labdane and isocupressic-acid

labdane has been researched along with isocupressic-acid* in 1 studies

Other Studies

1 other study(ies) available for labdane and isocupressic-acid

ArticleYear
Changes in the rumen bacterial microbiome of cattle exposed to ponderosa pine needles.
    Journal of animal science, 2017, Volume: 95, Issue:5

    Consumption of ponderosa pine needles, as well as needles and bark from a number of other trees, can cause abortions in cattle. The abortifacient compounds in these trees are labdane resin acids, including isocupressic acid and agathic acid. Previous research has demonstrated that cattle conditioned to pine needles metabolize the labdane resin acids more quickly than naïve cattle. The results from that study indicated that changes had occurred in the rumen of conditioned cattle. Therefore, in this study, the changes that occurred in the rumen bacterial microflora of cattle during exposure to ponderosa pine needles were evaluated. Cattle were dosed with ground pine needles twice daily for 7 d. Rumen samples were collected on d 0, 3, 7, and 14 (7 d after treatment stopped) and ruminal bacterial microbiome analyses were performed. There were 372 different genera of bacteria identified in the rumen samples. Principal coordinate analysis indicated that there was a significant difference in the rumen bacterial composition between the time points. There were 18 genera that increased in abundance from d 0 to d 7. Twenty three genera decreased in abundance from d 0 to d 7. The results from this study demonstrated that exposure of cattle to pine needles caused a clear shift in the rumen microbiome composition. In general, this shift lasted less than 1 wk post exposure, which indicates that any prophylactic treatment to manipulate the ruminal metabolism of the abortifacient compounds in pine needles would need to be continuously administered to maintain the necessary microbial composition in the rumen.

    Topics: Abortifacient Agents; Animals; Carboxylic Acids; Cattle; Dicarboxylic Acids; Diterpenes; Female; Microbiota; Pinus ponderosa; Plant Leaves; Pregnancy; Resins, Plant; Rumen; Tetrahydronaphthalenes; Trees

2017