l 648051 has been researched along with histamine in 3 studies
*Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. [MeSH]
*Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. [MeSH]
| Studies (l 648051) | Trials (l 648051) | Recent Studies (post-2010) (l 648051) | Studies (histamine) | Trials (histamine) | Recent Studies (post-2010) (histamine) |
|---|---|---|---|---|---|
| 24 | 6 | 0 | 37,718 | 1,372 | 3,457 |
| Protein | Taxonomy | l 648051 (IC50) | histamine (IC50) |
|---|---|---|---|
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | 0.1585 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.1585 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Björck, T; Dahlén, SE | 1 |
| Barnes, NC; Costello, JF; Evans, JM; Piper, PJ; Sciberras, DG; Stahl, EG; Zakrzewski, JT | 1 |
| Ford-Hutchinson, AW; Garceau, D | 1 |
1 trial(s) available for l 648051 and histamine
| Article | Year |
|---|---|
L-648,051, a novel cysteinyl-leukotriene antagonist is active by the inhaled route in man.
Topics: Administration, Inhalation; Adult; Bronchi; Dose-Response Relationship, Drug; Double-Blind Method; Forced Expiratory Volume; Histamine; Histamine Antagonists; Humans; Keto Acids; Male; Respiratory Function Tests; SRS-A; Sulfones; Time Factors | 1989 |
2 other study(ies) available for l 648051 and histamine
| Article | Year |
|---|---|
Evidence indicating that leukotrienes C4, D4 and E4 are major mediators of contraction induced by anti-IgE in human bronchi.
Topics: Acetylcholine; Antibodies, Anti-Idiotypic; Bronchi; Histamine; Humans; Immunoglobulin E; Keto Acids; Leukotriene E4; Leukotrienes; Metiamide; Muscle Contraction; Phenylbutyrates; Pyrilamine; SRS-A; Sulfones | 1989 |
The role of leukotriene D4 as a mediator of allergic conjunctivitis in the guinea-pig.
Topics: Animals; Capillary Permeability; Conjunctivitis, Allergic; Guinea Pigs; Histamine; Indomethacin; Keto Acids; Male; Phenylbutyrates; SRS-A; Sulfones | 1987 |