Page last updated: 2024-09-05

l 734005 and nevirapine

l 734005 has been researched along with nevirapine in 4 studies

*Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS. [MeSH]

*Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS. [MeSH]

Compound Research Comparison

Studies
(l 734005)
Trials
(l 734005)
Recent Studies (post-2010)
(l 734005)
Studies
(nevirapine)
Trials
(nevirapine)
Recent Studies (post-2010) (nevirapine)
7023,2125091,108

Protein Interaction Comparison

ProteinTaxonomyl 734005 (IC50)nevirapine (IC50)
Chain B, Hiv-1 Reverse TranscriptaseHuman immunodeficiency virus 10.08
Chain A, Hiv-1 Reverse TranscriptaseHuman immunodeficiency virus 10.08
Chain A, Hiv-1 Reverse TranscriptaseHuman immunodeficiency virus 10.08
Chain A, Hiv-1 Reverse TranscriptaseHuman immunodeficiency virus 10.08
Chain B, Hiv-1 Reverse TranscriptaseHuman immunodeficiency virus 10.08
Chain A, Reverse transcriptase/ribonuclease HHuman immunodeficiency virus 11.165
Prothrombin Bos taurus (cattle)1.15
Gag-Pol polyproteinHuman immunodeficiency virus type 1 BH101.4504
Gag-Pol polyproteinHuman immunodeficiency virus type 2 (ISOLATE ROD)2.05
Gag-Pol polyproteinHIV-1 M:B_HXB2R1.4353
Imidazoleglycerol-phosphate dehydrataseSaccharomyces cerevisiae S288C1.7
Cytochrome P450 3A4Homo sapiens (human)0.181
Cytochrome P450 2C9 Homo sapiens (human)0.181
Gag-Pol polyproteinHuman immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)0.69
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.7
Microsomal triglyceride transfer protein large subunitHomo sapiens (human)5.75
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)0.18
Reverse transcriptase/RNaseH Human immunodeficiency virus 12.071
Protease Human immunodeficiency virus 10.101
Reverse transcriptase Human immunodeficiency virus 13.995

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Balani, SK; Ciccarone, TM; Condra, JH; Emini, EA; Goldman, ME; Greenlee, WJ; Kauffman, LR; MacTough, SC; Rooney, CS; Williams, TM1
Artico, M; De Martino, G; La Colla, P; La Regina, G; Loi, AG; Marceddu, T; Massa, S; Mura, M; Silvestri, R; Vargiu, L1
Artico, M; Coluccia, A; De Martino, G; Di Pasquali, A; La Regina, G; Ragno, R; Silvestri, R1
Artico, M; Bergamini, A; Ciaprini, C; Coluccia, A; Crespan, E; De Martino, G; La Regina, G; Lavecchia, A; Maga, G; Novellino, E; Piscitelli, F; Ragno, R; Silvestri, R; Sinistro, A1

Other Studies

4 other study(ies) available for l 734005 and nevirapine

ArticleYear
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
    Journal of medicinal chemistry, 1993, Apr-30, Volume: 36, Issue:9

    Topics: Animals; Antiviral Agents; Base Sequence; Biological Availability; HIV; HIV Reverse Transcriptase; HIV-1; Indoles; Macaca mulatta; Molecular Sequence Data; Molecular Structure; Reverse Transcriptase Inhibitors; Sulfoxides

1993
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
    Journal of medicinal chemistry, 2003, Jun-05, Volume: 46, Issue:12

    Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV-1; Humans; Indoles; Mutation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Sulfones

2003
Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivatives.
    Journal of medicinal chemistry, 2005, Jan-13, Volume: 48, Issue:1

    Topics: Binding Sites; Cells, Cultured; Drug Design; Drug Evaluation, Preclinical; HIV Reverse Transcriptase; Humans; Hydrazines; Microbial Sensitivity Tests; Models, Molecular; Nucleosides; Protein Conformation; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Software; Sulfones

2005
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.
    Journal of medicinal chemistry, 2006, Jun-01, Volume: 49, Issue:11

    Topics: Anti-HIV Agents; Cells, Cultured; Drug Design; Drug Resistance, Viral; HIV-1; Humans; Indoles; Lymphocytes; Macrophages; Models, Molecular; Pyrrolidinones; Quantitative Structure-Activity Relationship; Solubility; Sulfones

2006