lactic acid has been researched along with bromopyruvate in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 9 (45.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chapman, SK; Dubois, J; Lederer, F; Mathews, FS; Reid, GA | 1 |
| Cook, RA; Lang, VJ; Leystra-Lantz, C | 1 |
| Alliel, PM; Lederer, F; Urban, P | 1 |
| Bubb, WA; Jones, AR | 1 |
| Geschwind, JF; Ko, YH; Pedersen, PL | 1 |
| El-Mansi, M | 1 |
| Almeida, FC; Da Poian, AT; da-Silva, WS; dos Santos, RS; El-Bacha, T; Galina, A; Kyaw, N; Pereira da Silva, AP | 1 |
| Angenendt, P; Cheong, I; Diaz, LA; Kinzler, KW; Lengauer, C; Markowitz, S; Pagliarini, R; Papadopoulos, N; Rago, C; Rajagopalan, H; Schmidt, K; Velculescu, VE; Vogelstein, B; Willson, JK; Yun, J; Zhou, S | 1 |
| Chung, SP; Diem, TH; El Sayed, SM; El-Magd, RM; Fukui, K; Kagami, S; Sakai, T; Shishido, Y; Watanabe, H | 1 |
| Azevedo-Silva, J; Baltazar, F; Casal, M; Ko, YH; Moreira, R; Pacheco, A; Pedersen, PL; Pedro, M; Pinheiro, C; Preto, A; Queirós, O | 1 |
| Buijs, M; Ganapathy-Kanniappan, S; Geschwind, JF; Kwak, BK; Ota, S; Wijlemans, JW | 1 |
| Abdelaal, EA; Abdelmoaty, MA; Ahmed, NS; El Sawy, SA; El Sayed, SM; Fouad, AM; Gabr, AG; Hashim, MS; Hemdan, SB; Kadry, ZM; Mahmoud, AA; Nabo, MM; Omran, FM; Yousif, RS | 1 |
| Augustyniak, D; Bartkowiak, A; Goffeau, A; Gonchar, M; Ko, YH; Lis, P; Majkowska-Skrobek, G; Pedersen, PL; Ułaszewski, S | 1 |
| Abd-Allah, AA; Ahmed, AS; Ahmed, NS; Amer, WH; El Sayed, SM; Hamed, AR; Helmy Nabo, MM; Mahmoud, AG; Mohamed, WG; Seddik, MA | 1 |
| Arend, C; Dringen, R; Ehrke, E | 1 |
| Karagiannis, TC; Ngo, H; Tortorella, SM; Ververis, K | 1 |
| Futagi, Y; Ideno, M; Iseki, K; Kobayashi, M; Narumi, K; Sasaki, S | 1 |
| Dong, J; Dong, X; Jiang, Q; Li, H; Liu, J; Liu, L; Sheng, Y; Wang, H; Wang, L; Yang, X | 1 |
| Bastien, E; Corbet, C; De Smet, C; Feron, O; Guilbaud, C; Loriot, A; Martherus, R; Petit, L; Vander Linden, C; Wauthier, L | 1 |
| Chen, L; Gao, H; Li, J; Mao, Z; Min, Z; Qin, Q; Wang, CY; Wang, D; Xiong, Y; Xue, Z; Yan, M; Yuan, X; Zhang, J; Zhao, J; Zou, Y | 1 |
2 review(s) available for lactic acid and bromopyruvate
| Article | Year |
|---|---|
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Disease Progression; Drug Therapy, Combination; Enzyme Inhibitors; Glutathione; Glycolysis; Hexokinase; Humans; L-Lactate Dehydrogenase; Lactic Acid; Lung Neoplasms; Male; Melanoma; Necrosis; Neovascularization, Pathologic; Pleural Neoplasms; Prognosis; Pyruvates; Treatment Outcome | 2014 |
The Warburg effect: molecular aspects and therapeutic possibilities.
Topics: Antineoplastic Agents; Dichloroacetic Acid; Epigenesis, Genetic; Genes; Glycolysis; Humans; Lactic Acid; Neoplasms; Pyruvates | 2015 |
18 other study(ies) available for lactic acid and bromopyruvate
| Article | Year |
|---|---|
Substitution of Tyr254 with Phe at the active site of flavocytochrome b2: consequences on catalysis of lactate dehydrogenation.
Topics: Binding Sites; Catalysis; Deuterium; Fungal Proteins; Hydroxybutyrates; L-Lactate Dehydrogenase; L-Lactate Dehydrogenase (Cytochrome); Lactates; Lactic Acid; Models, Molecular; Phenylalanine; Protein Conformation; Pyruvates; Saccharomyces cerevisiae; Tyrosine | 1990 |
Characterization of the specific pyruvate transport system in Escherichia coli K-12.
Topics: Alanine; Biological Transport, Active; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Escherichia coli; Kinetics; Lactates; Lactic Acid; Methylphenazonium Methosulfate; Phosphotransferases; Phosphotransferases (Paired Acceptors); Pyruvates; Pyruvic Acid; Time Factors | 1987 |
On the transhydrogenase activity of baker's yeast flavocytochrome b2.
Topics: Heme; Kinetics; L-Lactate Dehydrogenase; L-Lactate Dehydrogenase (Cytochrome); Lactates; Lactic Acid; Oxidation-Reduction; Pyruvates; Saccharomyces cerevisiae | 1983 |
Substrates for endogenous metabolism by mature boar spermatozoa.
Topics: Acetates; Acetylcarnitine; Adenosine Triphosphate; Animals; Cells, Cultured; Diglycerides; Enzyme Inhibitors; Glycerol; Glycolysis; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Phospholipids; Pyruvate Dehydrogenase Complex; Pyruvates; Saponins; Spermatozoa; Swine; Triglycerides | 2000 |
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Cell Survival; Deoxyglucose; Drug Delivery Systems; Enzyme Inhibitors; Glucose; Glycolysis; Hexokinase; Kinetics; Lactic Acid; Liver; Liver Neoplasms, Experimental; Phenotype; Pyruvates; Rabbits | 2001 |
Flux to acetate and lactate excretions in industrial fermentations: physiological and biochemical implications.
Topics: Acetate Kinase; Acetates; Citric Acid; Coenzyme A; Enzyme Inhibitors; Escherichia coli; Gluconates; Glucose; Isocitrates; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Lactic Acid; Oxidation-Reduction; Phosphate Acetyltransferase; Pyruvates; Pyruvic Acid | 2004 |
Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate.
Topics: Adenosine Triphosphate; Carcinoma, Hepatocellular; Energy Metabolism; Enzyme Inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Humans; Lactic Acid; Liver Neoplasms; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Pyruvates; Succinate Dehydrogenase | 2009 |
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Gene Targeting; Genes, ras; Glucose; Glucose Transporter Type 1; Glycolysis; Humans; Lactic Acid; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins B-raf; Pyruvates; Transplantation, Heterologous | 2009 |
3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Survival; Citric Acid; D-Amino-Acid Oxidase; Electrophoresis, Polyacrylamide Gel; Glioblastoma; Glioma; Glycolysis; Humans; Hydrogen Peroxide; Immunoblotting; Lactic Acid; Oxidative Stress; Pyruvates; Pyruvic Acid; Tetrazolium Salts; Thiazoles | 2012 |
Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Breast Neoplasms; Butyrates; Cell Line, Tumor; Cell Survival; Chemotherapy, Adjuvant; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Lactic Acid; Monocarboxylic Acid Transporters; Muscle Proteins; Pyruvates; Tetrazolium Salts; Thiazoles | 2012 |
Ultrasound-guided direct delivery of 3-bromopyruvate blocks tumor progression in an orthotopic mouse model of human pancreatic cancer.
Topics: Adenosine Triphosphate; Animals; Cell Death; Cell Line, Tumor; Female; Humans; Ki-67 Antigen; Lactic Acid; Mice; Mice, Nude; Pancreatic Neoplasms; Pyruvates; Random Allocation; Ultrasonography, Interventional; Xenograft Model Antitumor Assays | 2013 |
Warburg effect increases steady-state ROS condition in cancer cells through decreasing their antioxidant capacities (anticancer effects of 3-bromopyruvate through antagonizing Warburg effect).
Topics: Citric Acid Cycle; Glucose-6-Phosphatase; Glycolysis; Humans; Lactic Acid; Models, Biological; Neoplasms; Pyruvates; Reactive Oxygen Species | 2013 |
Killing multiple myeloma cells with the small molecule 3-bromopyruvate: implications for therapy.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Benzamides; Buthionine Sulfoximine; Cell Survival; Glutathione; Humans; Imatinib Mesylate; Inhibitory Concentration 50; Lactic Acid; Monocarboxylic Acid Transporters; Multiple Myeloma; Piperazines; Pyrimidines; Pyruvates; Symporters; Tumor Cells, Cultured | 2014 |
3-bromopyruvate inhibits glycolysis, depletes cellular glutathione, and compromises the viability of cultured primary rat astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Brain; Cell Survival; Enzyme Inhibitors; Extracellular Fluid; Glucose; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Hexokinase; Lactic Acid; Pyruvates; Rats; Rats, Wistar; Temperature | 2015 |
Influence of high glucose state on bromopyruvate-induced cytotoxity by human colon cancer cell lines.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Down-Regulation; Glucose; Humans; Lactic Acid; Pyruvates | 2016 |
3-Bromopyruvate inhibits the malignant phenotype of malignantly transformed macrophages and dendritic cells induced by glioma stem cells in the glioma microenvironment via miR-449a/MCT1.
Topics: Cell Transformation, Neoplastic; Cells, Cultured; Dendritic Cells; Glioma; Lactic Acid; Macrophages; MicroRNAs; Monocarboxylic Acid Transporters; Neoplastic Stem Cells; Pyruvates; Symporters; Tumor Microenvironment | 2020 |
Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Respiration; DNA Methylation; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Lactic Acid; Mice; Models, Biological; Monocarboxylic Acid Transporters; Muscle Proteins; Phenotype; Promoter Regions, Genetic; Pyruvates; Symporters | 2021 |
Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Dopaminergic Neurons; Hexokinase; Humans; L-Lactate Dehydrogenase; Lactic Acid; Mice; Motor Activity; Parkinsonian Disorders; Pars Compacta; Pyruvates; Up-Regulation | 2022 |