kynurenine and melatonin

kynurenine has been researched along with melatonin in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19905 (13.16)18.7374
1990's5 (13.16)18.2507
2000's6 (15.79)29.6817
2010's14 (36.84)24.3611
2020's8 (21.05)2.80

Authors

AuthorsStudies
Blake, P; Kennaway, DJ; Webb, HA1
Hirata, F1
Kostellow, AB; Morrill, GA2
Hayaishi, O; Hirata, F; Seno, S; Tokuyama, T1
Acuña-Castroviejo, D; Molina-Carballo, A; Muñóz-Hoyos, A; Rodríguez-Cabezas, T; Ruiz-Cosano, C; Uberos-Fernández, J1
Acuña-Castroviejo, D; Camacho, E; Escames, G; Espinosa, A; Gallo, MA; Gómez, I; León, J; Vives, F1
Acuña-Castroviejo, D; Camacho, E; Crespo, E; Escames, G; Espinosa, A; Gallo, MA; León, J; Vives, F1
Hu, DN; McCormick, SA; Roberts, JE1
Acuña-Castroviejo, D; Macías, M; Martín-Medina, E; Molina-Carballo, A; Muñoz-Hoyos, A; Narbona-López, E; Rodríguez-Cabezas, T; Valenzuela-Ruiz, A1
Chignell, CF; Hu, DN; Martinez, L; Roberts, JE1
Acuña-Castroviejo, D; Camacho, E; Escames, G; Espinosa, A; Gallo, MA; Khaldy, H; León, J; Macías, M; Martín, M1
Dryhurst, G; Horstman, JA; Wrona, MZ1
Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW; Stoy, N1
Acuña-Castroviejo, D; Camacho, E; Escames, G; Espinosa, A; Gallo, MA; García-Navarro, A; González-Puga, C; López, A; López, LC; López-Cantarero, M1
Ducrocq, C; Peyrot, F1
Dougherty, GG; Kaddurah-Daouk, R; Keshavan, MS; Krishnan, RR; Matson, WR; McEvoy, J; Montrose, DM; Reddy, RD; Rozen, S; Yao, JK1
Molina-Carballo, A; Muñoz-Hoyos, A; Romero, J; Uberos, J1
Augustin-Morales, M; Contreras-Chova, F; Justicia-Martínez, F; Molina-Carballo, A; Muñoz-Hoyos, A; Naranjo-Gómez, A; Uberos, J1
Brzozowska, I; Brzozowski, T; Drozdowicz, D; Hubalewska-Mazgaj, M; Laidler, PM; Stelmaszynska, T; Zagajewski, J1
Barboni, L; Graham, D; Liao, Z; Nzowa, LK; Tapondjou, LA; Teponno, RB; Verotta, L; Zink, MC1
Albuquerque, RC; Campa, A; Clara, RO; Coimbra, JB; Júlio, AR; Maria-Engler, SS; Moreno, AC; Oliveira, EM1
Buttar, HS; Nayak, BN1
Anderson, G; Bellivier, F; Geoffroy, PA; Jacob, A1
Anderson, G1
Kaminski, T; Michalowska, M; Oksztulska-Kolanek, E; Pawlak, D; Znorko, B1
Al-Dhabi, NA; Bai, M; Duraipandiyan, V; Liu, G; Liu, H; Oso, AO; Tossou, MC; Wu, X; Xi, Q; Xu, K; Yin, Y1
Hu, N; Li, Y; Oxenkrug, G; Yang, D; Yang, Q1
Levy, HL; Murali, SG; Nair, N; Ney, DM; Rohr, F; Sawin, EA; Stroup, BM1
Blank, C; Canazei, M; Griesmacher, A; Hanser, F; Leichtfried, V; Schobersberger, W1
Babyak, MA; Boyle, SH; Georgiades, A; Grichnik, K; Kaddurah-Daouk, R; Kuhn, CM; Matson, SA; Matson, WR; Mirjankar, N; Reavis, ZW; Sarangi, S; Siegler, IC; Stafford-Smith, M; Suarez, EC; Williams, RB1
Dei Cas, M; Foschino, R; Iriti, M; Laganaro, A; Paroni, R; Vigentini, I; Vitalini, S1
Kanova, M; Kohout, P1
Alavinejad, N; Apetz, N; Drzezga, A; Endepols, H; Neumaier, B; Vus, S; Zischler, J; Zlatopolskiy, BD1
Bendová, Z; Hrubcová, L; Kubištová, A; Moravcová, S; Novotný, J; Pačesová, D; Spišská, V1
Ejtemaei-Mehr, S; Ghahremani, MH; Ghanbari, A; Ghazi-Khansari, M; Guillemin, GJ; Jand, Y1
Benninga, MA; Boneh, RS; de Jonge, WJ; Emond, P; Ghiboub, M; Lefèvre, A; Sovran, B; Van Limbergen, JE; Verburgt, CM; Wine, E1
Berger, F; Duchesne Blanes, IL; Fulzele, S; Gupta, SK; Isales, C; Vyavahare, S1

Reviews

6 review(s) available for kynurenine and melatonin

ArticleYear
Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species.
    Journal of pineal research, 2008, Volume: 45, Issue:3

    Topics: Animals; Antioxidants; Carcinogens; Humans; Kynuramine; Kynurenine; Melatonin; Mutagens; Nitric Oxide Donors; Nitrogen Dioxide; Nitroso Compounds; Oxidation-Reduction; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; Serotonin; Stress, Physiological; Tryptophan

2008
Bipolar Disorder: The Role of the Kynurenine and Melatonergic Pathways.
    Current pharmaceutical design, 2016, Volume: 22, Issue:8

    Topics: Animals; Bipolar Disorder; Humans; Kynurenine; Melatonin; Signal Transduction; Tryptophan

2016
New insights into tryptophan and its metabolites in the regulation of bone metabolism.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2015, Volume: 66, Issue:6

    Topics: Animals; Bone and Bones; Humans; Kynurenine; Melatonin; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Serotonin; Tryptophan; Xanthurenates

2015
A review of the immunomodulatory role of dietary tryptophan in livestock and poultry.
    Amino acids, 2017, Volume: 49, Issue:1

    Topics: Animal Feed; Animals; Dietary Supplements; Humans; Immunity, Innate; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Livestock; Lymphocytes; Melatonin; Poultry; Quinolinic Acid; Serotonin; Swine; Tryptophan

2017
Tryptophan: A Unique Role in the Critically Ill.
    International journal of molecular sciences, 2021, Oct-28, Volume: 22, Issue:21

    Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Melatonin; Muscle, Skeletal; Sepsis; Serotonin; Tryptophan

2021
Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease.
    Experimental gerontology, 2023, Volume: 183

    Topics: Indoles; Kynurenine; Melatonin; Microbiota; Tryptophan

2023

Trials

3 trial(s) available for kynurenine and melatonin

ArticleYear
Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin.
    British journal of clinical pharmacology, 2007, Volume: 64, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Rheumatoid; Cytokines; Female; Humans; Kynurenine; Male; Melatonin; Middle Aged; Treatment Outcome

2007
Metabolomic changes demonstrate reduced bioavailability of tyrosine and altered metabolism of tryptophan via the kynurenine pathway with ingestion of medical foods in phenylketonuria.
    Molecular genetics and metabolism, 2017, Volume: 121, Issue:2

    Topics: Adolescent; Adult; Amino Acids; Biological Availability; Caseins; Catecholamines; Cross-Over Studies; Diet; Female; Food, Formulated; Gastrointestinal Microbiome; Humans; Kynurenine; Male; Melatonin; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Peptide Fragments; Phenylketonurias; Prebiotics; Serotonin; Tryptophan; Tyrosine; Young Adult

2017
Sustained Diet-Induced Remission in Pediatric Crohn's Disease Is Associated With Kynurenine and Serotonin Pathways.
    Inflammatory bowel diseases, 2023, 05-02, Volume: 29, Issue:5

    Topics: Child; Crohn Disease; Diet; Humans; Kynurenine; Melatonin; Prospective Studies; Quinolinic Acid; Remission Induction; Serotonin; Tryptophan

2023

Other Studies

29 other study(ies) available for kynurenine and melatonin

ArticleYear
A melatonin agonist and N-acetyl-N2-formyl-5-methoxykynurenamine accelerate the reentrainment of the melatonin rhythm following a phase advance of the light-dark cycle.
    Brain research, 1989, Aug-28, Volume: 495, Issue:2

    Topics: Animals; Darkness; Kynurenine; Light; Male; Melatonin; Periodicity; Rats; Rats, Inbred Strains

1989
[Melatonin (author's transl)].
    No shinkei geka. Neurological surgery, 1974, Volume: 2, Issue:3

    Topics: Animals; Circadian Rhythm; Humans; Kynurenine; Melatonin; Pigmentation; Pineal Gland; Serotonin

1974
Factors controlling the selection of tissue-specific metabolic pathways in early embryonic cells.
    Experimental cell research, 1973, Mar-15, Volume: 77, Issue:1

    Topics: Animals; Anura; Carbon Isotopes; Cells, Cultured; Culture Media; Embryo, Nonmammalian; Female; Kynurenine; Melatonin; Methods; Protein Biosynthesis; Proteins; Rana pipiens; Serotonin; Time Factors; Tryptophan; Tryptophan Hydroxylase; Tryptophan Oxygenase

1973
In vitro and in vivo formation of two new metabolites of melatonin.
    The Journal of biological chemistry, 1974, Feb-25, Volume: 249, Issue:4

    Topics: Acetamides; Ammonium Sulfate; Animals; Brain; Carbon Radioisotopes; Central Nervous System; Chromatography, Ion Exchange; Enzymes; Kynurenine; Male; Melatonin; Ozone; Rabbits; Rats; Streptomycin; Urine

1974
Tryptophan induction of the serotonin and kynurenine pathways in the early amphibian embryo.
    Nature: New biology, 1971, May-26, Volume: 231, Issue:21

    Topics: 5-Hydroxytryptophan; Animals; Anura; Carbon Isotopes; Chloramphenicol; Chlorpromazine; Chromatography, Thin Layer; Culture Techniques; Depression, Chemical; Embryo, Nonmammalian; Enzyme Induction; Ethanol; Indoles; Iproniazid; Kynurenine; Melatonin; Mixed Function Oxygenases; Protein Biosynthesis; RNA; Serotonin; Tryptophan; Tryptophan Oxygenase

1971
Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures.
    Clinical endocrinology, 1997, Volume: 47, Issue:6

    Topics: 3-Hydroxyanthranilic Acid; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infant; Kynurenic Acid; Kynurenine; Male; Melatonin; Seizures, Febrile; Tryptophan; Xanthurenates

1997
Modulation of rat striatal glutamatergic response in search for new neuroprotective agents: evaluation of melatonin and some kynurenine derivatives.
    Brain research bulletin, 1998, Mar-15, Volume: 45, Issue:5

    Topics: Animals; Corpus Striatum; Electric Stimulation; Electrophysiology; Evoked Potentials; Glutamic Acid; Iontophoresis; Kynurenic Acid; Kynurenine; Male; Melatonin; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Reaction Time; Structure-Activity Relationship

1998
Modification of nitric oxide synthase activity and neuronal response in rat striatum by melatonin and kynurenine derivatives.
    Journal of neuroendocrinology, 1998, Volume: 10, Issue:4

    Topics: Animals; Corpus Striatum; Electric Stimulation; Glutamic Acid; Kynurenine; Melatonin; Neurons; Nitric Oxide Synthase; Rats; Somatosensory Cortex

1998
Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells.
    Melanoma research, 1998, Volume: 8, Issue:3

    Topics: Cell Division; Dose-Response Relationship, Drug; Humans; Kynurenine; Melanoma; Melatonin; Serotonin; Tryptophan; Tumor Cells, Cultured; Uveal Neoplasms

1998
Comparison between tryptophan methoxyindole and kynurenine metabolic pathways in normal and preterm neonates and in neonates with acute fetal distress.
    European journal of endocrinology, 1998, Volume: 139, Issue:1

    Topics: Acute Disease; Circadian Rhythm; Female; Fetal Blood; Fetal Distress; Humans; Indoles; Infant, Newborn; Infant, Premature; Kynurenine; Male; Melatonin; Reference Values; Tryptophan; Umbilical Arteries; Umbilical Veins

1998
Photophysical studies on melatonin and its receptor agonists.
    Journal of pineal research, 2000, Volume: 29, Issue:2

    Topics: Acetamides; Hematoporphyrins; Kynurenine; Luminescent Measurements; Melatonin; Oxygen; Phenalenes; Photochemistry; Polycyclic Compounds; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Spectrophotometry, Ultraviolet; Thiazoles; Thiosemicarbazones; Ultraviolet Rays

2000
Structure-related inhibition of calmodulin-dependent neuronal nitric-oxide synthase activity by melatonin and synthetic kynurenines.
    Molecular pharmacology, 2000, Volume: 58, Issue:5

    Topics: Animals; Antioxidants; Calmodulin; Corpus Striatum; Enzyme Inhibitors; Kynurenine; Male; Melatonin; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar

2000
Further insights into the reaction of melatonin with hydroxyl radical.
    Bioorganic chemistry, 2002, Volume: 30, Issue:5

    Topics: Free Radical Scavengers; Hydroxyl Radical; Kynurenine; Melatonin; Spectrometry, Mass, Electrospray Ionization; Tryptamines

2002
Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture.
    Journal of pineal research, 2007, Volume: 43, Issue:2

    Topics: Cell Proliferation; Colonic Neoplasms; Glutathione; Glutathione Peroxidase; Glutathione Reductase; HT29 Cells; Humans; Inhibitory Concentration 50; Kynurenine; Melatonin; Molecular Structure; Receptors, Melatonin; Structure-Activity Relationship; Thiazoles; Thiosemicarbazones

2007
Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia.
    Molecular psychiatry, 2010, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Antipsychotic Agents; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Melatonin; Oxidative Stress; Schizophrenia; Serotonin; Tryptophan; Young Adult

2010
Melatonin and elimination of kynurenines in children with Down's syndrome.
    Journal of pediatric endocrinology & metabolism : JPEM, 2010, Volume: 23, Issue:3

    Topics: Child; Child, Preschool; Circadian Rhythm; Down Syndrome; Female; Humans; Kynurenic Acid; Kynurenine; Male; Melatonin; ortho-Aminobenzoates; Oxidative Stress; Serotonin; Tryptophan

2010
Psychosocial dwarfism: psychopathological aspects and putative neuroendocrine markers.
    Psychiatry research, 2011, Jun-30, Volume: 188, Issue:1

    Topics: Adolescent; Adrenocorticotropic Hormone; Analysis of Variance; beta-Endorphin; Chi-Square Distribution; Child; Child Behavior Disorders; Child, Preschool; Circadian Rhythm; Developmental Disabilities; Dwarfism; Failure to Thrive; Female; Humans; Kynurenine; Male; Melatonin; Neurosecretory Systems; Psychopathology; Serotonin

2011
Conversion L-tryptophan to melatonin in the gastrointestinal tract: the new high performance liquid chromatography method enabling simultaneous determination of six metabolites of L-tryptophan by native fluorescence and UV-VIS detection.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2012, Volume: 63, Issue:6

    Topics: 5-Hydroxytryptophan; Administration, Oral; Animals; Biotransformation; Chromatography, High Pressure Liquid; Female; Gastrointestinal Tract; Indoleacetic Acids; Kynurenine; Male; Melatonin; Rats; Rats, Wistar; Serotonin; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan

2012
Two new tryptophan derivatives from the seed kernels of Entada rheedei: effects on cell viability and HIV infectivity.
    Fitoterapia, 2013, Volume: 87

    Topics: Acquired Immunodeficiency Syndrome; Brain; Cell Line; Cell Survival; Dopamine; Fabaceae; Glutamic Acid; HIV; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukocytes, Mononuclear; Melatonin; Molecular Structure; Plant Extracts; Psychotropic Drugs; Seeds; Serotonin; Tryptophan; Virus Replication

2013
The expanding roles of 1-methyl-tryptophan (1-MT): in addition to inhibiting kynurenine production, 1-MT activates the synthesis of melatonin in skin cells.
    The FEBS journal, 2013, Volume: 280, Issue:19

    Topics: Cell Line; Cell Line, Tumor; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melatonin; Real-Time Polymerase Chain Reaction; Skin; Tryptophan

2013
Evaluation of the antioxidant properties of tryptophan and its metabolites in in vitro assay.
    Journal of complementary & integrative medicine, 2016, Jun-01, Volume: 13, Issue:2

    Topics: Anti-Inflammatory Agents; Antioxidants; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Growth Inhibitors; Humans; Interferon-gamma; Interleukin-6; Kynurenine; Melatonin; Milk, Human; Neuroglia; ortho-Aminobenzoates; Oxygen Radical Absorbance Capacity; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates

2016
Editorial: The Kynurenine and Melatonergic Pathways in Psychiatric and CNS Disorders.
    Current pharmaceutical design, 2016, Volume: 22, Issue:8

    Topics: Central Nervous System Diseases; Humans; Kynurenine; Melatonin; Mental Disorders; Signal Transduction

2016
Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism.
    The FEBS journal, 2017, Volume: 284, Issue:6

    Topics: Animals; Arylalkylamine N-Acetyltransferase; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; MAP Kinase Kinase 4; Melatonin; Metabolic Networks and Pathways; Nerve Tissue Proteins; Oncogene Protein v-akt; PC12 Cells; Promoter Regions, Genetic; Rats; Serotonin; Tryptophan

2017
Impact of a single, short morning bright light exposure on tryptophan pathways and visuo- and sensorimotor performance: a crossover study.
    Journal of physiological anthropology, 2018, Apr-23, Volume: 37, Issue:1

    Topics: Adult; Cross-Over Studies; Female; Humans; Kynurenine; Light; Male; Melatonin; Psychomotor Performance; Random Allocation; Tryptophan

2018
Sex and race differences of cerebrospinal fluid metabolites in healthy individuals.
    Metabolomics : Official journal of the Metabolomic Society, 2021, 01-18, Volume: 17, Issue:2

    Topics: Adult; alpha-Tocopherol; Cerebrospinal Fluid; Cysteine; Female; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; Male; Melatonin; Metabolome; Metabolomics; Race Factors; Serotonin; Sex Characteristics; Sex Factors; Uric Acid; Xanthine; Xanthines

2021
Tryptophan Derivatives by
    International journal of molecular sciences, 2021, Jan-05, Volume: 22, Issue:1

    Topics: Chromatography, Liquid; Culture Media; Fermentation; Glycine max; Humans; Kynurenic Acid; Kynurenine; Melatonin; Neurotransmitter Agents; Saccharomyces cerevisiae; Signal Transduction; Tandem Mass Spectrometry; Tryptophan

2021
Imaging of cerebral tryptophan metabolism using 7-[
    NeuroImage, 2022, 02-15, Volume: 247

    Topics: Animals; Disease Models, Animal; Fluorine Radioisotopes; Hippocampus; Kynurenine; Male; Melatonin; Oxidopamine; Parkinson Disease; Pineal Gland; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Long-Evans; Serotonin; Tryptophan

2022
Circadian control of kynurenine pathway enzymes in the rat pineal gland, liver, and heart and tissue- and enzyme-specific responses to lipopolysaccharide.
    Archives of biochemistry and biophysics, 2022, 06-15, Volume: 722

    Topics: Animals; Circadian Rhythm; Kynurenine; Lipopolysaccharides; Liver; Melatonin; Pineal Gland; Rats; Serotonin

2022
Melatonin ameliorates disease severity in a mouse model of multiple sclerosis by modulating the kynurenine pathway.
    Scientific reports, 2022, 09-24, Volume: 12, Issue:1

    Topics: Animals; Biological Factors; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melatonin; Mice; Mice, Inbred C57BL; Multiple Sclerosis; NAD; Nicotinamide N-Methyltransferase; Receptors, Aryl Hydrocarbon; RNA, Messenger; Severity of Illness Index; Tryptophan

2022