Page last updated: 2024-09-02

l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide and indomethacin

l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide has been researched along with indomethacin in 9 studies

Compound Research Comparison

Studies
(l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide)
Trials
(l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide)
Recent Studies (post-2010)
(l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
1387229,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyl-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (77.78)18.2507
2000's2 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rivier, C; Saperas, ES; Taché, Y; Yang, H1
Taché, Y; Yoneda, M2
Kato, K; Taché, Y; Yang, H1
LePard, KJ; Mohammed, JR; Stephens, RL1
Guth, PH; Király, A; Sütó, G; Taché, Y1
Makino, I; Nakamura, K; Tamori, K; Yoneda, M1
Makino, I; Nakamura, K; Sato, Y; Terano, A; Yoneda, M1
Hiraishi, H; Kono, T; Nakamura, K; Shimada, T; Tamano, M; Watanobe, H; Yoneda, M1

Other Studies

9 other study(ies) available for l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide and indomethacin

ArticleYear
Central action of recombinant interleukin-1 to inhibit acid secretion in rats.
    Gastroenterology, 1990, Volume: 99, Issue:6

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Gastric Acid; Indomethacin; Injections; Injections, Intraperitoneal; Interleukin-1; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Recombinant Proteins; Thyrotropin-Releasing Hormone

1990
Potentiating interactions between medullary serotonin and thyrotropin-releasing hormone-induced gastric erosions in rats.
    Neuroscience letters, 1993, Oct-29, Volume: 161, Issue:2

    Topics: Animals; Cold Temperature; Indomethacin; Injections; Injections, Intravenous; Ketanserin; Male; Medulla Oblongata; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Restraint, Physical; Serotonin; Stomach Ulcer; Stress, Psychological; Thyrotropin-Releasing Hormone

1993
Vagal regulation of gastric prostaglandin E2 release by central TRH in rats.
    The American journal of physiology, 1993, Volume: 264, Issue:2 Pt 1

    Topics: Animals; Brain; Dinoprostone; Extracellular Space; Gastric Acid; Gastric Mucosa; Indomethacin; Injections, Intraventricular; Male; Omeprazole; Pyrrolidonecarboxylic Acid; Rats; Thyrotropin-Releasing Hormone; Vagotomy; Vagus Nerve

1993
Role of prostaglandins and calcitonin gene-related peptide in central vagal cholinergic-dependent protection against gastric injury in urethane-anesthetized rats.
    Digestion, 1996, Volume: 57, Issue:5

    Topics: Anesthesia; Animals; Atropine; Calcitonin Gene-Related Peptide; Ethanol; Gastric Mucosa; Indomethacin; Male; Prostaglandins; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Urethane; Vagotomy; Vagus Nerve

1996
Gastric ECL-cell hyperplasia produces enhanced basal and stimulated gastric acid output but not gastric erosion formation in the rat.
    General pharmacology, 1997, Volume: 28, Issue:3

    Topics: Animals; Carbachol; Enterochromaffin Cells; Female; Gastric Acid; Gastric Mucosa; Histamine; Hyperplasia; Indomethacin; Pentagastrin; Pyrrolidonecarboxylic Acid; Ranitidine; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Stress, Physiological; Thyrotropin-Releasing Hormone

1997
Mechanisms mediating gastric hyperemic and acid responses to central TRH analog at a cytoprotective dose.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 1

    Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Gastric Acid; Gastric Mucosa; Hemodynamics; Hyperemia; Indomethacin; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Reference Values; Thyrotropin-Releasing Hormone; Time Factors; Vascular Resistance

1997
Effect of intracisternal thyrotropin-releasing hormone on hepatic blood flow in rats.
    The American journal of physiology, 1998, Volume: 274, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Blood Pressure; Enzyme Inhibitors; Hydrogen; Indomethacin; Liver; Liver Circulation; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Parasympatholytics; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thyrotropin-Releasing Hormone; Vagotomy

1998
Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats.
    Journal of hepatology, 2003, Volume: 39, Issue:1

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Indomethacin; Injections, Intraventricular; Liver; Liver Diseases; Male; Necrosis; NG-Nitroarginine Methyl Ester; Oxidopamine; Parasympatholytics; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Sympatholytics; Thyrotropin-Releasing Hormone; Vagotomy

2003
Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats.
    Peptides, 2005, Volume: 26, Issue:9

    Topics: Animals; Atropine; Cell Proliferation; Cholinergic Fibers; Cyclic AMP; DNA; Dose-Response Relationship, Drug; Indomethacin; Injections, Intraventricular; Liver; Male; Oxidopamine; Prostaglandins; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Signal Transduction; Thyrotropin-Releasing Hormone; Vagotomy; Vagus Nerve

2005