Compounds > l-697661
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l-697661 and zidovudine

l-697661 has been researched along with zidovudine in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bamberger, DL; Fisher, TE; Goldman, ME; Hoffman, JM; Jones, JH; Rooney, CS; Saari, WS; Smith, AM; Thomas, CM; Wai, JS1
Bethell, RC; Cammack, N; Green, DV; Hancock, AP; Hann, MM; Lamont, RB; Livermore, DG; Noble, SA; Orr, DC; Payne, JJ1
Balani, SK; Ciccarone, TM; Condra, JH; Emini, EA; Goldman, ME; Greenlee, WJ; Kauffman, LR; MacTough, SC; Rooney, CS; Williams, TM1
Althaus, IW; Biles, C; Busso, M; Genin, MJ; Morge, RA; Resnick, L; Reusser, F; Romero, DL; Tarpley, WG; Thomas, RC1
Bell, FW; Cantrell, AS; Högberg, M; Jaskunas, SR; Johansson, NG; Jordan, CL; Kinnick, MD; Lind, P; Morin, JM; Noréen, R1
Altamura, S; Campiani, G; De Filippis, MP; Di Renzo, L; Fiorini, I; Garofalo, A; Greco, G; Nacci, V; Novellino, E1
Anderson, KW; Bakshi, KK; Durr, S; Göhler, R; Kober, A; Massari, FE; Schneider, CL; Staszewski, S; Taylor, VI; Waterbury, JA1
Chen, S; Chopra, P; Emini, EA; Hahn, BH; Kappes, JC; McFarland, R; Piatak, M; Saag, MS; Shaw, GM; Yang, LC1
Byrnes, VW; Douglas, J; Emini, EA; Hildebrand, C; Kappes, JC; Lapidus, WI; Laskin, OL; Saag, MS; Schleif, WA; Whitley, RJ1
Davey, RT; Dewar, RL; Falloon, J; Haneiwich, SE; Kovacs, JA; Masur, H; Polis, MA; Reed, GF; Vasudevachari, MB; Walker, RE1
Blaschke, T; Campbell, TB; Collier, A; Kahn, J; Kuritzkes, DR; Messari, F; Phair, J; Pottage, JC; Rosandich, ME; Schooley, RT; Stein, DS1
Baumberger, C; Hirschel, B; Kinloch-de Loës, S; Pechère, M; Perrin, L; Rakik, A; Yerly, S1

Trials

5 trial(s) available for l-697661 and zidovudine

ArticleYear
Combination therapy with zidovudine prevents selection of human immunodeficiency virus type 1 variants expressing high-level resistance to L-697,661, a nonnucleoside reverse transcriptase inhibitor.
    The Journal of infectious diseases, 1995, Volume: 171, Issue:5

    Topics: Adult; Antiviral Agents; Base Sequence; Benzoxazoles; CD4 Lymphocyte Count; Double-Blind Method; Drug Resistance, Microbial; Drug Therapy, Combination; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Molecular Sequence Data; Mutation; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Zidovudine

1995
Assessment of antiretroviral therapy by plasma viral load testing: standard and ICD HIV-1 p24 antigen and viral RNA (QC-PCR) assays compared.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1995, Oct-01, Volume: 10, Issue:2

    Topics: Antiviral Agents; Benzoxazoles; Biomarkers; CD4 Lymphocyte Count; Double-Blind Method; HIV Core Protein p24; HIV Infections; HIV-1; Humans; Immunoassay; Polymerase Chain Reaction; Prospective Studies; Pyridones; Reverse Transcriptase Inhibitors; RNA, Viral; Viremia; Zidovudine

1995
A short-term clinical evaluation of L-697,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. L-697,661 Working Group.
    The New England journal of medicine, 1993, Oct-07, Volume: 329, Issue:15

    Topics: Adult; Antiviral Agents; Base Sequence; Benzoxazoles; CD4-Positive T-Lymphocytes; DNA, Viral; Double-Blind Method; Female; Follow-Up Studies; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Leukocyte Count; Male; Molecular Sequence Data; Pyridones; Reverse Transcriptase Inhibitors; Zidovudine

1993
Plasma viremia as a sensitive indicator of the antiretroviral activity of L-697,661.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Jun-15, Volume: 90, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Benzoxazoles; beta 2-Microglobulin; Biomarkers; CD4 Antigens; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; HIV Core Protein p24; HIV Seropositivity; HIV-1; Humans; Male; Neoplasms; Pyridones; Time Factors; Viremia; Zidovudine

1993
Phase 1 study of combination therapy with L-697,661 and zidovudine. The ACTG 184 Protocol Team.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, Aug-01, Volume: 12, Issue:4

    Topics: Adult; Antipyrine; Antiviral Agents; Base Sequence; Benzoxazoles; Cross-Over Studies; DNA Primers; DNA, Viral; Drug Interactions; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Genes, pol; Genotype; HIV Seropositivity; HIV-1; Humans; Male; Molecular Sequence Data; Pilot Projects; Pyridones; Reverse Transcriptase Inhibitors; Zidovudine

1996

Other Studies

7 other study(ies) available for l-697661 and zidovudine

ArticleYear
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one.
    Journal of medicinal chemistry, 1992, Oct-16, Volume: 35, Issue:21

    Topics: Aminopyridines; Antiviral Agents; Benzoxazoles; Cells, Cultured; HIV Reverse Transcriptase; HIV-1; Pyridones; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

1992
Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines.
    Journal of medicinal chemistry, 1993, Nov-26, Volume: 36, Issue:24

    Topics: Antiviral Agents; Cell Division; Cell Line; Crystallization; HIV Reverse Transcriptase; HIV-1; Imidazoles; Molecular Structure; Pyridazines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Virus Replication; Zidovudine

1993
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
    Journal of medicinal chemistry, 1993, Apr-30, Volume: 36, Issue:9

    Topics: Animals; Antiviral Agents; Base Sequence; Biological Availability; HIV; HIV Reverse Transcriptase; HIV-1; Indoles; Macaca mulatta; Molecular Sequence Data; Molecular Structure; Reverse Transcriptase Inhibitors; Sulfoxides

1993
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]pi
    Journal of medicinal chemistry, 1993, May-14, Volume: 36, Issue:10

    Topics: Antiviral Agents; Delavirdine; Indoles; Piperazines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Virus Replication

1993
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.
    Journal of medicinal chemistry, 1995, Dec-08, Volume: 38, Issue:25

    Topics: Animals; Antiviral Agents; Cell Line; HIV-1; Humans; Isothiocyanates; Rats; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Thiourea

1995
Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity.
    Journal of medicinal chemistry, 1996, Jul-05, Volume: 39, Issue:14

    Topics: Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Molecular Structure; Oxazepines; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thiazepines

1996
Combined therapy with zidovudine and L-697,661 in primary HIV infection.
    AIDS (London, England), 1996, Volume: 10, Issue:11

    Topics: Adult; Anti-HIV Agents; Benzoxazoles; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; DNA, Viral; Drug Therapy, Combination; HIV Infections; Humans; Pyridones; Reverse Transcriptase Inhibitors; RNA, Viral; Viral Load; Viremia; Zidovudine

1996