labdane and andrographolide

labdane has been researched along with andrographolide* in 2 studies

Other Studies

2 other study(ies) available for labdane and andrographolide

ArticleYear
Synthesis of new ent-labdane diterpene derivatives from andrographolide and evaluation of their anti-inflammatory activities.
    European journal of medicinal chemistry, 2019, Jan-15, Volume: 162

    Two series of andrographolide derivatives with nitrogen-containing heterocycles, phenols and aromatic acids as bioisostere moiety of lactone ring were synthesized. 8 from 18 tested compounds showed stronger inhibitory effect on LPS-induced NO production in RAW264.7 macrophage than hydrocortisone. Among them, compound 8m exhibited the most potent inhibition with IC

    Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Diterpenes; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Structure-Activity Relationship

2019
Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2019, Apr-17, Volume: 25, Issue:22

    Stachyonic acid A, arising from the first in-depth phytochemical investigation of the herb Basilicum polystachyon, was found to display potent inhibitory activity against dengue virus, with limited cytotoxicity. Andrographolide, a known dengue virus inhibitor and closely related labdane-type diterpene, is structurally more complex but displayed poor antiviral activity in the PRNT assay, and increased cytotoxicity in comparison. Furthermore, a Diels-Alder reaction with PTAD identified the active pharmacophore of stachyonic acid to be the conjugated diene.

    Topics: Antiviral Agents; Dengue; Dengue Virus; Diterpenes; Drug Discovery; Humans; Lamiaceae; Models, Molecular; Virus Replication

2019