l-159884 and methyl-iodide

l-159884 has been researched along with methyl-iodide* in 1 studies

Other Studies

1 other study(ies) available for l-159884 and methyl-iodide

Article	Year
Development of [11C]L-159,884: a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 1996, Volume: 47, Issue:2 [11C]L-159,884 ([11C] N-[[4'[(2-ethyl-5,7-dimethyl-3H- imidazo[4,5-b]pyridin-3-yl) methyl] [1,1'-biphenyl]-2-yl] sulfonyl]-4-methoxybenzamide) and [11C]L-162,574 ([11C] N-[[4'[2-ethyl-5,7- dimethyl-3H-imidazo[4,5-b] pyridin-3-yl)methyl] [1,1'-biphenyl]-2-yl]sulfonyl]-3- methoxybenzamide), both potent and selective ligands for the AT1 receptor, were prepared by C-11 methylation of the corresponding desmethyl phenolic precursors. The radiotracers were purified by semi-preparative reverse-phase HPLC. Non-decay corrected radiochemical yields were 5 and 3% for L-159,884 and L-162,574 respectively, and the average specific activity was 2979 mCi/mumol at end-of-synthesis (EOS). The average time of synthesis was 18 min. Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Hydrocarbons, Iodinated; Image Processing, Computer-Assisted; Imidazoles; Isotope Labeling; Pyridines; Receptors, Angiotensin; Tomography, Emission-Computed	1996

Article

Year

Development of [11C]L-159,884: a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 1996, Volume: 47, Issue:2

[11C]L-159,884 ([11C] N-[[4'[(2-ethyl-5,7-dimethyl-3H- imidazo[4,5-b]pyridin-3-yl) methyl] [1,1'-biphenyl]-2-yl] sulfonyl]-4-methoxybenzamide) and [11C]L-162,574 ([11C] N-[[4'[2-ethyl-5,7- dimethyl-3H-imidazo[4,5-b] pyridin-3-yl)methyl] [1,1'-biphenyl]-2-yl]sulfonyl]-3- methoxybenzamide), both potent and selective ligands for the AT1 receptor, were prepared by C-11 methylation of the corresponding desmethyl phenolic precursors. The radiotracers were purified by semi-preparative reverse-phase HPLC. Non-decay corrected radiochemical yields were 5 and 3% for L-159,884 and L-162,574 respectively, and the average specific activity was 2979 mCi/mumol at end-of-synthesis (EOS). The average time of synthesis was 18 min.

Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Hydrocarbons, Iodinated; Image Processing, Computer-Assisted; Imidazoles; Isotope Labeling; Pyridines; Receptors, Angiotensin; Tomography, Emission-Computed

1996