l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide has been researched along with pyrrolidonecarboxylic acid in 132 studies
Studies (l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide) | Trials (l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide) | Recent Studies (post-2010) (l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide) | Studies (pyrrolidonecarboxylic acid) | Trials (pyrrolidonecarboxylic acid) | Recent Studies (post-2010) (pyrrolidonecarboxylic acid) |
---|---|---|---|---|---|
138 | 7 | 2 | 3,005 | 101 | 671 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 45 (34.09) | 18.7374 |
1990's | 63 (47.73) | 18.2507 |
2000's | 20 (15.15) | 29.6817 |
2010's | 4 (3.03) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Dickinson, SL; McDermott, AM; Wilkin, GP | 2 |
McTigue, DM; Rogers, RC; Stephens, RL | 1 |
Garrick, T; Livingston, E; Taché, Y; Trauner, M; Yang, H | 1 |
Stephens, RL; Taché, Y; Yang, H | 1 |
Taché, Y; Yoneda, M | 4 |
LePard, KJ; Shockley, RA; Stephens, RL | 1 |
Rahwan, RG; Stephens, RL | 1 |
Sharif, NA; To, ZP; Whiting, RL | 1 |
Bennett, GW; Fone, KC; Johnson, JV; Putland, AP | 1 |
Stephens, RL | 1 |
Taché, Y; Yanagisawa, K | 1 |
Dixon, DM; Fone, KC | 1 |
Bennett, GW; Lynn, AG | 1 |
Garrick, T; Heymann-Mönnikes, I; Taché, Y; Trauner, M; Weiner, H | 1 |
Taché, Y; Walsh, JH; Yanagisawa, K; Yang, H | 1 |
Brooks, FP; Feng, HS; Han, J; Lynn, RB | 1 |
Rivier, C; Saperas, ES; Taché, Y; Yang, H | 1 |
Eckland, DJ; Guiloff, RJ; Lightman, SL; Modarres-Sadeghi, H | 1 |
Rahwan, RG; Stephens, RL; Wong, WS | 1 |
Guiloff, RJ; Modarres-Sadeghi, H | 1 |
Ishikawa, T; Taché, Y; Yang, H | 2 |
Garrick, T; Heymann-Mönnikes, I; Livingston, EH; Sierra, A; Taché, Y; Weiner, H | 1 |
Garrick, T; Stephens, RL; Taché, Y; Weiner, H | 2 |
Bennett, GW; Fone, KC; Johnson, JV; Marsden, CA | 3 |
Bennett, GW; Dixon, DM; Fone, KC; Marsden, CA | 1 |
Stephens, RL; Tache, Y | 1 |
Bennett, GW; Fone, KC; Havler, ME; Johnson, JV; Marsden, CA; Tulloch, IF | 1 |
Avidan, A; Garrick, T; Ishikawa, T; Sierra, A; Stephens, R; Taché, Y; Weiner, H | 1 |
O'Shaughnessy, CT; Rothwell, NJ; Shrewsbury-Gee, J | 1 |
Michel, AD; Sharif, NA; To, Z; Whiting, RL | 1 |
Eckland, DJ; Lightman, SL | 1 |
Bennett, GW; Elliott, JM; Heal, DJ; Marsden, CA; Stoodley, N; Youdim, MB | 1 |
Ambrose, F; Barbaz, B; Bittiger, H; Iyengar, S; Neale, RF; Petrack, B; Rinehart, RK; Steel, DJ; Williams, M; Wood, PL | 1 |
Clarke, KA | 1 |
Griffiths, EC | 1 |
Buack, S; Garrick, T; Tache, Y; Veiseh, A | 1 |
Eckland, DJ; Guiloff, RJ | 1 |
Maeda-Hagiwara, M; Taché, Y | 1 |
Demaine, C; Eckland, DJ; Guiloff, RJ; Hoare, RC; Lightman, SL; MacRae, KD | 1 |
Eckland, DJ; Guiloff, RJ; Lightman, SL; Stålberg, E | 1 |
Griffiths, EC; Rothwell, NJ; Stock, MJ | 1 |
Ishikawa, T; Novin, D; Stephens, RL; Taché, Y; Weiner, H | 1 |
Faden, AI; Noble, LJ; Sacksen, I | 1 |
Latham, A; Lye, RH; Shrewsbury-Gee, J; Slater, P | 1 |
Garrick, T; Sierra, A; Taché, Y; Veiseh, A; Weiner, H | 1 |
Guiloff, RJ; Modarres-Sadeghi, H; Rogers, H; Stålberg, E | 1 |
Garrick, T; Taché, Y; Veiseh, A; Weiner, H | 1 |
Emami, J; Guiloff, RJ; Modarres-Sadeghi, H; Rogers, H | 1 |
Clarke, RW; Ford, TW; Harris, SM; Taylor, JS | 1 |
Clarke, KA; Parker, AJ; Stirk, GC | 2 |
Clarke, KA; Parker, AJ | 1 |
Dettmar, PW; Metcalf, G | 1 |
Bennett, GW; Dettmar, PW; Marsden, CA; Metcalf, G; Sharp, T; Tulloch, IF | 1 |
Debas, H; Goto, Y; Lauffenburger, M; Pappas, T; Taché, Y; Walsh, JH | 1 |
Clarke, KA; Stirk, G | 1 |
Goto, Y; Lauffenburger, M; Lesiege, D; Taché, Y | 1 |
Bennett, GW; Marsden, CA; Sharp, T; Tulloch, IF | 1 |
Dettmar, PW; Fortune, D; Lynn, AG; Metcalf, G; Morgan, BA | 1 |
Brewster, D; Dettmar, PW; Metcalf, G | 1 |
Brewster, D; Dettmar, PW; Havler, ME; Lynn, AG; Metcalf, G | 1 |
Dettmar, PW; Fortune, D; Lynn, AG; Metcalf, G; Tulloch, IF | 1 |
Bennett, GW; Marsden, CA; Sharp, T | 1 |
Clifford, JM; Dettmar, PW; Lynn, AG; Metcalf, G | 1 |
Malagelada, JR; Moncada, S; Mourelle, M; Santos, J; Saperas, E | 1 |
Garrick, T; Morrow, NS; Quinonez, G; Taché, Y; Weiner, H | 1 |
Király, A; Sütö, G; Taché, Y | 1 |
Deshpande, SB; Warnick, JE | 1 |
Hornby, PJ; Krowicki, ZK | 1 |
Guth, PH; Kiràly, A; Livingston, EH; St Pierre, S; Sütö, G; Taché, Y | 1 |
Goonetilleke, A; Guiloff, RJ | 1 |
Kaneko, H; Kato, K; Király, A; Sütö, G; Taché, Y; Yoneda, M | 1 |
Kato, K; Taché, Y; Yang, H | 3 |
Ohning, G; Taché, Y; Yang, H | 1 |
Guth, PH; Taché, Y; Tanaka, T | 1 |
Guth, P; Taché, Y; Tanaka, T | 1 |
Bailey, JE; Coupland, NJ; Glue, P; Nutt, DJ | 1 |
Chi, J; Kemerer, J; Stephens, RL | 1 |
Chen, CH; Rogers, RC; Stephens, RL | 1 |
Chi, J; Gidener, S; Lepard, KJ; Mohammed, JR; Stephens, RL | 1 |
Garrick, T; Hodgson, DM; Morrow, NS | 1 |
Ballard, TM; Bennett, GW; Hunter, AJ | 1 |
Antolín, M; Malagelada, JR; Mourelle, M; Santos, J; Saperas, E | 1 |
Guth, PH; Kaneko, H; Kaunitz, JD; Taché, Y; Tanaka, S | 1 |
LePard, KJ; Mohammed, JR; Stephens, RL | 1 |
O-Lee, TJ; Taché, Y; Wei, JY | 1 |
Taché, Y; Yang, H | 1 |
Guth, PH; Király, A; Sütó, G; Taché, Y | 3 |
Kono, T; Makino, I; Nakamura, K; Sato, Y; Tamori, K; Yokohama, S; Yoneda, M | 1 |
Chi, J; Stephens, RL; Varanasi, S | 1 |
Guth, P; Király, A; Sütó, G; Taché, Y | 1 |
Makino, I; Nakamura, K; Tamori, K; Yoneda, M | 1 |
Chi, J; Rogers, RC; Stephens, RL; Varanasi, S | 1 |
Adelson, DW; O-Lee, TJ; Taché, Y; Wei, JY; Yashar, M | 1 |
Ohning, G; Song, M; Taché, Y; Walsh, JH; Wong, H; Yang, H | 1 |
Kawakubo, K; Taché, Y; Yang, H | 2 |
Kawakubo, K; Ohning, G; Taché, Y; Walsh, J; Wong, H; Yang, H | 1 |
Berthoud, HR; Patterson, LM; Zheng, H | 1 |
Miampamba, M; Sharkey, KA; Taché, Y; Yang, H | 1 |
Go, VL; Ohning, G; Taché, Y; Yang, H | 1 |
Kurosawa, M; Terano, A; Watanobe, H; Yoneda, M | 1 |
Doong, ML; Yang, H | 1 |
Chen, CY; Doong, ML; Rivier, JE; Taché, Y | 1 |
Bennett, GW; Ebling, FJ; Horan, TL; Schuhler, S; Steward, CA | 1 |
Makino, I; Nakamura, K; Sato, Y; Terano, A; Yoneda, M | 1 |
Biehl, AM; Ferreira, M; Gillis, RA; Jones, AR; Niedringhaus, MS; Pearson, RJ; Sahibzada, N; Shi, M; Verbalis, JG | 1 |
Kono, T; Nakamura, K; Sato, Y; Terano, A; Watanobe, H; Yokohama, S; Yoneda, M | 1 |
Hashimoto, T; Kono, T; Nakamura, K; Tamori, K; Terano, A; Watanobe, H; Yokohama, S; Yoneda, M | 1 |
Itoh, M; Joh, T; Kaneko, H; Kataoka, H; Nomura, T; Ohara, H; Oshima, T; Sasaki, M; Sobue, M; Suzuki, H; Takahashi, N; Watanabe, K | 1 |
Goto, M; Haneda, M; Hiraishi, H; Nakamura, K; Shimada, T; Terano, A; Yoneda, M | 1 |
Goto, M; Hiraishi, H; Kono, T; Nakamura, K; Shimada, T; Tanamo, M; Yokohama, S; Yoneda, M | 1 |
Hiraishi, H; Kono, T; Nakamura, K; Shimada, T; Tamano, M; Watanobe, H; Yoneda, M | 1 |
Adelson, D; Akiba, Y; Engel, E; Guth, PH; Kaunitz, JD; Kawakubo, K; Taché, Y | 1 |
Ao, Y; Go, VL; Song, MK; Toy, N; Yang, H | 1 |
Ao, Y; Go, VL; Li, T; Liu, Y; Reeve, JR; Song, MK; Toy, N; Wang, Y; Yang, H | 1 |
Adelson, D; Ao, Y; Chen, A; Go, VL; Ko, M; Liu, YY; Marvizon, JC; Song, MK; Yang, H | 1 |
Goebel, M; Luckey, A; Stengel, A; Taché, Y; Wang, L; Yuan, PQ | 1 |
Miampamba, M; Million, M; Taché, Y | 1 |
Adelson, DW; Ao, Y; Chen, A; Go, VL; Nyby, MD; Smutko, V; Tuck, ML; Wijesuriya, J; Yang, H | 1 |
1 review(s) available for l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide and pyrrolidonecarboxylic acid
Article | Year |
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Observations on the clinical assessment of patients with motor neuron disease. Experience with a TRH analogue.
Topics: Clinical Trials as Topic; Humans; Motor Neurons; Muscle Contraction; Muscles; Neuromuscular Diseases; Pyrrolidonecarboxylic Acid; Speech; Thyroid Gland; Thyrotropin; Thyrotropin-Releasing Hormone | 1987 |
7 trial(s) available for l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide and pyrrolidonecarboxylic acid
Article | Year |
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Comparative efficacy and safety of intravenous and oral administration of a TRH analogue (RX77368) in motor neuron disease.
Topics: Administration, Oral; Adult; Aged; Amyotrophic Lateral Sclerosis; Bulbar Palsy, Progressive; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Motor Neurons; Neurologic Examination; Neuromuscular Diseases; Pyrrolidonecarboxylic Acid; Thyrotropin-Releasing Hormone | 1990 |
The TSH, T4, T3 and prolactin responses to consecutive infusions of a potent and stabilized thyrotrophin releasing hormone analogue, RX77368, in man.
Topics: Adult; Central Nervous System; Humans; Male; Prolactin; Pyrrolidonecarboxylic Acid; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Thyroid Hormones; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine | 1988 |
Observations on the clinical assessment of patients with motor neuron disease. Experience with a TRH analogue.
Topics: Clinical Trials as Topic; Humans; Motor Neurons; Muscle Contraction; Muscles; Neuromuscular Diseases; Pyrrolidonecarboxylic Acid; Speech; Thyroid Gland; Thyrotropin; Thyrotropin-Releasing Hormone | 1987 |
Controlled acute trial of a thyrotrophin releasing hormone analogue (RX77368) in motor neuron disease.
Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Motor Neurons; Neuromuscular Diseases; Pyrrolidonecarboxylic Acid; Random Allocation; Thyrotropin-Releasing Hormone | 1987 |
Electrophysiological observations in patients with motor neuron disease receiving a thyrotropin releasing hormone analogue (RX77368).
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Electromyography; Female; Humans; Male; Middle Aged; Motor Neurons; Neuromuscular Diseases; Pyrrolidonecarboxylic Acid; Random Allocation; Thyrotropin-Releasing Hormone | 1987 |
Continuous response variable trial design in motor neuron disease: long term treatment with a TRH analogue (RX77368).
Topics: Adult; Aged; Analysis of Variance; Female; Humans; Male; Middle Aged; Motor Neuron Disease; Pyrrolidonecarboxylic Acid; Research Design; Survival Analysis; Thyrotropin-Releasing Hormone; Time Factors | 1995 |
The cardiovascular and subjective effects of thyrotropin releasing hormone (TRH) and a stable analogue, dimethyl proline-TRH, in healthy volunteers.
Topics: Adult; Blood Pressure; Cardiovascular System; Female; Heart Rate; Humans; Injections, Intravenous; Male; Placebo Effect; Pyrrolidonecarboxylic Acid; Thyrotropin-Releasing Hormone; Time Factors; Volunteers | 1995 |
125 other study(ies) available for l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide and pyrrolidonecarboxylic acid
Article | Year |
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Thyrotropin releasing hormone (TRH) and a degradation stabilized analogue (RX77368) stimulate phosphoinositide turnover in cultured astrocytes in a regionally specific manner.
Topics: Animals; Animals, Newborn; Astrocytes; Brain; Brain Stem; Cells, Cultured; Cerebellum; Cerebral Cortex; Organ Specificity; Phosphatidylinositols; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Thyrotropin-Releasing Hormone | 1992 |
Thyrotropin-releasing hormone analogue and serotonin interact within the dorsal vagal complex to augment gastric acid secretion.
Topics: Animals; Atropine; Gastric Acid; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Serotonin; Thyrotropin-Releasing Hormone; Vagus Nerve | 1992 |
Thyrotropin-releasing hormone analog injected into the raphe pallidus and obscurus increases gastric contractility in rats.
Topics: Animals; Atropine; Gastrointestinal Motility; Male; Medulla Oblongata; Microinjections; Parasympatholytics; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vagotomy | 1992 |
TRH analogue microinjected into specific medullary nuclei stimulates gastric serotonin secretion in rats.
Topics: Animals; Gastric Acid; Gastric Mucosa; Male; Medulla Oblongata; Microinjections; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Serotonin; Thyrotropin-Releasing Hormone; Vagus Nerve | 1992 |
Central thyrotropin-releasing factor analog prevents ethanol-induced gastric damage through prostaglandins in rats.
Topics: Animals; Brain; Dinoprostone; Ethanol; Gastric Acid; Gastric Mucosa; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone; Vagus Nerve | 1992 |
Fluoxetine pretreatment potentiates intracisternal TRH analogue-stimulated gastric acid secretion in rats.
Topics: Animals; Fluoxetine; Gastric Acid; Kinetics; Male; Neurons; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Serotonin; Thyrotropin-Releasing Hormone | 1992 |
Antiulcer activity of the calcium antagonist propyl-methylenedioxyindene--V. Localization of site of action.
Topics: Animals; Anti-Ulcer Agents; Calcium Channel Blockers; Cisterna Magna; Cold Temperature; Gastric Acid; In Vitro Techniques; Injections; Male; Pylorus; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1992 |
Analogs of thyrotropin-releasing hormone (TRH): receptor affinities in brains, spinal cords, and pituitaries of different species.
Topics: Animals; Binding, Competitive; Brain; Cattle; Dogs; Pituitary Gland, Anterior; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Sheep; Species Specificity; Spinal Cord; Thiazolidines; Thyrotropin-Releasing Hormone | 1991 |
Ventral horn neuropeptides modulate the release of noradrenaline from tissue slices of rat brainstem and ventral thoracic spinal cord.
Topics: Adrenergic alpha-Antagonists; Animals; Brain Stem; Chromatography, High Pressure Liquid; Dioxanes; Dose-Response Relationship, Drug; Electrochemistry; Idazoxan; Male; Neuropeptides; Norepinephrine; Oligopeptides; Potassium; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Thorax; Thyrotropin-Releasing Hormone | 1991 |
Disparate effects of intracisternal RX 77368 and ODT8-SS on gastric acid and serotonin release: role of adrenal catecholamines.
Topics: Adrenal Glands; Animals; Brain; Catecholamines; Gastric Acid; Gastric Mucosa; Injections, Intraventricular; Male; Pyrrolidonecarboxylic Acid; Rats; Serotonin; Somatostatin; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 1991 |
Intracisternal TRH analogue RX 77368 stimulates gastric histamine release in rats.
Topics: Animals; Dialysis; Gastric Acid; Gastric Mucosa; Histamine Release; In Vitro Techniques; Kinetics; Liver Circulation; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reference Values; Thyrotropin-Releasing Hormone | 1990 |
Acute and chronic effects of intrathecal galanin on behavioural and biochemical markers of spinal motor function in adult rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain Stem; Calcitonin Gene-Related Peptide; Choline O-Acetyltransferase; Galanin; Hydroxyindoleacetic Acid; Hypothalamus; Injections, Spinal; Insulin; Male; Methoxydimethyltryptamines; Motor Activity; Muscle Contraction; Peptides; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Spinal Cord; Stereotyped Behavior; Substance P; Thyrotropin-Releasing Hormone | 1991 |
Development of a radioimmunoassay for RX77368 (pGlu-His-3,3-dimethyl proline amide)--a stable analogue of thyrotrophin releasing hormone (TRH).
Topics: Animals; Cross Reactions; Humans; Immune Sera; Pyrrolidonecarboxylic Acid; Rabbits; Radioimmunoassay; Sheep; Thyrotropin-Releasing Hormone | 1991 |
CRF microinjected into the dorsal vagal complex inhibits TRH analog- and kainic acid-stimulated gastric contractility in rats.
Topics: Animals; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Gastrointestinal Motility; Kainic Acid; Male; Medulla Oblongata; Microinjections; Muscle Contraction; Muscle, Smooth; Organ Specificity; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Inbred Strains; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 1991 |
Pharmacological and biochemical comparison of thyrotropin releasing hormone (TRH) and di-methyl proline-TRH on pituitary GH3 cells.
Topics: Cell Line; Hydrolysis; Kinetics; Phosphatidylinositols; Pituitary Gland; Pyrrolidonecarboxylic Acid; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Structure-Activity Relationship; Thyrotropin-Releasing Hormone | 1990 |
Role of acetylcholine, histamine and gastrin in the acid response to intracisternal injection of TRH analog, RX 77368, in the rat.
Topics: Acetylcholine; Animals; Antibodies, Monoclonal; Cisterna Magna; Gastric Acid; Gastrins; Histamine; Injections, Intravenous; Male; Pirenzepine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1990 |
Gastric effects of TRH analogue and bicuculline injected into dorsal motor vagal nucleus in cats.
Topics: Animals; Bicuculline; Cats; Electric Stimulation; Gastric Acid; Gastric Mucosa; Gastrointestinal Motility; Male; Medulla Oblongata; Microinjections; Muscle, Smooth; Pyrrolidonecarboxylic Acid; Reference Values; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 1990 |
Central action of recombinant interleukin-1 to inhibit acid secretion in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Gastric Acid; Indomethacin; Injections; Injections, Intraperitoneal; Interleukin-1; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Recombinant Proteins; Thyrotropin-Releasing Hormone | 1990 |
The effects of repeated administration of a long acting TRH analogue (RX77368), on TSH, T4, T3 and prolactin in patients with motor neuron disease.
Topics: Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Motor Neurons; Neuromuscular Diseases; Prolactin; Pyrrolidonecarboxylic Acid; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine | 1990 |
Antiulcer activity of the calcium antagonist propyl-methylenedioxyindene. IV. Effects on gastric lesions in rats induced by cold-restraint stress and thyrotropin-releasing hormone.
Topics: Animals; Anti-Ulcer Agents; Calcium Channel Blockers; Cold Temperature; Gastric Acid; Gastric Emptying; Gastric Juice; Indenes; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Thyrotropin-Releasing Hormone | 1990 |
Microinjection of TRH analogs into the raphe pallidus stimulates gastric acid secretion in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Gastric Acid; Gastric Juice; Kinetics; Male; Medulla Oblongata; Microinjections; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Inbred Strains; Reference Values; Thyrotropin-Releasing Hormone | 1990 |
Bombesin microinjected into the dorsal vagal complex inhibits TRH-stimulated gastric contractility in rats.
Topics: Animals; Bombesin; Carbachol; Cisterna Magna; Gastrointestinal Motility; Injections; Male; Microinjections; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 1990 |
Endogenous serotonin produces an inhibitory tone on vagally stimulated gastric function.
Topics: Animals; Baclofen; Brain; Cisterna Magna; Fenclonine; Male; Neural Inhibition; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Serotonin; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 1990 |
Effect of intrathecal proctolin administration on the behaviour evoked by the thyrotrophin-releasing hormone (TRH) analogue (RX 77368) and the indoleamine, TRH, substance P and calcitonin gene-related peptide levels and choline acetyltransferase activity
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Choline O-Acetyltransferase; Drug Interactions; Hydroxyindoleacetic Acid; Injections, Spinal; Male; Neuropeptides; Neurotransmitter Agents; Oligopeptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Spinal Cord; Stereotyped Behavior; Substance P; Thyrotropin-Releasing Hormone | 1988 |
Comparative behavioural and biochemical effects of repeated intrathecal administration of thyrotrophin-releasing hormone (TRH) or two analogues of TRH in adult rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Calcitonin Gene-Related Peptide; Choline O-Acetyltransferase; Hydroxyindoleacetic Acid; Injections, Spinal; Male; Neuropeptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Serotonin; Thyrotropin; Thyrotropin-Releasing Hormone | 1989 |
Intrathecal substance P and galanin attenuate TRH analogue-induced wet-dog shake behaviour.
Topics: Animals; Galanin; Injections, Spinal; Male; Motor Activity; Peptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P; Thyrotropin-Releasing Hormone | 1989 |
Intracisternal injection of a TRH analogue stimulates gastric luminal serotonin release in rats.
Topics: Animals; Fistula; Gastric Acid; Gastric Juice; Injections, Spinal; Kinetics; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Stomach; Thyrotropin-Releasing Hormone | 1989 |
A comparison of the motor behaviours produced by the intrathecal administration of thyrotrophin-releasing hormone and thyrotrophin-releasing hormone analogues in the conscious rat.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Male; Motor Activity; Prazosin; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1989 |
Medullary sites for TRH analogue stimulation of gastric contractility in the rat.
Topics: Animals; Gastrointestinal Motility; Microinjections; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reference Values; Stomach; Thyrotropin-Releasing Hormone; Vagotomy; Vagus Nerve | 1989 |
Effects of an analogue of thyrotrophin-releasing hormone, RX77368, on infarct size and cerebral blood flow in focal cerebral ischaemia in the rat.
Topics: Adipose Tissue; Animals; Blood Gas Analysis; Body Temperature; Brain Ischemia; Cerebrovascular Circulation; Injections, Intraperitoneal; Injections, Intraventricular; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1989 |
Differential affinities of TRH analogs at the mammalian spinal cord TRH receptor: implications for therapy in spinal injuries.
Topics: Animals; Binding, Competitive; Guinea Pigs; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Spinal Cord; Spinal Injuries; Thiazolidines; Thyrotropin-Releasing Hormone | 1989 |
Functional interactions between TRH and 5-hydroxytryptamine (5-HT) and proctolin in rat brain and spinal cord.
Topics: 5,7-Dihydroxytryptamine; Animals; Brain; Cerebral Ventricles; Male; Methoxydimethyltryptamines; Motor Activity; Neuropeptides; Neurotransmitter Agents; Oligopeptides; Pentobarbital; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reference Values; Ritanserin; Sleep; Spinal Cord; Stereotyped Behavior; Thyrotropin-Releasing Hormone; Tryptamines | 1989 |
Serotonin depletion potentiates gastric secretory and motor responses to vagal but not peripheral gastric stimulants.
Topics: Animals; Baclofen; Bethanechol; Bethanechol Compounds; Fenclonine; Gastric Acid; Gastrointestinal Motility; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Serotonin; Thyrotropin-Releasing Hormone; Vagus Nerve | 1989 |
Behavioural and biochemical evidence for the release of noradrenaline in mouse brain by TRH and some of its biologically stable analogues.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Brain; Clonidine; Hypothalamus; Male; Mice; Mice, Inbred C57BL; Motor Activity; Norepinephrine; Pyrrolidonecarboxylic Acid; Thyrotropin-Releasing Hormone | 1987 |
Benzodiazepine interactions with central thyroid-releasing hormone binding sites: characterization and physiological significance.
Topics: Amygdala; Animals; Benzodiazepines; Brain; Cerebral Cortex; Chlordiazepoxide; Corpus Striatum; Cyclic GMP; Flunitrazepam; Kinetics; Male; Membranes; Midazolam; Pentobarbital; Pyrazoles; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Thyrotropin-Releasing Hormone; Sleep; Thiazolidines; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
TRH analogue affects information transfer through the ventrobasal thalamus.
Topics: Afferent Pathways; Animals; Evoked Potentials, Somatosensory; Female; Motor Activity; Pyrrolidonecarboxylic Acid; Rats; Reaction Time; Somatosensory Cortex; Thalamic Nuclei; Thyrotropin-Releasing Hormone | 1986 |
TRH and amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Humans; Pyrrolidonecarboxylic Acid; Thyrotropin-Releasing Hormone | 1987 |
Thyrotropin-releasing hormone (TRH) acts centrally to stimulate gastric contractility in rats.
Topics: Animals; Atropine; Food; Gastrointestinal Motility; Male; Muscle Contraction; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Stomach; Thyrotropin-Releasing Hormone; Time Factors | 1987 |
Central nervous system action of TRH to stimulate gastric emptying in rats.
Topics: Animals; Atropine; Carbachol; Gastric Emptying; Injections, Intravenous; Injections, Intraventricular; Male; Pyrrolidonecarboxylic Acid; Rats; Thyrotropin-Releasing Hormone | 1987 |
Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat.
Topics: Adipose Tissue, Brown; Animals; Body Temperature Regulation; Body Weight; Male; Oxygen Consumption; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1988 |
TRH analogue, RX 77368, injected into dorsal vagal complex stimulates gastric secretion in rats.
Topics: Animals; Gastric Acid; Gastric Fistula; Male; Microinjections; Peptides, Cyclic; Piperazines; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone; Vagus Nerve | 1988 |
Structure-activity relationships of TRH analogs in rat spinal cord injury.
Topics: Animals; Evoked Potentials, Somatosensory; Molecular Conformation; Pyrrolidonecarboxylic Acid; Rats; Spinal Cord Injuries; Thyrotropin-Releasing Hormone; Time Factors | 1988 |
The effects of TRH analogues on cerebral ischaemia produced by middle cerebral artery occlusion in the rat.
Topics: Animals; Cerebral Arteries; Dihydrolipoamide Dehydrogenase; Evoked Potentials, Somatosensory; Female; Ischemic Attack, Transient; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone; Time Factors | 1988 |
Corticotropin-releasing factor acts centrally to suppress stimulated gastric contractility in the rat.
Topics: Animals; Atropine; Carbachol; Cisterna Magna; Corticotropin-Releasing Hormone; Deoxyglucose; Gastrointestinal Motility; Injections, Intravenous; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reference Values; Thyrotropin-Releasing Hormone | 1988 |
Short-term stability of single motor unit recordings in motor neuron disease: a macro EMG study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Bulbar Palsy, Progressive; Electromyography; Female; Humans; Male; Middle Aged; Motor Neurons; Muscles; Muscular Atrophy, Spinal; Neuromuscular Diseases; Pyrrolidonecarboxylic Acid; Thyrotropin-Releasing Hormone | 1988 |
Medullary sites of action of the TRH analogue, RX 77368, for stimulation of gastric acid secretion in the rat.
Topics: Animals; Binding Sites; Gastric Acid; Injections, Intraventricular; Male; Medulla Oblongata; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Stimulation, Chemical; Thyrotropin-Releasing Hormone; Vagus Nerve | 1988 |
Corticotropin-releasing factor acts on the brain to reduce gastric contractility.
Topics: Animals; Brain; Carbachol; Corticotropin-Releasing Hormone; Deoxyglucose; Dose-Response Relationship, Drug; Gastric Emptying; Injections, Intraventricular; Pyrrolidonecarboxylic Acid; Rats; Stomach; Thyrotropin-Releasing Hormone | 1987 |
Subacute administration of a TRH analogue (RX77368) in motorneuron disease: an open study.
Topics: Activities of Daily Living; Adult; Aged; Amyotrophic Lateral Sclerosis; Bulbar Palsy, Progressive; Dose-Response Relationship, Drug; Dysarthria; Electromyography; Female; Humans; Male; Middle Aged; Motor Neurons; Muscle Contraction; Muscle Spasticity; Neuromuscular Diseases; Pyrrolidonecarboxylic Acid; Respiratory Insufficiency; Thyrotropin-Releasing Hormone; Voice Disorders | 1988 |
Thyrotropin releasing hormone, cholecystokinin and endogenous opioids in the modulation of spinal reflexes in the rabbit.
Topics: Animals; Cholecystokinin; Endorphins; Female; Male; Naloxone; Pyrrolidonecarboxylic Acid; Rabbits; Reflex; Sincalide; Spinal Nerves; Sural Nerve; Thyrotropin-Releasing Hormone | 1988 |
Potentiation of motoneurone excitability by combined administration of 5-HT agonist and TRH analogue.
Topics: Animals; Anterior Horn Cells; Drug Synergism; Female; Fenclonine; Ketanserin; Methoxydimethyltryptamines; Methysergide; Motor Neurons; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Serotonin; Stimulation, Chemical; Thyrotropin-Releasing Hormone | 1985 |
Effects of a thyrotropin releasing hormone analogue on locomotor and other motor activity in the rat.
Topics: Animals; Female; Locomotion; Motor Activity; Pyrrolidonecarboxylic Acid; Rats; Thyrotropin-Releasing Hormone | 1985 |
Is thyrotropin releasing hormone an endogenous ergotropic substance in the brain?
Topics: Body Temperature; Brain; Humans; Mental Disorders; Narcotic Antagonists; Neuromuscular Diseases; Pyrrolidonecarboxylic Acid; Thyrotropin-Releasing Hormone | 1981 |
Analeptic effects of centrally injected TRH and analogues of TRH in the pentobarbitone-anaesthetized rat.
Topics: Anesthesia; Animals; Body Temperature; Central Nervous System Stimulants; Corpus Striatum; Male; Pentobarbital; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Respiration; Septum Pellucidum; Sleep; Thyrotropin-Releasing Hormone | 1984 |
Calcitonin gene-related peptide: potent peripheral inhibitor of gastric acid secretion in rats and dogs.
Topics: Animals; Bethanechol; Bethanechol Compounds; Calcitonin Gene-Related Peptide; Dogs; Dose-Response Relationship, Drug; Gastric Acid; Histamine; Male; Nerve Tissue Proteins; Pentagastrin; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone; Time Factors; Vagotomy | 1984 |
Motoneurone excitability after administration of a thyrotrophin releasing hormone analogue.
Topics: Action Potentials; Animals; Female; Motor Neurons; Pyrrolidonecarboxylic Acid; Rats; Thyrotropin-Releasing Hormone | 1983 |
Potent central nervous system action of p-Glu-His-(3,3'-dimethyl)-Pro NH2, a stabilized analog of TRH, to stimulate gastric secretion in rats.
Topics: Animals; Gastric Acid; Gastric Juice; Gastric Mucosa; Injections, Spinal; Male; Pepsin A; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Stimulation, Chemical; Thyrotropin-Releasing Hormone; Urethane; Vagus Nerve | 1984 |
Motoneurone excitability during antidromically evoked inhibition after administration of a thyrotrophin releasing hormone (TRH) analogue.
Topics: Animals; Anterior Horn Cells; Evoked Potentials; Female; Motor Neurons; Pyrrolidonecarboxylic Acid; Rats; Thyrotropin-Releasing Hormone | 1984 |
A comparison of the locomotor effects induced by centrally injected TRH and TRH analogues.
Topics: Animals; Corpus Striatum; Dopamine; Male; Motor Activity; Nucleus Accumbens; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Septal Nuclei; Thyrotropin-Releasing Hormone | 1984 |
Biological evaluation of a TRH analogue with a modified proline residue.
Topics: Amitriptyline; Amphetamine; Doxapram; Humans; Pyrrolidonecarboxylic Acid; Thyrotropin-Releasing Hormone | 1980 |
Biologically stable analogues of TRH with increased neuropharmacological potency.
Topics: Animals; Body Temperature Regulation; Brain; Fever; Kinetics; Male; Mice; Organ Specificity; Pyrrolidonecarboxylic Acid; Rabbits; Reserpine; Structure-Activity Relationship; Thyrotropin-Releasing Hormone; Tremor | 1981 |
Thyrotropin-releasing hormone (TRH) analogues show enhanced CNS selectivity because of increased biological stability.
Topics: Animals; Biological Availability; Blood-Brain Barrier; Central Nervous System; Fever; Male; Pituitary Gland; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Thyrotropin; Thyrotropin-Releasing Hormone | 1981 |
Neuropharmacological evaluation of RX 77368--a stabilised analogue of thyrotropin-releasing hormone (TRH).
Topics: Adult; Animals; Body Temperature; Clonidine; Electroencephalography; Humans; Male; Motor Activity; Pyrrolidonecarboxylic Acid; Rats; Reserpine; Sleep; Thyrotropin-Releasing Hormone; Tremorine | 1982 |
Thyrotrophin-releasing hormone analogues increase dopamine release from slices of rat brain.
Topics: Animals; Brain; Dopamine; Dose-Response Relationship, Drug; Male; Potassium; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1982 |
The ability of RX 77368 - a stabilised analogue of TRH - to provoke the secretion of prolactin and TSH in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Humans; Kinetics; Male; Prolactin; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin; Thyrotropin-Releasing Hormone | 1982 |
Central vagal activation by an analogue of TRH stimulates gastric nitric oxide release in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Gastric Acid; Gastric Mucosa; Male; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vagus Nerve | 1995 |
Serotonin enhances gastric acid response to TRH analogue in dorsal vagal complex through 5-HT2 receptors in rats.
Topics: Animals; Drug Synergism; Gastric Acid; Globus Pallidus; Ketanserin; Male; Medulla Oblongata; Microinjections; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thyrotropin-Releasing Hormone; Vagus Nerve | 1995 |
Interleukin-1 beta in the dorsal vagal complex inhibits TRH analogue-induced stimulation of gastric contractility.
Topics: Animals; Brain; Functional Laterality; Interleukin-1; Male; Mice; Microinjections; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 1995 |
Role of nitric oxide in the gastric cytoprotection induced by central vagal stimulation.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Ethanol; Gastric Mucosa; Gastrointestinal Hemorrhage; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vagus Nerve | 1993 |
Analogs of thyrotropin-releasing hormone in potentiating the spinal monosynaptic reflex in vitro.
Topics: Animals; In Vitro Techniques; Pyrrolidonecarboxylic Acid; Rats; Reflex, Monosynaptic; Spinal Cord; Structure-Activity Relationship; Thiazolidines; Thyrotropin-Releasing Hormone | 1994 |
Serotonin and thyrotropin-releasing hormone do not augment their effects on gastric motility on their microinjection into the nucleus raphe obscurus of the rat.
Topics: Animals; Drug Synergism; Gastrointestinal Motility; Male; Medulla Oblongata; Microinjections; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Serotonin; Stomach; Thyrotropin-Releasing Hormone | 1995 |
Central vagal activation by TRH induces gastric hyperemia: role of CGRP in capsaicin-sensitive afferents in rats.
Topics: Animals; Bethanechol; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Gastric Mucosa; Hyperemia; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vagus Nerve | 1994 |
Intracisternal thyrotropin-releasing hormone-induced vagally mediated gastric protection against ethanol lesions: central and peripheral mechanisms.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dinoprostone; Ethanol; Gastric Acid; Gastric Mucosa; Injections, Intraventricular; Neurons, Afferent; Nitric Oxide; Pyrrolidonecarboxylic Acid; Rats; Stomach; Stomach Ulcer; Thyrotropin-Releasing Hormone; Vagus Nerve | 1994 |
Role of peripheral capsaicin-sensitive neurons and CGRP in central vagally mediated gastroprotective effect of TRH.
Topics: Animals; Antibodies, Monoclonal; Calcitonin Gene-Related Peptide; Capsaicin; Ethanol; Gastric Mucosa; Male; Motor Neurons; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vagus Nerve | 1994 |
TRH in dorsal vagal complex mediates acid response to excitation of raphe pallidus neurons in rats.
Topics: Animals; Antibodies; Brain Mapping; Gastric Acid; Globus Pallidus; Kainic Acid; Male; Microinjections; Neurons; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reference Values; Thyrotropin-Releasing Hormone; Vagotomy; Vagus Nerve | 1993 |
Potentiating interactions between medullary serotonin and thyrotropin-releasing hormone-induced gastric erosions in rats.
Topics: Animals; Cold Temperature; Indomethacin; Injections; Injections, Intravenous; Ketanserin; Male; Medulla Oblongata; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Restraint, Physical; Serotonin; Stomach Ulcer; Stress, Psychological; Thyrotropin-Releasing Hormone | 1993 |
Involvement of vagal pathway in the anti-secretory effect of a novel xanthine derivative.
Topics: Animals; Anti-Ulcer Agents; Deoxyglucose; Gastric Acid; Gastric Mucosa; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vagus Nerve; Xanthines | 1993 |
Vagal regulation of gastric prostaglandin E2 release by central TRH in rats.
Topics: Animals; Brain; Dinoprostone; Extracellular Space; Gastric Acid; Gastric Mucosa; Indomethacin; Injections, Intraventricular; Male; Omeprazole; Pyrrolidonecarboxylic Acid; Rats; Thyrotropin-Releasing Hormone; Vagotomy; Vagus Nerve | 1993 |
Role of nitric oxide in gastric hyperemia induced by central vagal stimulation.
Topics: Animals; Arginine; Brain; Gastric Acid; Hyperemia; Injections, Intraventricular; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Stereoisomerism; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 1993 |
Low doses of TRH analogue act in the dorsal motor nucleus to induce gastric protection in rats.
Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Male; Medulla Oblongata; Microinjections; Perfusion; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stomach; Stomach Diseases; Thyrotropin-Releasing Hormone; Vagus Nerve | 1995 |
5-HT in DVC: disparate effects on TRH analogue-stimulated gastric acid secretion, motility, and cytoprotection.
Topics: Animals; Brain; Gastric Acid; Gastrointestinal Motility; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Serotonin; Solitary Nucleus; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 1996 |
Intracisternal injection of peptide YY inhibits gastric emptying in rats.
Topics: Animals; Bombesin; Gastric Emptying; Gastrointestinal Hormones; Male; Peptide YY; Peptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone; Vagotomy | 1996 |
Role of prostaglandins and calcitonin gene-related peptide in central vagal cholinergic-dependent protection against gastric injury in urethane-anesthetized rats.
Topics: Anesthesia; Animals; Atropine; Calcitonin Gene-Related Peptide; Ethanol; Gastric Mucosa; Indomethacin; Male; Prostaglandins; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Urethane; Vagotomy; Vagus Nerve | 1996 |
Gastric antisecretory effect of serotonin: quantitation of release and site of action.
Topics: Animals; Autonomic Nervous System; Gastric Juice; Gastric Mucosa; Male; Mast Cells; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Secretory Rate; Serotonin; Somatostatin; Splanchnic Nerves; Tetrodotoxin; Thyrotropin-Releasing Hormone; Vagus Nerve | 1996 |
Microinjection of thyrotropin-releasing hormone analogue into the central nucleus of the amygdala stimulates gastric contractility in rats.
Topics: Amygdala; Animals; Gastric Emptying; Male; Microinjections; Muscle Contraction; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 1996 |
Effect of a thyrotrophin-releasing hormone analogue, RX77368, on AMPA-induced septal-hippocampal lesioned rats in an operant delayed non-matching to position test.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Hippocampus; Male; Memory; Motor Activity; Pyrrolidonecarboxylic Acid; Rats; Thyrotropin-Releasing Hormone | 1996 |
Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropin-releasing hormone in rats.
Topics: Animals; Female; Intestinal Mucosa; Intestine, Small; Mast Cells; Prostaglandin D2; Pyrrolidonecarboxylic Acid; Rats; Serine Endopeptidases; Thyrotropin-Releasing Hormone | 1996 |
Central vagal activation increases mucus gel thickness and surface cell intracellular pH in rat stomach.
Topics: Animals; Brain; Gases; Gastric Acid; Gastric Mucosa; Gels; Hydrogen; Hydrogen-Ion Concentration; Injections, Intraventricular; Male; Mucus; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Thyrotropin-Releasing Hormone; Vagus Nerve | 1997 |
Gastric ECL-cell hyperplasia produces enhanced basal and stimulated gastric acid output but not gastric erosion formation in the rat.
Topics: Animals; Carbachol; Enterochromaffin Cells; Female; Gastric Acid; Gastric Mucosa; Histamine; Hyperplasia; Indomethacin; Pentagastrin; Pyrrolidonecarboxylic Acid; Ranitidine; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Stress, Physiological; Thyrotropin-Releasing Hormone | 1997 |
Intracisternal TRH and RX 77368 potently activate gastric vagal efferent discharge in rats.
Topics: Analysis of Variance; Animals; Cisterna Magna; Efferent Pathways; Evoked Potentials; Gastric Mucosa; Injections; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 1997 |
Substance P in the dorsal vagal complex inhibits medullary TRH-induced gastric acid secretion in rats.
Topics: Animals; Biphenyl Compounds; Cerebral Ventricles; Gastric Acid; Kainic Acid; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Substance P; Thyrotropin-Releasing Hormone; Vagus Nerve | 1997 |
Mechanisms mediating gastric hyperemic and acid responses to central TRH analog at a cytoprotective dose.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Gastric Acid; Gastric Mucosa; Hemodynamics; Hyperemia; Indomethacin; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Reference Values; Thyrotropin-Releasing Hormone; Time Factors; Vascular Resistance | 1997 |
Central thyrotropin-releasing hormone stimulates hepatic DNA synthesis in rats.
Topics: Animals; Antibodies; Atropine; Brain; DNA; Injections, Intraventricular; Insulin; Liver; Male; Organ Size; Oxidopamine; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Sympathectomy; Thyrotropin-Releasing Hormone; Vagotomy | 1997 |
Ketotifen prevents gastric hyperemia induced by intracisternal thyrotropin-releasing hormone at a low dose.
Topics: Animals; Blood Pressure; Cisterna Magna; Gastric Acid; Gastric Mucosa; Hyperemia; Injections; Ketotifen; Male; Mast Cells; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vascular Resistance | 1997 |
5-CT or DOI augments TRH analog-induced gastric acid secretion at the dorsal vagal complex.
Topics: Amphetamines; Animals; Drug Synergism; Gastric Acid; Gastric Mucosa; Male; Medulla Oblongata; Microinjections; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Thyrotropin-Releasing Hormone; Vagus Nerve | 1997 |
Influence of [4Cl-D-Phe6,Leu17]VIP on VIP- and central TRH-induced gastric hyperemia.
Topics: Animals; Cisterna Magna; Efferent Pathways; Gastric Mucosa; Hyperemia; Male; Microinjections; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Stomach Diseases; Thyrotropin-Releasing Hormone; Vagus Nerve; Vasoactive Intestinal Peptide | 1997 |
Peripheral mediators involved in gastric hyperemia to vagal activation by central TRH analog in rats.
Topics: Animals; Arginine; Atropine; Blood Pressure; Capsaicin; Cisterna Magna; Electric Stimulation; Gastric Acid; Gastric Mucosa; Hyperemia; Male; NG-Nitroarginine Methyl Ester; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stereoisomerism; Stereotaxic Techniques; Thyrotropin-Releasing Hormone; Vagus Nerve; Vascular Resistance | 1998 |
Effect of intracisternal thyrotropin-releasing hormone on hepatic blood flow in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Blood Pressure; Enzyme Inhibitors; Hydrogen; Indomethacin; Liver; Liver Circulation; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Parasympatholytics; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thyrotropin-Releasing Hormone; Vagotomy | 1998 |
Methiothepin but not methysergide antagonizes TRH effects at the dorsal vagal complex.
Topics: Animals; Methiothepin; Methysergide; Neurons; Pyrrolidonecarboxylic Acid; Rats; Receptors, Serotonin; Thyrotropin-Releasing Hormone; Vagus Nerve | 1998 |
Central autonomic activation by intracisternal TRH analogue excites gastric splanchnic afferent neurons.
Topics: Animals; Autonomic Nervous System; Catheterization; Central Nervous System; Evoked Potentials; Injections, Intraventricular; Male; Neurons, Afferent; Physical Stimulation; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Stomach; Thyrotropin-Releasing Hormone; Time Factors | 1999 |
Intracisternal TRH analog increases gastrin release and corpus histidine decarboxylase activity in rats.
Topics: Animals; Antibodies, Monoclonal; Atropine; Gastric Mucosa; Gastrins; GTP-Binding Proteins; Histidine Decarboxylase; Kinetics; Male; Microinjections; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Time Factors | 1999 |
Intracisternal PYY increases gastric mucosal resistance: role of cholinergic, CGRP, and NO pathways.
Topics: Animals; Calcitonin Gene-Related Peptide; Cholinergic Fibers; Electric Impedance; Ethanol; Gastric Acid; Gastric Mucosa; Injections, Intraventricular; Male; Nitric Oxide; Oligonucleotides, Antisense; Peptide YY; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Thyrotropin-Releasing Hormone; Stomach; Stomach Diseases; Thyrotropin-Releasing Hormone | 1999 |
Intracisternal PYY inhibits gastric lesions induced by ethanol in rats: role of PYY-preferring receptors?
Topics: Animals; Cisterna Magna; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Gastric Mucosa; Injections; Male; Peptide YY; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Gastrointestinal Hormone; Stomach Diseases; Thyrotropin-Releasing Hormone | 2000 |
Peripheral PYY inhibits intracisternal TRH-induced gastric acid secretion by acting in the brain.
Topics: Animals; Antibodies; Brain Chemistry; Gastric Acid; Gastric Mucosa; Injections, Intravenous; Injections, Intraventricular; Male; Neutralization Tests; Peptide Fragments; Peptide YY; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vagus Nerve | 2000 |
Vagal-enteric interface: vagal activation-induced expression of c-Fos and p-CREB in neurons of the upper gastrointestinal tract and pancreas.
Topics: Activating Transcription Factor 1; Animals; Cell Count; Digestive System; DNA-Binding Proteins; Electric Stimulation; Enteric Nervous System; Fluorescent Antibody Technique, Indirect; Male; Myenteric Plexus; Neurons; Pancreas; Proto-Oncogene Proteins c-fos; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Submucous Plexus; Thyrotropin-Releasing Hormone; Transcription Factors; Vagus Nerve | 2001 |
Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats.
Topics: Animals; Atropine; Biomarkers; Carrier Proteins; Cisterna Magna; Efferent Pathways; Genes, fos; Glial Fibrillary Acidic Protein; Hexamethonium; Male; Membrane Transport Proteins; Microinjections; Myenteric Plexus; Neuroglia; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; S100 Proteins; Stomach; Thiolester Hydrolases; Thyrotropin-Releasing Hormone; Ubiquitin Thiolesterase; Vagus Nerve; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 2001 |
Activation of raphe pallidus neurons increases insulin through medullary thyrotropin-releasing hormone (TRH)-vagal pathways.
Topics: Animals; Gastric Acid; Immunoglobulin G; Insulin; Kainic Acid; Male; Medulla Oblongata; Microinjections; Neural Conduction; Neurons; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vagotomy; Vagus Nerve | 2002 |
Lafutidine increases hepatic blood flow via potentiating the action of central thyrotropin-releasing hormone in rats.
Topics: Acetamides; Analysis of Variance; Animals; Capsaicin; Drug Combinations; Drug Synergism; Gastric Mucosa; Histamine H2 Antagonists; Laser-Doppler Flowmetry; Liver; Liver Circulation; Male; Neurons, Afferent; Piperidines; Pyridines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Thyrotropin-Releasing Hormone | 2003 |
Intravenous glucose infusion decreases intracisternal thyrotropin-releasing hormone induced vagal stimulation of gastric acid secretion in anesthetized rats.
Topics: Anesthetics, Intravenous; Animals; Cisterna Magna; Gastric Acid; Glucose; Infusions, Intravenous; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vagus Nerve | 2003 |
Intravenous urocortin II decreases blood pressure through CRF(2) receptor in rats.
Topics: Animals; Blood Pressure; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Thyrotropin-Releasing Hormone; Time Factors; Urocortins | 2003 |
Central administration of thyrotropin releasing hormone (TRH) and related peptides inhibits feeding behavior in the Siberian hamster.
Topics: Animals; Behavior, Animal; Body Weight; Cricetinae; Eating; Feeding Behavior; Female; Injections, Intraventricular; Phodopus; Photoperiod; Pyrrolidonecarboxylic Acid; Thyrotropin-Releasing Hormone | 2003 |
Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Indomethacin; Injections, Intraventricular; Liver; Liver Diseases; Male; Necrosis; NG-Nitroarginine Methyl Ester; Oxidopamine; Parasympatholytics; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Sympatholytics; Thyrotropin-Releasing Hormone; Vagotomy | 2003 |
Glucose acts in the CNS to regulate gastric motility during hypoglycemia.
Topics: Animals; Bethanechol; Blood Glucose; Brain; Catheterization; Gastric Emptying; Glucose; Hypoglycemia; Hypoglycemic Agents; Injections, Intravenous; Insulin; Male; Microinjections; Models, Animal; Parasympathomimetics; Pyloric Antrum; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Vagus Nerve | 2003 |
Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection.
Topics: Animals; Aspartate Aminotransferases; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cisterna Magna; Injections; Liver; Liver Function Tests; Male; Neurons, Afferent; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thyrotropin-Releasing Hormone | 2003 |
Thyrotropin-releasing hormone in the dorsal vagal complex stimulates hepatic blood flow in rats.
Topics: Animals; Blood Pressure; Liver Circulation; Male; Microinjections; Portal Pressure; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thyrotropin-Releasing Hormone; Vagotomy; Vagus Nerve | 2003 |
Evaluation of early gastric mucosal permeability induced by central thyrotropin-releasing hormone administration.
Topics: Animals; Anti-Ulcer Agents; Atropine; Brain; Gastric Mucosa; Hydrochloric Acid; Injections, Intraventricular; Male; Muscarinic Antagonists; Omeprazole; Permeability; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Thyrotropin-Releasing Hormone; Vagotomy | 2005 |
Protective effect of central thyrotropin-releasing hormone analog on cerulein-induced acute pancreatitis in rats.
Topics: Adrenergic Agents; Amylases; Animals; Central Nervous System; Ceruletide; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Male; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidopamine; Pancreas; Pancreatitis; Peptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thyrotropin-Releasing Hormone; Time Factors | 2005 |
Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats.
Topics: Animals; Atropine; Blood Pressure; Enzyme Inhibitors; Laser-Doppler Flowmetry; Male; Medulla Oblongata; Microinjections; NG-Nitroarginine Methyl Ester; Pancreas; Parasympatholytics; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Regional Blood Flow; Thyrotropin-Releasing Hormone; Vagotomy; Vagus Nerve | 2005 |
Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats.
Topics: Animals; Atropine; Cell Proliferation; Cholinergic Fibers; Cyclic AMP; DNA; Dose-Response Relationship, Drug; Indomethacin; Injections, Intraventricular; Liver; Male; Oxidopamine; Prostaglandins; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Signal Transduction; Thyrotropin-Releasing Hormone; Vagotomy; Vagus Nerve | 2005 |
Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats.
Topics: Animals; Blood Pressure; Cell Count; Cell Degranulation; Connective Tissue Cells; Cromolyn Sodium; Dose-Response Relationship, Drug; Gastric Mucosa; Histamine Antagonists; Hyperemia; Injections, Intraventricular; Ketotifen; Male; Mast Cells; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Serotonin Antagonists; Stomach; Thioxanthenes; Thyrotropin-Releasing Hormone; Vascular Resistance; Xanthones | 2005 |
Altered glucose and insulin responses to brain medullary thyrotropin-releasing hormone (TRH)-induced autonomic activation in type 2 diabetic Goto-Kakizaki rats.
Topics: Adrenalectomy; Animals; Autonomic Nervous System; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Injections, Intraventricular; Insulin; Male; Medulla Oblongata; Pancreas; Protein Isoforms; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; RNA, Messenger; Thyrotropin-Releasing Hormone; Vagotomy | 2005 |
Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion.
Topics: Anesthesia; Animals; Antibodies, Monoclonal; Atropine; Brain Stem; Cholinergic Fibers; Cisterna Magna; Eating; Fasting; Ghrelin; Injections; Lateral Ventricles; Pentobarbital; Peptide Hormones; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Ghrelin; Receptors, Neuropeptide Y; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone; Vagus Nerve | 2006 |
Potent hyperglycemic and hyperinsulinemic effects of thyrotropin-releasing hormone microinjected into the rostroventrolateral medulla and abnormal responses in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Hyperglycemia; Hyperinsulinism; Insulin; Male; Medulla Oblongata; Microinjections; Nerve Fibers; Neural Pathways; Protein Precursors; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Thyrotropin-Releasing Hormone; Vagus Nerve | 2010 |
Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats.
Topics: Abdomen; Animals; Blood Glucose; Cold Temperature; Gastric Emptying; Ghrelin; Male; Postoperative Complications; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone | 2010 |
Brain-gut interactions between central vagal activation and abdominal surgery to influence gastric myenteric ganglia Fos expression in rats.
Topics: Animals; Brain; Immunohistochemistry; Male; Myenteric Plexus; Proto-Oncogene Proteins c-fos; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stomach; Thyrotropin-Releasing Hormone; Vagus Nerve | 2011 |
Role of brainstem thyrotropin-releasing hormone-triggered sympathetic overactivation in cardiovascular mortality in type 2 diabetic Goto-Kakizaki rats.
Topics: Adrenal Glands; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blood Glucose; Blood Pressure; Brain Stem; Cardiovascular Diseases; Cisterna Magna; Diabetes Mellitus, Type 2; Heart Rate; Inflammation; Injections; Irbesartan; Male; Myocardium; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; RNA, Messenger; Sympathetic Nervous System; Tetrazoles; Thyrotropin-Releasing Hormone; Vascular Cell Adhesion Molecule-1 | 2012 |