l-701324 and 1-aminocyclopropane-1-carboxylic-acid

To examine the role of glycineB receptors in the stimulus effects induced by psychostimulants, separate groups of rats were trained to discriminate amphetamine (AMPH; 1 mg/kg) from saline (SAL), or cocaine (COC; 10 mg/kg) from SAL, using a two-lever operant procedure. Substitution studies showed that neither 1-aminocyclopropanecarboxylic acid (ACPC; 200 mg/kg) nor 7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-(H)quinolone (L-701,324; 3 mg/kg), being a partial agonist or an antagonist at glycineB receptors, respectively, generalized for the training drugs. Combination tests of glycineB ligands demonstrated that injection of a fixed dose of ACPC (200 mg/kg) or L-701,324 (3 mg/kg) together with different doses of AMPH or COC practically did not modify dose-response curves of the psychostimulants, nor did it affect their ED50 values. Our results indicate that glycineB receptors do not play a role in the discriminative effects of AMPH and COC.

Topics: Amino Acids; Amino Acids, Cyclic; Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Discrimination, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ligands; Male; Quinolones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate