lactic acid and deoxycytidine

lactic acid has been researched along with deoxycytidine in 29 studies

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (3.45)	18.2507
2000's	3 (10.34)	29.6817
2010's	22 (75.86)	24.3611
2020's	3 (10.34)	2.80

Authors

Authors	Studies
Brown, TJ; Jain, RK; Kristjansen, PE; Shipley, LA	1
Brundage, RC; Elmquist, WF; Guire, DE; Kirstein, MN; Marker, PH; Remmel, RP; Yee, D	1
Melkaoui, K; Setzer, B; Venhoff, N; Walker, UA	1
Armand, R; Kintner, J; Lewis, LD; Perez, R; Yeo, TK	1
Berenberg, JL; Christian, D; Delaune, R; Loprinzi, CL; Menon, SP; Pajon, ER; Qin, R; Rowland, KM; Satele, DV; Thomas, S; Wolf, SL	1
Aggarwal, S; Gupta, S; Yadav, S	1
Banerjee, D; Basu, S; Harfouche, R; Papa, AL; Sengupta, P; Sengupta, S	1
Celano, M; Cosco, D; Fresta, M; Moretti, S; Paolino, D; Puxeddu, E; Russo, D	1
Cui, Z; Kumar, A; Lansakara-P, DS; Li, X; Zhu, S	1
Arias, JL; Durán-Lobato, MM; Holgado, MÁ; Martín-Banderas, L; Melguizo, C; Prados, JC; Sáez-Fernández, E	1
Gabor, F; Kählig, H; Neutsch, L; Pichl, C; Spijker, S; Wirth, EM; Wirth, M	1
Gabor, F; Kählig, H; Neutsch, L; Spijker, S; Wambacher, M; Wirth, EM; Wirth, M	1
Chitkara, D; Kumar, N	1
Pai, RS; Singh, G	2
Alam, N; Dubey, RD; Gupta, AP; Gupta, PN; Khare, V; Koul, M; Kour, S; Saneja, A; Saxena, AK; Singh, D; Singh, SK	1
Joshi, G; Kumar, A; Sawant, K	1
Jaidev, LR; Krishnan, UM; Sethuraman, S	1
Chen, G; Svirskis, D; Wen, J	1
Devulapally, R; Foygel, K; Paulmurugan, R; Sekar, TV; Willmann, JK	1
Ark, M; Ibisoglu, B; Ilbasmis-Tamer, S; Özdemir, A; Takka, S; Yalcin, TE	1
Fei, S; He, H; Liang, Y; Tang, X; Wang, X; Yin, T; Zhang, Y	1
Alkaff, SMF; Chan, CY; Chan, ECY; Goh, S; Kam, JH; Leow, WQ; Lim, TKH; Phua, LC; Tai, DWM	1
Esumi, H; Fujioka, R; Ikeda, M; Kishino, S; Mochizuki, N; Nomura, S; Owada, S; Sato, A; Tsuchihara, K; Yomoda, S	1
Huang, C; Kwon, GS; Poellmann, M; Tam, YT	1
Ilbasmis-Tamer, S; Takka, S; Yalcin, TE	1
Fu, X; Mao, L; Qiu, YD; Tang, N; Xie, WQ	1
Cui, J; Guo, Y; Peng, T; Wu, H; Xiong, J	1
Feng, M; Gu, Z; He, Y; Kong, X; Mao, H; Wu, L	1

Trials

2 trial(s) available for lactic acid and deoxycytidine

Article	Year
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35 Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind Method; Drug Combinations; Female; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Keratolytic Agents; Lactic Acid; Male; Middle Aged; Neoplasms; Syndrome; Urea	2010
Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer. PloS one, 2018, Volume: 13, Issue:6 Topics: Antineoplastic Agents, Phytogenic; Arctium; Area Under Curve; Biomarkers; Carcinoma, Adenosquamous; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Furans; Gemcitabine; Gluconeogenesis; Humans; Kaplan-Meier Estimate; Kidney; Lactic Acid; Lignans; Liver; Mitochondria; Oxidative Phosphorylation; Pancreatic Neoplasms; Plant Extracts	2018

Article

Year

Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35

Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind Method; Drug Combinations; Female; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Keratolytic Agents; Lactic Acid; Male; Middle Aged; Neoplasms; Syndrome; Urea

2010

Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer.

PloS one, 2018, Volume: 13, Issue:6

Topics: Antineoplastic Agents, Phytogenic; Arctium; Area Under Curve; Biomarkers; Carcinoma, Adenosquamous; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Furans; Gemcitabine; Gluconeogenesis; Humans; Kaplan-Meier Estimate; Kidney; Lactic Acid; Lignans; Liver; Mitochondria; Oxidative Phosphorylation; Pancreatic Neoplasms; Plant Extracts

2018

Other Studies

27 other study(ies) available for lactic acid and deoxycytidine

Article	Year
Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Small Cell; Deoxycytidine; Female; Gemcitabine; Humans; Lactic Acid; Lung Neoplasms; Mice; Mice, Nude; Oxygen Consumption	1996
Characterization of an in vitro cell culture bioreactor system to evaluate anti-neoplastic drug regimens. Breast cancer research and treatment, 2006, Volume: 96, Issue:3 Topics: Antimetabolites, Antineoplastic; Area Under Curve; Bioreactors; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Deoxycytidine; Female; Flow Cytometry; Gemcitabine; Humans; Lactic Acid	2006
Mitochondrial toxicity of tenofovir, emtricitabine and abacavir alone and in combination with additional nucleoside reverse transcriptase inhibitors. Antiviral therapy, 2007, Volume: 12, Issue:7 Topics: Adenine; Anti-HIV Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Dideoxynucleosides; DNA, Mitochondrial; Emtricitabine; Humans; Lactic Acid; Lipid Metabolism; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir	2007
Sublethal concentrations of gemcitabine (2',2'-difluorodeoxycytidine) alter mitochondrial ultrastructure and function without reducing mitochondrial DNA content in BxPC-3 human pancreatic carcinoma cells. Human & experimental toxicology, 2007, Volume: 26, Issue:12 Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Deoxycytidine; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Inhibitory Concentration 50; Lactic Acid; Mitochondria; Pancreatic Neoplasms; Reverse Transcriptase Inhibitors; Zalcitabine	2007
EGFR targeted PLGA nanoparticles using gemcitabine for treatment of pancreatic cancer. Journal of biomedical nanotechnology, 2011, Volume: 7, Issue:1 Topics: Antibodies, Monoclonal; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Compounding; ErbB Receptors; Gemcitabine; Humans; Lactic Acid; Nanocapsules; Pancreatic Neoplasms; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Treatment Outcome	2011
Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells. BMC cancer, 2012, Sep-22, Volume: 12 Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cholesterol; Deoxycytidine; Gemcitabine; Humans; Lactic Acid; Liposomes; Microscopy, Electron, Transmission; Nanotechnology; Pancreatic Neoplasms; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2012
Gemcitabine-loaded biocompatible nanocapsules for the effective treatment of human cancer. Nanomedicine (London, England), 2013, Volume: 8, Issue:2 Topics: Animals; Cell Line; Cell Survival; Deoxycytidine; Gemcitabine; HEK293 Cells; Humans; Lactic Acid; Mice; Mice, Inbred NOD; Mice, SCID; Microscopy, Confocal; Nanocapsules; Nanomedicine; Polyesters; Polymers; Treatment Outcome; Xenograft Model Antitumor Assays	2013
A nanoparticle depot formulation of 4-(N)-stearoyl gemcitabine shows a strong anti-tumour activity. The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:2 Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Deoxycytidine; Female; Lactic Acid; Mice; Mice, Inbred C57BL; Microspheres; Nanoparticles; Neoplasms; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2013
Biocompatible gemcitabine-based nanomedicine engineered by Flow Focusing for efficient antitumor activity. International journal of pharmaceutics, 2013, Feb-25, Volume: 443, Issue:1-2 Topics: Antimetabolites, Antineoplastic; Biocompatible Materials; Cell Survival; Colloids; Deoxycytidine; Drug Carriers; Drug Compounding; Female; Gemcitabine; Humans; Lactic Acid; MCF-7 Cells; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Technology, Pharmaceutical	2013
Synergistic targeting/prodrug strategies for intravesical drug delivery--lectin-modified PLGA microparticles enhance cytotoxicity of stearoyl gemcitabine by contact-dependent transfer. Journal of controlled release : official journal of the Controlled Release Society, 2013, Jul-10, Volume: 169, Issue:1-2 Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Gemcitabine; Humans; Lactic Acid; Lectins; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prodrugs; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium	2013
UPEC biomimickry at the urothelial barrier: lectin-functionalized PLGA microparticles for improved intravesical chemotherapy. International journal of pharmaceutics, 2013, Jun-25, Volume: 450, Issue:1-2 Topics: Administration, Intravesical; Antineoplastic Agents; Biomimetic Materials; Cell Adhesion; Cell Line, Tumor; Cell Survival; Deoxycytidine; Doxorubicin; Drug Carriers; Gemcitabine; Humans; Lactic Acid; Mitomycin; Phosphatidylcholines; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prodrugs; Stearic Acids; Urinary Bladder Neoplasms; Urothelium; Wheat Germ Agglutinins	2013
BSA-PLGA-based core-shell nanoparticles as carrier system for water-soluble drugs. Pharmaceutical research, 2013, Volume: 30, Issue:9 Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Carriers; Gemcitabine; Humans; Lactic Acid; Nanoparticles; Osteosarcoma; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Serum Albumin, Bovine; Solubility; Water	2013
Pharmacokinetics and in vivo biodistribution of optimized PLGA nanoparticulate drug delivery system for controlled release of emtricitabine. Drug delivery, 2014, Volume: 21, Issue:8 Topics: Animals; Antiviral Agents; Chemistry, Pharmaceutical; Delayed-Action Preparations; Deoxycytidine; Drug Delivery Systems; Drug Stability; Emtricitabine; Excipients; Lactic Acid; Male; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Reproducibility of Results; Tissue Distribution	2014
Optimization (central composite design) and validation of HPLC method for investigation of emtricitabine loaded poly(lactic-co-glycolic acid) nanoparticles: in vitro drug release and in vivo pharmacokinetic studies. TheScientificWorldJournal, 2014, Volume: 2014 Topics: Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Deoxycytidine; Emtricitabine; In Vitro Techniques; Lactic Acid; Limit of Detection; Male; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet	2014
Synthesis, characterization and mechanistic-insight into the anti-proliferative potential of PLGA-gemcitabine conjugate. International journal of pharmaceutics, 2014, Aug-15, Volume: 470, Issue:1-2 Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Gemcitabine; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Nucleoside Transport Proteins; Poly(ADP-ribose) Polymerases; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2014
Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Aug-18, Volume: 60 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Availability; Caco-2 Cells; Cell Survival; Deoxycytidine; Gemcitabine; Humans; Intestinal Absorption; Intestinal Mucosa; K562 Cells; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Wistar	2014
Gemcitabine loaded biodegradable PLGA nanospheres for in vitro pancreatic cancer therapy. Materials science & engineering. C, Materials for biological applications, 2015, Volume: 47 Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Gemcitabine; Humans; In Vitro Techniques; Lactic Acid; Microscopy, Confocal; Microscopy, Electron, Scanning; Nanospheres; Pancreatic Neoplasms; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2015
Development and validation of a stability indicating isocratic HPLC method for gemcitabine with application to drug release from poly lactic-co-glycolic acid nanoparticles and enzymatic degradation studies. The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:11 Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Carriers; Drug Liberation; Drug Stability; Drug Storage; Gemcitabine; Lactic Acid; Limit of Detection; Nanoparticles; Oxidation-Reduction; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Time Factors	2015
Gemcitabine and Antisense-microRNA Co-encapsulated PLGA-PEG Polymer Nanoparticles for Hepatocellular Carcinoma Therapy. ACS applied materials & interfaces, 2016, Dec-14, Volume: 8, Issue:49 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Gemcitabine; Humans; Lactic Acid; Liver Neoplasms; MicroRNAs; Nanoparticles; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2016
Gemcitabine hydrochloride-loaded liposomes and nanoparticles: comparison of encapsulation efficiency, drug release, particle size, and cytotoxicity. Pharmaceutical development and technology, 2018, Volume: 23, Issue:1 Topics: Cell Line, Tumor; Chemistry, Pharmaceutical; Deoxycytidine; Drug Liberation; Gemcitabine; Humans; Lactic Acid; Liposomes; MCF-7 Cells; Nanoparticles; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2018
Formulation and Pharmacokinetics of HSA-core and PLGA-shell Nanoparticles for Delivering Gemcitabine. AAPS PharmSciTech, 2018, Volume: 19, Issue:2 Topics: Delayed-Action Preparations; Deoxycytidine; Diffusion; Drug Carriers; Drug Liberation; Gemcitabine; Lactic Acid; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Serum Albumin, Human	2018
Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine. Cancer chemotherapy and pharmacology, 2018, Volume: 81, Issue:2 Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Biomarkers; Carcinoma, Pancreatic Ductal; Deoxycytidine; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; Female; Gas Chromatography-Mass Spectrometry; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Lactic Acid; Male; Metabolomics; Middle Aged; Pancreatic Neoplasms; Retrospective Studies; ROC Curve; Survival Analysis; Treatment Outcome	2018
Stereocomplex Prodrugs of Oligo(lactic acid) ACS nano, 2018, 07-24, Volume: 12, Issue:7 Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Drug Screening Assays, Antitumor; Female; Gemcitabine; Humans; Lactates; Lactic Acid; Mice; Mice, Nude; Micelles; Molecular Structure; Neoplasms, Experimental; Polyethylene Glycols; Prodrugs; Stereoisomerism	2018
Development and characterization of gemcitabine hydrochloride loaded lipid polymer hybrid nanoparticles (LPHNs) using central composite design. International journal of pharmaceutics, 2018, Sep-05, Volume: 548, Issue:1 Topics: Antimetabolites, Antineoplastic; Deoxycytidine; Drug Compounding; Drug Delivery Systems; Drug Liberation; Drug Stability; Gemcitabine; Lactic Acid; Nanoparticles; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer	2018
MUC1 promotes glycolysis through inhibiting BRCA1 expression in pancreatic cancer. Chinese journal of natural medicines, 2020, Volume: 18, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Fluorouracil; Gemcitabine; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Glucose; Glycolysis; Humans; Irinotecan; Lactic Acid; Leucovorin; Male; Mice, Nude; Mucin-1; Neoplasm Transplantation; Oxaliplatin; Pancreatic Neoplasms	2020
Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling. Molecular medicine (Cambridge, Mass.), 2021, 04-13, Volume: 27, Issue:1 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Survival; Deoxycytidine; Drug Resistance, Neoplasm; Everolimus; Gemcitabine; Glucose; Humans; Lactic Acid; Male; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases	2021
Biodegradable gemcitabine-loaded microdevice with sustained local drug delivery and improved tumor recurrence inhibition abilities for postoperative pancreatic tumor treatment. Drug delivery, 2022, Volume: 29, Issue:1 Topics: Animals; Cell Line, Tumor; Deoxycytidine; Drug Delivery Systems; Gemcitabine; Humans; Lactic Acid; Mice; Neoplasm Recurrence, Local; Pancreatic Neoplasms; Polyethylene Glycols	2022