Compounds > l 648051
Page last updated: 2024-09-03

l 648051 and indomethacin

l 648051 has been researched along with indomethacin in 4 studies

Compound Research Comparison

Studies
(l 648051)		Trials
(l 648051)		Recent Studies (post-2010)
(l 648051)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
246029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyl 648051 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19903 (75.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Banner, BL; Chiu, AM; Cohen, N; Focella, A; Lopresti, RJ; O'Donnell, M; Schaer, B; Todaro, L; Weber, G; Zenchoff, GB1
Lindén, A; Löfdahl, CG; Skoogh, BE; Ullman, A1
Charette, L; Denis, D; Jones, TR1
Ford-Hutchinson, AW; Garceau, D1

Other Studies

4 other study(ies) available for l 648051 and indomethacin

ArticleYear
3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:8

    Topics: Animals; Benzopyrans; Chemical Phenomena; Chemistry; Chromans; Guinea Pigs; Leukotriene Antagonists; Male; Models, Molecular; Rats; Receptors, Immunologic; Receptors, Leukotriene; Stereoisomerism; Structure-Activity Relationship

1989
In vitro characteristics of spontaneous airway tone in the guinea-pig.
    Acta physiologica Scandinavica, 1991, Volume: 142, Issue:3

    Topics: Animals; Bronchi; Chromones; Cyclooxygenase Inhibitors; Guinea Pigs; In Vitro Techniques; Indomethacin; Keto Acids; Male; Muscle Contraction; Muscle Tonus; Parasympatholytics; Receptors, Immunologic; Receptors, Leukotriene; Respiratory Physiological Phenomena; Respiratory System; SRS-A; Sulfones; Sympathetic Nervous System; Trachea

1991
Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor.
    Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:6

    Topics: Animals; Antibodies, Anti-Idiotypic; Arachidonate Lipoxygenases; Atropine; Benzofurans; Chromones; Goats; Humans; In Vitro Techniques; Indomethacin; Keto Acids; Lipoxygenase Inhibitors; Muscle Contraction; Phenylbutyrates; Pyrilamine; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Sulfones; Trachea

1988
The role of leukotriene D4 as a mediator of allergic conjunctivitis in the guinea-pig.
    European journal of pharmacology, 1987, Feb-24, Volume: 134, Issue:3

    Topics: Animals; Capillary Permeability; Conjunctivitis, Allergic; Guinea Pigs; Histamine; Indomethacin; Keto Acids; Male; Phenylbutyrates; SRS-A; Sulfones

1987