l-683590 and adenosine-3--5--cyclic-phosphorothioate

l-683590 has been researched along with adenosine-3--5--cyclic-phosphorothioate* in 1 studies

Other Studies

1 other study(ies) available for l-683590 and adenosine-3--5--cyclic-phosphorothioate

ArticleYear
B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Apr-11, Volume: 92, Issue:8

    Treatment of small resting B cells with soluble F(ab')2 fragments of anti-IgM, an analogue of T-independent type 2 antigens, induced activation characterized by proliferation and the expression of surface CD5. In contrast, B cells induced to proliferate in response to thymus-dependent inductive signals provided by either fixed activated T-helper 2 cells or soluble CD40 ligand-CD8 (CD40L) recombinant protein displayed elevated levels of CD23 (Fc epsilon II receptor) and no surface CD5. Treatment with anti-IgM and CD40L induced higher levels of proliferation and generated a single population of B cells coexpressing minimal amounts of CD5 and only a slight elevation of CD23. Anti-IgM- but not CD40L-mediated activation was highly sensitive to inhibition by cyclosporin A and FK520. Sp-cAMPS, an analogue of cAMP, augmented CD40L and suppressed surface IgM-mediated activation. Taken together these results are interpreted to mean that there is a single population of small resting B cells that can respond to either T-independent type 2 (surface IgM)- or T-dependent (CD40)-mediated activation. In response to different intracellular signals these cells are induced to enter alternative differentiation pathways.

    Topics: Animals; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; CD40 Antigens; CD5 Antigens; Cells, Cultured; Cyclic AMP; Cyclosporine; Dose-Response Relationship, Drug; Flow Cytometry; Immunoglobulin M; Immunologic Capping; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Receptors, Antigen, B-Cell; Receptors, IgE; Signal Transduction; Spleen; Tacrolimus; Thionucleotides

1995