labdane and maslinic-acid

Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A-C (1-3) and eight known compounds, 5,4'-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4'-dihydroxy-7,3'-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC

Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Diterpenes; Drug Screening Assays, Antitumor; Enterovirus A, Human; Enterovirus B, Human; HeLa Cells; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Plant Extracts; Plant Leaves; Rhinovirus; Triterpenes; Vero Cells; Vitex