Page last updated: 2024-09-05

l 734217 and beta-alanine

l 734217 has been researched along with beta-alanine in 4 studies

*beta-Alanine: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported. [MeSH]

*beta-Alanine: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported. [MeSH]

Compound Research Comparison

Studies
(l 734217)
Trials
(l 734217)
Recent Studies (post-2010)
(l 734217)
Studies
(beta-alanine)
Trials
(beta-alanine)
Recent Studies (post-2010) (beta-alanine)
8003,1772071,807

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Anderson, PS; Chang, CT; Cook, JJ; Duggan, ME; Gould, RJ; Hartman, GD; Ihle, NC; Lynch, JJ; Naylor-Olsen, AM; Perkins, JJ1
Cook, JJ; Drag, MD; Duggan, ME; Gehret, JR; Gould, RJ; Hand, EL; Hartman, GD; Holahan, MA; Ihle, NC; Kothstein, T; Lyle, EA; Lynch, JJ; McCormick, GY; Perkins, JJ; Ramjit, DR; Sitko, GR; Stranieri, MT; Stupienski, RF; Wallace, AA1
Cook, JJ; Ellis, JD; Hand, EL; Holahan, MA; Prueksaritanont, T; Sitko, GR; Stranieri, MT1
Bednar, B; Bednar, RA; Cook, JJ; Cunningham, ME; Gould, RJ; Hartman, GD; Holahan, MA; Jumes, PA1

Other Studies

4 other study(ies) available for l 734217 and beta-alanine

ArticleYear
Non-peptide fibrinogen receptor antagonists. 7. Design and synthesis of a potent, orally active fibrinogen receptor antagonist.
    Journal of medicinal chemistry, 1995, Aug-18, Volume: 38, Issue:17

    Topics: Administration, Oral; Amino Acid Sequence; Animals; beta-Alanine; Cells, Cultured; Dogs; Drug Design; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Pan troglodytes; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins

1995
Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:1

    Topics: Animals; beta-Alanine; Dogs; Dose-Response Relationship, Drug; Glycoproteins; Guinea Pigs; Male; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley

1996
Effects of pentobarbital on pharmacokinetics and pharmacodynamics of a potent fibrinogen receptor antagonist, L-734,217, in dogs.
    Biopharmaceutics & drug disposition, 1997, Volume: 18, Issue:8

    Topics: Adenosine Diphosphate; Adjuvants, Anesthesia; Animals; Area Under Curve; beta-Alanine; Collagen; Cross-Over Studies; Dogs; Dose-Response Relationship, Drug; Half-Life; Injections, Intravenous; Male; Pentobarbital; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Radioimmunoassay

1997
Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa.
    Blood, 1999, Jul-15, Volume: 94, Issue:2

    Topics: Animals; Autoantibodies; Autoimmune Diseases; Azepines; beta-Alanine; Blood Platelets; Disease Susceptibility; Dogs; Epitopes; Female; Fibrinolytic Agents; Humans; Immunoglobulin G; Macaca mulatta; Macromolecular Substances; Male; Molecular Structure; Oligopeptides; Pan troglodytes; Piperazines; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Primates; Protein Binding; Sulfonamides; Thrombocytopenia

1999