Compounds > l 741626
Page last updated: 2024-09-04

l 741626 and l 745870

l 741626 has been researched along with l 745870 in 8 studies

Compound Research Comparison

Studies
(l 741626)		Trials
(l 741626)		Recent Studies (post-2010)
(l 741626)		Studies
(l 745870)		Trials
(l 745870)		Recent Studies (post-2010) (l 745870)
7603392029

Protein Interaction Comparison

ProteinTaxonomyl 741626 (IC50)l 745870 (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)9
D(4) dopamine receptorHomo sapiens (human)0.4785
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)9
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)9
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)9

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's4 (50.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baker, R; Broughton, HB; Curtis, NR; Emms, F; Freedman, SB; Kulagowski, JJ; Leeson, PD; Marwood, R; Mawer, IM; Patel, S; Ragan, CI; Ridgill, MP1
Ablordeppey, SY; Altundas, R; Nkansah, NT; Roth, BL; Setola, V; Sikazwe, DM; Zhu, XY1
Brown, NA; McAllister, G; Milligan, G; Pillai, G; Seabrook, GR1
Henry, BL; LaHoste, GJ; Marshall, JF1
Chapman, KL; Hutson, PH; Marston, D; Patel, S; Ragan, CI1
Chaperon, F; Neijt, HC; Tricklebank, MD; Unger, L1
Fan, X; Hess, EJ; Xu, M1
Arai, Y; Kikuchi, T; Mitazaki, S; Nakagawasai, O; Nakaya, K; Niijima, F; Onogi, H; Sato, A; Tadano, T; Tan-No, K1

Other Studies

8 other study(ies) available for l 741626 and l 745870

ArticleYear
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
    Journal of medicinal chemistry, 1996, May-10, Volume: 39, Issue:10

    Topics: Animals; Cell Line; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Pyridines; Pyrroles; Receptors, Dopamine D4

1996
Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.
    Bioorganic & medicinal chemistry, 2009, Feb-15, Volume: 17, Issue:4

    Topics: Antipsychotic Agents; Binding Sites; Butyrophenones; Haloperidol; Humans; Indoles; Kinetics; Ligands; Receptors, Dopamine D2; Structure-Activity Relationship

2009
Human D2 and D4 dopamine receptors couple through betagamma G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectively.
    Neuropharmacology, 1998, Volume: 37, Issue:8

    Topics: Dopamine Antagonists; Dopamine D2 Receptor Antagonists; GTP-Binding Proteins; Humans; Indoles; Ion Channel Gating; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines; Pyrroles; Receptors, Dopamine D4

1998
Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Sep-01, Volume: 20, Issue:17

    Topics: Action Potentials; Amphetamine; Animals; Corpus Striatum; Dopamine Antagonists; Genes, fos; Indans; Indoles; Male; Piperidines; Proto-Oncogene Proteins c-fos; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Tetrodotoxin

2000
Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina.
    Neuropharmacology, 2003, Volume: 44, Issue:8

    Topics: Animals; Binding Sites; Cyclic AMP; Darkness; Dopamine Agonists; Dopamine Antagonists; In Vitro Techniques; Indoles; Male; Piperidines; Pyridines; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Retina; Spiperone

2003
Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors.
    Neuropharmacology, 2003, Volume: 44, Issue:8

    Topics: Animals; Aporphines; Benzazepines; Benzopyrans; Body Temperature Regulation; Dopamine Agonists; Dopamine Antagonists; Hypothermia; Indoles; Oxazines; Piperazines; Piperidines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4

2003
D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD.
    Neurobiology of disease, 2010, Volume: 37, Issue:1

    Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Benzopyrans; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Extracellular Space; Indoles; Locomotion; Mice; Mice, Knockout; Mice, Mutant Strains; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4

2010
p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: contribution of dopamine neurotransmission.
    Behavioural brain research, 2010, Dec-25, Volume: 214, Issue:2

    Topics: Animals; Benzazepines; Clozapine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Oxidopamine; p-Hydroxyamphetamine; Piperazines; Piperidines; Pyridines; Pyrroles; Reflex, Startle; Salicylamides; Sensory Gating; Sympathomimetics; Synaptic Transmission

2010