Page last updated: 2024-09-05

l 753037 and bq 123

l 753037 has been researched along with bq 123 in 3 studies

Compound Research Comparison

Studies
(l 753037)
Trials
(l 753037)
Recent Studies (post-2010)
(l 753037)
Studies
(bq 123)
Trials
(bq 123)
Recent Studies (post-2010) (bq 123)
18111,39163152

Protein Interaction Comparison

ProteinTaxonomyl 753037 (IC50)bq 123 (IC50)
Endothelin-1 receptorHomo sapiens (human)0.017
Endothelin-1 receptorRattus norvegicus (Norway rat)0.014

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berens, KL; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Decker, ER; Dixon, RA; Holland, GW; Knowles, V; Wang, J; Wu, C; You, TJ1
Abraham, WT; Lamba, S; Suresh, DP1
Gebb, SA; Homma, N; Karoor, V; McMurtry, IF; Morio, Y; Nagaoka, T; Oka, M; Ota, H1

Reviews

1 review(s) available for l 753037 and bq 123

ArticleYear
New developments in heart failure: role of endothelin and the use of endothelin receptor antagonists.
    Journal of cardiac failure, 2000, Volume: 6, Issue:4

    Topics: Bosentan; Carboxylic Acids; Chronic Disease; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Humans; Indans; Peptides, Cyclic; Prognosis; Pyridines; Pyrimidines; Receptors, Endothelin; Sulfonamides; Treatment Outcome

2000

Trials

1 trial(s) available for l 753037 and bq 123

ArticleYear
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
    Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

    Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones

2004

Other Studies

1 other study(ies) available for l 753037 and bq 123

ArticleYear
Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation.
    Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:6

    Topics: Amides; Animals; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme Activation; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; Peptides, Cyclic; Perfusion; Potassium Chloride; Pulmonary Artery; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Serotonin; Signal Transduction; Vasoconstriction

2007