labdane has been researched along with halimane* in 2 studies
2 other study(ies) available for labdane and halimane
Article | Year |
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Labdane and ent-halimane diterpenoids with STAT3-inhibitory activity from Leonurus sibiricus.
Topics: Circular Dichroism; Diterpenes; Leonurus; Molecular Structure; STAT3 Transcription Factor | 2023 |
Diterpenoids with diverse scaffolds from Vitex trifolia as potential topoisomerase I inhibitor.
Eleven new compounds, including six labdane (1-6), three halimane (7-9), and two clerodane (10-11) diterpenoids and 16 known analogues (12-27), were isolated from the leaves of Vitex trifolia. The structures of 1-11 were established by extensive 1D- and 2D-NMR and HRMS spectroscopic data. The absolute configurations of compounds 3, 7, and 10 were assigned using X-ray diffraction. Compounds 1-27 were evaluated for DNA topoisomerases I (Top1) inhibitory activity and cytotoxicity against HCT 116 cells. Compounds 8 and 11 exhibited equipotent Top1 inhibitory activity to the positive control, camptothecin (CPT), at 100μM. Compounds 8, 9, 16, and 27 showed moderate cytotoxicity at low micromolar concentrations. Topics: Diterpenes; Diterpenes, Clerodane; DNA Topoisomerases, Type I; HCT116 Cells; Humans; Molecular Structure; Plant Leaves; Topoisomerase I Inhibitors; Vitex; X-Ray Diffraction | 2017 |