l 734005 has been researched along with nevirapine in 4 studies
*Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS. [MeSH]
*Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS. [MeSH]
| Studies (l 734005) | Trials (l 734005) | Recent Studies (post-2010) (l 734005) | Studies (nevirapine) | Trials (nevirapine) | Recent Studies (post-2010) (nevirapine) |
|---|---|---|---|---|---|
| 7 | 0 | 2 | 3,212 | 509 | 1,108 |
| Protein | Taxonomy | l 734005 (IC50) | nevirapine (IC50) |
|---|---|---|---|
| Chain B, Hiv-1 Reverse Transcriptase | Human immunodeficiency virus 1 | 0.08 | |
| Chain A, Hiv-1 Reverse Transcriptase | Human immunodeficiency virus 1 | 0.08 | |
| Chain A, Hiv-1 Reverse Transcriptase | Human immunodeficiency virus 1 | 0.08 | |
| Chain A, Hiv-1 Reverse Transcriptase | Human immunodeficiency virus 1 | 0.08 | |
| Chain B, Hiv-1 Reverse Transcriptase | Human immunodeficiency virus 1 | 0.08 | |
| Chain A, Reverse transcriptase/ribonuclease H | Human immunodeficiency virus 1 | 1.165 | |
| Prothrombin | Bos taurus (cattle) | 1.15 | |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 BH10 | 1.4504 | |
| Gag-Pol polyprotein | Human immunodeficiency virus type 2 (ISOLATE ROD) | 2.05 | |
| Gag-Pol polyprotein | HIV-1 M:B_HXB2R | 1.4353 | |
| Imidazoleglycerol-phosphate dehydratase | Saccharomyces cerevisiae S288C | 1.7 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.181 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 0.181 | |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) | 0.69 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.7 | |
| Microsomal triglyceride transfer protein large subunit | Homo sapiens (human) | 5.75 | |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | 0.18 | |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | 2.071 | |
| Protease | Human immunodeficiency virus 1 | 0.101 | |
| Reverse transcriptase | Human immunodeficiency virus 1 | 3.995 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balani, SK; Ciccarone, TM; Condra, JH; Emini, EA; Goldman, ME; Greenlee, WJ; Kauffman, LR; MacTough, SC; Rooney, CS; Williams, TM | 1 |
| Artico, M; De Martino, G; La Colla, P; La Regina, G; Loi, AG; Marceddu, T; Massa, S; Mura, M; Silvestri, R; Vargiu, L | 1 |
| Artico, M; Coluccia, A; De Martino, G; Di Pasquali, A; La Regina, G; Ragno, R; Silvestri, R | 1 |
| Artico, M; Bergamini, A; Ciaprini, C; Coluccia, A; Crespan, E; De Martino, G; La Regina, G; Lavecchia, A; Maga, G; Novellino, E; Piscitelli, F; Ragno, R; Silvestri, R; Sinistro, A | 1 |
4 other study(ies) available for l 734005 and nevirapine
| Article | Year |
|---|---|
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Topics: Animals; Antiviral Agents; Base Sequence; Biological Availability; HIV; HIV Reverse Transcriptase; HIV-1; Indoles; Macaca mulatta; Molecular Sequence Data; Molecular Structure; Reverse Transcriptase Inhibitors; Sulfoxides | 1993 |
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV-1; Humans; Indoles; Mutation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Sulfones | 2003 |
Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivatives.
Topics: Binding Sites; Cells, Cultured; Drug Design; Drug Evaluation, Preclinical; HIV Reverse Transcriptase; Humans; Hydrazines; Microbial Sensitivity Tests; Models, Molecular; Nucleosides; Protein Conformation; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Software; Sulfones | 2005 |
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.
Topics: Anti-HIV Agents; Cells, Cultured; Drug Design; Drug Resistance, Viral; HIV-1; Humans; Indoles; Lymphocytes; Macrophages; Models, Molecular; Pyrrolidinones; Quantitative Structure-Activity Relationship; Solubility; Sulfones | 2006 |