Page last updated: 2024-09-03

l 703606 and substance p

l 703606 has been researched along with substance p in 48 studies

Compound Research Comparison

Studies (l 703606)	Recent Studies (post-2010) (l 703606)	Studies (substance p)	Trials (substance p)	Recent Studies (post-2010) (substance p)
74	12	17,289	277	2,010
74	12	23	0	0
74	12	85	0	12

Protein Interaction Comparison

Protein	Taxonomy	substance p (IC50)
Substance-P receptor	Rattus norvegicus (Norway rat)	0.0005
Substance-K receptor	Rattus norvegicus (Norway rat)	0.2
Substance-K receptor	Homo sapiens (human)	0.2455
Substance-P receptor	Homo sapiens (human)	0.0011
Neuromedin-K receptor	Homo sapiens (human)	0.125
Substance-K receptor	Mesocricetus auratus (golden hamster)	0.148

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (25.00)	18.2507
2000's	27 (56.25)	29.6817
2010's	9 (18.75)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Anzini, M; Cappelli, A; Cupello, A; Fazio, F; Finetti, F; Gallelli, A; Giuliani, G; Matarrese, M; Morbidelli, L; Moresco, RM; Pericot Mohr Gl, Gl; Scarrone, S; Vomero, S; Ziche, M	1
Fong, TM; Huang, RR; Strader, CD	1
Bansal, A; Ber, E; Burns, D; Cascieri, MA; Fong, TM; Frances, B; Sadowski, S; Seward, E; Strader, CD; Swain, C	1
Ber, E; Cascieri, MA; Macleod, AM; Merchant, KJ; Sadowski, S; Shiao, LL; Strader, CD; Swain, CJ; Underwood, D; Yu, H	1
Fong, TM; Huang, RR; Strader, CD; Yu, H	1
Daniel, S; Fong, TM; Longmore, J; Mazina, KE; Sirotina, A; Strader, CD; Tota, MR	1
Bollinger, RR; Maggio, JE; Mantyh, CR; Mantyh, PW; Pappas, TN; Vigna, SR	1
Chung, FZ; Huang, CC; Pu, Y; Tian, Y; Wu, LH	1
Kramer, JH; Phillips, TM; Weglicki, WB	1
Bunnett, NW; Grady, EF; Martínez, V; Marvizón, JC; Mayer, EA	1
Löfgren, O; Lundeberg, T; Qi, Y	1
Chung, JM; Han, HC; Hong, SK; Kim, DY; Kim, SH; Kim, YI; Lee, HW; Na, HS; Shin, HC	1
Mustafa, S; Oriowo, MA	1
Gobbetti, A; Petrelli, C; Zerani, M	1
Han, HC; Hong, SK; Kang, HC; Kim, DY; Kim, YI; Lee, KJ; Na, HS; Shin, HC; Yoon, YW	1
Cassone, MC; Collino, M; Dianzani, C; Fantozzi, R; Ferrara, C; Lombardi, G	1
Han, HC; Han, JS; Hong, SK; Hwang, JM; Kim, YI; Min, SS; Na, HS; Yoon, YW	1
Marvizón, JC; Wang, X	1
Chen, B; Hu, D; Tang, C; Tao, K; Wang, J; Zhu, X	1
Heinke, B; Ikeda, H; Ruscheweyh, R; Sandkühler, J	1
Gear, RW; Levine, JD; Tambeli, CH; Young, A	1
Ikeda, M; Kadoi, J; Matsumoto, S; Nasu, M; Ohta, H; Shima, Y; Takeda, M; Tanimoto, T	1
Nies, M; Ro, JY; Zhang, Y	1
Bell, EB; Beresford, LJ; Miyan, JA; Shepherd, AJ	1
Ikeda, M; Kadoi, J; Matsumoto, S; Nasu, M; Takeda, M; Tanimoto, T	1
Endo, D; Ikeda, T; Ishida, Y; Nishimori, T; Yoshioka, D	1
Benetti, E; Collino, M; Dianzani, C; Fantozzi, R; Gallicchio, M; Rosa, AC	1
Coicou, LG; Groth, RD; Mermelstein, PG; Seybold, VS	1
Kim, JH; Lee, SE	1
Barrett-Jolley, R; Womack, MD	1
Barrett-Jolley, R; Gent, TC; Morris, R; Womack, MD	1
Kawana, S; Yamaoka, J	1
Adhikari, S; Bhatia, M; Hegde, A; Moochhala, SM; Ng, SW; Zhang, H	1
Dempsey, RJ; Park, SW; Satriotomo, I; Vemuganti, R; Yan, YP	1
Baumbauer, KM; Hoy, KC; Joynes, RL; Young, EE	1
Feng, NH; Lee, HH; Ma, MC; Shiang, JC	1
Sachs, JR; Wang, DH; Xie, C	1
Holden, JE; Pizzi, JA	1
Chen, YS; Huang, HS; Lee, SH; Ma, MC	1
Hamity, MV; Hammond, DL; White, SR	1
Barreto, SG; Carati, CJ; Saccone, GT; Schloithe, AC; Toouli, J	1
Ikeda, T; Matsushima, O; Naono-Nakayama, R; Nishimori, T; Sunakawa, N	1
Fish, EW; Heilig, M; Krouse, MC; Malanga, CJ; Robinson, JE; Thorsell, A	1
Nishishita, K; Okada, Y; Sato, T; Toda, K	1
Ikeda, K; Kawakami, K; Onimaru, H	1
Chen, PX; Guo, HM; Huang, JH; Luo, YL; Zhang, YL; Zhou, WL; Zhu, YX	1
He, JY; Jiang, LS; Jiang, SD; Zhang, YH; Zhao, ED; Zheng, XF	1
de Oliveira Borges, M; Fischer, L; Lavoranti, MI; Martynhak, BJ; Miksza, AF; Parada, CA; Sardi, NF; Tambeli, CH	1

Other Studies

48 other study(ies) available for l 703606 and substance p

Article	Year
A non-peptide NK1 receptor agonist showing subpicomolar affinity. Journal of medicinal chemistry, 2004, Mar-11, Volume: 47, Issue:6 Topics: Amides; Animals; Cattle; Cell Division; Cyclic GMP; Endothelium, Vascular; Humans; In Vitro Techniques; Inositol Phosphates; Nitric Oxide; Quinolines; Receptors, Neurokinin-1; Structure-Activity Relationship	2004
Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor. The Journal of biological chemistry, 1992, Dec-25, Volume: 267, Issue:36 Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Membrane; Chlorides; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin A; Neurokinin B; Oocytes; Polymerase Chain Reaction; Protein Conformation; Quinuclidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Proteins; Substance P; Xenopus	1992
Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor. Molecular pharmacology, 1992, Volume: 42, Issue:3 Topics: Amino Acid Sequence; Animals; Binding Sites; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Iodine Radioisotopes; Kinetics; Molecular Sequence Data; Quinuclidines; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P	1992
Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. The Journal of biological chemistry, 1994, Mar-04, Volume: 269, Issue:9 Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Histidine; Humans; Inositol Phosphates; Iodine Radioisotopes; Kinetics; Models, Molecular; Molecular Conformation; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Protein Conformation; Quinuclidines; Rats; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Transfection; Tryptophan	1994
Interaction of substance P with the second and seventh transmembrane domains of the neurokinin-1 receptor. Biochemistry, 1994, Mar-15, Volume: 33, Issue:10 Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Structure, Secondary; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Transfection	1994
Characterization of a fluorescent substance P analog. Biochemistry, 1994, Nov-08, Volume: 33, Issue:44 Topics: Amino Acid Sequence; Anisotropy; Binding, Competitive; Buffers; Fluorescein; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Iodine Radioisotopes; Lysine; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Quinuclidines; Receptors, Neurokinin-1; Reference Values; Spectrometry, Fluorescence; Substance P; Temperature	1994
Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors. Neuroscience letters, 1994, Sep-12, Volume: 178, Issue:2 Topics: Binding Sites; Biphenyl Compounds; Blood Vessels; Humans; Indoles; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Isoindoles; Lymphoid Tissue; Neurokinin-1 Receptor Antagonists; Quinuclidines; Receptors, Neurokinin-1; Substance P	1994
Structural motifs encoded by individual exons of the human neurokinin-1 receptor gene interact differentially with selective agonists and antagonists. Journal of neurochemistry, 1996, Volume: 67, Issue:3 Topics: Amino Acid Sequence; Cloning, Molecular; Exons; Humans; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phosphatidylinositols; Piperidines; Protein Binding; Pyrrolidonecarboxylic Acid; Quinuclidines; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Stereoisomerism; Substance P	1996
Magnesium-deficiency-enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade. Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:1 Topics: Animals; Cytokines; Drug Evaluation, Preclinical; Hemodynamics; Magnesium Deficiency; Male; Myocardial Reperfusion Injury; Neurokinin-1 Receptor Antagonists; Neuropeptides; Quinuclidines; Rats; Rats, Sprague-Dawley; Substance P	1997
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-01, Volume: 17, Issue:21 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Capsaicin; Electric Stimulation; Endocytosis; Evoked Potentials; Ganglia, Spinal; Hyperalgesia; Long-Term Potentiation; Male; Microscopy, Confocal; Microscopy, Fluorescence; Models, Neurological; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Substance P	1997
Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model. Burns : journal of the International Society for Burn Injuries, 1999, Volume: 25, Issue:2 Topics: Animals; Burns; Disease Models, Animal; Edema; Follow-Up Studies; Inflammation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Skin Diseases; Substance P	1999
Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat. Neuroscience letters, 1999, Oct-22, Volume: 274, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Animals; Circadian Rhythm; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Male; Neurotransmitter Agents; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Substance P; Suprachiasmatic Nucleus; Synaptic Transmission; Visual Pathways	1999
Inhibitory effect of capsaicin on cholinergic transmission in ovine airways: evidence for non-cholinergic contractions. European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3 Topics: Acetylcholine; Animals; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Peptides, Cyclic; Quinuclidines; Receptors, Drug; Receptors, Neurokinin-2; Serotonin; Sheep; Substance P; Synaptic Transmission; Trachea	1999
Substance P downregulates basal and gonadotropin-releasing hormone-induced gonadotropin in vitro secretion by pituitary gland of crested newt, Triturus carnifex. Journal of neuroendocrinology, 2000, Volume: 12, Issue:12 Topics: Androgens; Animals; Down-Regulation; Estivation; Female; Gonadotropin-Releasing Hormone; Gonadotropins; Hormone Antagonists; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pituitary Gland; Progesterone; Quinuclidines; Receptors, Neurokinin-1; Substance P; Triturus	2000
Substance p plays a critical role in photic resetting of the circadian pacemaker in the rat hypothalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jun-01, Volume: 21, Issue:11 Topics: Animals; Biological Clocks; Circadian Rhythm; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypothalamus; In Vitro Techniques; Male; Membrane Potentials; Neurons; Optic Nerve; Photoperiod; Quinuclidines; Rats; Rats, Sprague-Dawley; Substance P; Suprachiasmatic Nucleus	2001
Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils. Journal of leukocyte biology, 2001, Volume: 69, Issue:6 Topics: Adult; Biphenyl Compounds; Calcium; Calcium Channels; Calcium Signaling; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Humans; Interleukin-8; Ion Transport; Neutrophils; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Recombinant Proteins; Substance P	2001
Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat. Neuroscience letters, 2002, Mar-29, Volume: 322, Issue:1 Topics: Animals; Arthritis; Carrageenan; Dose-Response Relationship, Drug; Knee Joint; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociceptors; Pain; Peripheral Nerves; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Weight-Bearing	2002
Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neurons. Brain research, 2002, Jul-19, Volume: 944, Issue:1-2 Topics: Animals; Cell Culture Techniques; Cell Membrane; Dendrites; Endocytosis; Immunohistochemistry; Microscopy, Confocal; Nociceptors; Pain; Posterior Horn Cells; Protease Inhibitors; Protein Transport; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Temperature; Time Factors; Transport Vesicles	2002
[Substance P up-regulates the TGF-beta 1 mRNA expression of human dermal fibroblasts in vitro]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery, 2002, Volume: 18, Issue:4 Topics: Cell Division; Cells, Cultured; Dermis; Fibroblasts; Gene Expression; Neurokinin-1 Receptor Antagonists; Quinuclidines; RNA, Messenger; Substance P; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation	2002
Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia. Science (New York, N.Y.), 2003, Feb-21, Volume: 299, Issue:5610 Topics: Action Potentials; Animals; Calcium; Calcium Channels, T-Type; Excitatory Postsynaptic Potentials; Hyperalgesia; Ion Channel Gating; Long-Term Potentiation; Membrane Potentials; Nerve Fibers, Unmyelinated; Neurokinin-1 Receptor Antagonists; Nickel; Patch-Clamp Techniques; Posterior Horn Cells; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Signal Transduction; Substance P	2003
Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation. Pain, 2003, Volume: 106, Issue:1-2 Topics: Animals; Benzoates; Capsaicin; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Isoquinolines; Male; Nociceptors; Pyridines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P	2003
Temporomandibular joint inflammation potentiates the excitability of trigeminal root ganglion neurons innervating the facial skin in rats. Journal of neurophysiology, 2005, Volume: 93, Issue:5 Topics: Animals; Behavior, Animal; Cell Count; Cell Size; Cells, Cultured; Drug Interactions; Electric Stimulation; Escape Reaction; Face; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Immunohistochemistry; Male; Membrane Potentials; Neurofilament Proteins; Neurons; Patch-Clamp Techniques; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensory Thresholds; Skin; Stilbamidines; Substance P; Temporomandibular Joint Disorders; Trigeminal Ganglion	2005
Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle. Brain research, 2005, Jun-14, Volume: 1047, Issue:1 Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Edema; Inflammation Mediators; Male; Masseter Muscle; Mustard Plant; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Plant Extracts; Plant Oils; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P	2005
Mobilisation of specific T cells from lymph nodes in contact sensitivity requires substance P. Journal of neuroimmunology, 2005, Volume: 164, Issue:1-2 Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cell Movement; Dermatitis, Contact; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Drug Interactions; Immunohistochemistry; Lymph Nodes; Mice; Nerve Fibers; Quinuclidines; Skin; Substance P; Sympathectomy, Chemical; T-Lymphocytes	2005
Activation of NK1 receptor of trigeminal root ganglion via substance P paracrine mechanism contributes to the mechanical allodynia in the temporomandibular joint inflammation in rats. Pain, 2005, Volume: 116, Issue:3 Topics: Action Potentials; Animals; Behavior, Animal; Cell Count; Dose-Response Relationship, Drug; Drug Interactions; Escape Reaction; Freund's Adjuvant; Functional Laterality; Male; Models, Biological; Neural Conduction; Neurons; Nociceptors; Pain Threshold; Paracrine Communication; Physical Stimulation; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Temporomandibular Joint Disorders; Trigeminal Ganglion	2005
Effect of intrathecal administration of hemokinin-1 on the withdrawal response to noxious thermal stimulation of the rat hind paw. Neuroscience letters, 2006, Jan-09, Volume: 392, Issue:1-2 Topics: Animals; Behavior, Animal; Drug Interactions; Hindlimb; Hot Temperature; Male; Pain; Pain Measurement; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Tachykinins; Time Factors	2006
Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells. British journal of pharmacology, 2006, Volume: 147, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Benzamides; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Flavonoids; Furans; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurokinin-1 Receptor Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyridines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors; Umbilical Veins	2006
Substance P initiates NFAT-dependent gene expression in spinal neurons. Journal of neurochemistry, 2006, Volume: 97, Issue:2 Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Hippocampus; Indoles; Neurokinin A; Neurons, Afferent; NFATC Transcription Factors; Nimodipine; Phorbol 12,13-Dibutyrate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Spleen; Substance P; Tacrolimus	2006
Involvement of substance P and calcitonin gene-related peptide in development and maintenance of neuropathic pain from spinal nerve injury model of rat. Neuroscience research, 2007, Volume: 58, Issue:3 Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Lidocaine; Male; Neuralgia; Pain Measurement; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Spinal Nerves; Substance P; Time Factors	2007
Activation of paraventricular nucleus neurones by the dorsomedial hypothalamus via a tachykinin pathway in rats. Experimental physiology, 2007, Volume: 92, Issue:4 Topics: Action Potentials; Animals; Dorsomedial Hypothalamic Nucleus; Glutamic Acid; Neurons; Paraventricular Hypothalamic Nucleus; Quinuclidines; Rats; Receptors, Neurokinin-1; Substance P	2007
Substance P targets sympathetic control neurons in the paraventricular nucleus. Circulation research, 2007, Jun-08, Volume: 100, Issue:11 Topics: Animals; Blood Pressure; Enzyme Activators; Enzyme Inhibitors; gamma-Aminobutyric Acid; Heart Rate; Kidney; Male; Neural Inhibition; Neurons; Organ Culture Techniques; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Protein Kinase C; Quinuclidines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Neurokinin-1; Substance P; Sympathetic Nervous System	2007
A transient unresponsive state of self-scratching behaviour is induced in mice by skin-scratching stimulation. Experimental dermatology, 2007, Volume: 16, Issue:9 Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Physical Stimulation; Pruritus; Quinuclidines; Self Stimulation; Signal Transduction; Skin Physiological Phenomena; Substance P	2007
Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury. Journal of immunology (Baltimore, Md. : 1950), 2007, Sep-15, Volume: 179, Issue:6 Topics: Animals; Cecum; Gene Deletion; Hydrogen Sulfide; Inflammation Mediators; Ligation; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Protein Precursors; Punctures; Quinuclidines; Sepsis; Substance P; Sulfides; Tachykinins; Up-Regulation	2007
Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions. Journal of neurosurgery, 2007, Volume: 107, Issue:3 Topics: Adult Stem Cells; Animals; Brain Ischemia; Cell Culture Techniques; Cell Proliferation; Doublecortin Protein; Male; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Quinuclidines; Rats; Rats, Inbred SHR; Substance P	2007
Neurokinin receptors modulate the impact of uncontrollable stimulation on adaptive spinal plasticity. Behavioral neuroscience, 2007, Volume: 121, Issue:5 Topics: Adaptation, Psychological; Animals; Electroshock; Female; Learning; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuronal Plasticity; Pain; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Spinal Cord; Spinal Cord Injuries; Substance P; Vocalization, Animal	2007
Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys. American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:2 Topics: Action Potentials; Animals; Blood Pressure; Capsaicin; Cell Membrane; Cytosol; Diterpenes; Electrophysiology; Female; Kidney; Kidney Pelvis; Mechanoreceptors; Models, Biological; Neurokinin-1 Receptor Antagonists; Perfusion; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory System Agents; Substance P; TRPV Cation Channels; Ubiquitin Thiolesterase	2008
Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:3 Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Ganglia, Spinal; Isoindoles; Kidney Pelvis; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peptide Fragments; Quinuclidines; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Substance P; TRPV Cation Channels	2008
Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla. Brain research, 2008, Jun-12, Volume: 1214 Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Carbachol; Cobalt; Female; Hypothalamic Area, Lateral; Medulla Oblongata; Neurons; Pain Measurement; Pain Threshold; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin Antagonists; Stilbamidines; Substance P; Time Factors	2008
Mechanosensitive N-methyl-D-aspartate receptors contribute to sensory activation in the rat renal pelvis. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:5 Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Kidney; Kidney Cortex; Kidney Medulla; Mechanoreceptors; Neurons, Afferent; Quinuclidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Substance P	2008
Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception. Neuroscience, 2010, Feb-03, Volume: 165, Issue:3 Topics: Animals; Capsaicin; Central Nervous System Agents; Freund's Adjuvant; Hot Temperature; Male; Medulla Oblongata; Mustard Plant; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors	2010
The combination of neurokinin-1 and galanin receptor antagonists ameliorates caerulein-induced acute pancreatitis in mice. Peptides, 2010, Volume: 31, Issue:2 Topics: Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Edema; Galanin; Mice; Neurokinin-1 Receptor Antagonists; Pancreas; Pancreas, Exocrine; Pancreatitis; Peroxidase; Quinuclidines; Receptors, Galanin; Receptors, Neurokinin-1; Substance P	2010
Subcutaneous injection of endokinin C/D attenuates carrageenan-induced inflammation. Peptides, 2010, Volume: 31, Issue:9 Topics: Analgesics, Non-Narcotic; Animals; Carrageenan; Dose-Response Relationship, Drug; Edema; Hindlimb; Hot Temperature; Humans; Hyperalgesia; Inflammation; Injections, Subcutaneous; Male; Neuritis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peripheral Nervous System Agents; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Tachykinins	2010
Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism. Psychopharmacology, 2012, Volume: 220, Issue:1 Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Electric Stimulation; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Reinforcement, Psychology; Reward; Substance P	2012
Efferent fibers innervate gustatory and mechanosensitive afferent fibers in frog fungiform papillae. Chemical senses, 2012, Volume: 37, Issue:4 Topics: Action Potentials; Afferent Pathways; Animals; Efferent Pathways; Electric Stimulation; Electrodes; Glossopharyngeal Nerve; Mechanotransduction, Cellular; Nerve Fibers; Quinuclidines; Rana catesbeiana; Substance P; Synaptic Potentials; Taste Buds; Taste Perception	2012
Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats. The Journal of physiology, 2012, Apr-01, Volume: 590, Issue:7 Topics: Adenosine Diphosphate; Animals; Animals, Newborn; Cadmium; Calcium; Calcium Channel Blockers; Carbon Dioxide; Homeodomain Proteins; Hypercapnia; In Vitro Techniques; Magnesium; Medulla Oblongata; Neurokinin-1 Receptor Antagonists; Neurons; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Purinergic P2; Respiratory Center; Substance P; Tetrodotoxin; Transcription Factors	2012
Cellular mechanism underlying formaldehyde-stimulated Cl- secretion in rat airway epithelium. PloS one, 2013, Volume: 8, Issue:1 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anions; Biological Transport; Capsaicin; Cells, Cultured; Chlorides; Colforsin; Epinephrine; Epithelial Cells; Formaldehyde; Imines; Male; Nerve Endings; ortho-Aminobenzoates; Quinuclidines; Rats; Respiratory Mucosa; Substance P; Trachea; TRPV Cation Channels	2013
Inhibition of substance P signaling aggravates the bone loss in ovariectomy-induced osteoporosis. Progress in biophysics and molecular biology, 2016, Volume: 122, Issue:2 Topics: Animals; Body Weight; Bone Density; Down-Regulation; Estradiol; Female; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Organ Size; Osteogenesis; Osteoporosis; Ovariectomy; Quinuclidines; RANK Ligand; RNA, Messenger; Signal Transduction; Substance P; Tibia; Uterus	2016
TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017, Volume: 66, Issue:4 Topics: Acetanilides; Animals; Histamine; Histamine H1 Antagonists; Isothiocyanates; Male; Oligonucleotides, Antisense; p-Methoxy-N-methylphenethylamine; Pain; Piperazines; Purines; Pyrilamine; Quinuclidines; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Histamine H1; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Substance P; TRPA1 Cation Channel; TRPC Cation Channels	2017