Page last updated: 2024-09-03

kyotorphin and enkephalin, leucine

kyotorphin has been researched along with enkephalin, leucine in 18 studies

Compound Research Comparison

Studies
(kyotorphin)
Trials
(kyotorphin)
Recent Studies (post-2010)
(kyotorphin)
Studies
(enkephalin, leucine)
Trials
(enkephalin, leucine)
Recent Studies (post-2010) (enkephalin, leucine)
16802211,52480754

Protein Interaction Comparison

ProteinTaxonomykyotorphin (IC50)enkephalin, leucine (IC50)
Delta-type opioid receptorMus musculus (house mouse)0.0142
Kappa-type opioid receptorMus musculus (house mouse)0.0417
Mu-type opioid receptorHomo sapiens (human)9.5
Mu-type opioid receptorMus musculus (house mouse)0.0308
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.246

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199014 (77.78)18.7374
1990's3 (16.67)18.2507
2000's0 (0.00)29.6817
2010's1 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Akasaki, K; Tsuji, H1
Arai, H; Hosoda, K; Jogasaki, M; Mukoyama, M; Nakao, K; Ogawa, Y; Saito, Y; Shirakami, G; Suga, S; Yamada, T1
Shiomi, H; Ueda, H1
Abissova, NA; Bobrova, IV; Nikiforovich, GV; Podin'sh, LU; Vesterman, BG1
Iwama, T; Satoh, M; Takagi, H; Wada, T1
Amano, H; Kaneko, S; Morimoto, Y; Takagi, H1
Kimura, S1
Balderrama, N; Maldonado, H; Miralto, A; Núñez, J1
Laubie, M; Schmitt, H1
Manavalan, P; Momany, FA1
Kawamuki, K; Satoh, M; Takagi, H; Yamamoto, M1
Amano, H; Kojima, H; Kubota, M; Nagase, O; Takagi, H; Yajima, H1
Shiomi, H; Takagi, H; Ueda, H1
Amano, H; Harada, Y; Kuraishi, Y; Shiomi, H; Takagi, H; Ueda, H1
Baile, CA; Della-Fera, MA; Keim, DA; McLaughlin, CL1
Amano, H; Kubota, M; Nagase, O; Takagi, H; Yajima, H1
Kim, B; Kim, DH; Kim, HS; Kobashi, K; Sohng, IS1
Abu Hammad, I; Bachar, T; Grinberg, S; Heldman, E; Linder, C; Popov, M; Stepensky, D1

Reviews

2 review(s) available for kyotorphin and enkephalin, leucine

ArticleYear
[Isolation and analgesic mechanism of the opioid analgesic neuropeptide, kyotorphin (Tyr-Arg)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1985, Volume: 105, Issue:6

    Topics: Aminopeptidases; Analgesics; Animals; Brain Chemistry; Cattle; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endorphins; Enkephalins; Guinea Pigs; Male; Mice; Nerve Tissue Proteins; Rats; Receptors, Opioid

1985
[Trends in the study of opioid peptides].
    Nihon rinsho. Japanese journal of clinical medicine, 1983, Volume: 41, Issue:3

    Topics: Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry; Endorphins; Enkephalins; Peptides; Pituitary Hormones, Anterior; Pro-Opiomelanocortin; Protein Precursors

1983

Other Studies

16 other study(ies) available for kyotorphin and enkephalin, leucine

ArticleYear
An enkephalin-degrading aminopeptidase from rat brain catalyzes the hydrolysis of a neuropeptide, kyotorphin (L-Tyr-L-Arg).
    Chemical & pharmaceutical bulletin, 1991, Volume: 39, Issue:7

    Topics: Aminopeptidases; Animals; Brain; Endorphins; Enkephalins; Hydrolysis; Rats

1991
[Nerve tissue distribution and physiologic role of endogenous opioid peptides and their receptors--POMC-, proenkephalin A, proenkephalin B- derived opioid peptides and kyotorphin].
    Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48, Issue:5

    Topics: Amino Acid Sequence; Animals; Brain; Cell Communication; Eating; Endorphins; Enkephalins; Humans; Molecular Sequence Data; Pituitary Hormones; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid; Sexual Behavior; Sexual Behavior, Animal; Vasopressins

1990
[Synthesis, biological activity and conformation of enkephalin analogs structurally related to kyotorphin].
    Bioorganicheskaia khimiia, 1988, Volume: 14, Issue:6

    Topics: Analgesics; Dipeptides; Endorphins; Enkephalins; Protein Conformation; Spectrometry, Fluorescence

1988
Sites of analgesic actions of kyotorphin and D-kyotorphin in the central nervous system of rats.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Analgesics; Animals; Central Nervous System; Endorphins; Enkephalins; Leucine; Male; Naloxone; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reticular Formation; Spinal Cord

1985
Opioid activity of enkephalin analogues containing the kyotorphin-related structure in the N-terminus.
    Neuropharmacology, 1984, Volume: 23, Issue:4

    Topics: Analgesics; Animals; Brain; Cell Membrane; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Thiorphan; Tiopronin; Vas Deferens

1984
The stinging response of the honeybee: effects of morphine, naloxone and some opioid peptides.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:16

    Topics: Animals; Bees; Behavior, Animal; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Insect Bites and Stings; Morphine; Naloxone

1983
Indication for central vagal endorphinergic control of heart rate in dogs.
    European journal of pharmacology, 1981, May-22, Volume: 71, Issue:4

    Topics: Analgesia; Animals; Brain; Captopril; Dipeptides; Dogs; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Heart Rate; Male; Oligopeptides; Phenylalanine; Physostigmine; Potassium; Puromycin; Vagus Nerve; Veratridine

1981
Conformational studies on the enkephalin releasing peptides. Tyr-Arg and Tyr-D-Arg.
    Biochemical and biophysical research communications, 1982, Apr-14, Volume: 105, Issue:3

    Topics: Dipeptides; Endorphins; Enkephalins; Protein Conformation; Thermodynamics

1982
Kyotorphin (L-Tyr-L-Arg) inhibits extinction of pole-jumping avoidance response in the rat.
    Neuroscience letters, 1982, Aug-16, Volume: 31, Issue:2

    Topics: Animals; Avoidance Learning; Endorphins; Enkephalin, Leucine; Extinction, Psychological; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Rats; Rats, Inbred Strains

1982
Further synthesis of enkephalinol analogs containing the dipeptide unit Tyr-Arg (kyotorphin).
    Chemical & pharmaceutical bulletin, 1982, Volume: 30, Issue:7

    Topics: Analgesics; Animals; Endorphins; Enkephalins; Mice

1982
Isolation and identification of an analgesic opioid dipeptide kyotorphin (Tyr-Arg) from bovine brain.
    Neuropharmacology, 1981, Volume: 20, Issue:7

    Topics: Amino Acid Sequence; Animals; Brain Chemistry; Cattle; Cisterna Magna; Dipeptides; Endorphins; Enkephalin, Methionine; Enkephalins; Injections; Male; Mice; Morphine

1981
Mechanism of kyotorphin-induced release of Met-enkephalin from guinea pig striatum and spinal cord.
    Brain research, 1981, Sep-21, Volume: 221, Issue:1

    Topics: Animals; Calcium; Corpus Striatum; Dipeptides; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Potassium; Spinal Cord; Tetrodotoxin

1981
Opiate antagonists and agonists and feeding in sheep.
    Physiology & behavior, 1981, Volume: 26, Issue:6

    Topics: Animals; Dipeptides; Drinking; Drug Interactions; Endorphins; Enkephalins; Feeding Behavior; Male; Naloxone; Narcotic Antagonists; Sheep; Water Deprivation

1981
Enkephalin analogs containing the dipeptide unit Tyr-Arg (kyotorphin).
    Chemical & pharmaceutical bulletin, 1980, Volume: 28, Issue:9

    Topics: Analgesics; Animals; Dipeptides; Endorphins; Enkephalins; Mice

1980
Sulfation of parabens and tyrosylpeptides by bacterial arylsulfate sulfotransferases.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:10

    Topics: Animals; Arylsulfotransferase; Cholecystokinin; Endorphins; Enkephalin, Leucine; Eubacterium; Feces; Fungi; Haemophilus; Humans; Hydrogen-Ion Concentration; Hydroxybenzoates; Intestines; Klebsiella; Male; Mice; Naphthols; Parabens; Phenols; Rats; Staphylococcus aureus; Substrate Specificity

1994
Delivery of analgesic peptides to the brain by nano-sized bolaamphiphilic vesicles made of monolayer membranes.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2013, Volume: 85, Issue:3 Pt A

    Topics: Analgesics; Animals; Blood-Brain Barrier; Brain; Cations; Chitosan; Cholinesterases; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Endorphins; Enkephalin, Leucine; Furans; Male; Mice; Mice, Inbred ICR; Nanoparticles; Pain; Peptides; Pyridones; Tissue Distribution

2013