labetalol has been researched along with metoprolol in 93 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 39 (41.94) | 18.7374 |
1990's | 13 (13.98) | 18.2507 |
2000's | 15 (16.13) | 29.6817 |
2010's | 22 (23.66) | 24.3611 |
2020's | 4 (4.30) | 2.80 |
Authors | Studies |
---|---|
Topliss, JG; Yoshida, F | 1 |
Faller, B; Wohnsland, F | 1 |
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
Baker, JG | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Campillo, NE; Guerra, A; Páez, JA | 1 |
Akamatsu, M | 1 |
Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Thorling, CA; Zhang, Q | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
Bellman, K; Knegtel, RM; Settimo, L | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
Chang, Q; Chen, Z; Hu, G; Hu, L; Li, Q; Long, J | 1 |
Louis, WJ; McNeil, JJ | 1 |
Coulter, DM | 1 |
Mills, RG; Roberts, MS; Shen, JJ; Wanwimolruk, S | 1 |
Fransson, L; Koch, G | 3 |
Abrignani, MG; Corda, M; Cosentino, F; Liquori, M; Novo, S; Pinto, A; Strano, A | 1 |
Richardson, SB; Twente, S | 1 |
Blasucci, DJ; Chodosh, S; Tuck, J | 1 |
Ahmad, S; Glasser, SP; Lucas, C; Lutz, LJ; Materson, BJ; Morledge, JH; Ramanathan, KB; Saunders, E; Schnaper, HW; Vlachakis, ND | 1 |
Frishman, WH; Glasser, SP; Liebson, P; Poland, MP; Schoenberger, JA; Strom, JA | 1 |
Glasser, SP; Koehn, DK; Powell, R | 1 |
Atkins, J; Bugni, W; Cubbon, J; Fouad-Tarazi, F; Poland, MP; Strom, JA; Vidt, DG | 1 |
Barnett, AH; Odugbesan, O; Toop, M | 1 |
Carrageta, MO; Raftery, EB | 1 |
Palkama, A; Raij, K; Uusitalo, H; Uusitalo, R | 1 |
Lepäntalo, M | 1 |
Koch, G | 1 |
Fishbein, L; Jackson, CD | 1 |
Epstein, M; Oster, JR | 1 |
Dal Negro, RW; Pomari, C; Trevisan, F; Turco, P; Zoccatelli, O | 1 |
Bernini, F; Cighetti, G; Corsini, A; Fumagalli, R; Galli, G; Soma, M | 1 |
Viinikka, L; Ylikorkala, O | 1 |
Abou Hamdam, B; Bernard, R; Jacobs, P; Liebens, I; Renard, M | 1 |
Clifton, GG; Cook, ME; Poland, M; Wallin, JD | 1 |
Falliers, CJ; Medakovic, M; Vincent, ME | 1 |
Lopez, LM; Mehta, JL | 1 |
Giorgetti, F; Re, L; Rossini, L | 1 |
Re, L; Rossini, L | 1 |
Carlsen, JE; Christensen, NJ; Hartling, OJ; Svendsen, TL; Tangø, M; Trap-Jensen, J | 1 |
Adam, WR; Barter, CE; Meagher, EJ | 1 |
Bengtsson, C | 1 |
Coote, JH; Kubik, MM | 1 |
Chung, DC; Laschuk, MJ | 1 |
Frishman, WH; Johnson, BF; Michelson, EL; Poland, MP | 1 |
Hammerle, AF | 1 |
Gellatly, R; Hill, A; Mennie, BA; Stokes, GS | 1 |
Buch, J; Rasmussen, S | 1 |
Astengo, D; Bertulla, A; Brignole, M; Demarchi, PG; Mancini, A | 1 |
Attisano, N; Grenci, G; Martelli, G; Sarica, G; Schirripa, V | 2 |
Piterman, L | 1 |
Balasubramanian, V; Mann, S; Millar-Craig, MW; Raftery, EB | 1 |
Cho, CH; Yat, PC | 1 |
Janssen, BJ; Oosting, J; Struyker-Boudier, HA; Tyssen, CM | 1 |
Haenni, A; Lithell, H | 1 |
Polonský, J; Sádecká, J | 1 |
Allen, LV; Erickson, MA | 1 |
Burrin, JM; Hall, GM; Loughnan, BA; Matson, AM; Shaw, M | 1 |
Koscielniak-Nielsen, ZJ | 1 |
Cho, CH; Kaan, SK | 1 |
Du, A; Huang, M; Li, G; Su, Y; Wu, G; Yang, G | 1 |
Weber, MA | 1 |
Atlas, G; Delphin, E; Xiao, C; Ye, JH; Zhou, C | 1 |
Arima, Y; Hasegawa, C; Izawa, H; Kumazawa, T; Lee, XP; Sato, K; Umezawa, H | 1 |
Niemann, J; Rosborough, JP; Shah, AP; Sherman, L; Youngquist, ST | 1 |
Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Weiss, M; Zhang, Q | 1 |
Abudiab, MM; Odunukan, OW; Sinak, LJ | 1 |
Amidon, GL; Incecayir, T; Tsume, Y | 1 |
Freundlich, RE; Kheterpal, S; Mashour, GA; Matlen, L; Merte, J; Nallamothu, BK; Shanks, A; Sharifpour, M; Tremper, KK; Vlisides, PE; Weightman, A | 1 |
Amidon, GL; Dahan, A; Gasparini, M; Wolk, O; Zur, M | 1 |
Aschmann, HE; Belli, S; Brunner, C; Hatibovic, M; Hermann, KF; Krämer, SD; Neuhaus, CS | 1 |
Bateman, BT; Desai, RJ; Fischer, MA; Hernandez-Diaz, S; Huybrechts, KF; Maeda, A; Mogun, H; Patorno, E; Seely, EW | 1 |
Chen, W; Duan, L; Lee, MS; Ng, A; Nguyen, J; Shen, AY; Spencer, HT | 1 |
Madias, JE | 1 |
Tornvall, P; Y-Hassan, S | 1 |
Chen, W; Duan, L; Lee, MS; Ng, A; Spencer, HT | 1 |
Ansorge, M; Dovhunová, M; Galić, N; Habinovec, I; Pocrnić, M; Tesařová, E | 1 |
Jacobsen, SJ; Kalantar-Zadeh, K; Kovesdy, CP; Lee, MS; Neyer, JR; Shaw, SF; Shi, J; Sim, JJ; Zhou, H | 1 |
Ballotari, M; Gottardo, R; Tagliaro, F; Taus, F; Utzeri, C | 1 |
8 review(s) available for labetalol and metoprolol
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Hypertension and beta-blockers. Are they all the same?
Topics: Adrenergic beta-Antagonists; Atenolol; Blood Pressure; Circadian Rhythm; Humans; Hypertension; Labetalol; Metoprolol; Pindolol; Receptors, Adrenergic, alpha; Sotalol | 1985 |
A toxicological review of beta-adrenergic blockers.
Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Cocarcinogenesis; Ethanolamines; Female; Kinetics; Labetalol; Lethal Dose 50; Male; Metoprolol; Mice; Mutagens; Nadolol; Neoplasms, Experimental; Oxprenolol; Pindolol; Practolol; Propanolamines; Propranolol; Rats; Sotalol; Timolol | 1986 |
Beta blockers and renal function: a reappraisal.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Blood Urea Nitrogen; Cardiac Output; Creatinine; Dogs; Glomerular Filtration Rate; Heart; Humans; Hypertension; Kidney; Labetalol; Metoprolol; Nadolol; Propanolamines; Propranolol; Renal Circulation; Renin; Sympathomimetics; Vascular Resistance | 1985 |
The new beta-adrenergic antagonists.
Topics: Adrenergic beta-Antagonists; Atenolol; Humans; Labetalol; Metoprolol; Nadolol; Oxprenolol; Pindolol; Propanolamines; Timolol | 1984 |
[Comparison of metroprolol and labetalol. Antihypertensive activity at rest and during exertion and effect on some noninvasive parameters of cardiovascular function].
Topics: Adult; Clinical Trials as Topic; Ethanolamines; Female; Hemodynamics; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Physical Exertion; Propanolamines; Rest | 1981 |
The role of the new beta-blockers in treating cardiovascular disease.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Benzopyrans; Cardiovascular Diseases; Clinical Trials as Topic; Enalapril; Ethanolamines; Female; Heart Failure; Hemodynamics; Humans; Hypertension; Labetalol; Losartan; Male; Metoprolol; Middle Aged; Nebivolol; Nifedipine; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Sympathomimetics | 2005 |
When barriers ignore the "rule-of-five".
Topics: Animals; Humans; Hydrogen Bonding; Intestinal Absorption; Intestinal Mucosa; Labetalol; Lipid Bilayers; Liposomes; Metoprolol; Molecular Dynamics Simulation; Pharmaceutical Preparations; Rifampin; Tetracycline | 2016 |
23 trial(s) available for labetalol and metoprolol
Article | Year |
---|---|
A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Clinical Trials as Topic; Double-Blind Method; Ethanolamines; Female; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Pindolol; Time Factors | 1979 |
Regression of structural vascular changes after chronic treatment in hypertensives.
Topics: Acebutolol; Adult; Aged; Blood Pressure; Captopril; Female; Hemodynamics; Humans; Hypertension; Labetalol; Leg; Male; Metoprolol; Middle Aged; Regional Blood Flow; Vascular Resistance | 1991 |
Hemodynamic effects at rest and during exercise of combined alpha/beta-receptor blockade and of beta-receptor blockade alone in patients with ischemic heart disease.
Topics: Coronary Disease; Hemodynamics; Humans; Labetalol; Male; Metoprolol; Middle Aged; Physical Exertion; Rest | 1987 |
The effects of dilevalol, metoprolol, and placebo on ventilatory function in asthmatics.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Asthma; Female; Forced Expiratory Volume; Hemodynamics; Humans; Isoproterenol; Labetalol; Male; Metoprolol; Middle Aged; Respiratory Function Tests | 1988 |
Influence of beta 2 agonism and beta 1 and beta 2 antagonism on adverse effects and plasma lipoproteins: results of a multicenter comparison of dilevalol and metoprolol.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Cholesterol; Coronary Disease; Double-Blind Method; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Labetalol; Lipoproteins; Male; Metoprolol; Middle Aged; Multicenter Studies as Topic; Random Allocation; Risk Factors; Supination; Triglycerides | 1989 |
Effects of dilevalol, metoprolol and atenolol on left ventricular mass and function in nonelderly and elderly hypertensive patients.
Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Double-Blind Method; Echocardiography; Female; Heart; Heart Rate; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Random Allocation; Stroke Volume; Supination | 1989 |
Regression of left ventricular hypertrophy in treated hypertensive patients with dilevalol and metoprolol--a double blind randomized study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiomegaly; Double-Blind Method; Echocardiography; Electrocardiography; Female; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Randomized Controlled Trials as Topic | 1989 |
Hemodynamic and adrenergic effects of combined alpha/beta-receptor blockade versus combined beta-receptor and slow channel calcium blockade in patients with ischemic heart disease.
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Drug Therapy, Combination; Exercise Test; Hemodynamics; Humans; Labetalol; Male; Metoprolol; Middle Aged; Nifedipine; Random Allocation | 1989 |
Beta-and alpha-adrenergic blockade and metabolic responses to insulin induced hypoglycaemia in diabetics.
Topics: Blood Glucose; Blood Pressure; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Humans; Hypoglycemia; Insulin; Labetalol; Metoprolol; Pulse; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1987 |
Beta blockade and intermittent claudication.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Coronary Disease; Female; Gait; Hemodynamics; Humans; Hypertension; Intermittent Claudication; Labetalol; Leg; Male; Metoprolol; Middle Aged; Physical Exertion; Pindolol; Propranolol; Risk | 1985 |
Differential hemodynamic effects of beta-adrenoceptor blockers, Ca antagonists and combined alpha-beta-receptor blockade in ischemic heart disease.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Disease; Hemodynamics; Humans; Labetalol; Metoprolol; Middle Aged; Nifedipine; Vascular Resistance | 1986 |
Respiratory effects of four adrenergic blocking agents combined with a diuretic in treating hypertension with concurrent chronic obstructive lung disease.
Topics: Adrenergic beta-Antagonists; Airway Resistance; Atenolol; Chlorthalidone; Drug Therapy, Combination; Forced Expiratory Volume; Humans; Hypertension; Labetalol; Lung Diseases, Obstructive; Male; Maximal Midexpiratory Flow Rate; Metoprolol; Oxprenolol; Random Allocation | 1986 |
Renal function effects of dilevalol, a nonselective beta-adrenergic blocking drug with beta-2 agonist activity.
Topics: Administration, Oral; Adult; Aged; Atenolol; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Kidney Function Tests; Labetalol; Male; Metoprolol; Middle Aged | 1988 |
Effect of single doses of labetalol, metoprolol, and placebo on ventilatory function in patients with bronchial asthma: interaction with isoproterenol.
Topics: Adult; Asthma; Blood Pressure; Double-Blind Method; Drug Interactions; Female; Heart Rate; Humans; Labetalol; Male; Metoprolol; Middle Aged; Pulmonary Ventilation; Random Allocation | 1986 |
Beta-adrenoceptor blockade and psychic stress in man. A comparison of the acute effects of labetalol, metoprolol, pindolol and propranolol on plasma levels of adrenaline and noradrenaline.
Topics: Adrenergic beta-Antagonists; Adult; Catecholamines; Epinephrine; Humans; Labetalol; Male; Metoprolol; Norepinephrine; Pindolol; Propranolol; Stress, Psychological | 1982 |
Labetalol, beta blockers, and acute deterioration of chronic airway obstruction.
Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Ethanolamines; Humans; Hypertension; Labetalol; Lung Diseases, Obstructive; Lung Volume Measurements; Metoprolol; Middle Aged; Propranolol | 1982 |
Propranolol vs metoprolol vs labetalol: a comparative study in essential hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Double-Blind Method; Female; Humans; Hypertension; Isometric Contraction; Labetalol; Male; Metoprolol; Middle Aged; Peak Expiratory Flow Rate; Propranolol | 1984 |
Multiclinic comparison of labetalol to metoprolol in treatment of mild to moderate systemic hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Ethanolamines; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Labetalol; Lipids; Male; Metoprolol; Middle Aged | 1983 |
On the combination of alpha- and beta-adrenoceptor blockade in hypertension.
Topics: Adult; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Ethanolamines; Female; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Prazosin; Quinazolines; Random Allocation | 1983 |
[Comparison of metroprolol and labetalol. Antihypertensive activity at rest and during exertion and effect on some noninvasive parameters of cardiovascular function].
Topics: Adult; Clinical Trials as Topic; Ethanolamines; Female; Hemodynamics; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Physical Exertion; Propanolamines; Rest | 1981 |
[Clinical, ergometric and polygraphic evaluation of the effects of metoprolol and labetalol administration in essential arterial hypertension. Comparative study].
Topics: Adult; Electrocardiography; Ethanolamines; Female; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Physical Exertion; Posture; Propanolamines | 1982 |
Treatment with a beta-blocker with beta 2-agonism improves glucose and lipid metabolism in essential hypertension.
Topics: Adult; Aged; Blood Glucose; Double-Blind Method; Female; Humans; Hypertension; Insulin; Labetalol; Lipids; Lipoprotein Lipase; Lipoproteins; Metoprolol; Middle Aged; Muscles | 1994 |
Pituitary-adrenal, hormonal changes during induced hypotension with labetol or isoflurane for middle-ear surgery.
Topics: Adrenal Cortex Hormones; Adrenergic Antagonists; Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Adult; Aldosterone; Analysis of Variance; Anesthetics, Inhalation; Antihypertensive Agents; Arginine Vasopressin; Blood Pressure; Ear, Middle; Follow-Up Studies; Humans; Hydrocortisone; Hypotension, Controlled; Injections, Intravenous; Isoflurane; Labetalol; Metoprolol; Oxygen; Pituitary Hormones; Pituitary-Adrenal System; Sample Size | 1998 |
63 other study(ies) available for labetalol and metoprolol
Article | Year |
---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Algorithms; Animals; Cell Line; CHO Cells; Cricetinae; Dioxoles; Humans; Propanolamines; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3 | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Cations; Cytochrome P-450 Enzyme System; Disease Models, Animal; Emulsions; Fats; Fatty Liver; Liver; Liver Cirrhosis; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Drug repurposing and rediscovery: Design, synthesis and preliminary biological evaluation of 1-arylamino-3-aryloxypropan-2-ols as anti-melanoma agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Repositioning; Drug Screening Assays, Antitumor; Humans; Melanoma; Molecular Docking Simulation; Molecular Structure; Propanols; Skin Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
A comparison of scalp tingling, thirst and polyuria in patients on labetalol and metoprolol.
Topics: Ethanolamines; Humans; Labetalol; Metoprolol; Polyuria; Propanolamines; Scalp; Sensation; Thirst | 1979 |
Response to beta-blockers in maternal and fetal rat hearts in vitro.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Female; Heart; Heart Rate; Isoproterenol; Labetalol; Metoprolol; Pregnancy; Pregnancy, Animal; Propranolol; Rats; Rats, Inbred Strains | 1991 |
Acute effects of combined alpha/beta-adrenoceptor blockade v combined beta-receptor and slow channel calcium blockade in ischemic heart disease complicated by hypertension. Hemodynamic and adrenergic responses.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Calcium Channel Blockers; Cardiac Output; Coronary Disease; Epinephrine; Heart Rate; Hemodynamics; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Nifedipine; Renin; Stroke Volume; Vascular Resistance | 1991 |
Inhibition of hypothalamic somatostatin release by beta-adrenergic antagonists.
Topics: Adrenergic beta-Antagonists; Animals; Cells, Cultured; Clonidine; Growth Hormone; Hypothalamus; Labetalol; Male; Metoprolol; Ouabain; Pituitary Gland, Anterior; Propranolol; Rats; Rats, Inbred Strains; Somatostatin | 1990 |
Mechanism of antihypertensive action of dilevalol compared with that of "cardioselective" beta-blocking agents.
Topics: Adult; Aged; Atenolol; Female; Heart; Heart Rate; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Stroke Volume; Vascular Resistance | 1989 |
Comparison of the effects of adrenergic agonists and alpha-, beta 1-, beta 2-antagonists on the intraocular pressure and adenylate cyclase activity in the ciliary processes of the rabbit.
Topics: Acebutolol; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Ciliary Body; Intraocular Pressure; Isoproterenol; Labetalol; Metoprolol; Rats; Timolol; Water | 1985 |
Lipophilic beta-adrenoceptor antagonists stimulate cholesterol biosynthesis in human skin fibroblasts.
Topics: Adrenergic beta-Antagonists; Cholesterol; Fibroblasts; Humans; Hydroxymethylglutaryl CoA Reductases; Labetalol; Metoprolol; Pindolol; Propanolamines; Propranolol; Skin; Stereoisomerism | 1987 |
Beta blockers inhibit fetal thromboxane A2 production in vitro.
Topics: Adrenergic beta-Antagonists; Atenolol; Blood Platelets; Female; Fetal Blood; Humans; Infant, Newborn; Kinetics; Labetalol; Metoprolol; Pregnancy; Propranolol; Thromboxane A2 | 1988 |
A comparison of the effects of combined or separate alpha- and beta-blockade in the treatment of hypertension in the acute stage of myocardial infarction.
Topics: Adult; Aged; Blood Pressure; Carbon Dioxide; Female; Heart Rate; Humans; Hypertension; Infusions, Parenteral; Labetalol; Metoprolol; Middle Aged; Myocardial Infarction; Oxygen; Phentolamine | 1986 |
Rebound hypertension following abrupt cessation of clonidine and metoprolol. Treatment with labetalol.
Topics: Aged; Clonidine; Humans; Hypertension; Labetalol; Male; Metoprolol; Substance Withdrawal Syndrome | 1987 |
[Cholinergic antagonism by beta-blockers. I. Spectrum of interactions].
Topics: Abdominal Muscles; Acetylcholine; Adrenergic beta-Antagonists; Animals; Guinea Pigs; Heart; Ileum; Isoproterenol; Labetalol; Male; Metoprolol; Pindolol; Practolol; Propranolol; Receptors, Cholinergic; Sotalol | 1980 |
[Cholinergic antagonism by beta-blockers. II. Sequence of interactions and final steady state effects].
Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Drug Interactions; Guinea Pigs; Heart; Isoproterenol; Labetalol; Male; Metoprolol; Practolol; Propranolol; Receptors, Cholinergic; Time Factors | 1980 |
Impairment of physical performance after treatment with beta blockers and alpha blockers.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Alprenolol; Heart Rate; Humans; Hydrochlorothiazide; Labetalol; Male; Metoprolol; Physical Exertion; Pindolol; Prazosin; Propranolol; Running | 1984 |
[New aspects in the therapy of pregnancy-induced hypertension].
Topics: Anesthesia, Epidural; Epoprostenol; Female; Fenoterol; Humans; Hypertension; Labetalol; Metoprolol; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Prostaglandins E; Ritodrine | 1983 |
The use of systolic time intervals in the evaluation of antihypertensive treatment with metoprolol, labetalol and prazosin.
Topics: Adult; Aged; Ethanolamines; Female; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Myocardial Contraction; Prazosin; Quinazolines; Systole | 1983 |
Hypertension in general practice: a comparative study of labetalol and metoprolol (+/- prazosin) in general practice.
Topics: Adult; Benzothiadiazines; Diuretics; Ethanolamines; Humans; Hypertension; Labetalol; Metoprolol; Middle Aged; Patient Compliance; Propanolamines; Sodium Chloride Symporter Inhibitors | 1981 |
Effects of treatment on circadian rhythms of blood pressure.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Circadian Rhythm; Heart Rate; Humans; Hypertension; Labetalol; Metoprolol; Oxprenolol | 1981 |
[Clinical and polygraphic evaluation of the effects of metoprolol and labetalol in essential arterial hypertension. Comparative study].
Topics: Adult; Ethanolamines; Female; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Propanolamines | 1981 |
Effects of beta-adrenoceptor antagonists on portal vein hypertension and ethanol-induced gastric mucosal damage in rats.
Topics: Adrenergic beta-Antagonists; Animals; Ethanol; Gastric Mucosa; Hemodynamics; Hypertension, Portal; Labetalol; Male; Metoprolol; Nadolol; Pindolol; Propranolol; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 1994 |
Time-dependent efficacy of antihypertensive agents in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Circadian Rhythm; Clonidine; Felodipine; Heart Rate; Hypertension; Labetalol; Male; Metoprolol; Oxazoles; Prazosin; Propanolamines; Propranolol; Rats; Rats, Inbred SHR; Rilmenidine; Thiophenes | 1993 |
Determination of some cardiovascular drugs in serum and urine by capillary isotachophoresis.
Topics: Adrenergic beta-Antagonists; Amiloride; Cardiovascular Agents; Electrophoresis, Capillary; Furosemide; Humans; Hydrogen-Ion Concentration; Labetalol; Metipranolol; Metoprolol; Reproducibility of Results | 1996 |
Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride, and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diuretics; Dosage Forms; Drug Compounding; Drug Stability; Humans; Hydrochlorothiazide; Labetalol; Metoprolol; Sodium Chloride Symporter Inhibitors; Spironolactone; Suspensions; Verapamil | 1996 |
An unusual toxic reaction to axillary block by mepivacaine with adrenaline.
Topics: Absorption; Aged; Akathisia, Drug-Induced; Anesthetics, Local; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Fibrillation; Axilla; Cardiovascular Agents; Drug Interactions; Dupuytren Contracture; Epinephrine; Humans; Hypertension; Hypnotics and Sedatives; Intraoperative Complications; Labetalol; Male; Mepivacaine; Metoprolol; Midazolam; Nerve Block; Unconsciousness; Vasoconstrictor Agents | 1998 |
Study of propranolol and its related adrenoceptor antagonists on changes of gastric electrical parameters induced by ethanol in rats.
Topics: Adrenergic beta-Antagonists; Animals; Butoxamine; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; Ethanol; Gastric Mucosa; Labetalol; Male; Metoprolol; Nadolol; Propranolol; Rats; Rats, Sprague-Dawley | 1999 |
[The enantiomeric separation of aromatic alcohol amino drugs by thin-layer chromatography].
Topics: Amino Alcohols; Camphor; Chromatography, Thin Layer; Labetalol; Metoprolol; Stereoisomerism | 1999 |
Labetalol facilitates GABAergic transmission to rat periaqueductal gray neurons via antagonizing beta1-adrenergic receptors--a possible mechanism underlying labetalol-induced analgesia.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Adrenergic beta-1 Receptor Antagonists; Analgesics; Animals; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Labetalol; Metoprolol; Neural Inhibition; Neurons; Organ Culture Techniques; Pain; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Receptors, GABA-A; Synaptic Transmission | 2008 |
Simultaneous determination of beta-blockers in human plasma using liquid chromatography-tandem mass spectrometry.
Topics: Acebutolol; Adrenergic beta-Antagonists; Chromatography, Liquid; Humans; Labetalol; Linear Models; Metoprolol; Pindolol; Propranolol; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Beta-blockade causes a reduction in the frequency spectrum of VF but improves resuscitation outcome: A potential limitation of quantitative waveform measures.
Topics: Adrenergic beta-Antagonists; Animals; Cardiopulmonary Resuscitation; Confidence Intervals; Disease Models, Animal; Electric Countershock; Electrocardiography; Heart Arrest; Labetalol; Male; Metoprolol; Random Allocation; Statistics, Nonparametric; Survival Rate; Sus scrofa; Swine; Time Factors; Ventricular Fibrillation | 2012 |
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.
Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Atenolol; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Heart Failure; Labetalol; Linear Models; Liver; Liver Cirrhosis; Liver Diseases; Male; Metabolic Clearance Rate; Metoprolol; Microsomes, Liver; Models, Biological; Necrosis; Nonlinear Dynamics; Perfusion; Propranolol; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
48-year-old man with cough and leg swelling.
Topics: Acute Disease; Antihypertensive Agents; Cerebrovascular Circulation; Cough; Dyspnea; Echocardiography; Edema; Emergencies; Humans; Hydralazine; Hypertension; Labetalol; Lower Extremity; Male; Metoprolol; Middle Aged; Nitroglycerin; Sleep Apnea Syndromes; Vasodilator Agents | 2012 |
Comparison of the permeability of metoprolol and labetalol in rat, mouse, and Caco-2 cells: use as a reference standard for BCS classification.
Topics: Animals; Biological Transport; Caco-2 Cells; Humans; Ileum; Jejunum; Labetalol; Metoprolol; Mice; Mice, Inbred BALB C; Rats; Rats, Wistar; Verapamil | 2013 |
Perioperative metoprolol and risk of stroke after noncardiac surgery.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Analysis of Variance; Atenolol; Cohort Studies; Data Interpretation, Statistical; Female; Humans; Incidence; Labetalol; Logistic Models; Male; Metoprolol; Middle Aged; Monitoring, Intraoperative; Odds Ratio; Postoperative Complications; Propanolamines; Retrospective Studies; Risk Factors; Stroke; Treatment Outcome; Young Adult | 2013 |
The low/high BCS permeability class boundary: physicochemical comparison of metoprolol and labetalol.
Topics: Animals; Chromatography, Liquid; Intestinal Absorption; Labetalol; Male; Metoprolol; Permeability; Rats; Rats, Wistar; Solubility | 2014 |
Late Pregnancy β Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia.
Topics: Adrenergic beta-Antagonists; Atenolol; Bradycardia; Cohort Studies; Female; Humans; Hypertension; Hypertension, Pregnancy-Induced; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Labetalol; Male; Maternal Exposure; Metoprolol; Pregnancy; Pregnancy Complications, Cardiovascular; Propensity Score | 2016 |
β-Blocker Exposure in Pregnancy and Risk of Fetal Cardiac Anomalies.
Topics: Adrenergic beta-Antagonists; Age Factors; Arrhythmias, Cardiac; Atenolol; Body Mass Index; California; Cohort Studies; Confounding Factors, Epidemiologic; Diabetes Mellitus; Eclampsia; Female; Gestational Age; Heart Defects, Congenital; Heart Failure; Humans; Hyperlipidemias; Hypertension; Labetalol; Logistic Models; Metoprolol; Multivariate Analysis; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Complications, Cardiovascular; Propranolol; Retrospective Studies; Risk; Risk Factors | 2017 |
Metoprolol, propranolol, carvedilol, or labetalol for patients with Takotsubo syndrome?
Topics: Carvedilol; Humans; Labetalol; Metoprolol; Propranolol; Takotsubo Cardiomyopathy | 2018 |
Reply to: metoprolol, or propranolol, or carvedilol, or labetalol, for patients with takotsubo syndrome?
Topics: Carvedilol; Humans; Labetalol; Metoprolol; Propranolol; Takotsubo Cardiomyopathy | 2018 |
Beta-blocker subtypes and risk of low birth weight in newborns.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Atenolol; Birth Weight; California; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Infant, Small for Gestational Age; Labetalol; Male; Metoprolol; Pregnancy; Prevalence; Propranolol; Retrospective Studies | 2018 |
Chiral separation of beta-blockers by high-performance liquid chromatography and determination of bisoprolol enantiomers in surface waters.
Topics: Acebutolol; Adrenergic beta-Antagonists; Atenolol; Bisoprolol; Chromatography, High Pressure Liquid; Labetalol; Metoprolol; Water | 2020 |
β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Atenolol; Bisoprolol; Carvedilol; Cause of Death; Cohort Studies; Female; Heart Failure; Hospitalization; Humans; Kidney Failure, Chronic; Labetalol; Logistic Models; Male; Metoprolol; Middle Aged; Mortality; Nadolol; Proportional Hazards Models; Propranolol; Protective Factors; Renal Dialysis; Retrospective Studies; Risk; Risk Factors | 2021 |
Hair analysis for beta-blockers and calcium-channel blockers by using liquid chromatography-tandem mass spectrometry as a tool for monitoring adherence to antihypertensive therapy.
Topics: Adrenergic beta-Antagonists; Amlodipine; Antihypertensive Agents; Atenolol; Bisoprolol; Calcium; Calcium Channel Blockers; Chromatography, Liquid; Hair Analysis; Humans; Labetalol; Metoprolol; Nadolol; Nebivolol; Reproducibility of Results; Sotalol; Tandem Mass Spectrometry | 2022 |