l-689502 has been researched along with pepstatin* in 1 studies
1 other study(ies) available for l-689502 and pepstatin
| Article | Year |
|---|---|
HIV-1 protease inhibitory activity of L-694,746, a novel metabolite of L-689,502.
L-689,502 is a potent inhibitor of HIV-1 protease activity in vitro. Microbial biotransformations of L-689,502 by cultures belonging to the genus Streptomyces sp. were performed. Extracts of culture broths were examined for the production of metabolites of L-689,502 that could inhibit HIV-1 protease activity. One culture, MA 6804 (Streptomyces lavendulae, ATCC 55095), produced L-694,746 that, while being structurally related to L-689,502, is a novel metabolite and a potent inhibitor of HIV-1 protease. Topics: Amino Acid Sequence; Biotransformation; Chromatography, High Pressure Liquid; HIV Protease Inhibitors; HIV-1; Kinetics; Molecular Sequence Data; Molecular Structure; Morpholines; Oligopeptides; Pepstatins; Peptides; Protease Inhibitors; Streptomyces | 1991 |