l-651896 and flunixin-meglumine

Dogs were treated with flunixin meglumine, a cyclooxygenase inhibitor; L-651,896, a 5-lipoxygenase inhibitor; and matrine, a herbal anti-inflammatory drug. Acute inflammation was induced in the eyes by disruption of the anterior lens capsule, using a neodymium:yttrium aluminum garnet laser. Intraocular pressure, pupil diameter, and eicosanoid production in the aqueous humor were measured. Statistically significant effects were seen in the eyes of flunixin meglumine-treated dogs where mydriasis was maintained and aqueous prostaglandin E2 concentration was reduced.

Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Benzofurans; Clonixin; Dinoprostone; Dog Diseases; Dogs; Intraocular Pressure; Laser Therapy; Leukotriene B4; Lipoxygenase Inhibitors; Matrines; Pupil; Quinolizines; Uveitis