Page last updated: 2024-09-04

l 741742 and clozapine

l 741742 has been researched along with clozapine in 7 studies

Compound Research Comparison

Studies
(l 741742)
Trials
(l 741742)
Recent Studies (post-2010)
(l 741742)
Studies
(clozapine)
Trials
(clozapine)
Recent Studies (post-2010) (clozapine)
10049,6917473,148

Protein Interaction Comparison

ProteinTaxonomyl 741742 (IC50)clozapine (IC50)
Adenylate cyclase type 1 Rattus norvegicus (Norway rat)0.14
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)3.6
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.032
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.47
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.476
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.045
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.1233
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.1534
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.1534
5-hydroxytryptamine receptor 1AHomo sapiens (human)0.15
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.031
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.1534
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.013
Alpha-2A adrenergic receptorHomo sapiens (human)0.09
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.14
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.1534
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.0096
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)2
D(2) dopamine receptorHomo sapiens (human)0.2044
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0886
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0567
Alpha-2B adrenergic receptorHomo sapiens (human)0.023
Alpha-2C adrenergic receptorHomo sapiens (human)0.0079
DRattus norvegicus (Norway rat)1.066
D(3) dopamine receptorRattus norvegicus (Norway rat)0.9312
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.2695
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)3.5772
D(2) dopamine receptorBos taurus (cattle)1.804
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.078
D(1A) dopamine receptorHomo sapiens (human)0.107
D(4) dopamine receptorHomo sapiens (human)0.0796
Adenylate cyclase type 3Rattus norvegicus (Norway rat)0.14
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)3.5772
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)3.5772
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0567
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.47
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)5.7544
Histamine H2 receptorHomo sapiens (human)3.61
Alpha-1D adrenergic receptorHomo sapiens (human)0.035
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.9312
Adenylate cyclase type 2Rattus norvegicus (Norway rat)0.14
Adenylate cyclase type 4Rattus norvegicus (Norway rat)0.14
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0658
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.0658
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.373
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.587
D(4) dopamine receptorRattus norvegicus (Norway rat)0.9312
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.587
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.0338
Histamine H1 receptorRattus norvegicus (Norway rat)0.023
Sodium-dependent serotonin transporterHomo sapiens (human)0.546
5-hydroxytryptamine receptor 2C Mus musculus (house mouse)0.028
5-hydroxytryptamine receptor 2AMus musculus (house mouse)0.028
Histamine H1 receptorHomo sapiens (human)0.0049
D(3) dopamine receptorHomo sapiens (human)0.354
Adenylate cyclase type 8Rattus norvegicus (Norway rat)0.14
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.081
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0567
5-hydroxytryptamine receptor 6Homo sapiens (human)0.0171
D(2) dopamine receptorMus musculus (house mouse)0.29
D(2) dopamine receptorRattus norvegicus (Norway rat)0.6759
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)3.6
5-hydroxytryptamine receptor 2BMus musculus (house mouse)0.028
Adenylate cyclase type 6Rattus norvegicus (Norway rat)0.14
Adenylate cyclase type 5Rattus norvegicus (Norway rat)0.14
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.4162
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)3.6
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)3.6
5-hydroxytryptamine receptor 1AMus musculus (house mouse)2
Adenylyl cyclase 7 Rattus norvegicus (Norway rat)0.14
DBos taurus (cattle)4.09

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's2 (28.57)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baker, R; Broughton, HB; Collins, I; Emms, F; Freedman, SB; Leeson, PD; Marwood, R; Patel, S; Ragan, CI; Rowley, M1
Baker, R; Ball, R; Broughton, HB; Collins, I; Davey, WB; Emms, F; Freedman, SB; Leeson, PD; Marwood, R; Patel, S; Ragan, CI; Rowley, M1
Beer, M; Bonner, K; Carling, RW; Emms, F; Fletcher, AE; Jones, EA; Leeson, PD; Marwood, R; Moore, KW; Moyes, CR; Patel, S; Pike, A; Sohal, B1
Bristow, LJ; Hutson, PH; Rowley, M1
Hopkins, CR; Lindsley, CW1
Cao, BJ; Rodgers, RJ1
Bastianetto, S; Danik, M; Mennicken, F; Quirion, R; Williams, S1

Reviews

2 review(s) available for l 741742 and clozapine

ArticleYear
Current and novel approaches to the drug treatment of schizophrenia.
    Journal of medicinal chemistry, 2001, Feb-15, Volume: 44, Issue:4

    Topics: Animals; Antipsychotic Agents; Cholinergic Agonists; Disease Models, Animal; Dopamine Antagonists; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Mice; Mice, Transgenic; Nitric Oxide Synthase; Receptor, Serotonin, 5-HT2A; Receptors, AMPA; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotensin; Receptors, Serotonin; Schizophrenia; Serotonin Antagonists

2001
Return of D
    Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17

    Topics: Animals; Drug Discovery; Humans; Ligands; Molecular Targeted Therapy; Neoplasms; Parkinson Disease; Receptors, Dopamine D4; Small Molecule Libraries; Substance-Related Disorders

2017

Other Studies

5 other study(ies) available for l 741742 and clozapine

ArticleYear
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.
    Journal of medicinal chemistry, 1996, May-10, Volume: 39, Issue:10

    Topics: Cloning, Molecular; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Isoxazoles; Piperidines; Receptors, Dopamine D2; Receptors, Dopamine D4

1996
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.
    Journal of medicinal chemistry, 1997, Jul-18, Volume: 40, Issue:15

    Topics: Cell Line; Humans; Ligands; Piperidines; Receptors, Dopamine D2; Receptors, Dopamine D4

1997
1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.
    Journal of medicinal chemistry, 1999, Jul-15, Volume: 42, Issue:14

    Topics: Animals; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Dopamine Antagonists; Humans; Imidazoles; Ion Channels; Piperidines; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Structure-Activity Relationship

1999
Dopamine D4 receptor and anxiety: behavioural profiles of clozapine, L-745,870 and L-741,742 in the mouse plus-maze.
    European journal of pharmacology, 1997, Sep-24, Volume: 335, Issue:2-3

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Isoxazoles; Male; Maze Learning; Mice; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D4

1997
Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.
    BMC neuroscience, 2006, Mar-30, Volume: 7

    Topics: Animals; Anisoles; Antipsychotic Agents; Benzazepines; Butaclamol; Caspase Inhibitors; Cell Death; Cells, Cultured; Chlorpromazine; Clozapine; Domperidone; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Ginkgo biloba; Haloperidol; Hippocampus; Indans; Isoxazoles; Neurons; Neuroprotective Agents; Peptides; Piperidines; Plant Extracts; Propylamines; Raclopride; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Remoxipride; Risperidone; Sulpiride

2006
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