Compounds > l 658758
Page last updated: 2024-09-03

l 658758 and indomethacin

l 658758 has been researched along with indomethacin in 3 studies

Compound Research Comparison

Studies
(l 658758)		Trials
(l 658758)		Recent Studies (post-2010)
(l 658758)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
260029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyl 658758 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Harada, N; Liu, W; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M1
Harada, N; Mori, M; Okajima, K; Uchiba, M1
Harada, N; Kawai, M; Okajima, K; Takeyama, H1

Other Studies

3 other study(ies) available for l 658758 and indomethacin

ArticleYear
Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats.
    The Journal of laboratory and clinical medicine, 1997, Volume: 130, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cephalosporins; Cimetidine; Gastric Mucosa; Glycine; Granulocytes; Indomethacin; Leukocyte Elastase; Male; Methotrexate; Microcirculation; Neutrophil Activation; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Specific Pathogen-Free Organisms; Stomach Diseases; Sulfonamides

1997
Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Permeability; Cephalosporins; Chemokines, CXC; Cyclooxygenase Inhibitors; Endothelium; Enzyme Inhibitors; Epoprostenol; Glycine; Iloprost; Indomethacin; Intercellular Signaling Peptides and Proteins; Leukocyte Elastase; Liver; Liver Circulation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides; Transaminases; Vasodilator Agents

2004
Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats.
    Translational research : the journal of laboratory and clinical medicine, 2010, Volume: 155, Issue:6

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcitonin Gene-Related Peptide; Cephalosporins; Glycine; Hepatic Artery; Iloprost; Indomethacin; Insulin-Like Growth Factor I; Leukocyte Elastase; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Peroxidase; Platelet Aggregation Inhibitors; Portal Vein; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides

2010