l-084 and azetidine

l-084 has been researched along with azetidine* in 1 studies

Other Studies

1 other study(ies) available for l-084 and azetidine

Article	Year
A practical and facile synthesis of azetidine derivatives for oral carbapenem, L-084. Chemical & pharmaceutical bulletin, 2006, Volume: 54, Issue:10 An orally active carbapenem L-084, which exhibits high bioavailability in humans, has a 1-(1,3-thiazolin-2-yl)azetidin-3-ylthio moiety at the C-2 position of the 1beta-methylcarbapenem skeleton. We established a practical and cost-effective synthesis of 3-mercapto-1-(1,3-thiazolin-2-yl)azetidine (1) for further scale-up production of L-084. This synthesis method entails an industry-oriented reaction of azetidine ring-closure to yield N-benzyl-3-hydroxyazetidine (16), which is eventually converted to 1 via key intermediates, Bunte salts 19 and 20. Topics: Administration, Oral; Azetidines; Carbapenems; Drug Industry; Humans; Molecular Structure; Stereoisomerism; Thiazoles	2006

Article

Year

A practical and facile synthesis of azetidine derivatives for oral carbapenem, L-084.

Chemical & pharmaceutical bulletin, 2006, Volume: 54, Issue:10

An orally active carbapenem L-084, which exhibits high bioavailability in humans, has a 1-(1,3-thiazolin-2-yl)azetidin-3-ylthio moiety at the C-2 position of the 1beta-methylcarbapenem skeleton. We established a practical and cost-effective synthesis of 3-mercapto-1-(1,3-thiazolin-2-yl)azetidine (1) for further scale-up production of L-084. This synthesis method entails an industry-oriented reaction of azetidine ring-closure to yield N-benzyl-3-hydroxyazetidine (16), which is eventually converted to 1 via key intermediates, Bunte salts 19 and 20.

Topics: Administration, Oral; Azetidines; Carbapenems; Drug Industry; Humans; Molecular Structure; Stereoisomerism; Thiazoles

2006