phosphates; Potassium Chloride; Swine; Vasoconstriction	1995
Effects of dichloroacetate on exercise performance in healthy volunteers. Pflugers Archiv : European journal of physiology, 1993, Volume: 423, Issue:3-4 Topics: Adult; Bicycling; Blood Pressure; Cardiac Output; Dichloroacetic Acid; Exercise; Humans; Lactates; Lactic Acid; Male; Oxygen Consumption; Pyruvate Dehydrogenase Complex	1993
Glucose use in neonatal rabbit hearts reperfused after global ischemia. The American journal of physiology, 1993, Volume: 265, Issue:2 Pt 2 Topics: Aging; Animals; Animals, Newborn; Coronary Disease; Dichloroacetic Acid; Female; Glucose; Glycolysis; Heart; In Vitro Techniques; Lactates; Lactic Acid; Male; Myocardial Reperfusion; Myocardium; Rabbits	1993
Interrelationships between ureogenesis and gluconeogenesis in perfused rat liver. Biochimica et biophysica acta, 1993, Oct-03, Volume: 1158, Issue:2 Topics: Ammonium Chloride; Animals; Dichloroacetic Acid; Gluconeogenesis; Glucose; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Liver; Male; Oleic Acid; Oleic Acids; Ornithine; Perfusion; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar; Time Factors; Urea	1993
Effects of contraction and lactic acid on the discharge of group III muscle afferents in cats. Journal of neurophysiology, 1993, Volume: 69, Issue:4 Topics: Animals; Cats; Dichloroacetic Acid; Electrophysiology; Hindlimb; Lactates; Lactic Acid; Muscle Contraction; Muscles; Neurons, Afferent; Reflex; Rest	1993
Improvement of myocardial ischemic dysfunction with dichloroacetic acid: experimental study by repeated ischemia in dogs. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:6 Topics: Animals; Blood Glucose; Calcium; Coronary Circulation; Dichloroacetic Acid; Dogs; Fatty Acids, Nonesterified; Glucose; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Myocardial Ischemia; Myocardial Stunning; Technetium Tc 99m Pyrophosphate	1995
Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia. The Journal of clinical investigation, 1996, Feb-01, Volume: 97, Issue:3 Topics: Acetylcarnitine; Adenosine Triphosphate; Aerobiosis; Anaerobiosis; Animals; Carbohydrate Metabolism; Carnitine; Dichloroacetic Acid; Dogs; Electric Stimulation; Enzyme Activation; Female; In Vitro Techniques; Ischemia; Lactates; Lactic Acid; Muscle Contraction; Muscle, Skeletal; Peripheral Vascular Diseases; Pyruvate Dehydrogenase Complex	1996
Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate. Pediatric neurology, 1996, Volume: 14, Issue:1 Topics: Acidosis, Lactic; Amino Acids, Branched-Chain; Child, Preschool; Dichloroacetic Acid; Dihydrolipoamide Dehydrogenase; Enzyme Activation; Fatal Outcome; Female; Humans; Infant; Isoleucine; Lactates; Lactic Acid; Leigh Disease; Pyruvate Dehydrogenase Complex; Treatment Failure	1996
In vivo metabolic response of glucose to dichloroacetate in humans. The Journal of surgical research, 1996, Volume: 61, Issue:2 Topics: Adult; Alanine; Dichloroacetic Acid; Feedback; Glucose; Humans; Hyperglycemia; Lactates; Lactic Acid; Male; Muscle, Skeletal	1996
Therapeutic efficacy of a case of pyruvate dehydrogenase complex deficiency monitored by localized proton magnetic resonance spectroscopy. Magnetic resonance imaging, 1996, Volume: 14, Issue:1 Topics: Brain; Brain Chemistry; Dichloroacetic Acid; Humans; Infant; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvates; Pyruvic Acid	1996
Dichloroacetate reduces plasma lactate levels but does not reduce infarct size in rabbit myocardium. Shock (Augusta, Ga.), 1996, Volume: 5, Issue:1 Topics: Animals; Blood Glucose; Dichloroacetic Acid; Enzyme Activation; Hemodynamics; Lactic Acid; Myocardial Infarction; Myocardial Reperfusion Injury; Pyruvate Dehydrogenase Complex; Rabbits	1996
Calcium improves mechanical function and carbohydrate metabolism following ischemia in isolated Bi-ventricular working hearts from immature rabbits. Journal of molecular and cellular cardiology, 1996, Volume: 28, Issue:7 Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Dichloroacetic Acid; Dose-Response Relationship, Drug; Fatty Acids; Glucose; Glycogen; Heart; Heart Rate; Heart Ventricles; Lactic Acid; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Palmitates; Phosphates; Rabbits	1996
Use of labeling pattern of liver glutamate to calculate rates of citric acid cycle and gluconeogenesis. The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 1 Topics: Animals; Citric Acid Cycle; Dichloroacetic Acid; Enzyme Inhibitors; Glucagon; Gluconeogenesis; Glutamic Acid; Lactic Acid; Liver; Methods; Osmolar Concentration; Picolinic Acids; Pyruvate Kinase; Pyruvic Acid; Rats	1997
[The protective effects of dichloroacetate on cerebral ischemia after reperfusion of fed rats]. Zhonghua yi xue za zhi, 1996, Volume: 76, Issue:7 Topics: Animals; Brain Ischemia; Dichloroacetic Acid; Lactic Acid; Male; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury	1996
Activation of pyruvate dehydrogenase improves heart function and metabolism after hemorrhagic shock. Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:9 Topics: Adenosine Triphosphate; Animals; Arteries; Blood Chemical Analysis; Blood Pressure; Dichloroacetic Acid; Energy Metabolism; Heart; Hemodynamics; Lactic Acid; Male; Myocardium; Phosphates; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Ventricular Function	1997
Dynamic 13C NMR analysis of pyruvate and lactate oxidation in the in vivo canine myocardium: evidence of reduced utilization with increased work. Magnetic resonance in medicine, 1997, Volume: 38, Issue:6 Topics: Animals; Carbon Radioisotopes; Citric Acid Cycle; Dichloroacetic Acid; Dogs; Glutamic Acid; Heart; Lactic Acid; Magnetic Resonance Spectroscopy; Myocardium; Oxidation-Reduction; Pyruvic Acid	1997
Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise. The Journal of clinical investigation, 1998, Jan-01, Volume: 101, Issue:1 Topics: Acetylcarnitine; Adenosine Triphosphate; Adult; Blood Glucose; Cardiovascular Physiological Phenomena; Dichloroacetic Acid; Exercise; Glycogen; Humans; Lactic Acid; Male; Muscle, Skeletal; Phosphocreatine; Pyruvate Dehydrogenase Complex; Time Factors	1998
Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise. The American journal of physiology, 1998, Volume: 274, Issue:2 Topics: Acetylation; Adenosine Triphosphate; Adult; Blood Glucose; Dichloroacetic Acid; Enzyme Activation; Exercise; Humans; Lactic Acid; Male; Mitochondria, Muscle; Muscle, Skeletal; Oxygen Consumption; Phosphocreatine; Pyruvate Dehydrogenase Complex	1998
Regulation of pyruvate dehydrogenase activity and glucose metabolism in post-ischaemic myocardium. Biochimica et biophysica acta, 1998, Feb-27, Volume: 1406, Issue:1 Topics: Animals; Dichloroacetic Acid; Dogs; Glucose; Lactic Acid; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidation-Reduction; Pyruvate Dehydrogenase Complex	1998
Magnetic resonance spectroscopy: use in monitoring MELAS treatment. Archives of neurology, 1998, Volume: 55, Issue:6 Topics: Adult; Brain; Cerebrovascular Disorders; Creatine; Dichloroacetic Acid; Female; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; MELAS Syndrome; Treatment Outcome	1998
Age-related differences in the effect of dichloroacetate on postischemic lactate and acid clearance measured in vivo using magnetic resonance spectroscopy and microdialysis. Journal of neurochemistry, 1998, Volume: 71, Issue:3 Topics: Acids; Aging; Animals; Animals, Newborn; Body Temperature; Brain; Brain Ischemia; Dichloroacetic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Microdialysis; Swine	1998
Ionic and metabolic imbalance as potential factors of ischemia reperfusion injury. The American journal of cardiology, 1998, Sep-03, Volume: 82, Issue:5A Topics: Acetylcarnitine; Animals; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Fatty Acids; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Fluid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents; Ventricular Function, Left; Ventricular Pressure	1998
Mechanisms of fatigue-induced activation of group IV muscle afferents: the roles played by lactic acid and inflammatory mediators. Neuroscience letters, 1998, Nov-27, Volume: 257, Issue:2 Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dichloroacetic Acid; Electric Stimulation; Hindlimb; Inflammation Mediators; Lactic Acid; Muscle Fatigue; Muscle, Skeletal; Neurons, Afferent; Rabbits; Veins	1998
Pharmacokinetics and pharmacodynamics of dichloroacetate in patients with cirrhosis. Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:4 Topics: Adult; Blood Glucose; Case-Control Studies; Dichloroacetic Acid; Female; Humans; Hypoglycemia; Lactic Acid; Liver; Liver Cirrhosis; Male; Middle Aged; Time Factors	1999
Depletion of lactate by dichloroacetate reduces cardiac efficiency after hemorrhagic shock. Shock (Augusta, Ga.), 2000, Volume: 14, Issue:2 Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Drug Evaluation, Preclinical; Energy Metabolism; Enzyme Activation; Fatty Acids; Fluid Therapy; Hemodynamics; Isotonic Solutions; Lactic Acid; Myocardium; Pyruvate Dehydrogenase Complex; Resuscitation; Ringer's Lactate; Shock, Hemorrhagic	2000
Dichloroacetate reduces diaphragmatic lactate formation but impairs respiratory performance. American journal of respiratory and critical care medicine, 2001, Nov-01, Volume: 164, Issue:9 Topics: Airway Resistance; Analysis of Variance; Animals; Dichloroacetic Acid; In Vitro Techniques; Lactic Acid; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Respiratory Insufficiency; Respiratory Mechanics; Respiratory Muscles	2001
Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:1 Topics: Adult; Dichloroacetic Acid; Enzyme Activation; Humans; Lactic Acid; Male; Muscle, Skeletal; Oxygen; Oxygen Consumption; Phosphocreatine; Physical Exertion; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Regional Blood Flow; Thigh	2002
Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. The Journal of physiology, 2002, Jan-01, Volume: 538, Issue:Pt 1 Topics: Acetylcarnitine; Adenosine Triphosphate; Animals; Dichloroacetic Acid; Dogs; Enzyme Activation; Female; Homeostasis; In Vitro Techniques; Kinetics; Lactic Acid; Male; Muscle Contraction; Muscle, Skeletal; Oxygen Consumption; Pyruvate Dehydrogenase Complex	2002
Renal manifestations of congenital lactic acidosis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 39, Issue:1 Topics: Acidosis, Lactic; Adolescent; Adult; Bicarbonates; Blood Urea Nitrogen; Calcium; Child; Child, Preschool; Creatinine; Dichloroacetic Acid; Female; Humans; Infant; Kidney Diseases; Kidney Tubules; Lactic Acid; Male; Parathyroid Hormone; Phosphates; Pyruvate Dehydrogenase Complex Deficiency Disease; Treatment Outcome; Vitamin D	2002
Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries. The Journal of physiology, 2002, Feb-15, Volume: 539, Issue:Pt 1 Topics: Animals; Coronary Vessels; Dichloroacetic Acid; Dose-Response Relationship, Drug; Extracellular Space; Glucose; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techniques; Lactic Acid; Pressure; Swine; Vasodilation	2002
Is lactate a mediator of hypoxia-induced anapyrexia? Pflugers Archiv : European journal of physiology, 2002, Volume: 444, Issue:6 Topics: Animals; Body Temperature; Body Temperature Regulation; Dichloroacetic Acid; Fever; Hypoxia; Lactic Acid; Male; Oxygen; Rats; Rats, Wistar	2002
[Adverse effects of dichloroacetate in a girl with mitochondrial disorder]. No to hattatsu = Brain and development, 2003, Volume: 35, Issue:1 Topics: Administration, Oral; Central Nervous System; Child, Preschool; Dichloroacetic Acid; Dose-Response Relationship, Drug; Electroencephalography; Female; Hepatomegaly; Humans; Hypokinesia; Lactic Acid; Mitochondrial Diseases	2003
Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo. Proceedings of the National Academy of Sciences of the United States of America, 2003, Apr-15, Volume: 100, Issue:8 Topics: Animals; Astrocytes; Brain; Cells, Cultured; Citric Acid Cycle; Dichloroacetic Acid; Glucose; In Vitro Techniques; Kinetics; Lactic Acid; Male; Neurons; Oxidation-Reduction; Rats; Rats, Sprague-Dawley	2003
Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans. Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 95, Issue:3 Topics: Adenosine Triphosphate; Adult; Algorithms; Dichloroacetic Acid; Exercise; Humans; Hydrogen-Ion Concentration; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Models, Biological; Muscle, Skeletal; Oxygen Consumption; Phosphates; Phosphocreatine; Pulmonary Gas Exchange; Pyruvate Dehydrogenase Complex	2003
Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:1 Topics: Acetyl Coenzyme A; Alanine; Animals; Buffers; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Glucose; Heart; Heart Function Tests; Heart Rate; Hypoglycemic Agents; In Vitro Techniques; Insulin; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Myocardium; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Ventricular Function, Left	2003
Lactate as a modulator of hypoxia-induced hyperventilation. Respiratory physiology & neurobiology, 2003, Oct-16, Volume: 138, Issue:1 Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Enzyme Inhibitors; Hyperventilation; Hypoxia; Lactic Acid; Male; Oxygen Consumption; Pulmonary Ventilation; Rats; Rats, Wistar; Respiration	2003
The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion. Journal of the American College of Surgeons, 2003, Volume: 197, Issue:4 Topics: Animals; Dichloroacetic Acid; Disease Models, Animal; Female; Hindlimb; Ischemia; Lactic Acid; Muscle, Skeletal; Necrosis; Oxygen; Rabbits; Regional Blood Flow; Reperfusion	2003
Effects of dichloroacetate and ubiquinone infusions on glycolysis activity and thermal sensitivity during sepsis. The Journal of laboratory and clinical medicine, 2004, Volume: 143, Issue:6 Topics: Animals; Body Temperature Regulation; Coenzymes; Dichloroacetic Acid; Electron Transport Complex III; Enzyme Activation; Glucose; Glycolysis; Infusions, Intravenous; Lactic Acid; Male; Mitochondria; Muscle, Skeletal; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; Sepsis; Ubiquinone	2004
Chasing the "ghost" of the acetyl group deficit. Medicine and science in sports and exercise, 2005, Volume: 37, Issue:1 Topics: Dichloroacetic Acid; Enzyme Activation; Exercise; Humans; Kinetics; Lactic Acid; Oxygen Consumption; Physical Exertion; Pyruvate Dehydrogenase Complex	2005
A case of Melas (A3243G) on chronic dichloroacetate treatment. European neurology, 2006, Volume: 55, Issue:1 Topics: Adolescent; Brain Ischemia; Dichloroacetic Acid; Disease Progression; DNA Mutational Analysis; Dominance, Cerebral; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; Lactic Acid; Long-Term Care; Male; MELAS Syndrome; Neuritis; Occipital Lobe; Temporal Lobe; Tomography, Emission-Computed, Single-Photon	2006
Lactate interferes with ATP release from red blood cells. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6 Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Dichloroacetic Acid; Erythrocytes; Hydrogen-Ion Concentration; In Vitro Techniques; Lactic Acid; Oxygen; Partial Pressure; Rabbits	2007
Differential effects of in vivo and in vitro lactate treatments on liver carbohydrate metabolism of rainbow trout. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2008, Volume: 151, Issue:2 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amino Acids; Animals; Blood Glucose; Carbohydrate Metabolism; Cinnamates; Deoxyglucose; Dichloroacetic Acid; Dose-Response Relationship, Drug; Glucokinase; Glycogen; Injections, Intraperitoneal; Lactate Dehydrogenases; Lactic Acid; Liver; Oncorhynchus mykiss; Sodium Chloride; Time Factors	2008
Restoration of electron transport without proton pumping in mammalian mitochondria. Proceedings of the National Academy of Sciences of the United States of America, 2008, Dec-02, Volume: 105, Issue:48 Topics: Animals; Cell Line; Dichloroacetic Acid; DNA, Mitochondrial; Electron Transport; Electron Transport Complex I; Fungal Proteins; Humans; Lactic Acid; Mice; Mitochondria; Mitochondrial Proteins; NADH Dehydrogenase; Oxidation-Reduction; Oxidoreductases; Oxygen; Plant Proteins; Proton Pumps; Protons; Pyruvic Acid; Saccharomyces cerevisiae Proteins; Transformation, Genetic; Ubiquinone; Uridine	2008
No acetyl group deficit is evident at the onset of exercise at 90% of maximal oxygen uptake in humans. Journal of sports sciences, 2010, Volume: 28, Issue:3 Topics: Acetylation; Acetylcarnitine; Adenosine Triphosphate; Adult; Creatine; Dichloroacetic Acid; Energy Metabolism; Exercise; Glycogen; Humans; Infusions, Intravenous; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Phosphocreatine; Phosphorylation; Pulmonary Gas Exchange; Pyruvate Dehydrogenase Complex	2010
Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. British journal of cancer, 2010, Jun-08, Volume: 102, Issue:12 Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dichloroacetic Acid; Enzyme Inhibitors; G2 Phase; Humans; Lactic Acid; Oxygen; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase	2010
Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion. Human molecular genetics, 2010, Aug-15, Volume: 19, Issue:16 Topics: Acidosis, Lactic; Animals; Behavior, Animal; Cell Respiration; Dichloroacetic Acid; Disease Models, Animal; DNA, Mitochondrial; Electron Transport Complex IV; Female; Gene Expression; Genes, Mitochondrial; Humans; Lactic Acid; Male; Mice; Mice, Inbred Strains; Mitochondria; Mitochondrial Diseases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Sequence Deletion; Trans-Activators; Transcription Factors	2010
Enhanced production and isotope enrichment of recombinant glycoproteins produced in cultured mammalian cells. Journal of biomolecular NMR, 2010, Volume: 48, Issue:2 Topics: Amino Acids; Animals; Carbon Isotopes; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Dichloroacetic Acid; Glucose; Glycoproteins; Isotope Labeling; Lactic Acid; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Recombinant Proteins	2010
Skeletal muscle metabolic gene expression is not affected by dichloroacetate-mediated modulation of substrate utilisation. Annals of nutrition & metabolism, 2011, Volume: 58, Issue:1 Topics: Adult; Dichloroacetic Acid; Fasting; Gene Expression Regulation; Humans; Immunoblotting; Infusions, Intravenous; Insulin; Lactic Acid; Male; Muscle, Skeletal; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Complex; Reverse Transcriptase Polymerase Chain Reaction	2011
Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene. Brain & development, 2012, Volume: 34, Issue:2 Topics: Alanine; Cells, Cultured; Child, Preschool; Dichloroacetic Acid; Electroencephalography; Fibroblasts; Humans; Lactic Acid; Leigh Disease; Male; Mutation; Pyruvate Dehydrogenase (Lipoamide); Pyruvic Acid; Statistics, Nonparametric	2012
The role of low-level lactate production in airway inflammation in asthma. American journal of physiology. Lung cellular and molecular physiology, 2012, Feb-01, Volume: 302, Issue:3 Topics: Adult; Aged; Animals; Asthma; Case-Control Studies; Cell Proliferation; Cells, Cultured; Cytokines; Dichloroacetic Acid; Female; Forkhead Transcription Factors; Gene Expression; Humans; Lactic Acid; Lung; Male; Mice; Mice, Inbred BALB C; Middle Aged; Protein Serine-Threonine Kinases; Pulmonary Disease, Chronic Obstructive; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Respiratory System; T-Lymphocytes; Young Adult	2012
Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism. NMR in biomedicine, 2012, Volume: 25, Issue:10 Topics: Animals; Carbon Isotopes; Dichloroacetic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Metabolome; Myocardium; Rats; Rats, Wistar; Time Factors	2012
Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2012, Volume: 188, Issue:5 Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Cell Proliferation; Coumaric Acids; Dichloroacetic Acid; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Hydrogen-Ion Concentration; Lactic Acid; Mice; Oxamic Acid; Oxygen Consumption; Transplantation, Heterologous	2012
Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy? Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 29, Issue:3-4 Topics: Acetyl Coenzyme A; Apoptosis; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Culture Media; Dichloroacetic Acid; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Lactic Acid; Mitochondria; Neuroblastoma; Oxidative Phosphorylation; Oxygen; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Reactive Oxygen Species	2012
Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation. Chemico-biological interactions, 2012, Jul-30, Volume: 199, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Culture Media, Conditioned; Cytokines; Dichloroacetic Acid; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; Hydrogen-Ion Concentration; Lactic Acid; Lymphoma, T-Cell; Male; Mice; Mice, Inbred BALB C; Monocarboxylic Acid Transporters; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Reactive Oxygen Species; Symporters; Thymocytes	2012
Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression. Journal of neuroscience methods, 2012, Aug-15, Volume: 209, Issue:2 Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Brain; Computer Simulation; Dichloroacetic Acid; Disease Models, Animal; Disease Progression; Female; Genotype; Humans; Lactic Acid; Male; Mice; Mice, Knockout; Muscle, Skeletal; Muscular Atrophy, Spinal; Mutation; Predictive Value of Tests; Survival Analysis; Survival of Motor Neuron 2 Protein	2012
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target. International journal of oncology, 2013, Volume: 42, Issue:1 Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Antimetabolites, Antineoplastic; Blotting, Western; Carcinoma, Signet Ring Cell; Cell Survival; Dichloroacetic Acid; Female; Fluorouracil; Glucose; Glucose Transporter Type 1; Glycolysis; Hexokinase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoenzyme Techniques; Lactic Acid; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Stomach Neoplasms; Survival Rate; Tissue Array Analysis; Tumor Cells, Cultured	2013
PDK1 inhibition is a novel therapeutic target in multiple myeloma. British journal of cancer, 2013, Jan-15, Volume: 108, Issue:1 Topics: Boronic Acids; Bortezomib; Cell Line, Tumor; Dichloroacetic Acid; Glucose; Glycolysis; Humans; Lactate Dehydrogenases; Lactic Acid; Molecular Targeted Therapy; Multiple Myeloma; Protein Serine-Threonine Kinases; Pyrazines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; RNA, Small Interfering	2013
Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity. International journal of cancer, 2013, Sep-01, Volume: 133, Issue:5 Topics: Animals; Arginase; Cell Line, Tumor; Dichloroacetic Acid; Female; Glycolysis; Interferon-gamma; Interleukin-17; Interleukin-23 Subunit p19; Lactic Acid; Lymphocyte Activation; Macrophages; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Poly I-C; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase	2013
Long-term safety of dichloroacetate in congenital lactic acidosis. Molecular genetics and metabolism, 2013, Volume: 109, Issue:2 Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; Lactic Acid; Male; Middle Aged; Randomized Controlled Trials as Topic; Treatment Outcome; Young Adult	2013
Lactate is a possible mediator of the glucose effect on platelet inhibition. Platelets, 2014, Volume: 25, Issue:4 Topics: Adult; Aged; Arginine; Aspirin; Blood Glucose; Blood Platelets; Dichloroacetic Acid; Female; Glucose; Glucose Transport Proteins, Facilitative; Humans; Lactic Acid; Male; Middle Aged; Nitroprusside; omega-N-Methylarginine; Platelet Aggregation; Platelet Aggregation Inhibitors; S-Nitrosoglutathione; Young Adult	2014
High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer chemotherapy and pharmacology, 2014, Volume: 73, Issue:3 Topics: Caspase 3; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Glucose; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Pancreatic Neoplasms; Phosphorylation; Pyruvate Dehydrogenase Complex; Reactive Oxygen Species; Thiamine	2014
Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate. ACS chemical biology, 2014, May-16, Volume: 9, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dichloroacetic Acid; Drug Carriers; Drug Delivery Systems; Glucose; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Neoplasms; Organophosphorus Compounds; Protein Kinase Inhibitors	2014
Dichloroacetate induces autophagy in colorectal cancer cells and tumours. British journal of cancer, 2014, Jul-15, Volume: 111, Issue:2 Topics: Animals; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Colorectal Neoplasms; Dichloroacetic Acid; Female; HCT116 Cells; HT29 Cells; Humans; Lactic Acid; Mice; Mice, Nude; Microscopy, Electron; NAD; Random Allocation; Reactive Oxygen Species; TNF-Related Apoptosis-Inducing Ligand; TOR Serine-Threonine Kinases	2014
Dichloroacetate selectively improves cardiac function and metabolism in female and male rainbow trout. American journal of physiology. Heart and circulatory physiology, 2014, Nov-15, Volume: 307, Issue:10 Topics: Animals; Calcium; Cardiac Pacing, Artificial; Citric Acid; Dichloroacetic Acid; Energy Metabolism; Enzyme Activation; Enzyme Activators; Female; Glucose; Heart Ventricles; Hypoxia; Lactic Acid; Male; Myocardial Contraction; Myocardium; Oncorhynchus mykiss; Phenotype; Pyruvate Dehydrogenase (Lipoamide); Sex Factors; Ventricular Dysfunction; Ventricular Function	2014
Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth. Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:21 Topics: Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Dichloroacetic Acid; Glycolysis; Hedgehog Proteins; Hexokinase; Immunohistochemistry; Lactic Acid; Medulloblastoma; Mice; Mice, Nude; Oncogene Proteins; Protein Kinase Inhibitors; Pyruvate Kinase; RNA, Messenger; Signal Transduction; Trans-Activators; Transplantation, Homologous; Zinc Finger Protein GLI1	2014
Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. Experimental cell research, 2015, Feb-01, Volume: 331, Issue:1 Topics: Blotting, Western; Cell Proliferation; Colorectal Neoplasms; Dichloroacetic Acid; Flow Cytometry; Glucose; Humans; Hypoxia; Ketone Oxidoreductases; Lactic Acid; Mitochondria; Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured	2015
Hypoxia enhances antitumor activity of dichloroacetate. Experimental oncology, 2014, Volume: 36, Issue:4 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Glioma; Humans; Hyperoxia; Hypoxia; Inhibitory Concentration 50; Lactic Acid; Necrosis; Neoplasms; Reactive Oxygen Species	2014
Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF. American journal of physiology. Heart and circulatory physiology, 2015, Volume: 309, Issue:9 Topics: Animals; Dichloroacetic Acid; Heart; Lactic Acid; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; NAD; Phosphorylation; Pressure; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Left; Ventricular Fibrillation; Ventricular Function, Left	2015
Hyperpolarized 13C NMR observation of lactate kinetics in skeletal muscle. The Journal of experimental biology, 2015, Volume: 218, Issue:Pt 20 Topics: Animals; Bicarbonates; Carbon-13 Magnetic Resonance Spectroscopy; Dichloroacetic Acid; Glutamic Acid; Lactic Acid; Male; Muscle, Skeletal; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley	2015
Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. Journal of pain & palliative care pharmacotherapy, 2015, Volume: 29, Issue:3 Topics: Acidosis; Aldehyde Dehydrogenase; Dichloroacetic Acid; Formaldehyde; Glutathione; Humans; Hydrogen-Ion Concentration; Lactic Acid; Neoplasms; Pain; Pain Management; Quality of Life; Resveratrol; Sodium Bicarbonate; Stilbenes	2015
Aconitine-containing agent enhances antitumor activity of dichloroacetate against Ehrlich carcinoma. Experimental oncology, 2015, Volume: 37, Issue:3 Topics: Aconitine; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Dichloroacetic Acid; Disease Models, Animal; Drug Synergism; Humans; Lactate Dehydrogenases; Lactic Acid; Mice; Nitric Oxide; Reactive Oxygen Species; Tumor Burden; Xenograft Model Antitumor Assays	2015
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus. Journal of immunology (Baltimore, Md. : 1950), 2016, Jan-01, Volume: 196, Issue:1 Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Glucose; Interferon-gamma; Interleukin-17; Lactic Acid; Lupus Erythematosus, Systemic; Lymphocyte Activation; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Pyruvic Acid	2016
Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells. Oncotarget, 2016, Sep-13, Volume: 7, Issue:37 Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Dichloroacetic Acid; Drug Synergism; Drug Therapy, Combination; Female; Growth Inhibitors; Humans; Lactic Acid; Metformin; Mice; Mice, Nude; Ovarian Neoplasms; Xenograft Model Antitumor Assays	2016
Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models. Oncotarget, 2016, Dec-06, Volume: 7, Issue:49 Topics: Antineoplastic Agents; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Energy Metabolism; Enzyme Inhibitors; Female; Glycolysis; Humans; Lactic Acid; Magnetic Resonance Imaging; Oxidation-Reduction; Oxygen Consumption; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvic Acid; Time Factors; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays	2016
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions. PloS one, 2017, Volume: 12, Issue:5 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dichloroacetic Acid; Drug Synergism; Gene Expression; Humans; Hypoxia; Immunohistochemistry; Lactic Acid; Molecular Targeted Therapy; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Reactive Oxygen Species; Retinoblastoma	2017
Dichloroacetate affects proliferation but not apoptosis in canine mammary cell lines. PloS one, 2017, Volume: 12, Issue:6 Topics: Animals; Apoptosis; Cell Count; Cell Line; Cell Proliferation; Cell Respiration; Dichloroacetic Acid; Dogs; Female; Inhibitor of Apoptosis Proteins; Lactic Acid; Mammary Glands, Animal; MicroRNAs; Microscopy, Fluorescence; Mitochondria; Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Time Factors	2017
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors. Journal of proteome research, 2018, 09-07, Volume: 17, Issue:9 Topics: A549 Cells; Acetyl Coenzyme A; Anilides; Antineoplastic Agents; Chromatography, Liquid; Citric Acid Cycle; Cytosol; Dichloroacetic Acid; Gene Expression Regulation; Glucose; Glycolysis; Humans; Isoenzymes; Lactic Acid; Mitochondria; Oxidative Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvic Acid; Tandem Mass Spectrometry	2018
Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis. Medical hypotheses, 2019, Volume: 122 Topics: Acetates; Acetyl Coenzyme A; Animals; Antineoplastic Agents; Brain Neoplasms; Chlorides; Dichloroacetic Acid; Evidence-Based Medicine; Glioblastoma; Heart; Humans; Ketones; Lactic Acid; Models, Theoretical; Neoplasms; Oxygen; Perfusion; Rats	2019
Regulation of lactate production through p53/β-enolase axis contributes to statin-associated muscle symptoms. EBioMedicine, 2019, Volume: 45 Topics: Animals; Dichloroacetic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactic Acid; Lovastatin; Mice; Muscle, Skeletal; Phosphopyruvate Hydratase; Physical Conditioning, Animal; Tumor Suppressor Protein p53	2019
Metformin enhances cytotoxic action of dichloroacetate against Lewis lung carcinoma cells in vitro. Experimental oncology, 2020, Volume: 42, Issue:1 Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Synergism; Glucose; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Metformin	2020
Distal control of mitochondrial biogenesis and respiratory activity by extracellular lactate caused by large-scale deletion of mitochondrial DNA. Pharmacological research, 2020, Volume: 160 Topics: Animals; Calcium Signaling; Cell Line; Citric Acid Cycle; Dichloroacetic Acid; DNA, Mitochondrial; Extracellular Space; Gene Deletion; HeLa Cells; Humans; Lactic Acid; Mice; Mutation; Organelle Biogenesis; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha	2020
Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis. PloS one, 2020, Volume: 15, Issue:11 Topics: Acetyl Coenzyme A; Animals; Citric Acid Cycle; Dichloroacetic Acid; Drosophila melanogaster; Glycolysis; Inflammation; Lactic Acid; Longevity; Oxidative Phosphorylation; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Sepsis	2020
Dysfunction in Sertoli cells participates in glucocorticoid-induced impairment of spermatogenesis. Molecular reproduction and development, 2021, Volume: 88, Issue:6 Topics: Animals; Calcium-Binding Proteins; Corticosterone; Cushing Syndrome; Dichloroacetic Acid; Follicle Stimulating Hormone; Glucocorticoids; Lactic Acid; Luteinizing Hormone; Male; Meiosis; Membrane Potential, Mitochondrial; Mice; Orchitis; Phagocytosis; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptors, G-Protein-Coupled; Sertoli Cells; Sperm Count; Spermatogenesis; Spermatozoa; Testis; Testosterone	2021
Restricting tumor lactic acid metabolism using dichloroacetate improves T cell functions. BMC cancer, 2022, Jan-06, Volume: 22, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Glycolysis; Humans; Lactic Acid; Lymphocyte Activation; Oxidation-Reduction; Reactive Oxygen Species; T-Lymphocytes; Tumor Microenvironment	2022
A Sub-6 nm MnFe Biomaterials, 2022, Volume: 284 Topics: Adenosine; Adenosine Triphosphate; Cell Line, Tumor; Dichloroacetic Acid; Glucose; Immunosuppressive Agents; Immunotherapy; Lactic Acid; Nanocomposites; Tumor Microenvironment	2022
Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma. American journal of physiology. Endocrinology and metabolism, 2023, 10-01, Volume: 325, Issue:4 Topics: Animals; Dichloroacetic Acid; Fatigue; Lactic Acid; Melanoma; Mice; Quality of Life	2023