Page last updated: 2024-09-03

l 649923 and indomethacin

l 649923 has been researched along with indomethacin in 8 studies

Compound Research Comparison

Studies
(l 649923)
Trials
(l 649923)
Recent Studies (post-2010)
(l 649923)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
364029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyl 649923 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19905 (62.50)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hu, W; Kinnaird, AA; Man, RY1
Hu, WM; Man, RY1
Charette, L; Denis, D; Jones, TR1
Flemström, G; Knutson, L; Nimbratt, C1
Ford-Hutchinson, AW; Garceau, D1
Bell, RL; Regal, JF1
Fitzsimmons, B; Foster, A; Letts, LG1
Gyömber, E; Rainsford, KD; Szabo, S; Vattay, P1

Other Studies

8 other study(ies) available for l 649923 and indomethacin

ArticleYear
Mechanisms of the coronary vascular effects of platelet-activating factor in the rat perfused heart.
    British journal of pharmacology, 1991, Volume: 103, Issue:1

    Topics: Animals; Blood Pressure; Coronary Circulation; Diterpenes; Ginkgolides; Heart; In Vitro Techniques; Indoles; Indomethacin; Lactones; Leukotriene Antagonists; Leukotriene B4; Perfusion; Phenylbutyrates; Piperazines; Platelet Activating Factor; Rats; Rats, Inbred Strains; SRS-A

1991
Interaction of vasoactive substances released by platelet-activating factor in the rat perfused heart.
    British journal of pharmacology, 1991, Volume: 104, Issue:4

    Topics: Animals; Arachidonic Acids; Blood Gas Analysis; Coronary Circulation; Cyclooxygenase Inhibitors; Heart; In Vitro Techniques; Indoles; Indomethacin; Leukotriene Antagonists; Perfusion; Phenylbutyrates; Platelet Activating Factor; Potassium; Rats; Rats, Inbred Strains; Sodium; SRS-A; Vasoconstriction

1991
Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor.
    Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:6

    Topics: Animals; Antibodies, Anti-Idiotypic; Arachidonate Lipoxygenases; Atropine; Benzofurans; Chromones; Goats; Humans; In Vitro Techniques; Indomethacin; Keto Acids; Lipoxygenase Inhibitors; Muscle Contraction; Phenylbutyrates; Pyrilamine; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Sulfones; Trachea

1988
Effects of leukotriene D4, the antagonist L-649-923, and arachidonic acid on duodenal bicarbonate secretion in the rat in vivo.
    Scandinavian journal of gastroenterology, 1988, Volume: 23, Issue:10

    Topics: Animals; Arachidonic Acids; Bicarbonates; Duodenum; Ethanol; Indomethacin; Intestinal Mucosa; Male; Phenylbutyrates; Rats; Secretory Rate; SRS-A

1988
The role of leukotriene D4 as a mediator of allergic conjunctivitis in the guinea-pig.
    European journal of pharmacology, 1987, Feb-24, Volume: 134, Issue:3

    Topics: Animals; Capillary Permeability; Conjunctivitis, Allergic; Guinea Pigs; Histamine; Indomethacin; Keto Acids; Male; Phenylbutyrates; SRS-A; Sulfones

1987
Mediators of C5a-induced bronchoconstriction in the guinea pig.
    International archives of allergy and applied immunology, 1987, Volume: 84, Issue:4

    Topics: Acetylcholine; Animals; Atropine; Bronchi; Bronchial Spasm; Chromones; Complement C5; Guinea Pigs; Histamine; Indomethacin; Male; Phenylbutyrates; Pyrilamine; SRS-A

1987
The synthesis of N-acetyl-leukotriene E4 and its effects on cardiovascular and respiratory function of the anesthetized pig.
    Prostaglandins, 1986, Volume: 31, Issue:6

    Topics: Animals; Blood Pressure; Cardiac Output; Cardiovascular System; Dose-Response Relationship, Drug; Drug Interactions; Female; Indomethacin; Injections, Intravenous; Leukotriene E4; Male; Phenylbutyrates; Respiratory System; SRS-A; Swine

1986
Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat.
    Journal of gastroenterology and hepatology, 1996, Volume: 11, Issue:10

    Topics: Animals; Aspirin; Benzofurans; Ethanol; Female; Gastritis; Indomethacin; Iodoacetamide; Leukotriene D4; Leukotrienes; Lipoxygenase Inhibitors; Peptic Ulcer Hemorrhage; Phenylbutyrates; Propionates; Quinolines; Rats; Rats, Sprague-Dawley; Stomach Ulcer

1996