Page last updated: 2024-09-05

l 753037 and bosentan anhydrous

l 753037 has been researched along with bosentan anhydrous in 2 studies

Compound Research Comparison

Studies (l 753037)	Trials (l 753037)	Recent Studies (post-2010) (l 753037)	Studies (bosentan anhydrous)	Trials (bosentan anhydrous)	Recent Studies (post-2010) (bosentan anhydrous)
18	1	1	1,836	215	630

Protein Interaction Comparison

Protein	Taxonomy	bosentan anhydrous (IC50)
Endothelin receptor type B	Rattus norvegicus (Norway rat)	0.095
Endothelin receptor type B	Homo sapiens (human)	0.3044
Endothelin-1 receptor	Homo sapiens (human)	0.2317
Endothelin-1 receptor	Rattus norvegicus (Norway rat)	0.0047
Endothelin-1 receptor	Sus scrofa (pig)	0.0075

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Berens, KL; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Decker, ER; Dixon, RA; Holland, GW; Knowles, V; Wang, J; Wu, C; You, TJ	1
Abraham, WT; Lamba, S; Suresh, DP	1

Reviews

1 review(s) available for l 753037 and bosentan anhydrous

Article	Year
New developments in heart failure: role of endothelin and the use of endothelin receptor antagonists. Journal of cardiac failure, 2000, Volume: 6, Issue:4 Topics: Bosentan; Carboxylic Acids; Chronic Disease; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Humans; Indans; Peptides, Cyclic; Prognosis; Pyridines; Pyrimidines; Receptors, Endothelin; Sulfonamides; Treatment Outcome	2000

Trials

1 trial(s) available for l 753037 and bosentan anhydrous

Article	Year
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist. Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8 Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones	2004

Article

Year

Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.

Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones

2004