Page last updated: 2024-09-03

kyotorphin and naloxone

kyotorphin has been researched along with naloxone in 18 studies

Compound Research Comparison

Studies
(kyotorphin)
Trials
(kyotorphin)
Recent Studies (post-2010)
(kyotorphin)
Studies
(naloxone)
Trials
(naloxone)
Recent Studies (post-2010) (naloxone)
16802220,1341,2573,321

Protein Interaction Comparison

ProteinTaxonomykyotorphin (IC50)naloxone (IC50)
Cytochrome P450 2D6Homo sapiens (human)2
Delta-type opioid receptorMus musculus (house mouse)0.043
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0219
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0019
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0019
Mu-type opioid receptorHomo sapiens (human)0.0397
Delta-type opioid receptorHomo sapiens (human)0.1896
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.05
Kappa-type opioid receptorHomo sapiens (human)0.0795
Mu-type opioid receptorMus musculus (house mouse)0.0154
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0089
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0055

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199014 (77.78)18.7374
1990's2 (11.11)18.2507
2000's1 (5.56)29.6817
2010's1 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hirai, K; Katayama, Y1
Chepkova, AN; Zotov, VM1
Iwama, T; Satoh, M; Takagi, H; Wada, T1
Bean, AJ; Vaught, JL2
Ijichi, H; Kizu, A; Nakagawa, M; Shimamura, O; Yamasaki, Y1
Balderrama, N; Maldonado, H; Miralto, A; Núñez, J1
Akutsu, Y; Kawamura, S; Kisara, K; Sakurada, S; Sakurada, T; Sasaki, Y; Suzuki, K1
Akutsu, Y; Kawamura, S; Kisara, K; Sakurada, S; Sakurada, T; Sasaki, Y; Sato, T; Suzuki, K; Watanabe, S1
Stone, TW1
Chipkin, RE; Vaught, JL1
Akaike, A; Kawajiri, S; Satoh, M; Takagi, H; Ukai, Y; Yamamoto, M1
Kawamuki, K; Satoh, M; Takagi, H; Yamamoto, M1
Baile, CA; Della-Fera, MA; Keim, DA; McLaughlin, CL1
Peng, SQ; Qiu, XC; Wang, C; Zhu, Y1
Kawabata, A; Takagi, H; Umeda, N1
Browning, KN; Kalyuzhny, AE; Travagli, RA1
Bocheva, AI; Bozhilova-Pastirova, AA; Dzambazova, EB; Landzhov, BV1

Other Studies

18 other study(ies) available for kyotorphin and naloxone

ArticleYear
Effect of the endogenous analgesic dipeptide, kyotorphin, on transmitter release in sympathetic ganglia.
    British journal of pharmacology, 1985, Volume: 85, Issue:3

    Topics: Acetylcholine; Action Potentials; Analgesics; Animals; Endorphins; Female; Ganglia, Sympathetic; In Vitro Techniques; Male; Membrane Potentials; Naloxone; Neurotransmitter Agents; Rana catesbeiana

1985
[Effect of kyotorphin on the reactivity of hippocampal neurons].
    Biulleten' eksperimental'noi biologii i meditsiny, 1986, Volume: 101, Issue:5

    Topics: Action Potentials; Animals; Electric Stimulation; Endorphins; Enkephalin, Methionine; Hippocampus; In Vitro Techniques; Naloxone; Neurons; Rats; Rats, Inbred Strains

1986
Sites of analgesic actions of kyotorphin and D-kyotorphin in the central nervous system of rats.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Analgesics; Animals; Central Nervous System; Endorphins; Enkephalins; Leucine; Male; Naloxone; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reticular Formation; Spinal Cord

1985
Physical dependence produced by chronic intracerebroventricular infusion of [D-Arg]kyotorphin or thiorphan to rats.
    European journal of pharmacology, 1984, Oct-15, Volume: 105, Issue:3-4

    Topics: Amino Acids, Sulfur; Analgesics; Animals; Cerebral Ventricles; Endorphins; Humans; Male; Morphine; Naloxone; Neprilysin; Opioid-Related Disorders; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance Withdrawal Syndrome; Thiorphan; Tiopronin

1984
Lack of active site for kyotorphin in rat mast cells: assessment by its effect on IgE-mediated 14C-serotonin release.
    Japanese journal of pharmacology, 1982, Volume: 32, Issue:6

    Topics: Alprostadil; Animals; Endorphins; Immunoglobulin E; In Vitro Techniques; Mast Cells; Naloxone; Narcotics; Prostaglandins E; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin

1982
[D-Arg]Kyotorphin-induced ipsilateral rotation: evidence for in vivo effects independent of Met-enkephalin release.
    Brain research, 1984, Nov-12, Volume: 321, Issue:2

    Topics: Animals; Endorphins; Enkephalin, Methionine; Male; Motor Activity; Naloxone; Rats; Rats, Inbred Strains; Rotation; Substantia Nigra

1984
The stinging response of the honeybee: effects of morphine, naloxone and some opioid peptides.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:16

    Topics: Animals; Bees; Behavior, Animal; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Insect Bites and Stings; Morphine; Naloxone

1983
Antinociceptive effect of centrally administered cyclo(N-methyl-L-Tyr-L-Arg) in the rat.
    European journal of pharmacology, 1983, Sep-16, Volume: 93, Issue:1-2

    Topics: Analgesics; Animals; Endorphins; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naloxone; Peptides, Cyclic; Rats; Rats, Inbred Strains; Reaction Time; Time Factors

1983
Comparison of the antinociceptive effects of intracerebroventricular injection of kyotorphin, cyclo (N-methyl-Tyr-Arg) and Met-enkephalin in mice.
    Neuropharmacology, 1984, Volume: 23, Issue:1

    Topics: Analgesia; Analgesics; Animals; Endorphins; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Naloxone; Nociceptors; Peptides, Cyclic

1984
A comparison of the effects of morphine, enkephalin, kyotorphin and D-phenylalanine on rat central neurones.
    British journal of pharmacology, 1983, Volume: 79, Issue:1

    Topics: Animals; Brain; Cerebral Cortex; Endorphins; Enkephalin, Methionine; Globus Pallidus; Iontophoresis; Male; Morphine; Naloxone; Neurons; Phenylalanine; Rats

1983
A characterization of kyotorphin (Tyr-Arg)-induced antinociception.
    European journal of pharmacology, 1982, Apr-23, Volume: 79, Issue:3-4

    Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Endorphins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Time Factors

1982
Effects of tyrosyl-arginine (kyotorphin), a new opioid dipeptide, on single neurons in the spinal dorsal horn of rabbits and the nucleus reticularis paragigantocellularis of rats.
    Neuroscience letters, 1980, Volume: 16, Issue:3

    Topics: Animals; Endorphins; Guinea Pigs; Iontophoresis; Male; Medulla Oblongata; Microinjections; Naloxone; Rabbits; Rats; Rats, Inbred Strains; Spinal Cord

1980
Kyotorphin (L-Tyr-L-Arg) inhibits extinction of pole-jumping avoidance response in the rat.
    Neuroscience letters, 1982, Aug-16, Volume: 31, Issue:2

    Topics: Animals; Avoidance Learning; Endorphins; Enkephalin, Leucine; Extinction, Psychological; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Rats; Rats, Inbred Strains

1982
Opiate antagonists and agonists and feeding in sheep.
    Physiology & behavior, 1981, Volume: 26, Issue:6

    Topics: Animals; Dipeptides; Drinking; Drug Interactions; Endorphins; Enkephalins; Feeding Behavior; Male; Naloxone; Narcotic Antagonists; Sheep; Water Deprivation

1981
[The permissive action of glucocorticoid on the analgesic effect of kyotorphin and its analogue].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:3

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Endorphins; Female; Hydrocortisone; Male; Naloxone; Pain Threshold; Rats; Rats, Wistar; Stereoisomerism

1993
L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: Analgesics; Animals; Arginine; Brain; Cyclic GMP; Endorphins; Enkephalin, Methionine; Injections, Intraventricular; Male; Methylene Blue; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain Measurement; Spinal Cord

1993
Opioid peptides inhibit excitatory but not inhibitory synaptic transmission in the rat dorsal motor nucleus of the vagus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Apr-15, Volume: 22, Issue:8

    Topics: Animals; Brain Stem; Digestive System; Electric Stimulation; Endorphins; Excitatory Postsynaptic Potentials; Immunohistochemistry; In Vitro Techniques; Motor Neurons; Naloxone; Narcotic Antagonists; Neural Inhibition; Opioid Peptides; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Receptors, Opioid, mu; Solitary Nucleus; Synaptic Transmission; Vagus Nerve

2002
Effects of D-kyotorphin on nociception and NADPH-d neurons in rat's periaqueductal gray after immobilization stress.
    Amino acids, 2011, Volume: 41, Issue:4

    Topics: Analgesics; Animals; Endorphins; Male; NADH Dehydrogenase; Naloxone; Neurons; Nitric Oxide; Nociception; Periaqueductal Gray; Rats; Rats, Wistar; Stress, Physiological

2011