labdane and barium-chloride

labdane has been researched along with barium-chloride* in 1 studies

Other Studies

1 other study(ies) available for labdane and barium-chloride

ArticleYear
Inhibitory effect of xanthomicrol and 3 alpha-angeloyloxy-2 alpha-hydroxy-13,14Z-dehydrocativic acid from Brickellia paniculata on the contractility of guinea-pig ileum.
    Planta medica, 2002, Volume: 68, Issue:5

    Chemical fractionation of Brickellia paniculata methanolic extract by monitoring its inhibitory effect on K(+)-induced contraction in guinea-pig ileum in vitro led to the isolation of 5,4'-dihydroxy-6,7,8-trimethoxyflavone (xanthomicrol) and the labdane-diterpene 3 alpha-angeloyloxy-2 alpha-hydroxy-13,14 Z-dehydrocativic acid (AAHDD). Both compounds inhibited the tonic contraction the effect being highly potent when a mixture in a proportion of 3 : 1 (xanthomicrol/AAHDD) was assayed. The phasic component of the contractile response with K(+) was also reduced by the compounds. Xanthomicrol depressed the spasms induced with ACh, Hist, and BaCl(2) and its effect on Ca (2+) concentration-response curve showed a type of non-surmountable calcium blocking action; unlike the flavonoid, AAHDD produced a parallel rightward shift of the concentration-response curve to calcium, suggesting a competitive antagonism with an estimated pA(2) of 4.66. Obtained results support, in part, the popular use of B. paniculata as a spasmolytic remedy.

    Topics: Acetylcholine; Animals; Asteraceae; Barium Compounds; Calcium; Chlorides; Diterpenes; Flavones; Flavonoids; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naphthalenes; Pentanoic Acids; Plant Extracts; Potassium Chloride

2002