l 733060 and cp 99994
l 733060 has been researched along with cp 99994 in 8 studies
Compound Research Comparison
| Studies (l 733060) | Trials (l 733060) | Recent Studies (post-2010) (l 733060) | Studies (cp 99994) | Trials (cp 99994) | Recent Studies (post-2010) (cp 99994) |
|---|---|---|---|---|---|
| 71 | 0 | 32 | 231 | 2 | 19 |
Protein Interaction Comparison
| Protein | Taxonomy | l 733060 (IC50) | cp 99994 (IC50) |
|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.0006 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 0.0006 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 0.0006 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 0.0006 | |
| Substance-P receptor | Homo sapiens (human) | 0.0004 |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Cascieri, MA; Hale, JJ; MacCoss, M; MacIntyre, DE; Mathre, DJ; Metzger, JM; Mills, SG; Qi, H; Sadowski, S; Shah, SK; Strader, CD | 1 |
| Beusen, DD; Marshall, GR; Shands, EF; Takeuchi, Y | 1 |
| Carlson, EC; de Felipe, C; Harrison, T; Hunt, S; Oates, B; Owen, S; Rupniak, NM; Seward, E; Wheeldon, A | 1 |
| Cohen-Williams, ME; Hunter, JC; Varty, GB | 1 |
| Huang, PQ; Liu, LX; Ruan, YP; Wei, BG | 1 |
| Charette, AB; Grenon, M; Lemire, A; Pourashraf, M | 1 |
| Fang, K; Lin, GQ; Liu, RH; Wang, B; Xu, MH | 1 |
| Pansare, SV; Paul, EK | 1 |
Other Studies
8 other study(ies) available for l 733060 and cp 99994
| Article | Year |
|---|---|
2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.
Topics: Administration, Oral; Animals; CHO Cells; Cricetinae; Humans; Morpholines; Neurokinin-1 Receptor Antagonists | 1996 |
Derivation of a three-dimensional pharmacophore model of substance P antagonists bound to the neurokinin-1 receptor.
Topics: Binding Sites; Biphenyl Compounds; Crystallography, X-Ray; Ligands; Models, Molecular; Molecular Conformation; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P | 1998 |
Pharmacological blockade or genetic deletion of substance P (NK(1)) receptors attenuates neonatal vocalisation in guinea-pigs and mice.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Buspirone; Diazepam; Dose-Response Relationship, Drug; Female; Fluoxetine; Gene Deletion; Guinea Pigs; Imipramine; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Social Isolation; Stress, Psychological; Substance P; Tetrazoles; Vocalization, Animal | 2000 |
The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test.
Topics: Animals; Antidepressive Agents; Aprepitant; Behavior, Animal; Dose-Response Relationship, Drug; Female; Gerbillinae; Immobilization; Morpholines; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines | 2003 |
Asymmetric synthesis of (+)-L-733, 060 and (+)-CP-99, 994 based on a new chiral 3-piperidinol synthon.
Topics: Acetylation; Glutamic Acid; Indicators and Reagents; Neurokinin-1 Receptor Antagonists; Piperidines; Plants, Medicinal; Stereoisomerism | 2003 |
Nucleophilic addition to 3-substituted pyridinium salts: expedient syntheses of (-)-L-733,061 and (-)-CP-99,994.
Topics: Molecular Structure; Piperidines; Pyridinium Compounds; Stereoisomerism; Structure-Activity Relationship; Substance P | 2004 |
Concise asymmetric synthesis of (+)-CP-99,994 and (+)-L-733,060 via efficient construction of homochiral syn-1,2-diamines and syn-1,2-amino alcohols.
Topics: Amino Alcohols; Diamines; Hydroxylation; Molecular Structure; Piperidines; Stereoisomerism | 2008 |
Synthesis of (+)-L-733,060, (+)-CP-99,994 and (2S,3R)-3-hydroxypipecolic acid: application of an organocatalytic direct vinylogous aldol reaction.
Topics: Aldehydes; Catalysis; Pipecolic Acids; Piperidines | 2012 |