Page last updated: 2024-09-05

l 778,123 and lonafarnib

l 778,123 has been researched along with lonafarnib in 11 studies

Compound Research Comparison

Studies (l 778,123)	Trials (l 778,123)	Recent Studies (post-2010) (l 778,123)	Studies (lonafarnib)	Trials (lonafarnib)	Recent Studies (post-2010) (lonafarnib)
23	3	2	224	34	90
15	0	5	224	34	90

Protein Interaction Comparison

Protein	Taxonomy	lonafarnib (IC50)
Chain A, Protein farnesyltransferase alpha subunit	Rattus norvegicus (Norway rat)	0.0019
Chain B, Protein farnesyltransferase beta subunit	Rattus norvegicus (Norway rat)	0.0019
GTPase HRas	Homo sapiens (human)	0.07
ATP-dependent translocase ABCB1	Homo sapiens (human)	2.7
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Bos taurus (cattle)	0.0081
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Homo sapiens (human)	0.1498
Protein farnesyltransferase subunit beta	Bos taurus (cattle)	0.0081
Protein farnesyltransferase subunit beta	Homo sapiens (human)	0.1498
Protein farnesyltransferase subunit beta	Rattus norvegicus (Norway rat)	0.0019
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Rattus norvegicus (Norway rat)	0.0019

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (81.82)	29.6817
2010's	1 (9.09)	24.3611
2020's	1 (9.09)	2.80

Authors

Authors	Studies
Bernhard, E; Hahn, SM; McKenna, WG	1
Adjei, AA; Dy, GK; Haluska, P	1
Kelland, LR	1
Helbig, G; Hołowiecki, J	1
Elhamri, M; Thomas, X	1
Abbruzzese, A; Budillon, A; Caponigro, F; Caraglia, M; Marra, M; Tagliaferri, P	1
Appels, NM; Beijnen, JH; Schellens, JH	1
Bauch, JL; Cohen, J; Gu, WZ; Hutchins, CW; Jakob, CG; Leonard, NM; Li, Q; Lin, NH; Marsh, K; Park, D; Rosenberg, SH; Sham, HL; Stoll, VS; Sullivan, G; Tong, Y; Wang, GT; Wang, L; Wang, X; Zhang, H	1
Bell, IM	1
Distefano, MD; Ochocki, JD	1
Korzeniecki, C; Priefer, R	1

Reviews

9 review(s) available for l 778,123 and lonafarnib

Article	Year
Farnesyltransferase inhibitors. Seminars in oncology, 2001, Volume: 28, Issue:5 Suppl 16 Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins	2001
Farnesyl transferase inhibitors as anticancer agents. European journal of cancer (Oxford, England : 1990), 2002, Volume: 38, Issue:13 Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzodiazepines; Cell Division; Clinical Trials as Topic; Combined Modality Therapy; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Imidazoles; Neoplasms; Piperidines; Pyridines; Quinolones; Tumor Cells, Cultured	2002
Farnesyl transferase inhibitors in the treatment of breast cancer. Expert opinion on investigational drugs, 2003, Volume: 12, Issue:3 Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Female; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins	2003
[Ras signaling pathway as a target for farnesyltransferase inhibitors--a new, promising prospects in the treatment for malignant disorders]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 2004, Volume: 57, Issue:9-10 Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Farnesyltranstransferase; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Imidazoles; Neoplasms; Piperidines; Point Mutation; Pyridines; Quinolones; Signal Transduction	2004
[Farnesyltransferase inhibitors: preliminary results in acute myeloid leukemia]. Bulletin du cancer, 2005, Volume: 92, Issue:3 Topics: Alkyl and Aryl Transferases; Benzodiazepines; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Leukemia, Myeloid, Acute; Mitogen-Activated Protein Kinase 1; Myeloproliferative Disorders; Piperidines; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Quinolones; ras Proteins; rho GTP-Binding Proteins	2005
Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications. Current drug targets, 2005, Volume: 6, Issue:3 Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Mevalonic Acid; Neoplasms; Phosphatidylinositol 3-Kinases; Piperidines; Protein Prenylation; Protein Processing, Post-Translational; Pyridines; Quinolones; ras Proteins	2005
Development of farnesyl transferase inhibitors: a review. The oncologist, 2005, Volume: 10, Issue:8 Topics: Animals; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins	2005
Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy? Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8 Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Design; Farnesyltranstransferase; Genes, ras; Humans; Neoplasms	2004
Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway. European journal of medicinal chemistry, 2021, Feb-05, Volume: 211 Topics: Humans; Models, Molecular; Molecular Structure; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Signal Transduction	2021

Other Studies

2 other study(ies) available for l 778,123 and lonafarnib

Article	Year
Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors. Journal of medicinal chemistry, 2004, Jan-29, Volume: 47, Issue:3 Topics: Administration, Oral; Alkyl and Aryl Transferases; Animals; Benzamides; Biological Availability; Cell Membrane Permeability; Crystallography, X-Ray; Dogs; Drug Design; Farnesyltranstransferase; Imidazoles; Models, Molecular; Molecular Structure; Nitriles; Structure-Activity Relationship	2004
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections. MedChemComm, 2013, Volume: 4, Issue:3 Topics:	2013

Article

Year

Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.

Journal of medicinal chemistry, 2004, Jan-29, Volume: 47, Issue:3

Topics: Administration, Oral; Alkyl and Aryl Transferases; Animals; Benzamides; Biological Availability; Cell Membrane Permeability; Crystallography, X-Ray; Dogs; Drug Design; Farnesyltranstransferase; Imidazoles; Models, Molecular; Molecular Structure; Nitriles; Structure-Activity Relationship

2004

Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.

MedChemComm, 2013, Volume: 4, Issue:3

Topics:

2013