Compounds > kynurenine

kynurenine and kynurenic acid

kynurenine has been researched along with kynurenic acid in 582 studies

Research

Studies (582)

TimeframeStudies, this research(%)All Research%
pre-1990143 (24.57)18.7374
1990's63 (10.82)18.2507
2000's64 (11.00)29.6817
2010's178 (30.58)24.3611
2020's134 (23.02)2.80

Authors

AuthorsStudies
Bühlen, E; Bühner, R; Byrd, DJ; Kochen, W1
Forman, P; Justice, P; Tabahoff, B; Wong, PW1
Guseĭnova, RS1
Bossé, TR; Donald, EA1
Muramatsu, S; Suzuki, M; Takahashi, T; Watanabe, M; Yoshida, M1
Allegri, G; Baccichetti, F; Costa, C; De Antoni, A; Vanzan, S1
Abdel-Tawab, GA; El-Kholy, ZA; El-Sewedy, SM; El-Zoghby, SM1
Allegri, G; Costa, C; De Antoni, A2
Abdel-Rafea, A; Abdel-Tawab, GA; El-Dardiri, N; El-Kabariti, H; El-Kholy, ZA; Mostafa, MH; Saad, AA1
De Bruin, EJ; Hankes, LV; Jansen, CR; Schmaeler, M1
Fokkens, W; Haije, WG; Hop, WC; Peters, HA; Portengen, H; Teulings, FA; van der Werf-Messing, B1
Brown, RR; Yeh, JK1
Bender, DA; Humm, RP; Smith, WR1
Kurbanov, Kh1
Arend, RA; Brown, RR; Leklem, JE; Linkswiler, H; Rose, DP1
Brown, RR; Hankes, LV; Jansen, CR; Leklem, JE1
Ionascu, L; Ionescu, G; Romas, NA; Sholem, S; Veenema, RJ1
Barlow, GB; Wilkinson, AW2
Korkhov, VV1
Budny, JA; Henderson, LM; Swan, PB; Triebwasser, KC1
Pewnim, T; Seifert, J1
Du, F; Gramsbergen, JB; Okuno, E; Roberts, RC; Schmidt, W; Schwarcz, R; Turski, WA1
Schwarcz, R2
Beal, MF; Bird, ED; Matson, WR; Milbury, P; Ogawa, T; Ryan, EA; Storey, E1
Schwab, F; Vécsei, L1
Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K1
Heyes, MP; Markey, SP; Saito, K1
Beal, MF; MacGarvey, U; Miller, JM1
Schwarcz, R; Ungerstedt, U; Wu, HQ2
Beal, MF; Nozaki, K1
Beal, MF; MacGarvey, U; Miller, J; Vécsei, L1
Du, F; Schwarcz, R1
Kido, R1
Rios, C; Santamaria, A1
Bender, DA; Njagi, EN2
Savvateeva, E1
Elderfield, A; Truscott, R1
Fukui, S; Rapoport, SI; Schwarcz, R; Smith, QR; Takada, Y1
During, MJ; Freese, A; Heyes, MP; Markey, SP; Martin, JB; Matson, WR; Roth, RH; Swartz, KJ1
Gramsbergen, JB; Schwarcz, R; Speciale, C; Vezzani, A1
Beal, MF; Vécsei, L2
Heyes, MP; Lackner, A1
Beal, MF; Bird, ED; Gamache, PH; Matson, WR; Swartz, KJ1
Beal, MF; During, MJ; Freese, A; Swartz, KJ1
Heyes, MP; Quearry, BJ1
Gramsbergen, JB; Schwarcz, R; Speciale, C; Turski, WA; Ungerstedt, U; Wu, HQ1
Kimbrough, TD; Llewellyn, GC; Weekley, LB1
Khaspekov, LG; Lapin, IP; Ryzhov, IV; Viktorov, IV1
Gramsbergen, JB; Schwarcz, R; Traitler, H; Turski, WA1
Izuta, S; Shibata, Y; Takeuchi, F; Tsubouchi, R1
Abdel-Hamied, HA; Abdel-Tawab, GA; Aboul-Azm, T; Ebied, SA; el-Kholy, ZA; el-Sharaky, AS; el-Toukhy, MA1
Stone, TW4
Palmieri, F; Quagliariello, E1
Brown, RR; Madsen, PO; Price, JM; Wolf, H1
Brown, RR; Hankes, LV; Lippincott, S; Schmaeler, M2
Brown, RR; Hankes, LV1
Brown, RR; Leklem, JE; Woodford, J1
Hochberg, K; Kochen, W1
Brown, RR; Burney, SW; Friedell, GH; Price, JM1
Hardy, J; Heeley, AF; Heeley, ME; Soothill, JF1
Leklem, JE1
Curzon, G; Green, AR1
Berg, CP; Loh, HH4
Allegri, G; Costa, C; Crepaldi, G; De Antoni, A; Muggeo, M1
Houpt, JB; Hunt, M; Ogryzlo, MA1
Chen, J; Matchett, WH1
Abdel-Daim, MH; Abdel-Tawab, GA; Amer, MS2
Brown, RR; Wolf, H1
Brown, RR; Hankes, LV; Jansen, CR; Leklem, J; Mekel, RC1
Eichelberg, D; Wessing, A1
Beisel, WR; Rapoport, MI2
Hardeland, R1
Binazzi, M; Calandra, P1
Linkswiler, HM; Shin, HK1
Allegri, G; Costa, C; De Antoni, A; Rubaltelli, FF1
Ricós, C; Sabater, J1
Abdel-Tawab, GA; el-Zoghby, SM; Mostafa, MH; Moursi, GE; Saad, AA1
Allegri, G; De Antoni, A1
Kido, R; Noguchi, T; Tsuda, H1
Chen, NC; Gholson, RK1
Brown, RR; Karp, WB; Robertson, AF; Schuerger, GS1
Elias, EG; Ezdinli, E; Gailani, S; Nussbaum, A; Silvernail, P1
Heinmets, F1
Abdel-Tawab, GA; Kelada, FS; Konbar, AA; Moustafa, MH1
Abul-Fadl, M; Hamza, S; Khalafallah, A; Khattab, M1
Bühner, R; Bührlen, E; Byrd, D; Kochen, W1
Brown, RR; Carlson, IH; Davis, HL; Leklem, J1
Payne, IR; Walsh, EM; Whittenburg, EJ1
Lu, GH; Meyer, K; Payne, IR1
Bryan, GT1
Beisel, WR; Hornick, RB; Rapoport, MI1
Kochen, W1
Abdel-Daim, MH; Abdel-Tawab, GA; el-Sawy, MF; el-Sewedy, SM1
Brown, RR; Hankes, LV; Jesseph, J; Leklem, J; Schmaeler, M1
Bakri, M; Carlson, JR1
Abdel-Daim, MH; Abdel-Tawab, GA; Girgis, LH; Kelada, NL; Moursi, GE1
Igari, T; Tsuchizawa, M1
McGinty, F; Rose, DP1
Gibbs, DA; Watts, RW2
Kido, R; Matsumura, Y; Noguchi, T1
Leibenguth, F2
Brown, RR; Hankes, LV; Leklem, JE; Schmaeler, M1
Abbassy, AS; Abdel-Tawab, GA; el-Sewedy, SW; Hassanein, EA; Kholief, TS; Zeitoun, MM1
Berger, H; Ziegler, E1
Abdel-Daim, MH; Abdel-Tawab, GA; Kholief, TS; Konbar, AA1
Brown, RR; DeGeorge, FV1
Abdel-Tawab, GA; el-Shafei, AK; el-Zoghby, SM; Kelada, FS1
Feuerstein, M; Sönnichsen, N1
Boruchow, IB; Ludwig, GD; Wontorsky, D1
Abdel-Tawab, GA; Abdel-Wahab, AF; Ibrahim, EK; Mousa, AH; Moustafa, MH; Saad, AA1
Jackson, M; McManus, IR1
Brown, RR; Rose, DP; Yao, YS1
Arakawa, T; Nakagawa, H; Tada, K; Yokoyama, Y; Yoshida, T1
Feuerstein, M; Kölzsch, J; Sönnichsen, N1
Heilmann, HH; Knapp, A; Stolp, A; von Sudhodoletz, O1
Nath, MC; Shastri, NV1
Consonni, V; Giovannini, M1
Hill, HD; Roszel, NO; Summer, GK1
Komrower, GM; Westall, R1
Banowsky, L; Pipkin, G; Schlegel, JU1
Drenick, EJ; Joven, CB; Swendseid, ME; Vinyard, E1
Abul-Fadl, MA; Hamza, SM; Khalafallah, AS; Khattab, M1
Linkswiler, H1
Lipton, R; Melicow, MM; Price, TD1
Brown, KS; Sakan, T; Senoh, S; Tokuyama, T; Witkop, B1
Benassi, CA; De Antoni, A; Veronese, FM1
Linkswiler, H; Miller, LT1
Crokaert, R; Geeraerts, F; Schimpfessel, L1
Perkins, MN; Stone, TW1
Beaudry, P; Civatte, J; Dreux, C; Garnier, JP; Jeanmougin, M1
Lapin, IP1
Bryan, GT; Ertürk, E; Matsushima, M; Takano, S1
Allegri, G; Cardin Dè Stefani, EL; Costa, C; De Antoni, A; Vanzan, S1
Kiseleva, IP; Lapin, IP; Prakh'e, IB1
Altemus, M; Demitrack, MA; Gold, PW; Heyes, MP; Pigott, TA1
Chen, CY; Heyes, MP; Markey, SP; Naritsin, DB; Saito, K1
Carpenedo, R; Chiarugi, A; Mattoli, L; Molina, MT; Moroni, F; Pellicciari, R1
Byar, D; De Pauw, M; Lockwood, R; Newling, DW; Robinson, MR; Smith, PH; Stevens, I; Sylvester, R1
Boni, RL; Markey, SP; Naritsin, DB1
Carlà, V; Carpenedo, R; Chiarugi, A; Lombardi, G; Mattoli, L; Moroni, F; Pellicciari, R; Russi, P1
Carpenedo, R; Chiarugi, A; Costantino, G; Mahmoud, MR; Mattoli, L; Moroni, F; Natalini, B; Pellicciari, R; Sadeghpour, BM1
Egawa, B; Horiguchi, K; Shindo, I; Yamamoto, H1
Heyes, MP; Major, EO; Markey, SP; Milstien, S; Saito, K; Vickers, JH1
Chase, TN; Jauch, DA; Schwarcz, R; Sethy, VH; Weick, BG1
Monno, A; Schwarcz, R; Vezzani, A; Wu, HQ1
Ceresoli, G; Fuller, MS; Schwarcz, R1
Behan, WM; Graham, DI; Jones, P; MacGregor, DG; Smith, RA; Stone, TW1
Guzeva, VI; Melnikova, NV; Mikhailov, IB1
Bormetti, R; Cini, M; Marconi, M; Molinari, A; Schwarcz, R; Speciale, C; Varasi, M; Veneroni, O1
Hokari, M; Schwarcz, R; Smith, QR; Wu, HQ1
Ofer, A; Scharfman, HE1
Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF1
Hansen, DK; Lunte, SM1
Watanabe, M1
Acuña-Castroviejo, D; Molina-Carballo, A; Muñóz-Hoyos, A; Rodríguez-Cabezas, T; Ruiz-Cosano, C; Uberos-Fernández, J1
Dong-Ruyl, L; Nakano, K; Sawada, M1
Acuña-Castroviejo, D; Camacho, E; Escames, G; Espinosa, A; Gallo, MA; Gómez, I; León, J; Vives, F1
Beninger, RJ; Boegman, RJ; Harris, CA; Jhamandas, K; Miranda, AF; Tanguay, JJ1
Poeggeler, B; Rassoulpour, A; Schwarcz, R; Wu, HQ1
Hodgkins, PS; Schwarcz, R2
Goodman, CB; Heyliger, SO; Ngong, JM; Soliman, KF1
Hodgkins, PS; Schwarcz, R; Wu, HQ; Zielke, HR1
Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF; Sutton, MA1
Baran, H; Deecke, L; Jellinger, K1
Lee, SC; Schwarcz, R; Wu, HQ1
Jirgensons, J; Jurika, E; Rudzite, V1
Guidetti, P; Schwarcz, R; Wu, HQ1
Ceresoli-Borroni, G; Goodman, JH; Guidetti, P; Scharfman, HE; Schwarcz, R; Speciale, C; Varasi, M; Wu, HQ1
Pawlak, D; Takada, A; Takada, Y; Urano, T1
Armati, PJ; Brew, BJ; Guillemin, GJ; Kapoor, V; Kerr, SJ; Smith, DG; Smythe, GA1
Chmielewski, M; Kocki, T; Turski, WA; Urbańska, EM1
Bragina, J; Heisenberg, M; Kamyshev, N; Kornhuber, J; Popov, A; Riederer, P; Savvateeva, E; Senitz, D1
Baran, H; Budka, H; Hainfellner, JA; Kepplinger, B; Mazal, PR; Schmid, H1
Baran, H; Gille, L; Kepplinger, B; Nohl, H; Staniek, K; Stolze, K1
Ballerini, C; Chiarugi, A; Cozzi, A; Massacesi, L; Moroni, F1
Lee, SC; Schwarcz, R1
Armati, PJ; Brew, BJ; Croitoru, J; Guillemin, GJ; Kapoor, V; Kerr, SJ; Smith, DG; Smythe, GA1
Baran, H; Herrera-Marschitz, M; Kepplinger, B; Lubec, G; Nohl, H; Stolze, K1
Medoff, D; Rassoulpour, A; Roberts, RC; Schwarcz, R; Tamminga, CA; Wu, HQ1
Buczko, W; Mysliwiec, P; Pawlak, D; Tankiewicz, A1
Buczko, W; Malyszko, J; Mysliwiec, M; Pawlak, D; Pawlak, K1
Albrecht, J; Dolińska, M; Dybel, A; Kocki, T; Turski, WA; Urbańska, EM1
Kleinrok, Z; Luchowski, P; Stazka, J; Urbańska, EM; Wielosz, M1
Pellicciari, R; Schwarcz, R1
Carpenedo, R; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F1
Hardeland, R; Zsizsik, BK1
Amirkhani, A; Bergquist, J; Heldin, E; Markides, KE1
Darlington, LG; Stone, TW1
Ceresoli-Borroni, G; Guidetti, P; Kiss, C; Schwarcz, R; Zielke, CL; Zielke, HR1
ADELBERG, EA; MILLER, IL; TSUCHIDA, M1
KNAPP, A1
BENASSI, CA; COPPINI, D; MONTORSI, M1
HAYAISHI, O; KOBAYASHI, S; TASHIRO, M; TSUKADA, K1
HELLSTROM, B; VASSELLA, F; WENGLE, B1
ALLEGRI, G; BENASSI, CA; PERISSINOTTO, B2
CAREDDU, P1
ALLEGRI, G; BENASSI, CA; BENASSI, P; RABASSINI, A1
CREPALDI, G; PARPAJOLA, A1
MIYATAKE, M; SHIBA, S; TERAWAKI, A1
MENCZYK, Z1
BROWN, RR; FLINN, JH; PRICE, JM; YESS, N1
CLAMP, JR; KOMROWER, GM; WESTALL, RG; WILSON, V1
BENSON, GD; HAEFFNER, LJ; KOWLESSAR, OD1
BROWN, RR; BRYAN, GT; MORRIS, CR; PRICE, JM1
BROWN, RR; BRYAN, GT; PRICE, JM1
ABUL-FADL, MA; KHALAFALLAH, AS1
PINALS, RS1
ALLERT, U; MELCHING, HJ; STREFFER, C1
PASQUARIELLO, G1
CAREDDU, P; MAINARDI, L; TENCONI, LT1
MAINARDI, L; TENCONI, LT1
Cai, T; Chen, A; Di Prospero, NA; Du, F; Guidetti, P; Melendez-Ferro, M; Sapko, MT; Schwarcz, R; Tagle, DA; Whetsell, WO; Yu, P1
Rho, JM1
Emanuelsson, C; Erhardt, S; Geyer, M; Schwieler, L1
Kocki, J; Kocki, T; Turski, WA; Urbanska, EM; Wielosz, M1
Koek, GH; Maes, M; Robaeys, G; Scharpé, S; Verkerk, R; Wichers, MC1
Albuquerque, EX; Rassoulpour, A; Schwarcz, R; Wu, HQ1
Dux, L; Hartai, Z; Janaky, T; Klivenyi, P; Penke, B; Vecsei, L3
Amirkhani, A; Arvidsson, B; Bencsik, K; Bergquist, J; Boda, K; Markides, KE; Rajda, C; Seres, E; Vécsei, L1
Guidetti, P; Pellicciari, R; Sapko, MT; Schwarcz, R; Tagle, DA; Yu, P1
Dulay, JR; Llenos, IC; Miller, CL; Weis, S1
Ceresoli-Borroni, G; Guidetti, P; Rassoulpour, A; Schwarcz, R; Wu, HQ1
Bates, GP; Graham, RK; Guidetti, P; Hayden, MR; Leavitt, BR; MacDonald, ME; Schwarcz, R; Slow, EJ; Wheeler, VC; Woodman, B1
Donkó, T; Dux, L; Hartai, Z; Janáky, T; Janka, Z; Juhász, A; Kálmán, J; Penke, B; Rimanóczy, A; Tóth, GK1
Darlington, LG; Forrest, CM; Mackay, GM; Oxford, L; Stone, TW; Stoy, N1
da Costa Ferreira, G; de Souza Wyse, AT; Dutra-Filho, CS; Duval Wannmacher, CM; Latini, A; Schuck, PF; Tonin, A; Viegas, CM; Wajner, M1
Kim, YK; Leonard, BE; Myint, AM; Park, SH; Scharpé, S; Steinbusch, HW; Verkerk, R1
Amori, L; Ceresoli-Borroni, G; Guidetti, P; Pellicciari, R; Schwarcz, R1
Bédard, PJ; Di Paolo, T; Grégoire, L; Guidetti, P; Izzo, E; Rassoulpour, A; Samadi, P; Schwarcz, R1
Bosmans, E; Kubera, M; Maes, M; Mihaylova, I; Ruyter, MD1
GULLBERG, ME; HEIDELBERGER, C2
Kuc, D; Parada-Turska, J; Turski, WA; Urbanik-Sypniewska, T; Zgrajka, W1
Luo, XB; Pi, LG; Tang, AG; Xiao, LD1
Farkas, T; Nagy, D; Robotka, H; Rozsa, E; Sas, K; Toldi, J; Vecsei, L1
Fukushima, T; Mitsuhashi, S; Sone, Y; Tomiya, M; Toyo'oka, T1
Agoston, M; Farkas, T; Gigler, G; Kis, Z; Marosi, M; Robotka, H; Rózsa, E; Sas, K; Szénási, G; Toldi, J; Vécsei, L1
Andersson, AS; Engberg, G; Erhardt, S; Holtze, M; Larsson, K; Linderholm, KR; Nilsson-Todd, LK; Olsson, E; Olsson, SK; Schwieler, L1
Ball, HJ; Hunt, NH; Mellor, AL; Miu, J1
Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K1
Amori, L; Guidetti, P; Marinozzi, M; Pellicciari, R; Schwarcz, R; Wu, HQ1
Fotopoulou, C; Hasper, D; Pschowski, R; Reinke, P; Schefold, JC; Schuett, C; Volk, HD; von Haehling, S; Zeden, JP1
Engberg, G; Erhardt, S; Olsson, SK1
Battsetseg, B; Battur, B; Boldbaatar, D; Fujisaki, K; Xuan, X1
Bohár, Z; Fülöp, F; Párdutz, A; Tajti, J; Toldi, J; Vámos, E; Varga, H; Vécsei, L1
Asp, L; Erhardt, S; Holtze, M; Karlsson, H; Powell, SB1
Luo, X; Mo, X; Pi, L; Tang, A; Xiao, L1
Albuquerque, EX; Bruno, JP; Pellicciari, R; Pereira, EF; Schwarcz, R; Wu, HQ1
Bellocchi, D; Carotti, A; Macchiarulo, A; Pellicciari, R1
Mysliwiec, M; Pawlak, D; Pawlak, K1
Kowalewska, A; Mysliwiec, M; Pawlak, D; Pawlak, K1
Fejes, A; Fülöp, F; Koch, J; Párdutz, A; Tajti, J; Toldi, J; Vámos, E; Vécsei, L1
Fukushima, T; Ishii, K; Ogaya, T; Song, Z1
Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP1
Chen, Y; Guillemin, GJ; Meininger, V1
Gao, P; Zhao, J; Zhu, D1
Luo, XB; Ren, YP; Tang, AG; Xiang, ZY; Zhou, QX1
Molina-Carballo, A; Muñoz-Hoyos, A; Romero, J; Uberos, J1
Bien, B; Gulaj, E; Pawlak, D; Pawlak, K1
Dahl, ML; Engberg, G; Erhardt, S; Holtze, M; Linderholm, KR; Olsson, SK; Samuelsson, M; Skogh, E1
Fukushima, T; Iizuka, H; Ishii, K; Ogaya, T; Song, Z2
Casazza, V; Rizzi, M; Rossi, F1
Hirose, Y; Minami, A; Nakamura, T; Oguri, H; Oikawa, H; Watanabe, K1
Carlà, V; Cavone, L; Cosi, C; Cozzi, A; Mannaioni, G; Maratea, D; Moroni, F; Sili, M1
Akagbosu, CO; Bucci, DJ; Evans, GC; Gulick, D; Suckow, RF1
Albuquerque, EX; Alkondon, M; Eisenberg, HM; Kajii, Y; Pereira, EF; Schwarcz, R1
Müller, N; Myint, AM; Schwarz, MJ1
Kim, YK; Leonard, BE; Mueller, HH; Myint, AM; Scharpé, S; Schwarz, MJ; Steinbusch, HW; Verkerk, R; Zach, J1
Breda, C; Campesan, S; Giorgini, F; Green, EW; Kyriacou, CP; Muchowski, PJ; Sathyasaikumar, KV; Schwarcz, R1
Kloc, R; Kocki, J; Kocki, T; Owe-Larsson, B; Urbanska, EM; Wnuk, S1
Fukuwatari, T; Okuno, A; Shibata, K1
Ares, AM; Bernal, J; Bernal, JL; Nozal, MJ; Soto, ME1
Chen, H; Gao, P; Luo, X; Ni, P; Xu, B; Zhan, Y; Zhao, J; Zhu, D1
Erhardt, S; Larsson, MK; Olsson, SK1
Agraharm, SG; Gundae, S; Munipally, PK; Turlapati, NR; Valavala, VK1
Alexander, KS; Bruno, JP; Schwarcz, R; Wu, HQ1
Bermudez, I; Franklin, M; Gaburro, S; Murck, H; Singewald, N1
Honjo, H; Iwamoto, K; Uwai, Y1
Amori, L; Notarangelo, FM; Pérez-de la Cruz, V; Sathyasaikumar, KV; Schwarcz, R; Wang, XD; Wu, HQ1
Demeter, I; Fülöp, F; Gellért, L; Nagy, K; Toldi, J; Vécsei, L1
Buurman, WA; Dekker, J; Jonkers, DM; Keszthelyi, D; Masclee, AA; Troost, FJ; van Donkelaar, EL1
Albuquerque, EX; Alkondon, M; Banerjee, J; Pereira, EF1
Chorągiewicz, T; Grieb, P; Junemann, A; Rejdak, R; Schuettauf, F; Thaler, S; Turski, WA; Zarnowski, T; Zrenner, E1
Maes, M; Rief, W1
Notarangelo, FM; Schwarcz, R; Wang, JZ; Wang, XD1
Bruno, JP; Elmer, GI; Pocivavsek, A; Schwarcz, R; Wu, HQ1
Du Preez, JL; Harvey, BH; Möller, M1
Dąbrowski, R; Dąbrowski, W; Kocki, T; Parada-Turska, J; Szczubiał, M1
Tan, L; Yu, JT1
Plangar, I; Szalardy, L; Vecsei, L1
Darlington, LG; Stone, TW; Stoy, N1
Buerger, K; Guillemin, GJ; Hampel, H; Schwarz, MJ; Teipel, SJ1
Brundin, L; Erhardt, S; Guillemin, GJ; Janelidze, S; Lim, CK; Linderholm, KR; Lindqvist, D; Lundberg, K; Postolache, TT; Samuelsson, M; Träskman-Bendz, L1
Kołosowska, K; Lehner, M; Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D1
Alexander, KS; Bruno, JP; Pershing, ML; Pocivavsek, A; Schwarcz, R; Wu, HQ1
Eussen, SJ; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE1
Fukuwatari, T; Hiratsuka, C; Saito, K; Sano, M; Sasaki, S; Shibata, K1
Zhao, J1
Fukuwatari, T; Funakoshi, H; Kadota, E; Kanai, M; Nakamura, T; Sano, M; Shibata, K; Terakata, M1
Gregory, JF; Nijhout, HF; Reed, MC; Rios-Avila, L; Sitren, HS1
Baranyi, A; Breitenecker, RJ; Kapfhammer, HP; Meinitzer, A; Putz-Bankuti, C; Rothenhäusler, HB; Stauber, R; Stepan, A1
Chi, YY; Coats, B; da Silva, VR; Garrett, TJ; Gregory, JF; Lamers, Y; Midttun, Ø; Muller, KE; Percival, SS; Quinlivan, EP; Ralat, MA; Rios-Avila, L; Shankar, MN; Stacpoole, PW; Ueland, PM1
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Chiappelli, J; Cui, Y; Hong, LE; Huang, J; Kochunov, P; Tan, S; Tan, Y; Tian, B; Tian, L; Tong, J; Wang, Z; Yang, F; Zhang, P; Zhou, Y1
Chatton, JY; Gallart-Ayala, H; Ivanisevic, J; Maillard, V; Rosenberg, N; Teav, T; van der Velpen, V1
Butoma, BG; Churilov, LP; Gilburd, B; Mayorova, MA; Petrova, NN; Shoenfeld, Y1
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Gawda, P; Kocki, T; Saran, T; Turska, M; Turski, WA; Zawadka, M; Zieliński, G1
Coppens, V; De Picker, L; Giltay, EJ; Hebbrecht, K; Morrens, M; Skorobogatov, K1
Cseh, EK; Janáky, T; Kecskeméti, G; Körtési, T; Nyári, A; Tajti, J; Tömösi, F; Tuka, B; Vécsei, L; Veréb, D1
Blanca-Jover, E; Cantarero-Malagón, AM; Checa-Ros, A; Cubero-Millán, I; Fernández-López, L; Jerez-Calero, A; Machado-Casas, I; Molina-Carballo, A; Muñoz-Hoyos, A; Uberos, J1
Klein, C; Maammar, M; Maitre, M; Mensah-Nyagan, AG; Taleb, O1
Allers, KA; Beekman, ATF; Giltay, EJ; Keller, S; Milaneschi, Y; Niessen, HG; Penninx, BWJH; Schoevers, RA; Süssmuth, SD1
Kazimierczak, P; Plech, T; Szalast, K; Walczak, K1
Notarangelo, FM; Schwarcz, R1
Braidy, N; Guillemin, GJ; Joisten, N; Ruas, JL; Zimmer, P1
Afia, AB; Artuch, R; Garcia-Bueno, B; Haro, JM; Leza, JC; MacDowell, KS; Ormazabal, A; Ramos, B; Vila, È1
Büki, A; Horvath, G; Kekesi, G; Vécsei, L1
Baran, H; Draxler, M; Kepplinger, B; Kronsteiner, C1
de Timary, P; Delzenne, NM; Leclercq, S; Schwarz, M; Stärkel, P1
Chen, W; Fang, J; Feng, C; Han, Y; Hou, P; Liu, Z; Melino, G; Shao, C; Shi, Y; Verkhratsky, A; Wang, Y; Xu, C; Zuo, M1
Di Pasquale, P; Dischinger, K; Dreger, P; Luft, T; Monteagudo, E; Müller-Tidow, C; Orsatti, L; Radujkovic, A; Speziale, R; Stiehl, T1
Ataei, S; Azcarate-Peril, A; Carroll, I; Fransson, E; Jin, W; Kimmel, M; Knickmeyer, R; Lun, K; Meltzer-Brody, S; Plantinga, A; Rackers, H; Wu, M; Xia, K1
Butler, MI; Clarke, G; Cryan, JF; Dinan, TG; Long-Smith, C; Moloney, GM; Morkl, S; O'Mahony, SM1
Cui, Y; Hong, LE; Huang, J; Kochunov, P; Tan, S; Tan, Y; Tian, B; Tian, L; Tong, J; Wang, Z; Yang, F; Zhang, P; Zhou, Y1
Ostapiuk, A; Urbanska, EM1
Giltay, EJ; Hebbrecht, K; Morrens, M; Sabbe, B; van den Ameele, S; van Nuijs, ALN1
Fukushima, T; Onozato, M; Sakamoto, T; Umino, M1
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Brown, AM; Brown, SJ; Huang, XF; Newell, KA; Purves-Tyson, TD; Shannon Weickert, C1
Altunçekiç Yıldırım, A; Ceran Serdar, C; Cihan, M; Doğan, Ö; Kurt, C; Serdar, MA1
Biagini, G; Cannazza, G; Capriotti, AL; Carbone, L; Citti, C; Fulvio, F; Gigli, G; Laganà, A; Paris, R; Russo, F; Tolomeo, F; Vandelli, MA1
Cameron-Smith, D; Chong, MFF; Chong, YS; Eriksson, JG; Fortier, MV; Gluckman, PD; Godfrey, KM; Kothandaraman, N; Lee, YS; Michael, N; Sadananthan, SA; Tan, KH; Tan, KM; Tint, MT; Velan, SS; Yap, F1
Cai, H; Cao, T; Chen, Q; Jiao, S; Wang, L; Wu, X; Yang, C; Yang, D; Yang, P; Zeng, C; Zhang, S; Zhu, Z1
Al-Hakeim, HK; Almulla, AF; Maes, M; Solmi, M; Tunvirachaisakul, C; Vasupanrajit, A; Verkerk, R1
Chou, CC; Hung, CC; Lee, YH; Lin, CH1
Akdoğan, N; Altıngöz, SM; Balcı, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, MA1
Abusoglu, S; Eryavuz Onmaz, D; Kuzu, M; Sivrikaya, A; Tezcan, D; Unlu, A; Yerlikaya, FH; Yilmaz, S1
Betti, L; Carmassi, C; Carpita, B; Cremone, IM; Dell'Osso, L; Giannaccini, G; Massimetti, G; Nardi, B; Palego, L1
Jin, F; Li, C; Li, J; Tian, Y; Wang, H; Wang, L; Wang, Z1
Bhide, M; Buralova, M; Golisova, G; Hanes, J; Kovac, A; Majerova, P; Michalicova, A; Olesova, D; Piestansky, J; Vegh, J1
Li, R; Long, X; Mu, L; Qiao, J; Wang, S; Zhang, C; Zhang, Y; Zhao, Y1
Al-Hakeim, HK; Almulla, AF; Amrapala, A; Jaleel, AKA; Maes, M; Oxenkrug, G; Supasitthumrong, T; Tunvirachaisakul, C1
Buyukkoruk, M; Candansayar, S; Deveci-Bulut, TS; Gulbahar, O; Kucukkarapinar, M; Senol, E; Yay-Pence, A; Yaz-Aydin, G; Yildiz, Y1
Aupperle, RL; Burrows, K; Figueroa-Hall, LK; Khalsa, SS; Paulus, MP; Savitz, J; Teague, TK; Yeh, FC; Zheng, H1
Boersma, E; Boomars, KA; Cai, Z; de Rijke, YB; Duncker, DJ; Geenen, LW; Guignabert, C; Kema, I; Klein, T; Koudstaal, T; Merkus, D; Reiss, IKM; Tian, S; Tran-Lundmark, K; Tu, L; van den Bosch, AE; van der Ley, C; Van Faassen, M1
Arakawa, M; Miyake, Y; Okubo, H; Sasaki, S; Tanaka, K1
Allison, DJ; Baranowski, BJ; Copeland, EN; Fajardo, VA; Kurgan, N; MacNeil, AJ; MacPherson, REK; Watson, CJF; Whitley, KC1
Dai, M; Huang, X; Jiang, Z; Kou, S; Li, X; Sun, L; Wang, Q1
Arnhard, K; Fuchs, D; Geisler, S; Gleissenthall, GV; Kemmler, G; Mechtcheriakov, S; Oberacher, H; Schurr, T; Unterberger, C1
Chiappelli, J; Hong, LE; Huang, J; Kochunov, P; Li, Y; Tan, S; Tan, Y; Tian, B; Tian, L; Tong, J; Wang, Z; Yang, F; Zhang, P; Zhou, Y1
Błońska, A; Chojnacki, C; Chojnacki, J; Konrad, P; Medrek-Socha, M; Poplawski, T; Przybylowska-Sygut, K1
Ji, Y; Jiang, Y; Li, S; Shen, Y; Yang, Z; Yao, M; Yin, J; Zhu, H1
Budzynska, B; Kaszubska, K; Kotlinska, JH; Lemieszek, MK; Marciniak, S; Marszalek-Grabska, M; Rzeski, W; Turski, WA; Winiarczyk, S; Zakrocka, I1
Chen, L; Chen, Y; Li, H; Sun, D; Xiang, K; Yang, Y; Zhang, J1
Chen, GJ; Feng, R; Kong, L; Liu, KY; Sang, YR; Tao, FB; Wang, S; Yu, SX1
Andrea, G; Cristina, B; Fabio, T; Luca, P; M C, BJ; Nicoletta, B; Sara, C; Silvia, A; Silvio, B; Veronica, R1
Fujigaki, H; Fujigaki, S; Hasegawa, M; Hirakawa, M; Kubota, H; Kunisawa, K; Mori, Y; Mouri, A; Nabeshima, T; Niijima, M; Saito, K; Yamamoto, Y1
Ad, Y; Baar, K; Pathak, SJ; Ramsey, JJ; Rutkowsky, JM; Steffen, D; Tran, T; Zhou, Z1
Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J1
Fujimaki, Y; Fukushima, T; Odera, K; Onozato, M; Sakamoto, T; Sugasawa, H; Takahashi, R1
Al-Hakeim, HK; Almulla, AF; Maes, M; Oxenkrug, G; Thipakorn, Y; Tunvirachaisakul, C; Vasupanrajit, A1
Fathi, M; Hajibeygi, R; Jazi, K; Klegeris, A; McElhinney, A; Sayehmiri, F; Shool, S; Sodeifian, F; Tavasol, A; Tavirani, MR; Vakili, K; Yaghoobpoor, S1
Ford, BN; Khalsa, S; Kuplicki, R; Paulus, MP; Savitz, J; Teague, TK1
An, H; Bai, L; Fan, H; Ma, B; Ma, T; Qi, S; Wang, Z; Yang, F; Yun, Y; Zhang, Q; Zhao, W1
Anderson, EW; Aranow, C; Arazi, A; Diamond, B; Furie, RA; Goodwin, S; Jin, Y; Mackay, M; Roeser, J; Shih, A; Volpe, B1
Guan, Q; Han, Q; Liao, C; Wang, G; Yang, C; Zhao, J1
Fathi, M; Hajiesmaeili, M; Jazi, K; Klegeris, A; Mafi, Z; McElhinney, A; Mohamadkhani, A; Sayehmiri, F; Tavasol, A; Vakili, K; Yaghoobpoor, S1
Banerjee, J; Chandra, PS; Dey, S; Dixit, AB; Dubey, V; Tripathi, M1
Bosia, M; Comai, S; Guillemin, GJ; Sapienza, J; Spangaro, M1
Coico, R; Pato, M; Sales, PMG; Schrage, E1
Körtési, T; Spekker, E; Vécsei, L1
Ageev, AA; Appolonova, SA; Belenkov, YN; Korobkova, EO; Kozhevnikova, MV; Krivova, AV; Moskaleva, NE; Privalova, EV; Shestakova, KM1
Bolaños-Jiménez, F; Croyal, M; García Santillán, JA; Gourdel, M; Mezo-González, CE; Reyes-Castro, LA1
Allers, KA; Beutel, ME; Borta, A; Koeck, T; Lackner, K; Michal, M; Münzel, T; Niessen, HG; Schulz, A; Schuster, AK; Strauch, K; Süssmuth, SD; Wild, PS; Zahn, D1
Zakrocka, I; Załuska, W1
Andersen, ML; Eggertsen, PP; Hansen, J; Nielsen, JF; Olsen, RKJ; Palmfeldt, J1
Blasiak, J; Chojnacki, C; Chojnacki, M; Fila, M; Gąsiorowska, A; Konrad, P; Popławski, T1
Błońska, A; Chojnacki, C; Chojnacki, M; Konrad, P; Podogrocki, M; Poplawski, T1
Hälsig, C; Hebbar, S; Knust, E; Traikov, S1
Janáky, T; Körtési, T; Nánási, N; Szok, D; Tajti, J; Tömösi, F; Tuka, B; Vécsei, L; Veréb, D1
Axelsson, J; Balter, LJ; Erhardt, S; Lasselin, J; Lekander, M; Li, X; Olsson, MJ; Schwieler, L1
Adhikari, BM; Buchanan, RW; Chen, S; Hare, SM; Kane-Gerard, S; Kelly, DL; Mo, C; Notarangelo, FM; Rowland, LM; Sathyasaikumar, KV; Schwarcz, R; Seneviratne, C; Wijtenburg, SA1
Huang, S; Li, L; Shang, D; Wang, Z; Wen, Y1
Chen, J; Fang, X; Ling, Y; Liu, S; Su, KP; Tang, W; Wang, G; Wang, Y; Yang, Y; Zhang, C; Zhang, X; Zhou, C1
Bi, Y; Chen, Y; Ju, Y; Li, L; Liao, M; Liu, B; Liu, J; Ma, M; Ou, W; Qin, Y; Zhang, Y1
Abusoglu, S; Ekmekci, AH; Isık, SMT; Onmaz, DE; Ozturk, S; Unlu, A1
Deuschle, M; Fornal, E; Gilles, M; Kozub, A; Lamadé, EK; Marszalek-Grabska, M; Pedraz-Petrozzi, B; Stachniuk, A; Szalaj, K; Trzpil, A; Turski, WA1
Baran, H; Kepplinger, B; Kronsteiner, C1
Bjørke-Monsen, AL; Ebbing, C; Sakkestad, ST; Ueland, PM; Ulvik, A; Varsi, K1
Ang, K; Ching, J; Gurung, RL; Kestenbaum, BR; Kovalik, JP; Lee, J; Lee, LS; Lim, SC; Liu, JJ; Liu, S; M, Y; Shao, YM; Sharma, K; Subramaniam, T; Sum, CF; Wee, HN; Zheng, H1
Berkecz, R; Domoki, F; Körmöczi, T; Kovács, V; Remzső, G; Tóth-Szűki, V; Vécsei, L1
Bakker, L; Choe, K; J P M Eussen, S; Kenis, G; Köhler, S; Ramakers, IHGB; Rutten, BPF; Staals, J; Ueland, PM; Ulvik, A; van den Hove, DLA; van Oostenbrugge, RJ; Verhey, FRJ1
Al-Hakeim, HK; Jasim, ZA; Stanek, A; Zolghadri, S1
Bours, MJL; Breukink, SO; Eussen, SJPM; Gsur, A; Holthuijsen, DDB; Janssen-Heijnen, MLG; Keulen, ETP; Kok, DE; Ueland, PM; Ulvik, A; van Roekel, EH; Weijenberg, MP1
Cetin, I; Dokuyucu, R; Simsek, S; Yildirim, V1

Reviews

54 review(s) available for kynurenine and kynurenic acid

ArticleYear
Kynurenic acid: a potential pathogen in brain disorders.
    Annals of the New York Academy of Sciences, 1992, May-11, Volume: 648

    Topics: Animals; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Lyases; Models, Neurological; Receptors, Neurotransmitter; Transaminases

1992
[Kynurenine and its metabolites in nervous system diseases].
    Orvosi hetilap, 1992, Jul-19, Volume: 133, Issue:29

    Topics: Humans; Kynurenic Acid; Kynurenine; Nervous System Diseases; Quinolinic Acid; Quinolinic Acids

1992
Quinolinic acid and kynurenic acid in the mammalian brain.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Brain Diseases; Dioxygenases; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans; Kynurenic Acid; Kynurenine; Lyases; Nerve Degeneration; Oxygenases; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Neurotransmitter; Transaminases

1991
Kynurenate forming enzymes in liver, kidney and brain.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: 2-Aminoadipate Transaminase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Brain; Humans; Kidney; Kynurenic Acid; Kynurenine; Liver; Lyases; Mitochondria, Liver; Rats; Substrate Specificity; Transaminases; Tyrosine Transaminase

1991
Quantitative aspects of tryptophan metabolism in humans and other species: a review.
    The American journal of clinical nutrition, 1971, Volume: 24, Issue:6

    Topics: Age Factors; Amides; Animals; Carbon Isotopes; Cats; Dogs; Female; Glucuronates; Glycine; Hippurates; Humans; Hydroxyindoleacetic Acid; Indican; Kynurenic Acid; Kynurenine; Lysine; Male; Mice; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Pyridones; Pyridoxine; Rats; Serotonin; Sex Factors; Species Specificity; Swine; Time Factors; Tryptophan; Xanthurenates

1971
The role of urinary tryptophan metabolites in the etiology of bladder cancer.
    The American journal of clinical nutrition, 1971, Volume: 24, Issue:7

    Topics: Alcohols; Amino Acids; Animals; Carcinogens; Ethers; Female; Humans; Indican; Kynurenic Acid; Kynurenine; Male; Mice; Mucous Membrane; ortho-Aminobenzoates; Phenylbutyrates; Quinolines; Rats; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms; Xanthurenates

1971
Neuropharmacology of quinolinic and kynurenic acids.
    Pharmacological reviews, 1993, Volume: 45, Issue:3

    Topics: Animals; Brain; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate

1993
Metabolism and function of brain kynurenines.
    Biochemical Society transactions, 1993, Volume: 21, Issue:1

    Topics: Animals; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate

1993
Basic mechanisms of kynurenine actions in the central nervous system.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Animals; Anticonvulsants; Central Nervous System; Humans; Indoles; Kynurenic Acid; Kynurenine; Mammals; Neurons; Neuroprotective Agents; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate

1996
[Microanalysis of tryptophan metabolites].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1997, Volume: 117, Issue:10-11

    Topics: 3-Hydroxyanthranilic Acid; Animals; Fluorometry; Humans; Kynurenic Acid; Kynurenine; Mice; Microchemistry; Tryptophan; Ultraviolet Rays; Urinary Bladder Neoplasms

1997
Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection.
    Trends in pharmacological sciences, 2000, Volume: 21, Issue:4

    Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate

2000
Kynurenic acid antagonists and kynurenine pathway inhibitors.
    Expert opinion on investigational drugs, 2001, Volume: 10, Issue:4

    Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neuroprotective Agents; Parkinson Disease; Prodrugs; Quinolinic Acid; Schizophrenia

2001
Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1

    Topics: Animals; Brain; Humans; Kynurenic Acid; Kynurenine; Neuroglia; Neurons; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate

2002
Endogenous kynurenines as targets for drug discovery and development.
    Nature reviews. Drug discovery, 2002, Volume: 1, Issue:8

    Topics: Animals; Drug Delivery Systems; Drug Design; Humans; Kynurenic Acid; Kynurenine; Signal Transduction; Technology, Pharmaceutical; Tryptophan

2002
Basic science behind the catastrophic epilepsies.
    Epilepsia, 2004, Volume: 45 Suppl 5

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies, Myoclonic; Epilepsy; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; N-Methylaspartate; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Spasms, Infantile; Tryptophan

2004
Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders.
    CNS drugs, 2009, Volume: 23, Issue:2

    Topics: Animals; Cognition Disorders; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Mental Disorders; Schizophrenia

2009
Kynurenine pathway in schizophrenia: pathophysiological and therapeutic aspects.
    Current pharmaceutical design, 2011, Volume: 17, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Antipsychotic Agents; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Mice; Molecular Targeted Therapy; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission; Tryptophan

2011
Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:6

    Topics: Aging; Animals; Humans; Kynurenic Acid; Kynurenine; Retina; Retinal Degeneration; Retinal Ganglion Cells; Transaminases

2011
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
    Journal of the neurological sciences, 2012, Dec-15, Volume: 323, Issue:1-2

    Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Microglia; Molecular Targeted Therapy; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Tryptophan

2012
An expanding range of targets for kynurenine metabolites of tryptophan.
    Trends in pharmacological sciences, 2013, Volume: 34, Issue:2

    Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Molecular Targeted Therapy; Oxidation-Reduction; Quinolinic Acid; Tryptophan

2013
Scavenging of reactive oxygen species by tryptophan metabolites helps Pseudomonas aeruginosa escape neutrophil killing.
    Free radical biology & medicine, 2014, Volume: 73

    Topics: Cystic Fibrosis; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydrolases; Immune Evasion; Kynurenic Acid; Kynurenine; Neutrophils; Oxygen Consumption; Pseudomonas aeruginosa; Pseudomonas Infections; Reactive Oxygen Species; Tryptophan

2014
[Depression and inflammation in rheumatic diseases].
    Postepy higieny i medycyny doswiadczalnej (Online), 2016, Mar-04, Volume: 70

    Topics: Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Monoamine Oxidase; Pituitary-Adrenal System; Quinolinic Acid; Rheumatic Diseases; Serotonin

2016
Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects.
    Current medicinal chemistry, 2018, Volume: 25, Issue:42

    Topics: Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Stroke; Tryptophan

2018
Kynurenine pathway in depression: A systematic review and meta-analysis.
    Neuroscience and biobehavioral reviews, 2018, Volume: 90

    Topics: Brain; Depression; Depressive Disorder; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid

2018
Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies.
    Neuroscience and biobehavioral reviews, 2018, Volume: 92

    Topics: Humans; Kynurenic Acid; Kynurenine; Mood Disorders; Quinolinic Acid; Serotonin; Signal Transduction; Tryptophan

2018
Rollercoaster ride of kynurenines: steering the wheel towards neuroprotection in Alzheimer's disease.
    Expert opinion on therapeutic targets, 2018, Volume: 22, Issue:10

    Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Drug Development; Humans; Kynurenic Acid; Kynurenine; Neuroprotection; Neuroprotective Agents; Quinolinic Acid

2018
An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder.
    Molecular psychiatry, 2021, Volume: 26, Issue:8

    Topics: Antidepressive Agents; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Tryptophan

2021
Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism.
    Molecules (Basel, Switzerland), 2020, Jan-28, Volume: 25, Issue:3

    Topics: Dementia; Feedback, Physiological; Humans; Kynurenic Acid; Kynurenine; Male; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2020
Possibility of Amino Acid Treatment to Prevent the Psychiatric Disorders via Modulation of the Production of Tryptophan Metabolite Kynurenic Acid.
    Nutrients, 2020, May-13, Volume: 12, Issue:5

    Topics: Amino Acids; Animals; Astrocytes; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Mental Disorders; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2020
Systematic Review of the Kynurenine Pathway and Psychoneurological Symptoms Among Adult Cancer Survivors.
    Biological research for nursing, 2020, Volume: 22, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Cancer Survivors; Female; Humans; Kynurenic Acid; Kynurenine; Male; Metabolic Networks and Pathways; Middle Aged; Neoplasms; Tryptophan

2020
Effect of immune activation on the kynurenine pathway and depression symptoms - A systematic review and meta-analysis.
    Neuroscience and biobehavioral reviews, 2020, Volume: 118

    Topics: Depression; Humans; Kynurenic Acid; Kynurenine; Prospective Studies; Tryptophan

2020
Blood-based kynurenine pathway alterations in schizophrenia spectrum disorders: A meta-analysis.
    Schizophrenia research, 2020, Volume: 223

    Topics: Aged; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan

2020
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites.
    Molecular psychiatry, 2021, Volume: 26, Issue:7

    Topics: Adult; Bipolar Disorder; Humans; Kynurenic Acid; Kynurenine; Observational Studies as Topic; Quinolinic Acid; Tryptophan

2021
The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies.
    Molecular psychiatry, 2021, Volume: 26, Issue:8

    Topics: Bipolar Disorder; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Schizophrenia

2021
A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes.
    International journal of molecular sciences, 2021, Jan-22, Volume: 22, Issue:3

    Topics: Animals; Carbazoles; Chloracne; Dermatitis, Atopic; Humans; Hyperpigmentation; Kynurenic Acid; Kynurenine; Ligands; Melanoma; Mice; Microbiota; Oxidative Stress; Psoriasis; Receptors, Aryl Hydrocarbon; Skin; Skin Diseases; Skin Neoplasms; Skin Physiological Phenomena; Tryptophan; Vitiligo

2021
Dysregulation of kynurenine pathway and potential dynamic changes of kynurenine in schizophrenia: A systematic review and meta-analysis.
    Neuroscience and biobehavioral reviews, 2021, Volume: 123

    Topics: Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan

2021
Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Bipolar Disorder; Depression; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan

2021
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
    Trends in molecular medicine, 2021, Volume: 27, Issue:10

    Topics: Chronic Disease; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2021
A Potential Interface between the Kynurenine Pathway and Autonomic Imbalance in Schizophrenia.
    International journal of molecular sciences, 2021, Sep-16, Volume: 22, Issue:18

    Topics: Animals; Autonomic Nervous System; Humans; Kynurenic Acid; Kynurenine; Schizophrenia

2021
Redressing the interactions between stem cells and immune system in tissue regeneration.
    Biology direct, 2021, 10-20, Volume: 16, Issue:1

    Topics: Animals; Cell Adhesion Molecules; Cell Differentiation; Cell Proliferation; COVID-19; Humans; Immune System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Insulin-Like Growth Factor II; Interferon-gamma; Kynurenic Acid; Kynurenine; Macrophages; Mice; Muscles; Oxidative Phosphorylation; Receptors, Aryl Hydrocarbon; Regeneration; Stem Cells; Tryptophan; Tumor Necrosis Factor-alpha

2021
Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword?
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:1

    Topics: Alzheimer Disease; Animals; Brain; Excitatory Amino Acid Antagonists; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Parkinson Disease; Quinolinic Acid; Signal Transduction

2022
A review of chromatographic methods for bioactive tryptophan metabolites, kynurenine, kynurenic acid, quinolinic acid, and others, in biological fluids.
    Biomedical chromatography : BMC, 2022, Volume: 36, Issue:5

    Topics: Chromatography, High Pressure Liquid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2022
The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments.
    Molecular psychiatry, 2022, Volume: 27, Issue:9

    Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan

2022
The Tryptophan Catabolite or Kynurenine Pathway in Alzheimer's Disease: A Systematic Review and Meta-Analysis.
    Journal of Alzheimer's disease : JAD, 2022, Volume: 88, Issue:4

    Topics: Aged; Alzheimer Disease; Brain; Humans; Kynurenic Acid; Kynurenine; Tryptophan

2022
Exploration for biomarkers of postpartum depression based on metabolomics: A systematic review.
    Journal of affective disorders, 2022, 11-15, Volume: 317

    Topics: Biomarkers; Depression, Postpartum; Eicosapentaenoic Acid; Female; Humans; Kynurenic Acid; Kynurenine; Metabolomics; Postpartum Period; Steroids

2022
Kynurenine-3-monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression.
    Journal of cellular physiology, 2022, Volume: 237, Issue:12

    Topics: Disease Progression; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Neurodegenerative Diseases; Tryptophan

2022
The Tryptophan Catabolite or Kynurenine Pathway in a Major Depressive Episode with Melancholia, Psychotic Features and Suicidal Behaviors: A Systematic Review and Meta-Analysis.
    Cells, 2022, 10-02, Volume: 11, Issue:19

    Topics: Albumins; Amino Acids; Depressive Disorder, Major; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Quinolinic Acids; Suicidal Ideation; Tryptophan

2022
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis.
    Frontiers in immunology, 2022, Volume: 13

    Topics: 3-Hydroxyanthranilic Acid; Adenosine; Alzheimer Disease; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; NAD; Niacinamide; Parkinson Disease; Tryptophan

2022
Dynamic changes in kynurenine pathway metabolites in multiple sclerosis: A systematic review.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Humans; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Multiple Sclerosis; Quinolinic Acid; Tryptophan

2022
Importance of the dysregulation of the kynurenine pathway on cognition in schizophrenia: a systematic review of clinical studies.
    European archives of psychiatry and clinical neuroscience, 2023, Volume: 273, Issue:6

    Topics: Cognition; Humans; Kynurenic Acid; Kynurenine; Psychotic Disorders; Quality of Life; Schizophrenia

2023
Linking nervous and immune systems in psychiatric illness: A meta-analysis of the kynurenine pathway.
    Brain research, 2023, 02-01, Volume: 1800

    Topics: Bipolar Disorder; Depressive Disorder, Major; Humans; Immune System; Kynurenic Acid; Kynurenine; Tryptophan

2023
Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms.
    Cells, 2022, Nov-27, Volume: 11, Issue:23

    Topics: Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Migraine Disorders; Pain; Serotonin; Tryptophan

2022
Kynurenine metabolite changes in individuals with alcohol use disorder: A systematic review and meta-analysis.
    Drug and alcohol dependence, 2023, Aug-01, Volume: 249

    Topics: Alcoholism; Humans; Kynurenic Acid; Kynurenine; Tryptophan

2023
The kynurenine pathway in major depressive disorder under different disease states: A systematic review and meta-analysis.
    Journal of affective disorders, 2023, 10-15, Volume: 339

    Topics: Biomarkers; Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2023

Trials

18 trial(s) available for kynurenine and kynurenic acid

ArticleYear
Metabolism of tryptophan and niacin in oral contraceptives users receiving controlled intakes of vitamin B6.
    The American journal of clinical nutrition, 1975, Volume: 28, Issue:2

    Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Female; Humans; Kynurenic Acid; Kynurenine; Nicotinic Acids; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1975
Studies on tryptophan metabolism in male subjects treated with female sex hormones.
    The Journal of clinical endocrinology and metabolism, 1970, Volume: 31, Issue:4

    Topics: Aminohippuric Acids; Chlorotrianisene; Chromatography, Ion Exchange; Clinical Trials as Topic; Diethylstilbestrol; Glucuronates; Humans; Indican; Isonicotinic Acids; Kynurenic Acid; Kynurenine; Male; Mestranol; Niacinamide; Norethindrone; Norethynodrel; ortho-Aminobenzoates; Progestins; Prostatic Diseases; Prostatic Hyperplasia; Prostatitis; Pyridones; Pyridoxine; Spectrophotometry; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1970
Tryptophan metabolism during infectious illness in man.
    The Journal of infectious diseases, 1970, Volume: 122, Issue:3

    Topics: Administration, Oral; Adult; Aminohippuric Acids; Clinical Trials as Topic; Diazonium Compounds; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Phlebotomus Fever; Rocky Mountain Spotted Fever; Tryptophan; Tularemia; Typhoid Fever; Xanthurenates

1970
Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group. EORTC Genito-Urinary Tract Cancer Cooperative G
    European urology, 1995, Volume: 27, Issue:2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Transitional Cell; Double-Blind Method; Europe; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Prospective Studies; Pyridoxine; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates

1995
IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity.
    Molecular psychiatry, 2005, Volume: 10, Issue:6

    Topics: Adult; Depression; Dioxygenases; Female; Follow-Up Studies; Hepatitis C, Chronic; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Tryptophan

2005
Interferon-beta affects the tryptophan metabolism in multiple sclerosis patients.
    European journal of neurology, 2005, Volume: 12, Issue:8

    Topics: Adjuvants, Immunologic; Adult; Chromatography; Female; Humans; Interferon-beta; Kynurenic Acid; Kynurenine; Male; Mass Spectrometry; Multiple Sclerosis, Relapsing-Remitting; Time Factors; Tryptophan

2005
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
    Scandinavian journal of infectious diseases, 2010, Volume: 42, Issue:3

    Topics: Aged; Calcitonin; Calcitonin Gene-Related Peptide; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-DR Antigens; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Placebos; Protein Precursors; Quinolinic Acid; Sepsis; Serotonin; Shock, Septic; Treatment Outcome; Tryptophan

2010
Does acute tryptophan depletion affect peripheral serotonin metabolism in the intestine?
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:3

    Topics: Adult; Central Nervous System; Double-Blind Method; Female; Humans; Hydroxyindoleacetic Acid; Intestinal Mucosa; Intestines; Kynurenic Acid; Kynurenine; Male; Serotonin; Tryptophan; Young Adult

2012
Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects.
    The Journal of nutrition, 2013, Volume: 143, Issue:6

    Topics: Adolescent; Adult; Biomarkers; Body Mass Index; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Humans; Kynurenic Acid; Kynurenine; Niacinamide; ortho-Aminobenzoates; Placebos; Tryptophan; Young Adult

2013
Plasma kynurenic acid/tryptophan ratio: a sensitive and reliable biomarker for the assessment of renal function.
    Renal failure, 2013, Volume: 35, Issue:5

    Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Humans; Hypertension; Kidney Function Tests; Kynurenic Acid; Kynurenine; Male; Middle Aged; Renal Insufficiency, Chronic; Tryptophan

2013
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o
    The Journal of nutrition, 2015, Volume: 145, Issue:1

    Topics: Adult; Biomarkers; Carbon; Contraceptives, Oral, Hormonal; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Metabolome; Pyridoxal Phosphate; Tryptophan; United States; Vitamin B 6; Vitamin B 6 Deficiency

2015
Exercise-mediated improvement of depression in patients with gastro-esophageal junction cancer is linked to kynurenine metabolism.
    Acta oncologica (Stockholm, Sweden), 2019, Volume: 58, Issue:5

    Topics: Aged; Anxiety; Depression; Exercise; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neoadjuvant Therapy; Stomach Neoplasms; Treatment Outcome

2019
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
    Psychoneuroendocrinology, 2019, Volume: 109

    Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Sex Factors; Tryptophan; Tumor Necrosis Factor-alpha

2019
Exercise and the Kynurenine pathway: Current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and resistance training.
    Exercise immunology review, 2020, Volume: 26

    Topics: Adult; Cross-Over Studies; Endurance Training; Exercise; Humans; Hydrocortisone; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Male; Quinolinic Acid; Resistance Training; Transaminases; Tryptophan

2020
A randomized cross-over trial to define neurophysiological correlates of AV-101 N-methyl-D-aspartate receptor blockade in healthy veterans.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021, Volume: 46, Issue:4

    Topics: Adult; Cross-Over Studies; Female; Humans; Kynurenic Acid; Kynurenine; Neuroprotective Agents; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Veterans

2021
Acute administration of ibuprofen increases serum concentration of the neuroprotective kynurenine pathway metabolite, kynurenic acid: a pilot randomized, placebo-controlled, crossover study.
    Psychopharmacology, 2022, Volume: 239, Issue:12

    Topics: Adult; Cross-Over Studies; Female; Humans; Ibuprofen; Kynurenic Acid; Kynurenine; Pilot Projects; Quinolinic Acid

2022
Lipopolysaccharide-induced changes in the kynurenine pathway and symptoms of sickness behavior in humans.
    Psychoneuroendocrinology, 2023, Volume: 153

    Topics: Adult; Female; Humans; Illness Behavior; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Niacinamide; Young Adult

2023
Tryptophan challenge in individuals with schizophrenia and healthy controls: acute effects on circulating kynurenine and kynurenic acid, cognition and cerebral blood flow.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023, Volume: 48, Issue:11

    Topics: Animals; Cerebrovascular Circulation; Cognition; Cross-Over Studies; Humans; Kynurenic Acid; Kynurenine; Rats; Rats, Wistar; Schizophrenia; Tryptophan

2023

Other Studies

510 other study(ies) available for kynurenine and kynurenic acid

ArticleYear
[Studies on tryptophan metabolism in untreated phenylketonuric patients].
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1975, Volume: 13, Issue:1

    Topics: Acetophenones; Adolescent; Adult; Biotransformation; Child; Child, Preschool; Chromatography, Ion Exchange; Chromatography, Thin Layer; Female; Humans; Kynurenic Acid; Kynurenine; Male; Mass Spectrometry; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Phenylalanine; Phenylketonurias; Quinolines; Tryptophan; Xanthurenates

1975
A defect in tryptophan metabolism.
    Pediatric research, 1976, Volume: 10, Issue:8

    Topics: Cerebellar Ataxia; Child; Chromatography, Paper; Drug Eruptions; Humans; Kynurenic Acid; Kynurenine; Male; Metabolic Clearance Rate; Metabolism, Inborn Errors; Nicotinic Acids; Photosensitivity Disorders; Tryptophan; Xanthurenates

1976
[Tryptophan metabolic indices in allergic dermatoses].
    Vestnik dermatologii i venerologii, 1979, Issue:4

    Topics: Chronic Disease; Dermatitis, Atopic; Female; Humans; Kynurenic Acid; Kynurenine; Male; Prurigo; Pyridoxal Phosphate; Tryptophan; Urticaria; Xanthurenates

1979
The vitamin B6 requirement in oral contraceptive users. II. Assessment by tryptophan metabolites, vitamin B6, and pyridoxic acid levels in urine.
    The American journal of clinical nutrition, 1979, Volume: 32, Issue:5

    Topics: Adolescent; Adult; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Female; Humans; Isonicotinic Acids; Kynurenic Acid; Kynurenine; Nutritional Requirements; Pyridoxic Acid; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1979
Relationship between tryptophan intake and urinary excretion of 3-hydroxy-kynurenine, 3-hydroxyanthranilic acid, xanthurenic acid and kynurenic acid.
    Journal of nutritional science and vitaminology, 1979, Volume: 25, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Kinetics; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Tryptophan; Xanthurenates

1979
Tryptophan metabolism in animals with dermatitis. I) In Rats.
    Bollettino della Societa italiana di biologia sperimentale, 1979, Sep-15, Volume: 55, Issue:17

    Topics: Animals; Dermatitis, Contact; Ficusin; Kynurenic Acid; Kynurenine; Photosensitivity Disorders; Rats; Tryptophan; Xanthurenates

1979
The spontaneous urinary excretion of tryptophan metabolites "via kynurenine" in women with regards to the prepuberty, sexual maturity and menopause.
    Acta vitaminologica et enzymologica, 1978, Volume: 32, Issue:5-6

    Topics: Adult; Age Factors; Aged; Aminohippuric Acids; Child; Female; Humans; Kynurenic Acid; Kynurenine; Menopause; Middle Aged; ortho-Aminobenzoates; Puberty; Sexual Maturation; Tryptophan; Xanthurenates

1978
A further contribution to the choice of the dose for L-tryptophan load test.
    Acta vitaminologica et enzymologica, 1978, Volume: 32, Issue:5-6

    Topics: Aminohippuric Acids; Body Weight; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Sex Factors; Tryptophan; Xanthurenates

1978
The effect of environment on tryptophan metabolism "via kynurenine" in oral contraceptives users.
    Acta vitaminologica et enzymologica, 1978, Volume: 32, Issue:5-6

    Topics: Aminohippuric Acids; Contraceptives, Oral; Contraceptives, Oral, Combined; Environment; Ethinyl Estradiol; Female; Humans; Kynurenic Acid; Kynurenine; Norethindrone; ortho-Aminobenzoates; Pregnancy; Rural Population; Tryptophan; Urban Population; Xanthurenates

1978
Influence of vitamin and amino acid supplements on tryptophan-kynurenine metabolism in South African Bantu.
    Acta vitaminologica et enzymologica, 1978, Volume: 32, Issue:5-6

    Topics: Adult; Aminohippuric Acids; Ascorbic Acid; Humans; Kynurenic Acid; Kynurenine; Leucine; ortho-Aminobenzoates; Pyridoxine; Racial Groups; Riboflavin; South Africa; Thiamine; Tryptophan; Vitamins; Xanthurenates

1978
A new aspect of the urinary excretion of tryptophan metabolites in patients with cancer of the bladder.
    International journal of cancer, 1978, Feb-15, Volume: 21, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Aspartate Aminotransferases; Creatinine; Female; Humans; Kidney Neoplasms; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Sodium; Tryptophan; Urea; Ureteral Obstruction; Urinary Bladder Neoplasms; Xanthurenates

1978
Effects of vitamin B-6 deficiency and tryptophan loading on urinary excretion of tryptophan metabolites in mammals.
    The Journal of nutrition, 1977, Volume: 107, Issue:2

    Topics: Adult; Animals; Cricetinae; Diet; Female; Guinea Pigs; Humans; Kynurenic Acid; Kynurenine; Pyridoxine; Quinolinic Acids; Rats; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1977
Effects of benserazide on tryptophan metabolism in the mouse.
    Biochemical pharmacology, 1977, Sep-01, Volume: 26, Issue:17

    Topics: Animals; Benserazide; Carbon Dioxide; Hydrazines; Hydrolases; In Vitro Techniques; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Inbred Strains; Time Factors; Transaminases; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1977
Studies on the kynurenine adminotransferase activity in rat liver and kidney.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1976, Volume: 357, Issue:12

    Topics: Animals; In Vitro Techniques; Kidney; Kinetics; Kynurenic Acid; Kynurenine; Liver; Male; Mitochondria; Mitochondria, Liver; Pyridoxal Phosphate; Rats; Transaminases; Xanthurenates

1976
[Relationship between tryptophan metabolism and the state of melaninogensis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1976, Volume: 82, Issue:12

    Topics: Animals; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Liver; Melanins; ortho-Aminobenzoates; Rabbits; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1976
A mechanism for the formation in vivo of the 8-methyl ether of xanthurenic acid in humans.
    Biochemical medicine, 1975, Volume: 12, Issue:1

    Topics: Adult; Female; Humans; Kynurenic Acid; Kynurenine; Male; Methionine; Methyl Ethers; Middle Aged; Pellagra; Scleroderma, Systemic; Time Factors; Tryptophan; Xanthurenates

1975
A new method for determination of urinary tryptophan metabolites in bladder carcinoma.
    The Journal of urology, 1975, Volume: 114, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Chromatography, Thin Layer; Female; Humans; Kynurenic Acid; Kynurenine; Male; Spectrometry, Fluorescence; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates

1975
Plasma pyridoxal phosphate levels and tryptophan metabolism in children with burns and scalds.
    Clinica chimica acta; international journal of clinical chemistry, 1975, Oct-01, Volume: 64, Issue:1

    Topics: Burns; Child; Child, Preschool; Humans; Kynurenic Acid; Kynurenine; Pyridoxal Phosphate; Pyridoxine; Tryptophan; Xanthurenates

1975
[State of interstitial metabolism of tryptophan during pregnancy and labor in women having received estrogen-progestagenic preparations].
    Akusherstvo i ginekologiia, 1975, Issue:7

    Topics: Adult; Contraceptives, Oral; Estradiol Congeners; Female; Humans; Kynurenic Acid; Kynurenine; Labor, Obstetric; Middle Aged; Pregnancy; Progesterone Congeners; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1975
Metabolism of D- and L-tryptophan in dogs.
    The Journal of nutrition, 1976, Volume: 106, Issue:5

    Topics: Animals; Carbon Dioxide; Dogs; Feces; Humans; Kynurenic Acid; Kynurenine; Liver; Male; Pyruvates; Species Specificity; Stereoisomerism; Structure-Activity Relationship; Tryptophan

1976
Alteration of mice L-tryptophan metabolism by the organophosphorous acid triester diazinon.
    Biochemical pharmacology, 1992, Dec-01, Volume: 44, Issue:11

    Topics: Animals; Arylformamidase; Diazinon; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Models, Biological; NAD; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1992
Minority ligands of excitatory amino acid receptors: focus on brain kynurenines.
    Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A

    Topics: Animals; Brain Chemistry; Humans; Kynurenic Acid; Kynurenine; Ligands; Quinolinic Acids; Receptors, Amino Acid; Receptors, Cell Surface

1992
Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex.
    Journal of the neurological sciences, 1992, Volume: 108, Issue:1

    Topics: Aged; Alzheimer Disease; Cerebral Cortex; Energy Metabolism; Free Radicals; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Middle Aged; Parkinson Disease; Purines; Tryptophan; Tyrosine

1992
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
    Brain : a journal of neurology, 1992, Volume: 115 ( Pt 5)

    Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynurenine; Macaca; Male; Middle Aged; Nervous System Diseases; Neuritis; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome

1992
Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.
    Neuroscience, 1992, Volume: 51, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Brain; Immune System; Interferon-gamma; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Models, Biological; Pokeweed Mitogens; Quinolinic Acid; Recombinant Proteins; Tryptophan

1992
The effect of peripheral loading with kynurenine and probenecid on extracellular striatal kynurenic acid concentrations.
    Neuroscience letters, 1992, Oct-26, Volume: 146, Issue:1

    Topics: Animals; Corpus Striatum; Dialysis; Extracellular Space; Kynurenic Acid; Kynurenine; Male; Nervous System; Probenecid; Rats; Rats, Sprague-Dawley

1992
Regulation of kynurenic acid synthesis studied by microdialysis in the dorsal hippocampus of unanesthetized rats.
    European journal of pharmacology, 1992, Mar-31, Volume: 213, Issue:3

    Topics: Aminooxyacetic Acid; Animals; Brain Diseases; Dialysis; Drug Interactions; Hippocampus; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tetrodotoxin; Veratridine

1992
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1992, Volume: 12, Issue:3

    Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; N-Methylaspartate; Probenecid; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains

1992
Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.
    Brain research bulletin, 1992, Volume: 28, Issue:2

    Topics: Analysis of Variance; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Probenecid; Seizures

1992
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates.
    Neurochemical research, 1991, Volume: 16, Issue:10

    Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Malondialdehyde; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Thiobarbiturates

1991
Tryptophan metabolism in mice infected with Schistosoma mansoni.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Cells, Cultured; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Niacinamide; Schistosomiasis mansoni; Serotonin; Tryptophan; Xanthurenates

1991
Kynurenines in the regulation of behavior in insects.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Action Potentials; Animal Communication; Animals; Bees; Behavior, Animal; Calmodulin; Drosophila melanogaster; Eye Color; Genes; Genotype; Insecta; Kynurenic Acid; Kynurenine; Learning; Phenothiazines; Stimulation, Chemical; Structure-Activity Relationship; Tryptophan; Xanthurenates

1991
Tryptophan metabolism in senile cataract patients assessed by high-performance liquid chromatography.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Aging; Cataract; Chromatography, High Pressure Liquid; Humans; Kynurenic Acid; Kynurenine; Tryptophan

1991
Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism.
    Journal of neurochemistry, 1991, Volume: 56, Issue:6

    Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains

1991
Indolic and kynurenine pathway metabolites of tryptophan in rat brain: effect of precursor availability on in vivo release.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Corpus Striatum; Dialysis; Extracellular Space; Indoles; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan

1991
Production of quinolinic acid and kynurenic acid by human glioma.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Astrocytoma; Brain Neoplasms; Dioxygenases; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neoplasm Proteins; Oxygenases; Quinolinic Acid; Quinolinic Acids

1991
Comparative behavioral and pharmacological studies with centrally administered kynurenine and kynurenic acid in rats.
    European journal of pharmacology, 1991, Apr-24, Volume: 196, Issue:3

    Topics: Animals; Avoidance Learning; Behavior, Animal; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; Rats; Rats, Inbred Strains

1991
Schistosoma mansoni: effects on tryptophan metabolism in mice.
    Experimental parasitology, 1990, Volume: 70, Issue:1

    Topics: Animals; Chemical Phenomena; Chemistry; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Niacinamide; Oxidation-Reduction; Pyridoxine; Schistosomiasis mansoni; Tryptophan

1990
Increased cerebrospinal fluid quinolinic acid, kynurenic acid, and L-kynurenine in acute septicemia.
    Journal of neurochemistry, 1990, Volume: 55, Issue:1

    Topics: Acute Disease; Animals; Female; Kynurenic Acid; Kynurenine; Macaca mulatta; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Sepsis

1990
Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid.
    Journal of neurochemistry, 1990, Volume: 55, Issue:4

    Topics: Aged; Autopsy; Corpus Striatum; Female; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Male; Middle Aged; Putamen; Reference Values; Tryptophan; Tyrosine

1990
Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:9

    Topics: Aminooxyacetic Acid; Animals; Corpus Striatum; Extracellular Space; Kinetics; Kynurenic Acid; Kynurenine; Lyases; Male; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Transaminases; Tryptophan

1990
Quantification of kynurenic acid in cerebrospinal fluid: effects of systemic and central L-kynurenine administration.
    Journal of chromatography, 1990, Aug-24, Volume: 530, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Animals; Chromatography, High Pressure Liquid; Cisterna Magna; Humans; Kynurenic Acid; Kynurenine; Macaca mulatta; Male; Rats; Rats, Inbred Strains; Retroviruses, Simian; Simian Acquired Immunodeficiency Syndrome

1990
Determination of extracellular kynurenic acid in the striatum of unanesthetized rats: effect of aminooxyacetic acid.
    Neuroscience letters, 1990, Aug-14, Volume: 116, Issue:1-2

    Topics: Aminooxyacetic Acid; Animals; Corpus Striatum; Dialysis; Dose-Response Relationship, Drug; Kinetics; Kynurenic Acid; Kynurenine; Male; Rats; Rats, Inbred Strains

1990
Intracerebroventricular injection of kynurenic acid, but not kynurenine, induces ataxia and stereotyped behavior in rats.
    Brain research bulletin, 1990, Volume: 25, Issue:4

    Topics: Animals; Ataxia; Exploratory Behavior; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; Rats; Rats, Inbred Strains; Stereotyped Behavior

1990
Disturbances in tryptophan metabolism in rats following chronic dietary aflatoxin treatment.
    Drug and chemical toxicology, 1985, Volume: 8, Issue:3

    Topics: Aflatoxins; Animals; Bile Ducts; Brain Chemistry; Cell Division; Diet; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Liver; Male; Precancerous Conditions; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase

1985
[Effects of antagonists of exciting amino acids on the neuro-destructive effect of quinolinic acid in vitro in comparison with their anticonvulsive action in situ].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 108, Issue:8

    Topics: Animals; Anticonvulsants; Cells, Cultured; Dicarboxylic Acids; Hippocampus; Imidazoles; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neurons; Pyridines; Quinolinic Acid; Quinolinic Acids

1989
Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine.
    Journal of neurochemistry, 1989, Volume: 52, Issue:5

    Topics: Aminooxyacetic Acid; Animals; Brain; Cerebellum; Cerebral Cortex; Chlorides; Corpus Striatum; Hippocampus; Ibotenic Acid; Kinetics; Kynurenic Acid; Kynurenine; Male; Potassium; Rats; Rats, Inbred Strains; Thalamus; Tissue Distribution

1989
Kynurenine metabolism and xanthurenic acid formation in vitamin B6-deficient rat after tryptophan injection.
    Journal of nutritional science and vitaminology, 1989, Volume: 35, Issue:2

    Topics: Animals; Hydrolases; Kidney; Kynurenic Acid; Kynurenine; Liver; Lyases; Male; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Transaminases; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1989
The correlation between certain tryptophan metabolites and the N-nitrosamine content in the urine of bilharzial bladder cancer patients.
    The Journal of urology, 1986, Volume: 135, Issue:4

    Topics: 3-Hydroxyanthranilic Acid; Adult; Aminohippuric Acids; Colorimetry; Humans; Indican; Kynurenic Acid; Kynurenine; Male; Middle Aged; Nitrosamines; ortho-Aminobenzoates; Schistosomiasis haematobia; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates

1986
Kynurenines do not antagonise GABA in rat hippocampus.
    European journal of pharmacology, 1986, Aug-22, Volume: 128, Issue:1-2

    Topics: Animals; Convulsants; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kynurenic Acid; Kynurenine; Male; Rats; Sodium Oxybate

1986
Effects of tryptophan metabolites on enzymes of oxidative phosphorylation.
    The American journal of clinical nutrition, 1971, Volume: 24, Issue:7

    Topics: Acetoacetates; Adenine Nucleotides; Amino Acids; Animals; Antimycin A; Cyanides; Cytochromes; Depression, Chemical; Dicumarol; Hydroxybutyrates; In Vitro Techniques; Ketoglutaric Acids; Kynurenic Acid; Kynurenine; Liver; Manometry; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; NAD; Nitriles; ortho-Aminobenzoates; Oxidative Phosphorylation; Oxygen Consumption; Phenylbutyrates; Phenylhydrazines; Polarography; Rats; Rotenone; Spectrophotometry; Stimulation, Chemical; Temperature; Tryptophan; Uncoupling Agents; Xanthurenates

1971
Effects of L-tryptophan load on the metabolism of tryptophan-2-C14 in man.
    The Journal of laboratory and clinical medicine, 1967, Volume: 69, Issue:2

    Topics: Aged; Aminohippuric Acids; Carbon Dioxide; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Niacinamide; Pyridines; Pyridones; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1967
Metabolism of D- and L-kynurenine-keto-14C in rats and the effects of unlabeled enantiomers.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1968, Volume: 129, Issue:1

    Topics: Animals; Autoradiography; Carbon Dioxide; Carbon Isotopes; Chromatography, Paper; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Methods; Niacinamide; Nicotinic Acids; Pyridines; Rats; Stereoisomerism; Xanthurenates

1968
Comparative tryptophan metabolism in cats and rats: differences in adaptation of tryptophan oxygenase and in vivo metabolism of tryptophan, kynurenine and hydroxykynurenine.
    Comparative biochemistry and physiology, 1969, Oct-01, Volume: 31, Issue:1

    Topics: Amino Acids; Aminohippuric Acids; Animals; Cats; Enzyme Induction; Glucuronates; Hydrocortisone; Indican; Kynurenic Acid; Kynurenine; Male; Niacinamide; ortho-Aminobenzoates; Phenylbutyrates; Rats; Species Specificity; Sulfates; Tryptophan; Tryptophan Oxygenase; Urinary Bladder Neoplasms; Xanthurenates

1969
[Tryptophan metabolism in bladder carcinoma].
    Zeitschrift fur Krebsforschung, 1970, Volume: 73, Issue:3

    Topics: Aged; Animals; Autoradiography; Carcinoma; Chromatography; Humans; Kynurenic Acid; Kynurenine; Middle Aged; ortho-Aminobenzoates; Papilloma; Rats; Tritium; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates

1970
Lack of effect of smoking on the excretion of tryptophan metabolites by man.
    Cancer research, 1970, Volume: 30, Issue:3

    Topics: Adult; Aminohippuric Acids; Female; Glucuronates; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Niacinamide; Pyridinium Compounds; Smoking; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates

1970
A disorder of tryptophan metabolism in chronic granulomatous disease.
    Archives of disease in childhood, 1970, Volume: 45, Issue:242

    Topics: Child; Child, Preschool; Chromatography, Paper; Chronic Disease; Granuloma; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infections; Kynurenic Acid; Kynurenine; Lymphadenitis; Male; Niacinamide; Pyridoxine; Tryptophan; Xanthurenates

1970
The effect of tryptophan metabolites on brain 5-hydroxytryptamine metabolism.
    Biochemical pharmacology, 1970, Volume: 19, Issue:6

    Topics: Alanine; Allopurinol; Amino Acids; Animals; Brain; Brain Chemistry; Carbon Isotopes; Carboxy-Lyases; Histamine; Kynurenic Acid; Kynurenine; Male; Methanol; Methyldopa; Mixed Function Oxygenases; Niacinamide; Nicotinic Acids; Nitroglycerin; ortho-Aminobenzoates; Phenylalanine; Phenylbutyrates; Picolinic Acids; Pyridines; Pyridoxal Phosphate; Pyridoxine; Rats; Serotonin; Sulfuric Acids; Time Factors; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1970
Conversion of D-tryptophan to nicotinic acid in the rat.
    The Journal of nutrition, 1971, Volume: 101, Issue:12

    Topics: Animals; Deficiency Diseases; Indoles; Kidney; Kynurenic Acid; Kynurenine; Liver; Male; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyruvates; Rats; Stereoisomerism; Sulfuric Acids; Tryptophan; Xanthurenates

1971
The influence of simultaneous administration of vitamin B 6 and nicotinamide on tryptophan metabolism in Hodgkin's disease.
    Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 40, Issue:1

    Topics: Acylation; Administration, Oral; Aminohippuric Acids; Hodgkin Disease; Humans; Hydroxylation; Infusions, Parenteral; Kynurenic Acid; Kynurenine; Methyl Ethers; Niacinamide; ortho-Aminobenzoates; Pyridoxine; Tryptophan; Xanthurenates

1972
Tryptophan metabolism in man (with special reference to rheumatoid arthritis and scleroderma).
    Seminars in arthritis and rheumatism, 1973, Volume: 2, Issue:4

    Topics: Arthritis, Rheumatoid; Aspirin; Cystinuria; Drug Synergism; Edetic Acid; Humans; Kynurenic Acid; Kynurenine; Methods; Niacinamide; Penicillamine; Pyridoxine; Scleroderma, Systemic; Tryptophan; Xanthurenates

1973
Occurrence of N-formylkynurenine in extracts of Neurospora crassa: evidence for the activity of tryptophan pyrrolase.
    Journal of bacteriology, 1974, Volume: 118, Issue:3

    Topics: Carbon Radioisotopes; Cell-Free System; Chromatography, Paper; Chromatography, Thin Layer; Culture Media; Filtration; Formates; Kynurenic Acid; Kynurenine; Neurospora; Neurospora crassa; ortho-Aminobenzoates; Spectrometry, Fluorescence; Stereoisomerism; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1974
Studies with tryptophan metabolites in vitro. 3. The effect of schistosomicidal drugs on kynureninase and kynurenine transaminase of normal mouse liver.
    Biochemical pharmacology, 1969, Volume: 18, Issue:4

    Topics: Animals; Anti-Infective Agents; Antimony; Benzenesulfonates; Calcium; Imidazoles; In Vitro Techniques; Kynurenic Acid; Kynurenine; Liver; Magnesium; Mice; ortho-Aminobenzoates; Pyridoxal Phosphate; Tartrates; Transaminases; Tryptophan

1969
Studies on tryptophan metabolism in male subjects treated with hydrocortisone.
    The Journal of clinical endocrinology and metabolism, 1971, Volume: 33, Issue:5

    Topics: Chromatography, Ion Exchange; Humans; Hydrocortisone; Kynurenic Acid; Kynurenine; Male; NAD; Pyridoxine; Statistics as Topic; Tryptophan

1971
Abnormal tryptophan metabolism in patients with scurvy-type skin.
    Biochemical medicine, 1973, Volume: 7, Issue:1

    Topics: Acetates; Adult; Aminohippuric Acids; Black or African American; Black People; Ethnicity; Glucuronates; Hemosiderosis; Humans; Indoles; Kynurenic Acid; Kynurenine; Male; NAD; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Scurvy; South Africa; Sulfuric Acids; Tryptophan; Xanthurenates

1973
[Fluorescing substances from the Malpighian tubules of wild-type and various eye color mutants of Drosophila melanogaster].
    Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete, 1968, Volume: 23, Issue:3

    Topics: Animals; Chromatography, Paper; Drosophila; Eye; Fluorescence; Kynurenic Acid; Kynurenine; Malpighian Tubules; Molecular Biology; Mutation; Pigments, Biological; Pteridines; Riboflavin; Spectrophotometry; Tryptophan; Xanthurenates

1968
Production of D-kynurenine and other metabolites from D-tryptophan by the intact rabbit and by rabbit tissue.
    The Journal of nutrition, 1971, Volume: 101, Issue:4

    Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Chromatography, Ion Exchange; Chromatography, Paper; Colorimetry; D-Amino-Acid Oxidase; Deamination; In Vitro Techniques; Indoles; Intestine, Small; Kidney; Kynurenic Acid; Kynurenine; Liver; Male; Pyruvates; Rabbits; Spectrophotometry; Spectrum Analysis; Tryptophan; Tryptophan Oxygenase

1971
Studies of tryptophan metabolism in experimental animals and man during infectious illness.
    The American journal of clinical nutrition, 1971, Volume: 24, Issue:7

    Topics: Adrenal Glands; Adrenalectomy; Amino Acids; Aminohippuric Acids; Animals; Azo Compounds; Carbon Isotopes; Circadian Rhythm; Fasting; Glucocorticoids; Humans; Indican; Kynurenic Acid; Kynurenine; Leucine; Liver; Mice; ortho-Aminobenzoates; Phenylbutyrates; Phlebotomus Fever; Pneumococcal Infections; Protein Biosynthesis; Rocky Mountain Spotted Fever; Salmonella Infections; Salmonella typhi; Streptococcus pneumoniae; Tryptophan; Tryptophan Oxygenase; Typhoid Fever; Xanthurenates

1971
Inversion in the metabolism of D-tryptophan in the rabbit and the rat.
    The Journal of nutrition, 1971, Volume: 101, Issue:10

    Topics: Aerobiosis; Amination; Anaerobiosis; Animals; Chromatography, Paper; D-Amino-Acid Oxidase; Deamination; Diet; Indoles; Kidney; Kynurenic Acid; Kynurenine; Liver; Male; Organ Specificity; ortho-Aminobenzoates; Oryza; Oxidation-Reduction; Oxygen Consumption; Pyridoxal Phosphate; Pyruvates; Rabbits; Rats; Species Specificity; Stereoisomerism; Tryptophan

1971
Complexity of in vivo induction of tryptophan oxygenase and tyrosine aminotransferase: effects of tryptophan metabolites.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1972, Jan-15, Volume: 41, Issue:1

    Topics: Animals; Carboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Hydrocortisone; Kynurenic Acid; Kynurenine; Liver; Male; ortho-Aminobenzoates; Picolinic Acids; Pyridines; Quinolines; Rats; Succinates; Theophylline; Tryptophan; Tryptophan Oxygenase; Tyrosine Transaminase; Xanthurenates

1972
Tryptophan metabolsim and serum fatty acids in acrodermatitis enteropathica.
    Archiv fur dermatologische Forschung, 1974, Jun-11, Volume: 249, Issue:4

    Topics: Acrodermatitis; Adolescent; Amino Acid Metabolism, Inborn Errors; Aminohippuric Acids; Arachidonic Acids; Child; Child, Preschool; Fatty Acids; Female; Humans; Indoles; Kynurenic Acid; Kynurenine; Linoleic Acids; Malabsorption Syndromes; Male; ortho-Aminobenzoates; Paronychia; Pyridoxine; Quinolines; Tryptophan; Xanthurenates

1974
Tryptophan and methionine metabolism of adult females as affected by vitamin B-6 deficiency.
    The Journal of nutrition, 1974, Volume: 104, Issue:10

    Topics: Adult; Body Weight; Cystathionine; Cysteine; Dietary Proteins; Female; Homocystine; Humans; Kynurenic Acid; Kynurenine; Methionine; Nutritional Physiological Phenomena; Pyridoxine; Sulfinic Acids; Taurine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1974
Urinary excretion of tryptophan metabolites during phototherapy.
    The Journal of pediatrics, 1974, Volume: 85, Issue:6

    Topics: Aminohippuric Acids; Humans; Hydroxyindoleacetic Acid; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Photochemistry; Phototherapy; Serotonin; Tryptophan; Xanthurenates

1974
Abnormalities of tryptophan metabolism (kynurenine pathway) found in a group of 830 mentally retarded children.
    Clinica chimica acta; international journal of clinical chemistry, 1974, Oct-30, Volume: 56, Issue:2

    Topics: Child; Child, Preschool; Chromatography, Paper; Female; Humans; Infant; Infant, Newborn; Intellectual Disability; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Phenols; Pyridoxine; Spectrophotometry; Tryptophan; Xanthurenates

1974
Relationship between pyridoxal phosphate and some synthetic oestrogens in their effect on kynurenine hydrolase and kynurenine aminotransferase enzymes of normal mouse liver.
    Biochemical pharmacology, 1974, Mar-01, Volume: 23, Issue:5

    Topics: Animals; Estradiol; Estradiol Congeners; Ethinyl Estradiol; Hydrolases; Kinetics; Kynurenic Acid; Kynurenine; Liver; Male; Mestranol; Mice; Progesterone; Pyridoxal Phosphate; Transaminases

1974
Transamination of kynurenines.
    Acta vitaminologica et enzymologica, 1974, Volume: 28, Issue:5

    Topics: Animals; Chickens; Grasshoppers; Horses; Humans; Kidney; Kynurenic Acid; Kynurenine; Liver; Neurospora; Nicotinic Acids; Pyridoxine; Rats; Transaminases; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1974
5-hydroxytryptophan pyrrolase in rat brain.
    Journal of neurochemistry, 1972, Volume: 19, Issue:3

    Topics: 5-Hydroxytryptophan; Animals; Ascorbic Acid; Brain; Chromatography, Ion Exchange; Chromatography, Paper; Chromatography, Thin Layer; Flavin-Adenine Dinucleotide; Fluorescence; Hydroxylation; In Vitro Techniques; Kynurenic Acid; Kynurenine; Male; Oxygenases; Quinolines; Rats; Rats, Inbred Strains; Spectrum Analysis; Ultraviolet Rays

1972
An improved column chromatographic method for isolation of tryptophan metabolites.
    Analytical biochemistry, 1972, Volume: 47, Issue:1

    Topics: 5-Hydroxytryptophan; Aldehydes; Amides; Animals; Chromatography, DEAE-Cellulose; Colorimetry; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Male; Methods; Nitriles; Rats; Serotonin; Spectrometry, Fluorescence; Tryptamines; Tryptophan; Urea; Vitamin B 6 Deficiency; Xanthurenates

1972
Tryptophan metabolism in acrodermatitis enteropathica.
    The Journal of pediatrics, 1973, Volume: 83, Issue:6

    Topics: Acrodermatitis; Aminohippuric Acids; Child; Child, Preschool; Creatinine; Female; Gastrointestinal Diseases; Humans; Iodoquinol; Kynurenic Acid; Kynurenine; Male; Mixed Function Oxygenases; Tryptophan; Xanthurenates

1973
Studies on tryptophan metabolism in patients with lymphoma.
    Cancer research, 1974, Volume: 34, Issue:7

    Topics: Hodgkin Disease; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Liver; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1974
Computer simulation and analysis of tryptophan metabolism via kynurenine pathway in liver.
    Computers in biology and medicine, 1974, Volume: 1, Issue:4

    Topics: Coenzymes; Computers, Analog; Diagnosis, Computer-Assisted; Feedback; Humans; Kynurenic Acid; Kynurenine; Liver; Mathematics; Metabolic Diseases; Models, Biological; Nutrition Disorders; ortho-Aminobenzoates; Pyridoxal; Pyridoxine; Systems Analysis; Tryptophan; Xanthurenates

1974
Comparative studies on the in vivo effects of tartar emetic, vitamin B 6 , and the chelating agent 2,3-dimercaptopropanol (BAL) on the functional capacity of the tryptophan-niacin pathway in patients with schistosomiasis.
    Metabolism: clinical and experimental, 1972, Volume: 21, Issue:12

    Topics: Acetates; Adolescent; Aminohippuric Acids; Antimony; Child; Dimercaprol; Emetics; Glucuronates; Humans; Indican; Isonicotinic Acids; Kynurenic Acid; Kynurenine; Male; Nicotinic Acids; ortho-Aminobenzoates; Pyridoxine; Schistosoma haematobium; Schistosomiasis; Tartrates; Tryptophan; Xanthurenates

1972
The effect of burns on the metabolism of tryptophan in children.
    Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 41

    Topics: Burns; Child; Child, Preschool; Creatinine; Humans; Kynurenic Acid; Kynurenine; Oxalates; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1972
Studies on the urinary excretion of certain tryptophan metabolites in diabetics.
    The Journal of the Egyptian Medical Association, 1972, Volume: 55, Issue:7

    Topics: Adolescent; Adult; Amino Acids; Diabetes Mellitus; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; Nitrogen; ortho-Aminobenzoates; Phenylbutyrates; Tryptophan; Xanthurenates

1972
[Proceedings: Tryptophan metabolism in untreated phenylketonuria and in vitamin B6 dependent cramps].
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1972, Volume: 10, Issue:4

    Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Carboxylic Acids; Child; Child, Preschool; Humans; Hydroxyquinolines; Intellectual Disability; Kynurenic Acid; Kynurenine; Muscle Cramp; Nicotinic Acids; Phenylalanine; Phenylketonurias; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1972
Tryptophan metabolism in breast cancer. Correlation with urinary steroid excretion.
    Cancer, 1973, Volume: 31, Issue:5

    Topics: 17-Hydroxycorticosteroids; Adult; Aged; Aminohippuric Acids; Androsterone; Breast Neoplasms; Etiocholanolone; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; ortho-Aminobenzoates; Tryptophan; Xanthurenates

1973
Relationship of dietary tryptophan and niacin to tryptophan metabolism in schizophrenics and nonschizophrenics.
    The American journal of clinical nutrition, 1974, Volume: 27, Issue:6

    Topics: Acetates; Aminohippuric Acids; Diet; Female; Humans; Hydroxyindoleacetic Acid; Indican; Indoles; Kynurenic Acid; Kynurenine; Male; Nicotinic Acids; ortho-Aminobenzoates; Schizophrenia; Tryptophan; Tryptophan Hydroxylase; Tryptophan Oxygenase; Vitamin B 6 Deficiency; Xanthurenates

1974
Relationship of dietary tryptophan and niacin to tryptophan metabolism in alcoholics and nonalcoholics.
    The American journal of clinical nutrition, 1974, Volume: 27, Issue:6

    Topics: Acetates; Alcoholism; Aminohippuric Acids; Diet; Dietary Proteins; Female; Humans; Hydroxyindoleacetic Acid; Indican; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Male; Nicotinic Acids; ortho-Aminobenzoates; Tryptophan; Xanthurenates

1974
[Tryptophan metabolism in pyridoxine-dependent convulsions].
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1971, Volume: 9, Issue:2

    Topics: Chemistry, Clinical; Child; Child, Preschool; Chromatography, Thin Layer; Epilepsy, Tonic-Clonic; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Spectroscopy; Mass Spectrometry; ortho-Aminobenzoates; Pyridoxine; Quinolines; Seizures; Tryptophan; Xanthurenates

1971
Studies with tryptophan metabolites in vitro. V. Effect of the methanesulphonate derivative of hycanthone (etrenol) and lead acetate on kynureninase and kynurenine transaminase of normal mouse liver.
    Biochemical pharmacology, 1972, Feb-01, Volume: 21, Issue:3

    Topics: Acetates; Anthelmintics; Ethylamines; Hydrolases; Ketones; Kynurenic Acid; Kynurenine; Lead; Liver; ortho-Aminobenzoates; Osmolar Concentration; Pyridoxal Phosphate; Spectrum Analysis; Sulfonic Acids; Sulfur; Transaminases; Tryptophan; Ultraviolet Rays; Xanthenes

1972
Metabolism of C 14 labeled enantiomers of tryptophan, kynurenine and hydroxykynurenine in humans with scleroderma.
    The Journal of investigative dermatology, 1972, Volume: 58, Issue:2

    Topics: Adult; Carbon Dioxide; Carbon Isotopes; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Phenols; Picolinic Acids; Respiration; Scleroderma, Localized; Scleroderma, Systemic; Stereoisomerism; Time Factors; Tryptophan; Xanthurenates

1972
D-Tryptophan pyrrolase activity in the liver and the intestine of the rat.
    The Journal of nutrition, 1972, Volume: 102, Issue:10

    Topics: Acetates; Adrenal Glands; Adrenalectomy; Animals; Cell Nucleus; Cortisone; Enzyme Induction; Intestinal Mucosa; Intestine, Small; Kynurenic Acid; Kynurenine; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Neomycin; ortho-Aminobenzoates; Rats; Stereoisomerism; Subcellular Fractions; Tryptophan; Tryptophan Oxygenase

1972
Chromatographic separation of tryptophan metabolites.
    Analytical biochemistry, 1970, Volume: 34

    Topics: 5-Hydroxytryptophan; Chromatography, Gel; Chromatography, Ion Exchange; Fluorometry; Hydrogen-Ion Concentration; Hydroxyindoleacetic Acid; Indoleacetic Acids; Indoles; Kynurenic Acid; Kynurenine; Methods; Methylcellulose; Picolinic Acids; Pyridines; Serotonin; Spectrophotometry; Tryptamines; Tryptophan; Ultraviolet Rays; Xanthurenates

1970
The influence of sex, age, synthetic oestrogens, progestogens and oral contraceptives on the excretion of urinary tryptophan metabolites.
    Bulletin of the World Health Organization, 1970, Volume: 43, Issue:5

    Topics: Adult; Age Factors; Carboxy-Lyases; Carcinogens; Contraceptives, Oral; Ethinyl Estradiol; Female; Glucuronates; Hippurates; Humans; Kynurenic Acid; Kynurenine; Male; Menopause; Menstruation; Middle Aged; Norethindrone; ortho-Aminobenzoates; Ovulation; Pyridoxine; Sex Factors; Tryptophan; Xanthurenates

1970
Tryptophan metabolism in the synovial fluid in rheumatoid arthritis and osteoarthritis.
    The Tohoku journal of experimental medicine, 1969, Volume: 99, Issue:1

    Topics: Arthritis, Rheumatoid; Blood Sedimentation; Humans; Kynurenic Acid; Kynurenine; Nicotinic Acids; ortho-Aminobenzoates; Osteoarthritis; Synovial Fluid; Tryptophan; Xanthurenates

1969
Influence of androgens upon tryptophan metabolism in man.
    Life sciences, 1969, Nov-15, Volume: 8, Issue:22

    Topics: Adult; Anabolic Agents; Humans; Hydrocortisone; Kynurenic Acid; Kynurenine; Male; Methyltestosterone; Tryptophan; Xanthurenates

1969
The action of pyridoxine in primary hyperoxaluria.
    Clinical science, 1969, Volume: 37, Issue:2

    Topics: Carbohydrate Metabolism, Inborn Errors; Glyoxylates; Humans; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Oxalates; Pyridoxine; Tryptophan

1969
Enzymic formation of 6-hydroxykynurenic acid and 5-hydroxyanthranilic acid from 5-hydroxykynurenine.
    Wakayama medical reports, 1969, Volume: 13, Issue:4

    Topics: Animals; Chickens; Chromatography, Paper; Enzyme Activation; Female; Humans; In Vitro Techniques; Kidney; Kynurenic Acid; Kynurenine; Liver; ortho-Aminobenzoates; Rats; Transaminases

1969
The action of pyridoxine in primary hyperoxaluria.
    Clinical science, 1970, Volume: 38, Issue:2

    Topics: Adolescent; Adult; Child; Female; Humans; Kynurenic Acid; Kynurenine; Male; Metabolic Diseases; Mixed Function Oxygenases; ortho-Aminobenzoates; Oxalates; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1970
Concerning non-darkening of mutant Habrobracon (Bracon hebetor) eyes as consequence of a new chromogen-reducing mechanism in insect larvae.
    Experientia, 1970, Jun-15, Volume: 26, Issue:6

    Topics: Amino Acids; Animals; Chromatography, Paper; Eye; Insecta; Kynurenic Acid; Kynurenine; Larva; Mutation; Phenylbutyrates; Pigments, Biological; Xanthurenates

1970
Metabolism of D- and L-tryptophan-7 alpha-14C in rats and the effects of unlabeled enantiomers.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1970, Volume: 133, Issue:4

    Topics: Aminohippuric Acids; Animals; Autoradiography; Carbon Dioxide; Carbon Isotopes; Chromatography, Paper; Kynurenic Acid; Kynurenine; Nicotinic Acids; Picolinic Acids; Pyridines; Rats; Stereoisomerism; Tryptophan; Xanthurenates

1970
Studies on tryptophan metabolism in protein-calorie malnutrition.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1970, Volume: 64, Issue:1

    Topics: Aminohippuric Acids; Blood Proteins; Child, Preschool; Diet Therapy; Female; Glucuronates; Humans; Infant; Kwashiorkor; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Protein Deficiency; Pyridoxine; Skin Diseases; Tryptophan; Xanthurenates

1970
Tryptophan metabolism in newborn low-birth-weight infants.
    Clinica chimica acta; international journal of clinical chemistry, 1970, Volume: 28, Issue:2

    Topics: Birth Weight; Glucuronidase; Humans; Infant, Newborn; Infant, Premature; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Tryptophan

1970
The functional capacity of the tryptophan-niacin pathway in pellagrous children.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1970, Volume: 64, Issue:3

    Topics: Amines; Aminohippuric Acids; Child; Child, Preschool; Glucuronates; Humans; Kynurenic Acid; Kynurenine; Nicotinic Acids; ortho-Aminobenzoates; Pellagra; Tryptophan

1970
Differences in tryptophan metabolism between breast cancer patients with and without cancer at other sites.
    Cancer, 1970, Volume: 26, Issue:4

    Topics: Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Female; Humans; Kynurenic Acid; Kynurenine; Lung Neoplasms; Male; Neoplasm Metastasis; Ovarian Neoplasms; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates

1970
Studies on the effect of reserpine therapy on the functional capacity of the tryptophan-niacin pathway in smoker and non-smoker males.
    Biochemical pharmacology, 1970, Volume: 19, Issue:5

    Topics: Adult; Aminohippuric Acids; Carboxy-Lyases; Catecholamines; Glucuronates; Humans; Isonicotinic Acids; Kynurenic Acid; Kynurenine; Male; Nicotine; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Pyridoxal Phosphate; Pyridoxine; Reserpine; Smoking; Tryptophan; Xanthurenates

1970
[Tryptophan and tyrosine administration in acrodermatitis enteropathica (Danbolt)].
    Klinische Wochenschrift, 1967, Oct-15, Volume: 45, Issue:20

    Topics: Acrodermatitis; Adult; Child; Female; Humans; Indican; Intestinal Diseases; Kynurenic Acid; Kynurenine; Male; Tryptophan; Tyrosine; Xanthurenates

1967
Potentiation of endotoxin shock by oral L-tryptophan.
    The American journal of physiology, 1968, Volume: 214, Issue:3

    Topics: Ammonia; Animals; Chromatography, Paper; Dogs; Endotoxins; Glucuronates; Hydrocortisone; Indoles; Kynurenic Acid; Kynurenine; Neomycin; ortho-Aminobenzoates; Portal Vein; Serotonin; Shock, Septic; Tryptophan

1968
Circadian periodicity of tryptophan metabolism.
    The Journal of clinical investigation, 1968, Volume: 47, Issue:4

    Topics: Adult; Circadian Rhythm; Female; Humans; Indican; Kynurenic Acid; Kynurenine; Male; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1968
Tryptophan metabolism in some intestinal helminthiases.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1968, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Aminohippuric Acids; Ancylostomiasis; Ascariasis; Humans; Indican; Intestinal Diseases, Parasitic; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1968
Isolation and assay of radioactive urinary kynurenic and xanthurenic acids.
    Analytical biochemistry, 1968, Volume: 23, Issue:1

    Topics: Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Humans; Kynurenic Acid; Kynurenine; Methods; Spectrum Analysis; Tryptophan; Ultraviolet Rays; Xanthurenates

1968
Transport and further metabolism on intermediate compounds of the tryptophan-nicotinic acid ribonucleotide pathway by rat small intestine.
    Biochimica et biophysica acta, 1968, Volume: 163, Issue:1

    Topics: Animals; Biological Transport; Chromatography, Paper; Female; In Vitro Techniques; Kynurenic Acid; Kynurenine; Nicotinic Acids; Nucleotides; Rats; Tryptophan

1968
Studies with tryptophan metabolites in vitro. Kynurenine metabolism in kidneys of mice infested with Schistosoma mansoni.
    The Biochemical journal, 1968, Volume: 109, Issue:4

    Topics: Animals; Hydrolases; In Vitro Techniques; Kidney; Kynurenic Acid; Kynurenine; Mice; ortho-Aminobenzoates; Pyridoxal Phosphate; Schistosomiasis; Tryptophan; Urinary Bladder Neoplasms

1968
Liver kynureninase activity of an infant with infantile spasm.
    The Tohoku journal of experimental medicine, 1968, Volume: 96, Issue:2

    Topics: Aspartate Aminotransferases; Cerebral Palsy; Child; Child, Preschool; Erythrocytes; Female; Humans; Hydrolases; Indoleacetic Acids; Infant; Kynurenic Acid; Kynurenine; Liver; ortho-Aminobenzoates; Pyridoxine; Seizures; Spasm; Tryptophan; Xanthurenates

1968
[Studies on the excretion of tryptophan metabolites in patients with circumscript and progressive scleroderma].
    Dermatologische Wochenschrift, 1968, Jun-29, Volume: 154, Issue:26

    Topics: Adult; Aged; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Scleroderma, Systemic; Tryptophan; Xanthurenates

1968
[On the influence of ovulation inhibitors on tryptophan metabolism in relation to vitamin B6].
    Klinische Wochenschrift, 1968, Oct-01, Volume: 46, Issue:19

    Topics: Adult; Contraceptives, Oral; Female; Gestational Age; Humans; Kynurenic Acid; Kynurenine; Pregnancy; Pregnancy Tests; Pyridoxine; Tryptophan; Xanthurenates

1968
Effect of acetoacetate on urinary excretion of xanthurenic acid and other tryptophan metabolites in rats.
    The British journal of nutrition, 1969, Volume: 23, Issue:1

    Topics: Acetoacetates; Animals; Hippurates; Kynurenic Acid; Kynurenine; Rats; Tryptophan; Xanthurenates

1969
[A new method for the identification of tryptophan metabolites: thin layer chromatography].
    Minerva pediatrica, 1966, Jun-30, Volume: 18, Issue:20

    Topics: Child; Child, Preschool; Chromatography, Thin Layer; Humans; Kynurenic Acid; Kynurenine; Tryptophan; Xanthurenates

1966
Determination of tryptophan derivatives by thin-layer chromatography.
    Analytical biochemistry, 1966, Volume: 16, Issue:1

    Topics: Chromatography, Thin Layer; Fluorometry; Humans; Kynurenic Acid; Kynurenine; Solvents; Spectrophotometry; Tryptophan; Xanthurenates

1966
Hydroxykynureninuria.
    American journal of diseases of children (1960), 1967, Volume: 113, Issue:1

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Female; Growth; Humans; Infant, Newborn; Intelligence Tests; Kynurenic Acid; Kynurenine; Kyphosis; Nicotinic Acids; Pyridoxine; Tryptophan; Xanthurenates

1967
Urine composition in the etiology of bladder tumor formation.
    The Journal of urology, 1967, Volume: 97, Issue:3

    Topics: Carcinogens; Humans; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Tryptophan; Urinary Bladder Neoplasms; Urine

1967
Vitamin B6 nutriture studied in obese subjects during 8 weeks of starvation.
    The American journal of clinical nutrition, 1967, Volume: 20, Issue:4

    Topics: Female; Humans; Kynurenic Acid; Kynurenine; Male; Obesity; Oxalates; Pyridoxine; Starvation; Transaminases; Tryptophan; Xanthurenates

1967
Studies on the urinary excretion of certain tryptophan metabolites in Egyptian pellagrins.
    The Journal of tropical medicine and hygiene, 1967, Volume: 70, Issue:4

    Topics: Adult; Egypt; Humans; Indoleacetic Acids; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Pellagra; Rural Health; Xanthurenates

1967
Biochemical and physiological changes in vitamin B6 deficiency.
    The American journal of clinical nutrition, 1967, Volume: 20, Issue:6

    Topics: Alanine Transaminase; Anemia, Hypochromic; Central Nervous System Diseases; Cysteine; Erythrocytes; Humans; Kynurenic Acid; Kynurenine; Male; Nicotinic Acids; Pyridoxal Phosphate; Pyridoxine; Serotonin; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1967
The degradation of tryptophan during paper chromatography with observations on some metabolites of tryptophan.
    Journal of chromatography, 1967, Volume: 26, Issue:2

    Topics: Autoradiography; Carbon Isotopes; Chromatography, Paper; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Tryptophan; Ultraviolet Rays; Xanthurenates

1967
The photoreduction of kynurenic acid to kynurenine yellow and the occurrence of 3-hydroxy-L-kynurenine in butterflies.
    Journal of the American Chemical Society, 1967, Feb-15, Volume: 89, Issue:4

    Topics: Fluorescence; Insecta; Kynurenic Acid; Kynurenine; Light; Oxidation-Reduction; Pigments, Biological

1967
On the determination of small amounts of tryptophan metabolites and their occurrence in normal human urine.
    Clinica chimica acta; international journal of clinical chemistry, 1967, Volume: 17, Issue:3

    Topics: Adult; Aminohippuric Acids; Chromatography, Ion Exchange; Chromatography, Paper; Colorimetry; Female; Fluorometry; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Tryptophan; Xanthurenates

1967
Effect of protein intake on the development of abnormal tryptophan metabolism by men during vitamin B6 depletion.
    The Journal of nutrition, 1967, Volume: 93, Issue:1

    Topics: Adult; Body Weight; Dietary Proteins; Humans; Kynurenic Acid; Kynurenine; Male; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1967
Regulation of tryptophan metabolism in the parasitic wasp, Habrobracon juglandis.
    Experientia, 1967, Dec-15, Volume: 23, Issue:12

    Topics: Animals; Insecta; Kynurenic Acid; Kynurenine; Molecular Biology; Mutation; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1967
The stability of tryptophan metabolites prior to urine analysis.
    Clinica chimica acta; international journal of clinical chemistry, 1980, Mar-28, Volume: 102, Issue:2-3

    Topics: 5-Hydroxytryptophan; Animals; Chromatography, High Pressure Liquid; Cold Temperature; Drug Stability; Humans; Hydrogen-Ion Concentration; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Rats; Serotonin; Tryptophan

1980
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.
    Brain research, 1982, Sep-09, Volume: 247, Issue:1

    Topics: Acetylcholine; Animals; Aspartic Acid; Cerebral Cortex; Convulsants; Drug Interactions; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Niacinamide; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats

1982
[Determination of urinary xanthurenic acid after oral loading of L-tryptophan in 88 cases of photodermatosis].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1984, Mar-29, Volume: 60, Issue:14

    Topics: Administration, Oral; Adolescent; Adult; Aged; Child; Female; Humans; Hydroa Vacciniforme; Kynurenic Acid; Kynurenine; Male; Middle Aged; Photosensitivity Disorders; Pyridoxine; Tryptophan; Xanthurenates

1984
Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acids.
    Journal of neural transmission, 1983, Volume: 56, Issue:2-3

    Topics: Animals; Dose-Response Relationship, Drug; Female; Kynurenic Acid; Kynurenine; Male; Muridae; Picolinic Acids; Seizures; Xanthurenates

1983
Induction of ornithine decarboxylase activity in mouse urinary bladder by L-tryptophan and some of its metabolites.
    Cancer research, 1982, Volume: 42, Issue:9

    Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Diet; Enzyme Induction; Epithelium; Female; Hyperplasia; Kynurenic Acid; Kynurenine; Ornithine Decarboxylase; ortho-Aminobenzoates; Quinolines; Stereoisomerism; Tryptophan; Urinary Bladder; Xanthurenates

1982
Alterations of the tryptophan--nicotinic acid metabolism in vitiligo.
    Acta vitaminologica et enzymologica, 1982, Volume: 4, Issue:3

    Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Melanins; Mixed Function Oxygenases; Models, Biological; Niacin; Tryptophan; Vitiligo; Xanthurenates

1982
[Stimulatory effects of intraventricular administration of kynurenines, amino acids, and convulsants: differences between rats and mice].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1982, Volume: 68, Issue:11

    Topics: Amino Acids; Animals; Convulsants; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; Mice; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures; Species Specificity

1982
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable.
    Biological psychiatry, 1995, Apr-15, Volume: 37, Issue:8

    Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Brain; Bulimia; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Thinness; Tryptophan

1995
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
    Journal of neurochemistry, 1995, Volume: 65, Issue:5

    Topics: 3-Hydroxyanthranilic Acid; Animals; Cell Line; Central Nervous System; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Lyases; Macaca mulatta; Quinolinic Acid; Transaminases; Tryptophan

1995
Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Alanine; Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Extracellular Space; Hydrolases; Hypnotics and Sedatives; Kinetics; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Quinolinic Acid; Rats; Rats, Wistar

1995
Pentafluorobenzylation method for quantification of acidic tryptophan metabolites using electron capture negative ion mass spectrometry.
    Analytical chemistry, 1995, Mar-01, Volume: 67, Issue:5

    Topics: Fluorobenzenes; Kynurenic Acid; Kynurenine; Mass Spectrometry; Molecular Structure; ortho-Aminobenzoates; Picolinic Acids; Quaternary Ammonium Compounds; Quinolinic Acid; Tryptophan; Xanthurenates

1995
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.
    Neuroscience, 1994, Volume: 61, Issue:2

    Topics: Alanine; Animals; Anticonvulsants; Brain Chemistry; Electroshock; Excitatory Amino Acid Antagonists; Hydrolases; Hypnotics and Sedatives; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Motor Activity; Neuroglia; Niacin; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate

1994
Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.
    Journal of medicinal chemistry, 1994, Mar-04, Volume: 37, Issue:5

    Topics: Alanine; Animals; Anticonvulsants; Binding, Competitive; Brain; Hippocampus; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Structure; Motor Activity; Rats; Seizures; Tryptophan

1994
Kynurenic acid is decreased in cerebrospinal fluid of patients with infantile spasms.
    Pediatric neurology, 1994, Volume: 10, Issue:1

    Topics: Asphyxia Neonatorum; Brain; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; Male; Spasms, Infantile; Synaptic Transmission; Tuberous Sclerosis

1994
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
    Brain : a journal of neurology, 1993, Volume: 116 ( Pt 6)

    Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Macaca mulatta; Myelitis; Neopterin; Poliomyelitis; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase

1993
Intravenous administration of L-kynurenine to rhesus monkeys: effect on quinolinate and kynurenate levels in serum and cerebrospinal fluid.
    Neuropharmacology, 1993, Volume: 32, Issue:5

    Topics: Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Kynurenic Acid; Kynurenine; Macaca mulatta; Quinolinic Acid; Time Factors

1993
L-alpha-aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats.
    European journal of pharmacology, 1995, Jul-25, Volume: 281, Issue:1

    Topics: 2-Aminoadipic Acid; Animals; Brain Diseases; Dialysis; Hippocampus; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Veratridine

1995
Electrical kindling is associated with a lasting increase in the extracellular levels of kynurenic acid in the rat hippocampus.
    Neuroscience letters, 1995, Sep-29, Volume: 198, Issue:2

    Topics: Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Extracellular Space; Hippocampus; Kindling, Neurologic; Kynurenic Acid; Kynurenine; Lyases; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Transaminases; Veratridine

1995
Excitotoxic lesions of the rat striatum: different responses of kynurenine pathway enzymes during ontogeny.
    Brain research. Developmental brain research, 1996, Mar-29, Volume: 92, Issue:1

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Aging; Animals; Animals, Newborn; Corpus Striatum; Dioxygenases; Enzymes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Ibotenic Acid; Kynurenic Acid; Kynurenine; Lyases; Male; Oxygenases; Rats; Rats, Sprague-Dawley; Transaminases

1996
The kynurenines and the seizures.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Animals; Cerebral Ventricles; Electroencephalography; Hippocampus; Kynurenic Acid; Kynurenine; Microinjections; Neurons; ortho-Aminobenzoates; Penicillin G; Quinolinic Acid; Rats; Seizures

1996
28833, a selective kynurenine 3-hydroxylase inhibitor. Effects on the kynurenine pathway metabolites in the gerbil.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Animals; Brain; Butyrates; Enzyme Inhibitors; Female; Gerbillinae; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley

1996
Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid.
    Neuroreport, 1996, Dec-20, Volume: 8, Issue:1

    Topics: Amino Acids; Animals; Biotransformation; Brain; Excitatory Amino Acid Antagonists; Kynurenic Acid; Kynurenine; Male; Perfusion; Prodrugs; Rats; Rats, Sprague-Dawley

1996
Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices.
    Neuroscience letters, 1997, Mar-14, Volume: 224, Issue:2

    Topics: Animals; Anticonvulsants; Buffers; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Female; Hippocampus; Kynurenic Acid; Kynurenine; Magnesium; Male; Organ Culture Techniques; Protein Precursors; Rats; Rats, Sprague-Dawley

1997
Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid.
    Neuroscience, 1997, Volume: 78, Issue:4

    Topics: Alanine; Animals; Corpus Striatum; Dopamine; Drug Combinations; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neurons; Neurotoxins; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase

1997
Determination of kynurenic acid by capillary electrophoresis with laser-induced fluorescence detection.
    Journal of chromatography. A, 1997, Sep-26, Volume: 781, Issue:1-2

    Topics: Animals; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Osmolar Concentration; Rats; Spectrometry, Fluorescence; Time Factors; Tryptophan; Zinc

1997
Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures.
    Clinical endocrinology, 1997, Volume: 47, Issue:6

    Topics: 3-Hydroxyanthranilic Acid; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infant; Kynurenic Acid; Kynurenine; Male; Melatonin; Seizures, Febrile; Tryptophan; Xanthurenates

1997
Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells.
    Neuroscience letters, 1998, Mar-06, Volume: 244, Issue:1

    Topics: Animals; Astrocytes; Cells, Cultured; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Quinolinic Acid; RNA, Messenger; Serotonin; Tryptophan

1998
Modulation of rat striatal glutamatergic response in search for new neuroprotective agents: evaluation of melatonin and some kynurenine derivatives.
    Brain research bulletin, 1998, Mar-15, Volume: 45, Issue:5

    Topics: Animals; Corpus Striatum; Electric Stimulation; Electrophysiology; Evoked Potentials; Glutamic Acid; Iontophoresis; Kynurenic Acid; Kynurenine; Male; Melatonin; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Reaction Time; Structure-Activity Relationship

1998
Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid.
    British journal of pharmacology, 1998, Volume: 124, Issue:2

    Topics: Alanine; Animals; Anticonvulsants; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Antagonists; Huntington Disease; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; NADP; Neurons, Afferent; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1998
Systemic d-amphetamine administration causes a reduction of kynurenic acid levels in rat brain.
    Brain research, 1998, Aug-17, Volume: 802, Issue:1-2

    Topics: Animals; Animals, Newborn; Brain; Central Nervous System Stimulants; Dextroamphetamine; Excitatory Amino Acid Antagonists; Extracellular Space; Kynurenic Acid; Kynurenine; Liver; Male; Rats; Rats, Sprague-Dawley; Tissue Distribution

1998
Interference with cellular energy metabolism reduces kynurenic acid formation in rat brain slices: reversal by lactate and pyruvate.
    The European journal of neuroscience, 1998, Volume: 10, Issue:6

    Topics: Animals; Brain; Electron Transport; Energy Metabolism; Formazans; Glucose; In Vitro Techniques; Kynurenic Acid; Kynurenine; Lactic Acid; Male; Neurons; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Tetrazolium Salts

1998
The analgesic effects of tryptophan and its metabolites in the rat.
    Pharmacological research, 1998, Volume: 38, Issue:4

    Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hypolipidemic Agents; Iron Chelating Agents; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Pain; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Tryptophan; Xanthurenates

1998
Metabolic control of kynurenic acid formation in the rat brain.
    Developmental neuroscience, 1998, Volume: 20, Issue:4-5

    Topics: Animals; Brain; Corpus Striatum; Electrophysiology; Energy Metabolism; Formazans; Kynurenic Acid; Kynurenine; Male; Potassium; Pyruvic Acid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Sodium; Substrate Specificity; Tetrazolium Salts; Veratridine

1998
2-Oxoacids regulate kynurenic acid production in the rat brain: studies in vitro and in vivo.
    Journal of neurochemistry, 1999, Volume: 72, Issue:2

    Topics: 2-Aminoadipic Acid; Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Agonists; Glucose; Hippocampus; Hypoglycemia; Kynurenic Acid; Kynurenine; Male; Microdialysis; Neurotoxins; Organ Culture Techniques; Pyruvic Acid; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Transaminases; Veratridine

1999
Quinolinic acid lesion of the nigrostriatal pathway: effect on turning behaviour and protection by elevation of endogenous kynurenic acid in Rattus norvegicus.
    Neuroscience letters, 1999, Mar-05, Volume: 262, Issue:2

    Topics: Alanine; Animals; Corpus Striatum; Excitatory Amino Acid Antagonists; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Motor Activity; Neurons; Neuroprotective Agents; Niacin; Parkinson Disease, Secondary; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase; Up-Regulation

1999
Kynurenine metabolism in Alzheimer's disease.
    Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Caudate Nucleus; Female; Humans; Kinetics; Kynurenic Acid; Kynurenine; Lyases; Male; Matched-Pair Analysis; Neurodegenerative Diseases; Pyruvic Acid; Transaminases

1999
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus.
    European journal of pharmacology, 2000, Mar-03, Volume: 390, Issue:3

    Topics: Animals; Brain Diseases; Dialysis Solutions; Hippocampus; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Microdialysis; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley

2000
Changes in membrane fluidity induced by tryptophan and its metabolites.
    Advances in experimental medicine and biology, 1999, Volume: 467

    Topics: Animals; Cell Cycle; Cell Membrane; Cholesterol; Fatty Acids; Hydroxyindoleacetic Acid; Kinetics; Kynurenic Acid; Kynurenine; Liver; Male; Membrane Fluidity; Membrane Lipids; Phospholipids; Picolinic Acids; Rats; Rats, Wistar; Tryptophan; Xanthurenates

1999
In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum.
    Experimental neurology, 2000, Volume: 163, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Animals; Biotransformation; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Infusions, Parenteral; Kynurenic Acid; Kynurenine; Male; Malonates; Neurons; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glycine

2000
Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo.
    Neuroscience, 2000, Volume: 97, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Animals; Blood-Brain Barrier; Butyrates; Enzyme Inhibitors; Hippocampus; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Neuroprotective Agents; Neurotoxins; Pyramidal Cells; Quinolinic Acid; Rats; Rats, Sprague-Dawley

2000
Serotonergic and kynurenic pathways in rats exposed to foot shock.
    Brain research bulletin, 2000, Volume: 52, Issue:3

    Topics: Animals; Brain; Brain Chemistry; Electroshock; Hydroxyindoleacetic Acid; Kidney; Kynurenic Acid; Kynurenine; Liver; Male; Rats; Rats, Wistar; Serotonin; Stress, Physiological; Tryptophan

2000
Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis.
    Redox report : communications in free radical research, 2000, Volume: 5, Issue:2-3

    Topics: Astrocytes; Cells, Cultured; Fetus; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferon-gamma; Interleukin-1; Interleukin-6; Kynurenic Acid; Kynurenine; Models, Biological; Neurotoxins; Quinolinic Acid; Tumor Necrosis Factor-alpha

2000
Formation of endogenous glutamatergic receptors antagonist kynurenic acid--differences between cortical and spinal cord slices.
    Brain research, 2000, Sep-29, Volume: 878, Issue:1-2

    Topics: Aminooxyacetic Acid; Animals; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Kynurenine; Male; Rats; Rats, Wistar; Receptors, Glutamate; Spinal Cord; Transaminases

2000
Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:5

    Topics: Age Factors; Animals; Courtship; Drosophila; Kynurenic Acid; Kynurenine; Learning; Male; Memory Disorders; Mutation; Neuroglia; Tryptophan

2000
Kynurenic acid metabolism in the brain of HIV-1 infected patients.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:10

    Topics: Adult; AIDS Dementia Complex; Brain; Cerebellum; Female; Frontal Lobe; HIV-1; Humans; Kynurenic Acid; Kynurenine; Lyases; Male; Transaminases; Tryptophan

2000
Kynurenic acid influences the respiratory parameters of rat heart mitochondria.
    Pharmacology, 2001, Volume: 62, Issue:2

    Topics: Animals; Cell Respiration; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Kynurenine; Malates; Male; Mitochondria, Heart; Oxygen Consumption; Quinolinic Acid; Rats; Rats, Sprague-Dawley

2001
Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis.
    Neuroscience, 2001, Volume: 102, Issue:3

    Topics: Animals; Astrocytes; Brain; Cytoplasmic Granules; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Immunohistochemistry; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Multiple Sclerosis; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Spinal Cord; Sulfonamides; Thiazoles

2001
Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo.
    Neuroscience letters, 2001, May-25, Volume: 304, Issue:3

    Topics: Animals; Corpus Striatum; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Osmolar Concentration; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley

2001
Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection.
    Journal of neurochemistry, 2001, Volume: 78, Issue:4

    Topics: AIDS Dementia Complex; Astrocytes; Brain; Cells, Cultured; Cytokines; Enzymes; Fetus; Humans; Kynurenic Acid; Kynurenine; Models, Biological; Neurons; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction

2001
Increased kynurenic acid in the brain after neonatal asphyxia.
    Life sciences, 2001, Aug-03, Volume: 69, Issue:11

    Topics: Animals; Animals, Newborn; Asphyxia; Brain; Disease Models, Animal; Kynurenic Acid; Kynurenine; Rats; Rats, Sprague-Dawley; Time Factors

2001
Increased cortical kynurenate content in schizophrenia.
    Biological psychiatry, 2001, Oct-01, Volume: 50, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Female; Frontal Lobe; Haloperidol; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Occipital Lobe; Rats; Rats, Sprague-Dawley; Schizophrenia

2001
Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.
    Nephron, 2002, Volume: 90, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Kidney; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Time Factors; Tryptophan; Urea; Xanthurenates

2002
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
    International urology and nephrology, 2001, Volume: 33, Issue:2

    Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Renal Dialysis; Tryptophan; Uremia; Xanthurenates

2001
Regulation of kynurenic acid synthesis in C6 glioma cells.
    Journal of neuroscience research, 2002, Jun-01, Volume: 68, Issue:5

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Buffers; Calcium; Glioma; Glutamic Acid; Guanosine Diphosphate; Kynurenic Acid; Kynurenine; Leucine; Magnesium; Potassium; Rats; Receptors, Metabotropic Glutamate; Sodium; Thionucleotides; Tumor Cells, Cultured; Veratridine

2002
Endothelium-dependent production and liberation of kynurenic acid by rat aortic rings exposed to L-kynurenine.
    European journal of pharmacology, 2002, Jul-19, Volume: 448, Issue:2-3

    Topics: Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Kynurenic Acid; Kynurenine; Male; Rats; Rats, Wistar

2002
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
    Journal of neurochemistry, 2002, Volume: 82, Issue:6

    Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhibitors; Glucose; Hippocampus; In Vitro Techniques; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neurons; Neuroprotective Agents; Pyramidal Cells; Quinolinic Acid; Rats; Sulfonamides; Thiazoles

2002
Formation of kynurenic and xanthurenic acids from kynurenine and 3-hydroxykynurenine in the dinoflagellate Lingulodinium polyedrum: role of a novel, oxidative pathway.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2002, Volume: 133, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Circadian Rhythm; Dinoflagellida; Kynurenic Acid; Kynurenine; Light; Oxidation-Reduction; Oxidative Stress; Transaminases; Tryptophan Transaminase; Xanthurenates

2002
Quantitation of tryptophan, kynurenine and kynurenic acid in human plasma by capillary liquid chromatography-electrospray ionization tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Nov-25, Volume: 780, Issue:2

    Topics: Calibration; Chromatography, Liquid; Humans; Kynurenic Acid; Kynurenine; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tryptophan

2002
Kynurenate production by cultured human astrocytes.
    Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:1

    Topics: Aminooxyacetic Acid; Astrocytes; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Glycine; Humans; Immunohistochemistry; Kynurenic Acid; Kynurenine; Leucine; Neuroprotective Agents; Nicotine; Oxaloacetic Acid; Phenylalanine; Pyruvic Acid; Receptors, Nicotinic; Transaminases

2003
The transamination of kynurenine.
    The Journal of biological chemistry, 1953, Volume: 203, Issue:1

    Topics: Fungi; Kynurenic Acid; Kynurenine; Pseudomonas

1953
[Tryptophan loading and vitamin B6 deficiency. I. Excretion of xanthurenic acid, kynurenine, trigonelline amide, and 5-hydroxyindoleacetic acid in various diseases].
    Das Deutsche Gesundheitswesen, 1961, May-25, Volume: 16

    Topics: Alkaloids; Amides; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Niacin; Nicotinic Acids; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates

1961
Quantitative determination of tryptophan metabolites (via kynurenine) in biologic fluids.
    Clinical chemistry, 1959, Volume: 5

    Topics: Biological Products; Body Fluids; Humans; Kynurenic Acid; Kynurenine; Tryptophan

1959
A new pathway of D-tryptophan metabolism: enzymic formation of kynurenic acid via D-kynurenine.
    Biochemical and biophysical research communications, 1961, Nov-20, Volume: 6

    Topics: Kynurenic Acid; Kynurenine; Tryptophan

1961
Urinary excretion of tryptophan metabolites in the healthy infant.
    Pediatrics, 1962, Volume: 30

    Topics: Chromatography; Humans; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Tryptophan; Urine

1962
THE METABOLISM OF TRYPTOPHAN IN PATIENTS WITH BLADDER CANCER AND OTHER UROLOGICAL DISEASES.
    Clinica chimica acta; international journal of clinical chemistry, 1963, Volume: 8

    Topics: Geriatrics; Humans; Kidney Neoplasms; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prostatic Neoplasms; Proteins; Tryptophan; Urinary Bladder Diseases; Urinary Bladder Neoplasms; Urine

1963
[CHANGES IN TRYPTOPHAN METABOLISM IN THE WINKING-NODDING SPASM IN INFANTS].
    Helvetica paediatrica acta, 1963, Volume: 18

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blinking; Blood Chemical Analysis; Chromatography; Electroencephalography; Hippurates; Humans; Infant; Kynurenic Acid; Kynurenine; Metabolism; Proteins; Pyridoxine; Research; Spasm; Spasms, Infantile; Tryptophan; Urine; Xanthurenates

1963
TRYPTOPHAN METABOLISM IN SPECIAL PAIRS OF TWINS.
    Clinica chimica acta; international journal of clinical chemistry, 1964, Volume: 9

    Topics: Chromatography; Diseases in Twins; Genetics, Medical; Kynurenic Acid; Kynurenine; Metabolic Diseases; ortho-Aminobenzoates; Proteins; Schizophrenia; Spectrophotometry; Tryptophan; Urine; Xanthurenates

1964
EXCRETION OF TRYPTOPHAN METABOLITES IN DIFFERENT FORMS OF HAEMOBLASTOSIS.
    Clinica chimica acta; international journal of clinical chemistry, 1964, Volume: 9

    Topics: Cortisone; Cyclophosphamide; Genetic Diseases, X-Linked; Hodgkin Disease; Humans; Kynurenic Acid; Kynurenine; Leukemia; Leukemia, Hairy Cell; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphatic Diseases; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechlorethamine; Multiple Myeloma; ortho-Aminobenzoates; Phenylbutazone; Polycythemia Vera; Proteins; Pyridoxal Phosphate; Pyridoxine; Sarcoma; Severe Combined Immunodeficiency; Tryptophan; Urine; Xanthurenates

1964
STUDIES ON THE TRYPTOPHAN METABOLISM IN TUMOR-BEARING ANIMALS.
    Gan, 1964, Volume: 55

    Topics: Animals; Kynurenic Acid; Kynurenine; Liver; Neoplasms; Neoplasms, Experimental; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Proteins; Rats; Research; Sarcoma; Tryptophan; Urine; Xanthurenates

1964
A METHOD FOR THE DETERMINATION OF EIGHT TRYPTOPHAN METABOLITES IN BIOLOGICAL FLUIDS.
    Canadian journal of medical technology, 1964, Volume: 26

    Topics: Blood Proteins; Cerebrospinal Fluid Proteins; Chromatography; Humans; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Spectrophotometry; Tryptophan; Urine; Xanthurenates

1964
METABOLISM OF 3-HYDROXYANTHRANILIC ACID-CARBOXYL-C14 IN THE HUMAN.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 115

    Topics: 3-Hydroxyanthranilic Acid; Achondroplasia; Blood; Carbon Isotopes; Chromatography; Hippurates; Humans; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Rats; Research; Tryptophan; Urine; Xanthurenates

1964
URINARY EXCRETION OF TRYPTOPHAN METABOLITES IN PATIENTS WITH RENAL PELVIS AND PARENCHYMA TUMOURS.
    Urologia internationalis, 1964, Volume: 17

    Topics: Chromatography; Humans; Kidney Neoplasms; Kidney Pelvis; Kynurenic Acid; Kynurenine; Neoplasms; ortho-Aminobenzoates; Spectrophotometry; Tryptophan; Urine; Xanthurenates

1964
EXCRETION OF TRYPTOPHAN METABOLITES BY PATIENTS WITH RHEUMATOID ARTHRITIS.
    Arthritis and rheumatism, 1964, Volume: 7

    Topics: Arthritis; Arthritis, Rheumatoid; Biomedical Research; Chromatography; Gout; Hippurates; Indoles; Kynurenic Acid; Kynurenine; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Proteins; Psoriasis; Pyridines; Pyridoxine; Spondylitis; Tryptophan; Urine; Xanthurenates

1964
HYDROXYKYNURENINURIA: A CASE OF ABNORMAL TRYPTOPHAN METABOLISM PROBABLY DUE TO A DEFICIENCY OF KYNURENINASE.
    Archives of disease in childhood, 1964, Volume: 39

    Topics: Amino Acid Metabolism, Inborn Errors; Child; Chromatography; Electrophoresis; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Metabolic Diseases; Niacin; ortho-Aminobenzoates; Proteins; Pyridoxine; Spectrophotometry; Tryptophan; Urine; Xanthurenates

1964
ABNORMAL TRYPTOPHAN METABOLISM IN PATIENTS WITH ADULT CELIAC DISEASE, WITH EVIDENCE FOR DEFICIENCY OF VITAMIN B6.
    The Journal of clinical investigation, 1964, Volume: 43

    Topics: Adult; Biochemical Phenomena; Biochemistry; Celiac Disease; Dietary Proteins; Glutens; Humans; Hydroxyindoleacetic Acid; Indican; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Proteins; Tetracycline; Tryptophan; Urine; Vitamin B 6; Vitamin B 6 Deficiency; Xanthurenates

1964
IN VIVO ELUTION OF TRYPTOPHAN METABOLITES AND OTHER AROMATIC NITROGEN COMPOUNDS FROM CHOLESTEROL PELLETS IMPLANTED INTO MOUSE BLADDERS.
    Cancer research, 1964, Volume: 24

    Topics: Amines; Animals; Carcinogens; Cholesterol; Fluorenes; Hydroxylamines; Kynurenic Acid; Kynurenine; Metabolism; Mice; Naphthalenes; Nitrogen; Nitrogen Compounds; ortho-Aminobenzoates; Pharmacology; Quinolines; Research; Stearic Acids; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms; Xanthurenates

1964
MOUSE BLADDER CARCINOGENICITY OF CERTAIN TRYPTOPHAN METABOLITES AND OTHER AROMATIC NITROGEN COMPOUNDS SUSPENDED IN CHOLESTEROL.
    Cancer research, 1964, Volume: 24

    Topics: Amines; Animals; Carcinogens; Cholesterol; Fluorenes; Hydroxylamines; Kynurenic Acid; Kynurenine; Metabolism; Mice; Naphthalenes; Neoplasms; Neoplasms, Experimental; Nitrogen; Nitrogen Compounds; ortho-Aminobenzoates; Pharmacology; Quinolines; Research; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates

1964
STUDIES ON THE URINARY EXCRETION OF CERTAIN TRYPTOPHAN METABOLITES BEFORE AND AFTER TRYPTOPHAN LOADING DOSE IN BILHARZIASIS, BILHARZIAL BLADDER CANCER AND CERTAIN OTHER TYPES OF MALIGNANCIES IN EGYPT.
    British journal of cancer, 1964, Volume: 13

    Topics: Amino Acids; Egypt; Epidemiology; Fluids and Secretions; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Neoplasms; ortho-Aminobenzoates; Schistosomiasis; Tryptophan; Urinary Bladder Neoplasms; Urine; Xanthurenates

1964
TRYPTOPHAN METABOLISM IN RHEUMATIC DISEASE.
    Arthritis and rheumatism, 1964, Volume: 7

    Topics: Amino Acids; Arthritis; Arthritis, Rheumatoid; Chromatography; Humans; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; ortho-Aminobenzoates; Rheumatic Diseases; Scleroderma, Systemic; Tryptophan; Urine; Xanthurenates

1964
[TUDIES ON BIOLOGICAL RADIATION PROTECTION. 53. THE EFFECT OF HISTAMINE ON RADIATION-INDUCED CHANGES IN AMINO ACID METABOLISM].
    Strahlentherapie, 1964, Volume: 124

    Topics: Amino Acids; Histamine; Kynurenic Acid; Kynurenine; Mice; ortho-Aminobenzoates; Pharmacology; Radiation Protection; Research; Urine

1964
[RESEARCH ON THE TRYPTOPHAN--NICOTINIC ACID PATHWAY IN DIABETES MELLITUS].
    Acta vitaminologica, 1964, Volume: 18

    Topics: Diabetes Mellitus; Geriatrics; Hippurates; Insulin; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Niacinamide; Nicotinic Acids; Research; Tryptophan; Urine

1964
[RESEARCH ON ELIMINATION OF METABOLITES OF THE TRYPTOPHAN TO NICOTINIC ACID PATHWAY IN INFANTS].
    Acta vitaminologica, 1964, Volume: 18

    Topics: Chromatography; Diet; Hippurates; Humans; Infant; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Tryptophan; Urine; Vitamins; Xanthurenates

1964
[CONTRIBUTION TO THE STUDY OF METABOLITES OF THE TRYPTOPHAN TO NICOTINIC ACID PATHWAY IN RELATION TO SEX].
    Acta vitaminologica, 1964, Volume: 18

    Topics: Humans; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Niacinamide; Nicotinic Acids; Research; Sex; Tryptophan; Urine; Xanthurenates

1964
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.
    Molecular and cellular biology, 2004, Volume: 24, Issue:16

    Topics: Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Motor Activity; Neurons; Phenotype; Pregnancy; Quinolinic Acid; Rats; Transaminases; Tryptophan

2004
Endogenous kynurenic acid disrupts prepulse inhibition.
    Biological psychiatry, 2004, Aug-15, Volume: 56, Issue:4

    Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Butyrates; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Radiation; Drug Interactions; Haloperidol; Kynurenic Acid; Kynurenine; Male; Neural Inhibition; Probenecid; Rats; Reflex, Startle

2004
Carbamazepine enhances brain production of kynurenic acid in vitro.
    European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3

    Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Carbamazepine; Cerebral Cortex; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; In Vitro Techniques; Isoenzymes; Kynurenic Acid; Kynurenine; Male; Rats; Rats, Wistar; Transaminases

2004
Prolonged nicotine administration results in biphasic, brain-specific changes in kynurenate levels in the rat.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Extracellular Fluid; Glutamic Acid; Hippocampus; Kynurenic Acid; Kynurenine; Male; Nicotine; Rats; Rats, Sprague-Dawley; Smoking; Tobacco Use Disorder; Up-Regulation

2005
Kynurenine metabolism in multiple sclerosis.
    Acta neurologica Scandinavica, 2005, Volume: 112, Issue:2

    Topics: Adolescent; Adult; Erythrocytes; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Multiple Sclerosis; Recurrence; Transaminases; Up-Regulation

2005
Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease.
    Experimental neurology, 2006, Volume: 197, Issue:1

    Topics: Animals; Brain Chemistry; Excitatory Amino Acid Agonists; Huntington Disease; Kainic Acid; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Knockout; Microinjections; Neostriatum; Neurons; Quinolinic Acid; Transaminases

2006
Kynurenine metabolism in plasma and in red blood cells in Parkinson's disease.
    Journal of the neurological sciences, 2005, Dec-15, Volume: 239, Issue:1

    Topics: Adaptation, Physiological; Aged; Brain; Erythrocytes; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Parkinson Disease; Receptors, Glutamate; Transaminases; Up-Regulation

2005
Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder.
    Brain research, 2006, Feb-16, Volume: 1073-1074

    Topics: Adult; Analysis of Variance; Bipolar Disorder; Chromatography, High Pressure Liquid; Demography; Depression; Female; Glial Fibrillary Acidic Protein; Gyrus Cinguli; Humans; Immunohistochemistry; Kynurenic Acid; Kynurenine; Male; Middle Aged; Models, Chemical; Postmortem Changes; Psychiatric Status Rating Scales; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schizophrenia; Sex Factors; Tryptophan Oxygenase; Up-Regulation

2006
Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain.
    Journal of neural transmission (Vienna, Austria : 1996), 2006, Volume: 113, Issue:10

    Topics: Animals; Antipsychotic Agents; Brain; Chromatography, High Pressure Liquid; Clozapine; Haloperidol; Kynurenic Acid; Kynurenine; Male; Microdialysis; Raclopride; Rats; Rats, Sprague-Dawley; Time Factors

2006
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
    Neurobiology of disease, 2006, Volume: 23, Issue:1

    Topics: Age Factors; Animals; Brain Chemistry; Chromatography, Gas; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Mice; Mice, Transgenic; Quinolinic Acid

2006
Decreased serum and red blood cell kynurenic acid levels in Alzheimer's disease.
    Neurochemistry international, 2007, Volume: 50, Issue:2

    Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoproteins E; Erythrocytes; Female; Genotype; Humans; Kynurenic Acid; Kynurenine; Male; Transaminases

2007
Kynurenine pathway metabolism in patients with osteoporosis after 2 years of drug treatment.
    Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:11

    Topics: 3-Hydroxyanthranilic Acid; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethacin; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Middle Aged; Molecular Structure; Neopterin; ortho-Aminobenzoates; Osteoporosis; Sodium Salicylate; Tryptophan

2006
Kynurenines impair energy metabolism in rat cerebral cortex.
    Cellular and molecular neurobiology, 2007, Volume: 27, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Animals; Carbon Dioxide; Cerebral Cortex; Electron Transport; Energy Metabolism; Glucose; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Rats; Rats, Wistar

2007
Tryptophan breakdown pathway in bipolar mania.
    Journal of affective disorders, 2007, Volume: 102, Issue:1-3

    Topics: Adult; Aspartic Acid; Bipolar Disorder; Brief Psychiatric Rating Scale; Female; Gyrus Cinguli; Humans; Kynurenic Acid; Kynurenine; Male; Schizophrenia; Severity of Illness Index; Tryptophan

2007
Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications.
    Journal of neuroscience research, 2007, Volume: 85, Issue:4

    Topics: Animals; Animals, Newborn; Brain Chemistry; Cyclopropanes; Deoxycholic Acid; Drug Administration Schedule; Embryo, Mammalian; Enzyme Inhibitors; Female; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Metabolic Networks and Pathways; Mice; Parturition; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley

2007
Peripheral kynurenine metabolism in focal dystonia.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2007, Volume: 3, Issue:3

    Topics: Acetyltransferases; Adult; Blepharospasm; Case-Control Studies; Dystonic Disorders; Erythrocytes; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged

2007
Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys.
    Behavioural brain research, 2008, Jan-25, Volume: 186, Issue:2

    Topics: Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Drug Interactions; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Female; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Levodopa; Macaca fascicularis; Motor Activity; Parkinsonian Disorders; Quinolinic Acid; Sulfonamides; Thiazoles; Time Factors

2008
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.
    Neuro endocrinology letters, 2007, Volume: 28, Issue:6

    Topics: Adult; Anti-Inflammatory Agents; Cytokines; Depressive Disorder; Female; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-10; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Quinolinic Acid; Reference Values; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates

2007
Tryptophan metabolism; concerning the mechanism of the mammalian conversion of tryptophan into kynurenine, kynurenic acid, and nicotinic acid.
    The Journal of biological chemistry, 1949, Volume: 179, Issue:1

    Topics: Animals; Kynurenic Acid; Kynurenine; Mammals; Niacin; Nicotinic Acids; Tryptophan

1949
Micromolar concentration of kynurenic acid in rat small intestine.
    Amino acids, 2008, Volume: 35, Issue:2

    Topics: Animals; Escherichia coli; Gastrointestinal Contents; Intestine, Small; Kynurenic Acid; Kynurenine; Male; Rats; Rats, Wistar; Receptors, G-Protein-Coupled

2008
Simultaneous determination of kynurenine and kynurenic acid concentrations in human serum by HPLC with dual wavelengths fluorescence detection.
    Clinica chimica acta; international journal of clinical chemistry, 2008, Volume: 395, Issue:1-2

    Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Reference Values; Sensitivity and Specificity; Spectrometry, Fluorescence

2008
The pentylenetetrazole-induced activity in the hippocampus can be inhibited by the conversion of L-kynurenine to kynurenic acid: an in vitro study.
    Brain research bulletin, 2008, Jul-30, Volume: 76, Issue:5

    Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; Kynurenic Acid; Kynurenine; Nitroarginine; Pentylenetetrazole; Rats; Rats, Wistar

2008
Alteration of kynurenic acid concentration in rat plasma following optically pure kynurenine administration: a comparative study between enantiomers.
    Chirality, 2009, Volume: 21, Issue:4

    Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Deoxyadenosines; Kynurenic Acid; Kynurenine; Male; Models, Chemical; Protein Binding; Pyrazoles; Pyrenes; Rats; Rats, Sprague-Dawley; Stereoisomerism; Time Factors

2009
Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus.
    Neurobiology of disease, 2008, Volume: 32, Issue:2

    Topics: Adjuvants, Pharmaceutic; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Infarction, Middle Cerebral Artery; Kynurenic Acid; Kynurenine; Long-Term Potentiation; Male; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Probenecid; Rats; Rats, Wistar

2008
Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia.
    The international journal of neuropsychopharmacology, 2009, Volume: 12, Issue:4

    Topics: Animals; Brain Chemistry; Data Interpretation, Statistical; Dextroamphetamine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Implants; Electrophysiology; Excitatory Amino Acid Antagonists; Extracellular Space; Kynurenic Acid; Kynurenine; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Schizophrenia

2009
Concerning the mechanism of the mammalian conversion of tryptophan into kynurenine, kynurenic acid, and nicotinic acid.
    The Journal of biological chemistry, 1948, Volume: 175, Issue:1

    Topics: Animals; Kynurenic Acid; Kynurenine; Mammals; Niacin; Nicotinic Acids; Tryptophan

1948
Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria.
    International journal for parasitology, 2009, Volume: 39, Issue:3

    Topics: Animals; Brain; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Malaria, Cerebral; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Picolinic Acids; Quinolinic Acid; RNA, Messenger; Sulfonamides; Thiazoles; Tryptophan Oxygenase

2009
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
    Atherosclerosis, 2009, Volume: 204, Issue:2

    Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies; Diabetes Complications; Disease Progression; Female; Humans; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Logistic Models; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peritoneal Dialysis, Continuous Ambulatory; Peroxides; Quinolinic Acid; Renal Dialysis; Risk Assessment; Risk Factors; Superoxide Dismutase; Ultrasonography; Uremia

2009
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.
    Neuroscience, 2009, Mar-03, Volume: 159, Issue:1

    Topics: Adenosine; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Extracellular Fluid; Functional Laterality; Kynurenic Acid; Kynurenine; Mice; Mice, Knockout; Microdialysis; Nerve Degeneration; Norbornanes; Quinolinic Acid; Transaminases; Tritium

2009
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:6

    Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; Middle Aged; Prognosis; Prospective Studies; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type I; Renal Dialysis; Renal Insufficiency, Chronic; Serotonin; Tryptophan; Uremia

2009
Cloning and molecular characterization of tick kynurenine aminotransferase (HlKAT) from Haemaphysalis longicornis (Acari: Ixodidae).
    Parasitology research, 2009, Volume: 105, Issue:3

    Topics: Amino Acid Sequence; Animal Structures; Animals; Antiprotozoal Agents; Babesia; Base Sequence; Cloning, Molecular; DNA, Complementary; Enzyme Stability; Gene Expression Profiling; Hydrogen-Ion Concentration; Ixodidae; Kynurenic Acid; Kynurenine; Molecular Sequence Data; Phylogeny; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology; Substrate Specificity; Temperature; Transaminases; Xanthurenates

2009
l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleus.
    Neuropharmacology, 2009, Volume: 57, Issue:4

    Topics: Animals; Central Nervous System Agents; Cervical Vertebrae; Drug Synergism; Kynurenic Acid; Kynurenine; Male; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitroglycerin; Probenecid; Quinolones; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors; Trigeminal Nuclei

2009
Neonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1-/- mice.
    The international journal of neuropsychopharmacology, 2010, Volume: 13, Issue:4

    Topics: Animals; Animals, Newborn; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Brain; Indoleamine-Pyrrole 2,3,-Dioxygenase; Influenza A virus; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; Orthomyxoviridae Infections; Sensory Gating; Signal Transduction; Time Factors; Up-Regulation

2010
[Simultaneous determination of kynurenine and kynurenic acid in serum by high performance liquid chromatography-fluorescence detection].
    Se pu = Chinese journal of chromatography, 2009, Volume: 27, Issue:2

    Topics: Adult; Chromatography, High Pressure Liquid; Female; Fluorescence; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Spectrometry, Fluorescence

2009
The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex.
    Journal of molecular neuroscience : MN, 2010, Volume: 40, Issue:1-2

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Cholinesterase Inhibitors; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Fluid; Galantamine; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Microdialysis; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Schizophrenia

2010
Quantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of L-kynurenine to kynurenic acid: the round dance of kynurenine aminotransferase II.
    Biochimica et biophysica acta, 2009, Volume: 1794, Issue:12

    Topics: Humans; In Vitro Techniques; Isoenzymes; Kynurenic Acid; Kynurenine; Ligands; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Structure; Pyridoxal Phosphate; Quantum Theory; Thermodynamics; Transaminases

2009
Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients.
    Thrombosis research, 2010, Volume: 125, Issue:2

    Topics: Adult; Antifibrinolytic Agents; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Fasting; Female; Fibrinolysin; Hemostasis; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Peptide Fragments; Peritoneal Dialysis, Continuous Ambulatory; Plasminogen Activator Inhibitor 1; Poland; Prevalence; Prothrombin; Quinolinic Acid; Receptors, Urokinase Plasminogen Activator; Thromboplastin; Tryptophan; Urokinase-Type Plasminogen Activator

2010
Kynurenine and its metabolites--kynurenic acid and anthranilic acid are associated with soluble endothelial adhesion molecules and oxidative status in patients with chronic kidney disease.
    The American journal of the medical sciences, 2009, Volume: 338, Issue:4

    Topics: Adult; Aged; Case-Control Studies; Female; Humans; Intercellular Adhesion Molecule-1; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Oxidative Stress; Vascular Cell Adhesion Molecule-1

2009
Kynurenate derivative attenuates the nitroglycerin-induced CamKIIα and CGRP expression changes.
    Headache, 2010, Volume: 50, Issue:5

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Gene Expression Regulation, Enzymologic; Isoenzymes; Kynurenic Acid; Kynurenine; Male; Nitroglycerin; Rats; Rats, Sprague-Dawley; Trigeminal Caudal Nucleus

2010
Changes in extracellular kynurenic acid concentrations in rat prefrontal cortex after D-kynurenine infusion: an in vivo microdialysis study.
    Neurochemical research, 2010, Volume: 35, Issue:4

    Topics: Animals; Chromatography, High Pressure Liquid; Kynurenic Acid; Kynurenine; Male; Microdialysis; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence

2010
Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:1

    Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Brain; D-Aspartic Acid; Functional Laterality; Humans; Japan; Kynurenic Acid; Kynurenine; Motor Neurons; N-Methylaspartate; Quinolinic Acid; Riluzole; Signal Transduction; Tryptophan

2009
Optimization of Zn2+-containing mobile phase for simultaneous determination of kynurenine, kynurenic acid and tryptophan in human plasma by high performance liquid chromatography.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Feb-15, Volume: 878, Issue:5-6

    Topics: Adult; Aged; Chromatography, High Pressure Liquid; Fluorescence; Humans; Kynurenic Acid; Kynurenine; Limit of Detection; Linear Models; Middle Aged; Tryptophan; Young Adult; Zinc

2010
Simultaneous determination of serum tryptophan metabolites in patients with systemic lupus erythematosus by high performance liquid chromatography with fluorescence detection.
    Clinical chemistry and laboratory medicine, 2010, Volume: 48, Issue:4

    Topics: Adult; Chromatography, High Pressure Liquid; Female; Fluorescence; Humans; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; Male; Middle Aged; Tryptophan

2010
Melatonin and elimination of kynurenines in children with Down's syndrome.
    Journal of pediatric endocrinology & metabolism : JPEM, 2010, Volume: 23, Issue:3

    Topics: Child; Child, Preschool; Circadian Rhythm; Down Syndrome; Female; Humans; Kynurenic Acid; Kynurenine; Male; Melatonin; ortho-Aminobenzoates; Oxidative Stress; Serotonin; Tryptophan

2010
Kynurenine and its metabolites in Alzheimer's disease patients.
    Advances in medical sciences, 2010, Volume: 55, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan

2010
Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia.
    Schizophrenia bulletin, 2012, Volume: 38, Issue:3

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Olanzapine; Schizophrenia; Tryptophan; Up-Regulation; Young Adult

2012
Changes in the plasma concentrations of D-kynurenine and kynurenic acid in rats after intraperitoneal administration of tryptophan enantiomers.
    Chirality, 2010, Volume: 22, Issue:10

    Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Optical Rotation; Pyrazoles; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tryptophan

2010
Biochemical and structural investigations on kynurenine aminotransferase II: an example of conformation-driven species-specific inhibition?
    Current topics in medicinal chemistry, 2011, Volume: 11, Issue:2

    Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Crystallization; Enzyme Inhibitors; Humans; Kinetics; Kynurenic Acid; Kynurenine; Models, Molecular; Molecular Dynamics Simulation; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Rats; Species Specificity; Transaminases

2011
Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics.
    The Journal of antibiotics, 2011, Volume: 64, Issue:1

    Topics: Antibiotics, Antineoplastic; Cloning, Molecular; DNA, Bacterial; Echinomycin; Escherichia coli; Genes, Bacterial; Kynurenic Acid; Kynurenine; Magnetic Resonance Spectroscopy; Multigene Family; Optical Rotation; Peptide Synthases; Polymerase Chain Reaction; Quinoxalines; Spectrometry, Mass, Electrospray Ionization

2011
G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.
    Neuropharmacology, 2011, Volume: 60, Issue:7-8

    Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Gene Expression; Inflammation; Kynurenic Acid; Kynurenine; Male; Mice; Neuroglia; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Probenecid; Purinones; Receptors, G-Protein-Coupled; Spinal Cord; Tryptophan

2011
Exposure to kynurenic acid during adolescence produces memory deficits in adulthood.
    Schizophrenia bulletin, 2012, Volume: 38, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Excitatory Amino Acid Antagonists; Fear; Kynurenic Acid; Kynurenine; Learning Disabilities; Male; Memory Disorders; Motor Activity; Nicotinic Antagonists; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Recognition, Psychology; Schizophrenia

2012
Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 337, Issue:3

    Topics: Adult; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Female; GABA-A Receptor Antagonists; Hippocampus; Humans; In Vitro Techniques; Interneurons; Kynurenic Acid; Kynurenine; Male; Nicotinic Antagonists; Nootropic Agents; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic

2011
Comparative study on kynurenic acid production in the rat striatum by tryptophan enantiomers: an in vivo microdialysis study.
    Chirality, 2011, Volume: 23 Suppl 1

    Topics: Animals; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Corpus Striatum; D-Amino-Acid Oxidase; Kynurenic Acid; Kynurenine; Male; Microdialysis; Models, Chemical; Pyrazoles; Rats; Rats, Sprague-Dawley; Time Factors; Tryptophan

2011
Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients.
    Brain, behavior, and immunity, 2011, Volume: 25, Issue:8

    Topics: Adult; Algorithms; Antipsychotic Agents; Chromatography, High Pressure Liquid; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Patient Discharge; Schizophrenia; Schizophrenic Psychology; Spectrophotometry, Ultraviolet; Treatment Outcome; Tryptophan

2011
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
    Current biology : CB, 2011, Jun-07, Volume: 21, Issue:11

    Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Huntington Disease; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Nerve Degeneration; Neuroprotective Agents; Tryptophan; Tryptophan Oxygenase

2011
New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio.
    Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:2

    Topics: Animals; Animals, Newborn; Antidepressive Agents; Cells, Cultured; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; Neural Pathways; Rats; Rats, Wistar; Stereoisomerism

2012
High tryptophan diet reduces extracellular dopamine release via kynurenic acid production in rat striatum.
    Journal of neurochemistry, 2011, Volume: 118, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Corpus Striatum; Diet; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Homovanillic Acid; In Vitro Techniques; Kynurenic Acid; Kynurenine; Male; Microdialysis; Rats; Rats, Wistar; Statistics, Nonparametric; Tryptophan

2011
Simultaneous determination of tryptophan, kynurenine, kynurenic and xanthurenic acids in honey by liquid chromatography with diode array, fluorescence and tandem mass spectrometry detection.
    Journal of chromatography. A, 2011, Oct-21, Volume: 1218, Issue:42

    Topics: Chromatography, Liquid; Formates; Honey; Kynurenic Acid; Kynurenine; Methanol; Reproducibility of Results; Sensitivity and Specificity; Spain; Tandem Mass Spectrometry; Tryptophan; Xanthurenates

2011
Simultaneous determination of urinary tryptophan, tryptophan-related metabolites and creatinine by high performance liquid chromatography with ultraviolet and fluorimetric detection.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Sep-15, Volume: 879, Issue:26

    Topics: Adult; Chromatography, High Pressure Liquid; Creatinine; Drug Stability; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Linear Models; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan

2011
Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:2

    Topics: Amphetamine; Animals; Brain; Drug Synergism; Excitatory Amino Acid Antagonists; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Up-Regulation

2012
Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients.
    Archives of physiology and biochemistry, 2011, Volume: 117, Issue:5

    Topics: Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetic Retinopathy; Female; Gene Expression; Humans; India; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Retina; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Tryptophan

2011
Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine.
    Psychopharmacology, 2012, Volume: 220, Issue:3

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cognition; Cognition Disorders; Disease Models, Animal; Galantamine; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Nootropic Agents; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Nicotinic; Schizophrenia

2012
Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity.
    Journal of psychiatric research, 2012, Volume: 46, Issue:2

    Topics: Aldosterone; Analysis of Variance; Animals; Body Weight; Brain; Calcium-Binding Proteins; Catecholamines; Chromatography, High Pressure Liquid; Corticosterone; Depression; Diet; Disease Models, Animal; DNA-Binding Proteins; Kynurenic Acid; Kynurenine; Male; Nerve Tissue Proteins; Nucleobindins; Paroxetine; Protein Binding; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Swimming; Time Factors; Tritium; Tryptophan

2012
Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.
    Pharmacological research, 2012, Volume: 65, Issue:2

    Topics: Animals; Biological Transport; Estrone; Humans; Kinetics; Kynurenic Acid; Kynurenine; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Quinolinic Acid; Xenopus laevis

2012
Enzymatic transamination of D-kynurenine generates kynurenic acid in rat and human brain.
    Journal of neurochemistry, 2012, Volume: 120, Issue:6

    Topics: Animals; Area Under Curve; Brain; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Kynurenic Acid; Kynurenine; Liver; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Time Factors; Transaminases

2012
A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study : special issue related to kynurenine.
    Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:2

    Topics: Action Potentials; Animals; Kynurenic Acid; Kynurenine; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures

2012
Regulation of GABAergic inputs to CA1 pyramidal neurons by nicotinic receptors and kynurenic acid.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:2

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; CA1 Region, Hippocampal; GABAergic Neurons; In Vitro Techniques; Kynurenic Acid; Kynurenine; Male; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Schizophrenia; Sodium Channel Blockers; Synaptic Transmission; Tetrodotoxin

2012
Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway.
    Psychiatry research, 2012, Apr-30, Volume: 196, Issue:2-3

    Topics: Adult; Analysis of Variance; Biomarkers; Chi-Square Distribution; Depression; Female; Humans; International Classification of Diseases; Kynurenic Acid; Kynurenine; Male; Middle Aged; Principal Component Analysis; Psychiatric Status Rating Scales; Somatoform Disorders; Tryptophan

2012
Kynurenic acid and 3-hydroxykynurenine production from D-kynurenine in mice.
    Brain research, 2012, May-21, Volume: 1455

    Topics: Animals; Brain Chemistry; Catalysis; Female; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred Strains; Stereoisomerism; Tryptophan

2012
Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood.
    The European journal of neuroscience, 2012, Volume: 35, Issue:10

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Chromatography, High Pressure Liquid; Cognition Disorders; Electrochemical Techniques; Female; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Maze Learning; Memory; Microdialysis; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Spatial Behavior

2012
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Jun-01, Volume: 898

    Topics: 3-Hydroxyanthranilic Acid; Animals; Charcoal; Chromatography, High Pressure Liquid; Depression; Kynurenic Acid; Kynurenine; Linear Models; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Schizophrenia; Social Isolation; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan

2012
Kynurenic acid in plasma and endometrium in bitches with pyometra.
    Inflammation, 2013, Volume: 36, Issue:1

    Topics: Animals; Biomarkers; Dog Diseases; Dogs; Endometrial Hyperplasia; Endometrium; Escherichia coli; Female; Kynurenic Acid; Kynurenine; Pyometra; Staphylococcus; Uterine Diseases; Uterus

2013
Manipulation with kynurenines: a possible tool for treating neurodegenerative diseases?
    Expert review of clinical pharmacology, 2012, Volume: 5, Issue:4

    Topics: Animals; Drug Design; Humans; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Quinolinic Acid

2012
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls.
    European archives of psychiatry and clinical neuroscience, 2013, Volume: 263, Issue:4

    Topics: Aged; Alzheimer Disease; Biomarkers; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Male; Neuropsychological Tests; Picolinic Acids; Quinolinic Acid; Spectrophotometry, Ultraviolet; Tryptophan

2013
Connecting inflammation with glutamate agonism in suicidality.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013, Volume: 38, Issue:5

    Topics: Adult; Aged; Encephalitis; Excitatory Amino Acid Agonists; Female; Follow-Up Studies; Humans; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Mental Disorders; Middle Aged; Psychiatric Status Rating Scales; Quinolinic Acid; Retrospective Studies; Somatosensory Disorders; Spinal Puncture; Suicide; Tritium; Young Adult

2013
The kynurenine pathway: a missing piece in the puzzle of valproate action?
    Neuroscience, 2013, Mar-27, Volume: 234

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dose-Response Relationship, Drug; Hippocampus; Ibuprofen; Kynurenic Acid; Kynurenine; Male; Rats; Signal Transduction; Tryptophan; Valproic Acid

2013
Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine.
    Neuroscience, 2013, May-15, Volume: 238

    Topics: Animals; Attention; Brain; Cognition; Female; Galantamine; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Nootropic Agents; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Set, Psychology

2013
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
    Clinical and experimental immunology, 2013, Volume: 173, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Motor Activity; Neopterin; Norway; ortho-Aminobenzoates; Reference Values; Smoking; Tryptophan; Xanthurenates

2013
The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
    The Journal of nutrition, 2013, Volume: 143, Issue:7

    Topics: 3-Hydroxyanthranilic Acid; Animals; Body Weight; Diet; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Niacin; Niacinamide; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates

2013
A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites.
    The Journal of nutrition, 2013, Volume: 143, Issue:9

    Topics: Animals; Brain; Contraceptives, Oral; Female; Humans; Hydrolases; Intestines; Kynurenic Acid; Kynurenine; Liver; Mice; Models, Theoretical; Muscles; ortho-Aminobenzoates; Rats; Transaminases; Tryptophan; Tryptophan Oxygenase; Vitamin B 6 Deficiency

2013
A biopsychosocial model of interferon-alpha-induced depression in patients with chronic hepatitis C infection.
    Psychotherapy and psychosomatics, 2013, Volume: 82, Issue:5

    Topics: Adult; Analysis of Variance; Depressive Disorder; Female; Hepatitis C, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Interview, Psychological; Kynurenic Acid; Kynurenine; Male; Models, Theoretical; Neuropsychological Tests; Personal Satisfaction; Prospective Studies; Psychiatric Status Rating Scales; Quality of Life; Risk Factors; Sex Factors; Social Support; Surveys and Questionnaires; Thyroid Function Tests; Tryptophan

2013
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
    The Journal of nutrition, 2013, Volume: 143, Issue:11

    Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Multivariate Analysis; Postprandial Period; Pyridoxal Phosphate; Serine; Tryptophan; Vitamin B 6; Vitamin B 6 Deficiency; Young Adult

2013
Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: cytokine challenge increases production of 3-hydroxykynurenine.
    Journal of psychiatric research, 2013, Volume: 47, Issue:11

    Topics: Adult; Bipolar Disorder; Cells, Cultured; Cytokines; Female; Fibroblasts; Gene Expression Regulation; Genotype; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Polymorphism, Single Nucleotide; Schizophrenia; Signal Transduction; Young Adult

2013
Concurrent quantification of tryptophan and its major metabolites.
    Analytical biochemistry, 2013, Dec-15, Volume: 443, Issue:2

    Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Limit of Detection; Rabbits; Serotonin; Tandem Mass Spectrometry; Tryptophan

2013
[Simultaneous determination of tryptophan and its metabolites in plasma by high performance liquid chromatography with on-column derivatization].
    Se pu = Chinese journal of chromatography, 2013, Volume: 31, Issue:6

    Topics: Acetonitriles; Chromatography, High Pressure Liquid; Female; Fluorescence; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Limit of Detection; Pregnancy; Reproducibility of Results; Tryptophan; Tyrosine; Zinc Acetate

2013
Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid.
    Brain, behavior, and immunity, 2014, Volume: 36

    Topics: Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Brain; Brain Chemistry; Conditioning, Psychological; Dopamine; Dopamine Agents; Female; Influenza A virus; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Orthomyxoviridae Infections

2014
A method for the determination of D-kynurenine in biological tissues.
    Analytical and bioanalytical chemistry, 2013, Volume: 405, Issue:30

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Female; Fluorometry; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Plasma

2013
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
    Schizophrenia research, 2014, Volume: 152, Issue:1

    Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neuroglia; Pyrimethamine; Quinolinic Acid; RNA, Messenger; Signal Transduction; Sulfadiazine; Time Factors; Toxoplasmosis; Tryptophan

2014
[Screening of urinary biomarkers in patients with type 2 diabetes mellitus].
    Wei sheng yan jiu = Journal of hygiene research, 2013, Volume: 42, Issue:6

    Topics: Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Tryptophan

2013
Evaluation of lipopeptide (daptomycin) aggregation using fluorescence, light scattering, and nuclear magnetic resonance spectroscopy.
    Journal of pharmaceutical sciences, 2014, Volume: 103, Issue:3

    Topics: Anti-Bacterial Agents; Calcium Signaling; Daptomycin; Drug Stability; Fluorescence Resonance Energy Transfer; Hot Temperature; Hydrogen-Ion Concentration; Ionophores; Kinetics; Kynurenic Acid; Kynurenine; Nephelometry and Turbidimetry; Nuclear Magnetic Resonance, Biomolecular; Osmolar Concentration; Particle Size; Protein Stability; Solubility; Spectrophotometry, Ultraviolet; Tryptophan

2014
Structural and mechanistic insights into the kynurenine aminotransferase-mediated excretion of kynurenic acid.
    Journal of structural biology, 2014, Volume: 185, Issue:3

    Topics: Amino Acid Sequence; Archaeal Proteins; Kynurenic Acid; Kynurenine; Molecular Sequence Data; Pyridoxamine; Pyrococcus horikoshii; Sequence Homology, Amino Acid; Transaminases

2014
Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats.
    Psychopharmacology, 2014, Volume: 231, Issue:14

    Topics: Age Factors; Animals; Avoidance Learning; Behavior, Animal; Cognition Disorders; Female; Hippocampus; Kynurenic Acid; Kynurenine; Male; Maze Learning; Memory Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Time Factors; Tissue Distribution

2014
A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats.
    Neuropharmacology, 2014, Volume: 82

    Topics: Animals; Central Nervous System Agents; Enzyme Inhibitors; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Membrane Potentials; Microdialysis; Microelectrodes; Nicotine; Nicotinic Agonists; Potassium Chloride; Prefrontal Cortex; Pyrazoles; Rats, Sprague-Dawley; Rats, Wistar; Transaminases

2014
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
    Brain, behavior, and immunity, 2014, Volume: 41

    Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Female; Gestational Age; Hyperkinesis; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Quinolinic Acid; Random Allocation; Rats; Rats, Wistar; Schizophrenia; Sexual Maturation; Sulfonamides; Tryptophan

2014
Modulation by kynurenine of extracellular kynurenate and glutamate in cerebral cortex of rats with acute liver failure.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:3

    Topics: Animals; Cerebral Cortex; Glutamic Acid; Kynurenic Acid; Kynurenine; Liver Failure, Acute; Male; Rats; Rats, Sprague-Dawley; Transaminases

2014
B7 costimulation and intracellular indoleamine 2,3-dioxygenase expression in umbilical cord blood and adult peripheral blood.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2014, Volume: 20, Issue:10

    Topics: Adult; B7 Antigens; CD28 Antigens; CTLA-4 Antigen; Fetal Blood; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant, Newborn; Kynurenic Acid; Kynurenine; Monocytes; Primary Cell Culture; Programmed Cell Death 1 Receptor; Signal Transduction; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer; Tryptophan

2014
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:2

    Topics: Adult; Amygdala; Anhedonia; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Depressive Disorder, Major; Female; Gray Matter; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Organ Size; Psychiatric Status Rating Scales; Quinolinic Acid; Receptors, Interleukin-1; Signal Transduction; Tryptophan

2015
Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest.
    Journal of the American Heart Association, 2014, Aug-04, Volume: 3, Issue:4

    Topics: 3-Hydroxyanthranilic Acid; Aged; Arterial Pressure; Cardiopulmonary Resuscitation; Chromatography, Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Logistic Models; Male; Mass Spectrometry; Middle Aged; Out-of-Hospital Cardiac Arrest; Prognosis; Prospective Studies; Shock, Cardiogenic; Tryptophan

2014
A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality.
    Brain, behavior, and immunity, 2015, Volume: 43

    Topics: Adult; Cytokines; Depressive Disorder; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Suicidal Ideation; Suicide, Attempted; Young Adult

2015
B7 costimulation and intracellular indoleamine-2,3-dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non-pregnant women.
    BMC pregnancy and childbirth, 2014, Sep-04, Volume: 14

    Topics: Adult; B7 Antigens; CD28 Antigens; CD4 Lymphocyte Count; CTLA-4 Antigen; Female; Flow Cytometry; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Monocytes; Pregnancy; Programmed Cell Death 1 Receptor; T-Lymphocytes; Tryptophan

2014
Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.
    Cell, 2014, Sep-25, Volume: 159, Issue:1

    Topics: Animals; Blood-Brain Barrier; Depression; Gene Expression Profiling; Humans; Kynurenic Acid; Kynurenine; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Conditioning, Animal; Physical Conditioning, Human; PPAR alpha; Stress, Psychological; Transaminases; Transcription Factors

2014
Strong muscles, strong mind.
    Lab animal, 2014, Volume: 43, Issue:11

    Topics: Animals; Depression; Exercise; Gene Expression Regulation; Humans; Kynurenic Acid; Kynurenine; Mice; Mice, Transgenic; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Endurance; Transcription Factors

2014
Involvement of the kynurenine pathway in human glioma pathophysiology.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Biosynthetic Pathways; Brain Neoplasms; Carboxy-Lyases; CD11b Antigen; Cells, Cultured; Chromatography, High Pressure Liquid; Disaccharides; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Glucuronates; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Kynurenine; Picolinic Acids; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured

2014
Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia.
    Neuropharmacology, 2015, Volume: 90

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Brain; Cognition; Dendritic Spines; Diet; Female; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Receptors, Metabotropic Glutamate; Reversal Learning; RNA, Messenger; Schizophrenia

2015
Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway.
    Journal of psychiatry & neuroscience : JPN, 2015, Volume: 40, Issue:2

    Topics: Adult; Astrocytes; Cells, Cultured; Cerebral Cortex; Chronic Disease; Female; Humans; Interleukin-6; Interleukin-8; Kynurenic Acid; Kynurenine; Male; Middle Aged; Schizophrenia; Tryptophan; Young Adult

2015
Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder.
    Psychoneuroendocrinology, 2015, Volume: 52

    Topics: Adult; Amygdala; Bipolar Disorder; Female; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid

2015
The chemical interaction between adrenochrome, three different classes of antipsychotic drugs and metabolites of the kynurenine pathway.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:3

    Topics: Adrenochrome; Antipsychotic Agents; Dose-Response Relationship, Drug; Drug Interactions; Hydrogen-Ion Concentration; Kynurenic Acid; Kynurenine; Melanins; Signal Transduction; Time Factors

2015
Kynurenic acid is a nutritional cue that enables behavioral plasticity.
    Cell, 2015, Jan-15, Volume: 160, Issue:1-2

    Topics: Animals; Behavior, Animal; Caenorhabditis elegans; Cues; Fasting; Feeding Behavior; Interneurons; Kynurenic Acid; Kynurenine; Neurons; Neuropeptides; Receptors, N-Methyl-D-Aspartate; Serotonin; Signal Transduction; Transaminases; Tryptophan

2015
A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma.
    Journal of pharmaceutical and biomedical analysis, 2015, Mar-25, Volume: 107

    Topics: Animals; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Plasma; Rats; Tryptophan

2015
Serum tryptophan and its metabolites in female dogs undergoing ovariohysterectomy as treatment of pyometra or as elective spay surgery.
    Theriogenology, 2015, Volume: 83, Issue:8

    Topics: Animals; Dog Diseases; Dogs; Escherichia coli; Female; Hysterectomy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Ovariectomy; Pyometra; Reference Values; Tryptophan; Uterus

2015
The impact of electroconvulsive therapy on the tryptophan-kynurenine metabolic pathway.
    Brain, behavior, and immunity, 2015, Volume: 48

    Topics: Adult; Aged; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Tryptophan; Young Adult

2015
Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.
    The Journal of nutrition, 2015, Volume: 145, Issue:4

    Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Arginine; Biomarkers; Dietary Supplements; Female; Healthy Volunteers; Humans; Kynurenic Acid; Kynurenine; Life Style; Male; Methionine; ortho-Aminobenzoates; Pyridoxal Phosphate; Sex Factors; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Xanthurenates; Young Adult

2015
Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes.
    Molecular neurobiology, 2015, Volume: 52, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Male; Metformin; Middle Aged; Prediabetic State; Pyridoxal Phosphate; Stress, Physiological; Tryptophan; Tryptophan Oxygenase; Xanthurenates

2015
A high-performance liquid chromatography assay with a triazole-bonded column for evaluation of d-amino acid oxidase activity.
    Biomedical chromatography : BMC, 2016, Volume: 30, Issue:3

    Topics: Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Hydrophobic and Hydrophilic Interactions; Kynurenic Acid; Kynurenine; Triazoles

2016
Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder.
    Psychoneuroendocrinology, 2015, Volume: 62

    Topics: Adult; Anhedonia; Biomarkers; Corpus Striatum; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Middle Aged; Organ Size; Quinolinic Acid; Young Adult

2015
Low-Level Stress Induces Production of Neuroprotective Factors in Wild-Type but Not BDNF+/- Mice: Interleukin-10 and Kynurenic Acid.
    The international journal of neuropsychopharmacology, 2015, Aug-01, Volume: 19, Issue:3

    Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Interleukin-10; Kynurenic Acid; Kynurenine; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuroimmunomodulation; Stress, Psychological; Uncertainty

2015
Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression.
    Journal of affective disorders, 2016, Jan-01, Volume: 189

    Topics: Adult; Depression, Postpartum; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Postpartum Period; Psychotic Disorders; Puerperal Disorders; Tandem Mass Spectrometry; Tryptophan; Young Adult

2016
Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease.
    European journal of nutrition, 2017, Volume: 56, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Aged; Animals; Biomarkers; Body Mass Index; Cholesterol; Coronary Artery Disease; Cross-Sectional Studies; Energy Intake; Fatty Acids, Omega-3; Female; Fishes; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neopterin; Norway; Nutrition Assessment; ortho-Aminobenzoates; Seafood; Triglycerides; Tryptophan; Xanthurenates

2017
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder.
    Brain, behavior, and immunity, 2016, Volume: 53

    Topics: Adult; Brain; C-Reactive Protein; Case-Control Studies; Cerebral Cortex; Depressive Disorder, Major; Female; Gray Matter; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Neurotoxicity Syndromes; Prefrontal Cortex; Quinolinic Acid; Tryptophan

2016
Central kynurenine pathway shift with age in women.
    Journal of neurochemistry, 2016, Volume: 136, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Middle Aged; Neopterin; Neurotoxins; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Young Adult

2016
Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase.
    Brain, behavior, and immunity, 2016, Volume: 54

    Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Citalopram; Fear; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Stress, Psychological; Tryptophan; Tumor Necrosis Factor-alpha

2016
Activity of the kynurenine pathway and its interplay with immunity in patients with pulmonary arterial hypertension.
    Heart (British Cardiac Society), 2016, Volume: 102, Issue:3

    Topics: Adult; Aged; Area Under Curve; Case-Control Studies; Disease Progression; Echocardiography, Doppler; Exercise Test; Female; Flow Cytometry; Humans; Hypertension, Pulmonary; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Prospective Studies; ROC Curve; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan

2016
Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set.
    Protein expression and purification, 2016, Volume: 121

    Topics: Chromatography, High Pressure Liquid; Codon; Escherichia coli; Gene Expression Regulation, Enzymologic; Humans; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Protein Conformation; Transaminases; X-Ray Diffraction

2016
Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis.
    Molecular psychiatry, 2016, Volume: 21, Issue:11

    Topics: Depression; Depressive Disorder, Major; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Male; Mast Cells; Mastocytosis; Middle Aged; Psychiatric Status Rating Scales; Serotonin; Stress, Psychological; Tryptophan

2016
Targeting tryptophan and tyrosine metabolism by liquid chromatography tandem mass spectrometry.
    Journal of chromatography. A, 2016, Feb-19, Volume: 1434

    Topics: Adult; Aged; Aggression; Animals; Chromatography, Liquid; Disruptive, Impulse Control, and Conduct Disorders; Female; Genetic Diseases, X-Linked; Healthy Volunteers; Humans; Intellectual Disability; Kynurenic Acid; Kynurenine; Male; Mice; Middle Aged; Monoamine Oxidase; Prefrontal Cortex; Serotonin; Tandem Mass Spectrometry; Tryptophan; Tyrosine; Young Adult

2016
Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats.
    Neural plasticity, 2016, Volume: 2016

    Topics: Animals; Brain; Corticosterone; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Limbic System; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stress, Psychological; Up-Regulation

2016
Altered serum levels of kynurenine metabolites in patients affected by cluster headache.
    The journal of headache and pain, 2015, Volume: 17

    Topics: Adult; Cluster Headache; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates

2015
In vitro and in silico evaluation of transactivation potencies of avian AHR1 and AHR2 by endogenous ligands: Implications for the physiological role of avian AHR2.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2016, Volume: 187

    Topics: Animals; Avian Proteins; Carbazoles; Chlorocebus aethiops; COS Cells; Crows; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, Reporter; Indican; Kynurenic Acid; Kynurenine; Ligands; Molecular Docking Simulation; Protein Binding; Receptors, Aryl Hydrocarbon; Species Specificity; Transcription, Genetic; Transcriptional Activation; Transfection

2016
Polymorphism of Kynurenine Pathway-Related Genes, Kynurenic Acid, and Psychopathological Symptoms in HIV.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2016, Volume: 11, Issue:3

    Topics: Adult; Female; HIV Infections; Humans; Kynurenic Acid; Kynurenine; Male; Mental Disorders; Middle Aged; Polymorphism, Genetic; Psychiatric Status Rating Scales

2016
Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression.
    Brain, behavior, and immunity, 2016, Volume: 56

    Topics: Adult; Depressive Disorder, Major; Female; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Memory, Episodic; Mental Recall; Middle Aged; Quinolinic Acid; Young Adult

2016
Altered kynurenine pathway metabolites in serum of chronic migraine patients.
    The journal of headache and pain, 2015, Volume: 17

    Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; Migraine Disorders; ortho-Aminobenzoates; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan; Xanthurenates

2015
Inhibition of Large Neutral Amino Acid Transporters Suppresses Kynurenic Acid Production Via Inhibition of Kynurenine Uptake in Rodent Brain.
    Neurochemical research, 2016, Volume: 41, Issue:9

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Transport Systems, Neutral; Animals; Brain; Kynurenic Acid; Kynurenine; Male; Rats, Wistar; Schizophrenia; Tryptophan

2016
Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice.
    Neurochemical research, 2016, Volume: 41, Issue:9

    Topics: Animals; Brain; Immune System; Inflammation; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Mice, Inbred C57BL; Quinolinic Acid

2016
Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.
    Psychoneuroendocrinology, 2016, Volume: 71

    Topics: Adult; Aggression; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Quinolinic Acid; Tryptophan

2016
Tryptophan catabolism in Pseudomonas aeruginosa and potential for inter-kingdom relationship.
    BMC microbiology, 2016, 07-08, Volume: 16, Issue:1

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Host-Pathogen Interactions; Immunity, Innate; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Mice; Murinae; ortho-Aminobenzoates; Pseudomonas aeruginosa; Pseudomonas Infections; Transaminases; Tryptophan

2016
Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression.
    Acta neuropsychiatrica, 2017, Volume: 29, Issue:1

    Topics: Animals; Cerebellum; Chromatography, Liquid; Corpus Striatum; Depressive Disorder; Disease Models, Animal; Hippocampus; Kynurenic Acid; Kynurenine; Prefrontal Cortex; Rats; Tryptophan

2017
Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding.
    Psychopharmacology, 2016, Volume: 233, Issue:21-22

    Topics: Age Factors; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cognition; Conditioning, Psychological; Fear; Female; Humans; Kynurenic Acid; Kynurenine; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia

2016
A Simple HPLC-MS/MS Method for Determination of Tryptophan, Kynurenine and Kynurenic Acid in Human Serum and its Potential for Monitoring Antidepressant Therapy.
    Journal of analytical toxicology, 2017, Volume: 41, Issue:1

    Topics: Antidepressive Agents; Case-Control Studies; Chromatography, High Pressure Liquid; Depression; Drug Monitoring; Healthy Volunteers; Humans; Kynurenic Acid; Kynurenine; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tryptophan

2017
Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes.
    Scandinavian journal of immunology, 2016, Volume: 84, Issue:5

    Topics: Flagellin; Gene Expression Regulation; Humans; Hydrolysis; Imidazoles; Kynurenic Acid; Kynurenine; Lipopeptides; Lipopolysaccharides; Listeria monocytogenes; Monocytes; Poly I-C; Primary Cell Culture; Protein Isoforms; Quinolinic Acid; Signal Transduction; Toll-Like Receptors; Tryptophan

2016
Kynurenine pathway and white matter microstructure in bipolar disorder.
    European archives of psychiatry and clinical neuroscience, 2018, Volume: 268, Issue:2

    Topics: Adult; Bipolar Disorder; Diffusion Tensor Imaging; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Middle Aged; Serotonin; Signal Transduction; Tryptophan; White Matter; Young Adult

2018
Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2
    Neurochemistry international, 2016, Volume: 100

    Topics: Animals; Autism Spectrum Disorder; Brain; Chromatography, Liquid; Female; Kynurenic Acid; Kynurenine; Methyl-CpG-Binding Protein 2; ortho-Aminobenzoates; Pregnancy; Rats, Wistar; Tandem Mass Spectrometry; Tryptophan

2016
Maternal protein restriction during gestation and lactation in the rat results in increased brain levels of kynurenine and kynurenic acid in their adult offspring.
    Journal of neurochemistry, 2017, Volume: 140, Issue:1

    Topics: Age Factors; Animals; Brain; Dietary Proteins; Female; Kynurenic Acid; Kynurenine; Lactation; Male; Pregnancy; Prenatal Exposure Delayed Effects; Protein Deficiency; Rats; Rats, Wistar

2017
Pilot study examining the relationship of childhood trauma, perceived stress, and medication use to serum kynurenic acid and kynurenine levels in schizophrenia.
    Schizophrenia research, 2017, Volume: 185

    Topics: Adult; Adult Survivors of Child Abuse; Antipsychotic Agents; Female; Humans; Kynurenic Acid; Kynurenine; Male; Pilot Projects; Schizophrenia; Schizophrenic Psychology; Stress, Psychological; Visual Analog Scale

2017
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Multivariate Analysis; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan

2017
Correlations of Kynurenic Acid, 3-Hydroxykynurenine, sIL-2R, IFN-α, and IL-4 with Clinical Symptoms During Acute Relapse of Schizophrenia.
    Neurotoxicity research, 2017, Volume: 32, Issue:1

    Topics: Adult; Antipsychotic Agents; Clozapine; Female; Humans; Interferon-alpha; Interleukin-4; Kynurenic Acid; Kynurenine; Male; Psychiatric Status Rating Scales; Receptors, Interleukin-2; Recurrence; Retrospective Studies; Schizophrenia; Signal Transduction; Statistics, Nonparametric; Time Factors; Up-Regulation; Young Adult

2017
Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex.
    Neuropharmacology, 2017, Jul-15, Volume: 121

    Topics: Administration, Oral; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Electrodes; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Heterocyclic Compounds, 3-Ring; Kynurenic Acid; Kynurenine; Male; Microdialysis; N-Methylaspartate; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Thiazolidinediones; Transaminases

2017
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
    The journal of pain, 2017, Volume: 18, Issue:10

    Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Kynurenic Acid; Kynurenine; Male; Prodrugs; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord

2017
Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets.
    Journal of proteome research, 2017, 06-02, Volume: 16, Issue:6

    Topics: Biomarkers; Humans; Hyperglycemia; Hypoxia; Inflammation; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Kynurenic Acid; Kynurenine; Metabolomics

2017
Serum kynurenic acid is reduced in affective psychosis.
    Translational psychiatry, 2017, 05-02, Volume: 7, Issue:5

    Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Depressive Disorder, Major; Female; GABAergic Neurons; Humans; Inflammation; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Psychotic Disorders; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia

2017
Tryptophan breakdown and cognition in bipolar disorder.
    Psychoneuroendocrinology, 2017, Volume: 81

    Topics: Adult; Bipolar Disorder; Case-Control Studies; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neuropsychological Tests; Sex Factors; Tryptophan

2017
Effects of tryptophan, kynurenine and kynurenic acid exerted on human reconstructed corneal epithelium in vitro.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:4

    Topics: Antidepressive Agents, Second-Generation; Cell Proliferation; Cell Survival; Epithelial Cells; Epithelium, Corneal; Gene Expression Regulation; Humans; Interleukin-10; Interleukin-6; Kynurenic Acid; Kynurenine; Nitric Oxide; Tissue Culture Techniques; Tryptophan

2017
Sleep disturbance and kynurenine metabolism in depression.
    Journal of psychosomatic research, 2017, Volume: 99

    Topics: Adult; Depression; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Sleep Wake Disorders

2017
Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria.
    Malaria journal, 2017, 07-28, Volume: 16, Issue:1

    Topics: Child; Child, Preschool; Cognition; Coma; Female; Humans; Infant; Kynurenic Acid; Kynurenine; Malaria, Cerebral; Malaria, Falciparum; Male; Neurocognitive Disorders; Plasmodium falciparum; Seizures; Uganda

2017
Acute Kynurenine Challenge Disrupts Sleep-Wake Architecture and Impairs Contextual Memory in Adult Rats.
    Sleep, 2017, 11-01, Volume: 40, Issue:11

    Topics: Animals; Brain Stem; Cerebral Cortex; Hippocampus; Kynurenic Acid; Kynurenine; Male; Memory; Rats; Rats, Wistar; Sleep; Wakefulness

2017
Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid.
    Developmental neuroscience, 2017, Volume: 39, Issue:6

    Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Mice; Placenta; Pregnancy; Tryptophan

2017
Determination of tryptophan derivatives in kynurenine pathway in fermented foods using liquid chromatography tandem mass spectrometry.
    Food chemistry, 2018, Mar-15, Volume: 243

    Topics: Beer; Cheese; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cultured Milk Products; Fermented Foods; Kynurenic Acid; Kynurenine; Tandem Mass Spectrometry; Tryptophan; Wine

2018
Simultaneous determination of tryptophan, kynurenine, kynurenic acid, xanthurenic acid and 5-hydroxytryptamine in human plasma by LC-MS/MS and its application to acute myocardial infarction monitoring.
    Biomedical chromatography : BMC, 2018, Volume: 32, Issue:4

    Topics: Case-Control Studies; Chromatography, Liquid; Humans; Kynurenic Acid; Kynurenine; Linear Models; Myocardial Infarction; Reproducibility of Results; Sensitivity and Specificity; Serotonin; Tandem Mass Spectrometry; Tryptophan; Xanthurenates

2018
A pilot resting-state functional connectivity study of the kynurenine pathway in adolescents with depression and healthy controls.
    Journal of affective disorders, 2018, Volume: 227

    Topics: Adolescent; Anhedonia; Brain; Case-Control Studies; Depressive Disorder, Major; Female; Gray Matter; Gyrus Cinguli; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Pilot Projects; Prefrontal Cortex

2018
A validated liquid chromatography-high resolution-tandem mass spectrometry method for the simultaneous quantitation of tryptophan, kynurenine, kynurenic acid, and quinolinic acid in human plasma.
    Electrophoresis, 2018, Volume: 39, Issue:9-10

    Topics: Chromatography, High Pressure Liquid; Humans; Isotope Labeling; Kynurenic Acid; Kynurenine; Limit of Detection; Metabolome; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan

2018
Influence of plasma cytokines on kynurenine and kynurenic acid in schizophrenia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:8

    Topics: Adolescent; Adult; Cytokines; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychotic Disorders; Schizophrenia; Young Adult

2018
Fragment Screening of Human Kynurenine Aminotransferase-II.
    SLAS discovery : advancing life sciences R & D, 2018, Volume: 23, Issue:6

    Topics: Drug Design; Enzyme Inhibitors; Humans; Kynurenic Acid; Kynurenine; Pyridoxal Phosphate; Small Molecule Libraries; Surface Plasmon Resonance; Transaminases

2018
Effect of Kynurenic Acid on Pupae Viability of Drosophila melanogaster cinnabar and cardinal Eye Color Mutants with Altered Tryptophan-Kynurenine Metabolism.
    Neurotoxicity research, 2018, Volume: 34, Issue:2

    Topics: Animals; Animals, Genetically Modified; Drosophila melanogaster; Excitatory Amino Acid Antagonists; Eye Color; Gene Expression; Kynurenic Acid; Kynurenine; Mercury Compounds; Microarray Analysis; Pupa; Signal Transduction; Tryptophan

2018
Kynurenine pathway changes in late-life depression.
    Journal of affective disorders, 2018, 08-01, Volume: 235

    Topics: Adult; Age Factors; Aged; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Tryptophan

2018
Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters.
    PloS one, 2018, Volume: 13, Issue:4

    Topics: Catalytic Domain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esters; Estradiol; Kynurenic Acid; Kynurenine; Models, Molecular; Molecular Docking Simulation; Molecular Mimicry; Sulfates; Transaminases

2018
Kynurenine Pathway in Autism Spectrum Disorders in Children.
    Neuropsychobiology, 2017, Volume: 76, Issue:2

    Topics: Autism Spectrum Disorder; Biomarkers; Child; Chromatography, High Pressure Liquid; Comorbidity; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan

2017
Sex Differences in Hippocampal Memory and Kynurenic Acid Formation Following Acute Sleep Deprivation in Rats.
    Scientific reports, 2018, 05-03, Volume: 8, Issue:1

    Topics: Animals; Cognition; Corticosterone; Female; Hippocampus; Kynurenic Acid; Kynurenine; Male; Memory; Rats; Rats, Wistar; Sex Characteristics; Sleep Deprivation; Tryptophan

2018
Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.
    Molecular neurobiology, 2019, Volume: 56, Issue:1

    Topics: Animals; Antidepressive Agents; Chronic Disease; Cytokines; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenic Acid; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stress, Psychological; Synaptic Transmission; Tryptophan

2019
Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts.
    Psychoneuroendocrinology, 2018, Volume: 94

    Topics: Adolescent; C-Reactive Protein; Child; Cohort Studies; Cross-Sectional Studies; Cytokines; Depression; Depressive Disorder; Female; Humans; Inflammation; Interferon-gamma; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Stress, Psychological; Tryptophan; Tumor Necrosis Factor-alpha

2018
Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes.
    Psychoneuroendocrinology, 2018, Volume: 95

    Topics: Adult; Biomarkers; C-Reactive Protein; CA1 Region, Hippocampal; CA2 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography, Liquid; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Hippocampus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan

2018
Simultaneous determination of tryptophan, kynurenine, kynurenic acid and two monoamines in rat plasma by HPLC-ECD/DAD.
    Journal of pharmaceutical and biomedical analysis, 2018, Sep-05, Volume: 158

    Topics: Amino Acids, Essential; Animals; Boron; Chemical Fractionation; Chromatography, High Pressure Liquid; Depression; Diamond; Electrochemical Techniques; Electrodes; Fluorescence; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Limit of Detection; Models, Animal; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Serotonin; Tryptophan

2018
Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: Relevance for schizophrenia.
    Neuropharmacology, 2018, Volume: 138

    Topics: Action Potentials; Animals; Antipsychotic Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mice, Knockout; Schizophrenia; Ventral Tegmental Area

2018
The Effects of Tryptophan Catabolites on Negative Symptoms and Deficit Schizophrenia are Partly Mediated by Executive Impairments: Results of Partial Least Squares Path Modeling.
    CNS & neurological disorders drug targets, 2018, Volume: 17, Issue:6

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Cognition Disorders; Executive Function; Female; Humans; Immunoglobulin A; Immunoglobulin M; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Neuropsychological Tests; Picolinic Acids; Psychiatric Status Rating Scales; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Tryptophan; Xanthurenates; Young Adult

2018
Alterations in the metabolism of tryptophan in patients with chronic hepatitis C six months after pegylated interferon-α 2a treatment.
    Psychoneuroendocrinology, 2018, Volume: 97

    Topics: Adult; Antiviral Agents; Depression; Depressive Disorder; Female; Hepatitis C; Hepatitis C, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Polyethylene Glycols; Recombinant Proteins; Tryptophan

2018
Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders.
    CNS & neurological disorders drug targets, 2018, Volume: 17, Issue:8

    Topics: 5-Hydroxytryptophan; Adolescent; Analysis of Variance; Autism Spectrum Disorder; Brain-Derived Neurotrophic Factor; Child; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan

2018
Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
    Medical hypotheses, 2018, Volume: 118

    Topics: Animals; Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Kynurenic Acid; Kynurenine; Male; Models, Theoretical; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Wistar; Tryptophan

2018
Dietary hydrogenated vegetable fat exacerbates the activation of kynurenine pathway caused by peripheral lipopolysaccharide immune challenge in aged mice.
    Chemico-biological interactions, 2018, Sep-25, Volume: 293

    Topics: Animals; Corpus Striatum; Corticosterone; Dietary Fats; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Lipopolysaccharides; Locomotion; Male; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Transaminases; Tryptophan; Tumor Necrosis Factor-alpha; Vegetables

2018
Tryptophan, kynurenine, kynurenic acid concentrations and indoleamine 2,3-dioxygenase activity in serum and milk of dairy cows with subclinical mastitis caused by coagulase-negative staphylococci.
    Reproduction in domestic animals = Zuchthygiene, 2018, Volume: 53, Issue:6

    Topics: Animals; Case-Control Studies; Cattle; Excitatory Amino Acid Antagonists; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Mastitis, Bovine; Milk; Poland; Staphylococcal Infections; Staphylococcus; Tryptophan

2018
[Correlation between kynurenine metabolites and postpartum depression].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2018, Jul-28, Volume: 43, Issue:7

    Topics: Biomarkers; Cesarean Section; China; Depression, Postpartum; Female; Humans; Incidence; Kynurenic Acid; Kynurenine; Pregnancy; Quinolinic Acid

2018
A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats.
    Journal of visualized experiments : JoVE, 2018, 08-19, Issue:138

    Topics: Animals; Chromatography, High Pressure Liquid; Cognition; Kynurenic Acid; Kynurenine; Male; Rats; Sleep

2018
Antidepressant effect of repeated ketamine administration on kynurenine pathway metabolites in patients with unipolar and bipolar depression.
    Brain, behavior, and immunity, 2018, Volume: 74

    Topics: Administration, Intravenous; Adult; Antidepressive Agents; Bipolar Disorder; China; Chromatography, Liquid; Depression; Depressive Disorder; Female; Humans; Ketamine; Kynurenic Acid; Kynurenine; Male; Tandem Mass Spectrometry; Tryptophan

2018
Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia.
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:11

    Topics: Animals; Brain; Cognitive Dysfunction; Female; Genotype; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Inbred C57BL; Mice, Knockout; Placenta; Pregnancy; Quinolinic Acid; Schizophrenia

2018
Ketamine and depression: A special kase for kynurenic acid?
    Brain, behavior, and immunity, 2019, Volume: 75

    Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder; Humans; Ketamine; Kynurenic Acid; Kynurenine

2019
Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder.
    Psychoneuroendocrinology, 2019, Volume: 101

    Topics: Adult; Chromatography, Liquid; Cognition; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tryptophan

2019
Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age.
    Oxidative medicine and cellular longevity, 2018, Volume: 2018

    Topics: Aged; Aged, 80 and over; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Quinolinic Acid; Tryptophan

2018
Presence of kynurenic acid in alcoholic beverages - Is this good news, or bad news?
    Medical hypotheses, 2019, Volume: 122

    Topics: Adult; Alcoholic Beverages; Beer; Ethanol; Female; Fermentation; Fluorometry; Food Analysis; Healthy Volunteers; Humans; Kynurenic Acid; Kynurenine; Male; Wine; Young Adult

2019
Investigating KYNA production and kynurenergic manipulation on acute mouse brain slice preparations.
    Brain research bulletin, 2019, Volume: 146

    Topics: Animals; Brain; Immunohistochemistry; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred C57BL; Transaminases

2019
Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms.
    Neurotoxicity research, 2019, Volume: 35, Issue:3

    Topics: Adenosine Triphosphate; Brain; Cell Survival; HEK293 Cells; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; NAD; Neurons; Oxidative Stress; Primary Cell Culture; Quinolinic Acid; Reactive Oxygen Species

2019
Acute liver failure increases kynurenic acid production in rat brain via changes in tryptophan metabolism in the periphery.
    Neuroscience letters, 2019, 05-14, Volume: 701

    Topics: Animals; Kynurenic Acid; Kynurenine; Liver Failure, Acute; Male; Rats; Rats, Wistar; Thioacetamide

2019
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
    Schizophrenia research, 2019, Volume: 208

    Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prodromal Symptoms; Psychotic Disorders; Quinolinic Acid; Risk; Schizophrenia; Tryptophan; Xanthurenates; Young Adult

2019
Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia.
    Molecular psychiatry, 2020, Volume: 25, Issue:11

    Topics: Adult; Attention; Cytokines; Female; Humans; Inflammation Mediators; Kynurenic Acid; Kynurenine; Male; Middle Aged; Prefrontal Cortex; Schizophrenia; Young Adult

2020
Assessment of Prenatal Kynurenine Metabolism Using Tissue Slices: Focus on the Neosynthesis of Kynurenic Acid in Mice.
    Developmental neuroscience, 2019, Volume: 41, Issue:1-2

    Topics: Animals; Brain; Female; Fetus; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Knockout; Organ Culture Techniques; Placenta; Pregnancy; Transaminases

2019
Changes in tryptophan and kynurenine pathway metabolites in the blood of children treated with ketogenic diet for refractory epilepsy.
    Seizure, 2019, Volume: 69

    Topics: Adolescent; Biomarkers; Child; Child, Preschool; Diet, Ketogenic; Drug Resistant Epilepsy; Female; Humans; Infant; Kynurenic Acid; Kynurenine; Male; Prospective Studies; Treatment Outcome; Tryptophan

2019
Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms.
    Journal of affective disorders, 2019, 08-01, Volume: 255

    Topics: Adult; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Postpartum Period; Pregnancy; Psychiatric Status Rating Scales; Tryptophan

2019
Kinetic evaluation of the formation of tryptophan derivatives in the kynurenine pathway during wort fermentation using Saccharomyces pastorianus and Saccharomyces cerevisiae.
    Food chemistry, 2019, Nov-01, Volume: 297

    Topics: Beer; Biosynthetic Pathways; Fermentation; Kinetics; Kynurenic Acid; Kynurenine; Logistic Models; Neuroprotective Agents; Plant Preparations; Saccharomyces; Saccharomyces cerevisiae; Triticum; Tryptophan

2019
Development of an underivatized LC-MS/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats.
    Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174

    Topics: Animals; Blood Chemical Analysis; Chromatography, Liquid; Depression; Disease Models, Animal; Glutamic Acid; Hippocampus; Kynurenic Acid; Kynurenine; Limit of Detection; Linear Models; Male; Neurotransmitter Agents; Phenylalanine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Tryptophan; Urinalysis

2019
Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues.
    Scientific reports, 2019, 07-15, Volume: 9, Issue:1

    Topics: Animals; Brain; Computational Biology; Glycyrrhizic Acid; Humans; Isoenzymes; Kynurenic Acid; Kynurenine; Mice; Molecular Docking Simulation; Pyridoxal Phosphate; Receptors, Nicotinic; Transaminases

2019
Plasma xanthurenic acid in a context of insulin resistance and obesity in schizophrenia.
    Schizophrenia research, 2019, Volume: 211

    Topics: Case-Control Studies; Humans; Insulin Resistance; Kynurenic Acid; Kynurenine; Obesity; Schizophrenia; Xanthurenates

2019
Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice.
    Molecular psychiatry, 2020, Volume: 25, Issue:11

    Topics: Animals; Case-Control Studies; Dopamine; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Humans; Kynurenic Acid; Kynurenine; Male; Mice; Schizophrenia; Schizophrenic Psychology; Serotonin; Tryptophan

2020
Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma.
    Scientific reports, 2019, 08-21, Volume: 9, Issue:1

    Topics: B7-H1 Antigen; CD4-Positive T-Lymphocytes; Cell Line; Cell Proliferation; Coculture Techniques; Culture Media, Conditioned; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Kynurenine; Melanoma; Melanoma, Cutaneous Malignant; Metabolic Networks and Pathways; Metabolomics; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Tryptophan; Tumor Microenvironment; Up-Regulation

2019
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
    The Journal of infectious diseases, 2020, 01-14, Volume: 221, Issue:3

    Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Inflammation; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; Neopterin; Quinolinic Acid; Tryptophan; Waist-Hip Ratio

2020
Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy.
    Brain, behavior, and immunity, 2020, Volume: 83

    Topics: 3-Hydroxyanthranilic Acid; Affect; Case-Control Studies; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Tryptophan; Xanthurenates

2020
The kynurenine pathway and bipolar disorder: intersection of the monoaminergic and glutamatergic systems and immune response.
    Molecular psychiatry, 2021, Volume: 26, Issue:8

    Topics: Adolescent; Adult; Aged; Bipolar Disorder; Humans; Immunity; Kynurenic Acid; Kynurenine; Middle Aged; Tryptophan; Young Adult

2021
Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020, Volume: 45, Issue:6

    Topics: Depression; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan

2020
The relationship between plasma serotonin and kynurenine pathway metabolite levels and the treatment response to escitalopram and desvenlafaxine.
    Brain, behavior, and immunity, 2020, Volume: 87

    Topics: Citalopram; Depressive Disorder, Major; Desvenlafaxine Succinate; Humans; Kynurenic Acid; Kynurenine; Plasma; Serotonin

2020
The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women.
    Brain and behavior, 2020, Volume: 10, Issue:4

    Topics: Adult; Alleles; Cesarean Section; Depression, Postpartum; Female; Genotype; Humans; Kynurenic Acid; Kynurenine; Polymorphism, Single Nucleotide; Pregnancy; Quinolinic Acid; Transaminases

2020
Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task.
    Psychopharmacology, 2020, Volume: 237, Issue:6

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Brain; Kynurenic Acid; Kynurenine; Male; Memory, Short-Term; Nicotine; Psychomotor Performance; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

2020
Preliminary comparative analysis of kynurenine pathway metabolites in chronic ketamine users, schizophrenic patients, and healthy controls.
    Human psychopharmacology, 2020, Volume: 35, Issue:4

    Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Ketamine; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Substance-Related Disorders; Tandem Mass Spectrometry; Time Factors; Tryptophan; Young Adult

2020
Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity.
    Progress in neuro-psychopharmacology & biological psychiatry, 2020, 08-30, Volume: 102

    Topics: Adolescent; Adult; Aged; Aging; Alcohol Abstinence; Alcoholism; Body Mass Index; Cross-Sectional Studies; Diagnosis, Dual (Psychiatry); Female; Humans; Kynurenic Acid; Kynurenine; Male; Mental Disorders; Metabolic Networks and Pathways; Middle Aged; Serotonin; Sex Characteristics; Tryptophan; Young Adult

2020
Rickettsial pathogen uses arthropod tryptophan pathway metabolites to evade reactive oxygen species in tick cells.
    Cellular microbiology, 2020, Volume: 22, Issue:10

    Topics: Anaplasma phagocytophilum; Animals; Hemin; Host-Pathogen Interactions; Hydrolases; Ixodes; Kynurenic Acid; Kynurenine; NADP; Reactive Oxygen Species; RNA Interference; Transaminases; Tryptophan; Tryptophan Oxygenase; Up-Regulation; Xanthurenates

2020
Neural production of kynurenic acid in
    Genes & development, 2020, 08-01, Volume: 34, Issue:15-16

    Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Eating; Kynurenic Acid; Kynurenine; Large Neutral Amino Acid-Transporter 1; Learning; Mutation; Neurons

2020
Characterization of kynurenine pathway in patients with diarrhea-predominant irritable bowel syndrome.
    European journal of histochemistry : EJH, 2020, Jun-19, Volume: 64, Issue:s2

    Topics: Diarrhea; Female; Humans; Intestinal Mucosa; Irritable Bowel Syndrome; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate

2020
Aortic stiffness-Is kynurenic acid a novel marker? Cross-sectional study in patients with persistent atrial fibrillation.
    PloS one, 2020, Volume: 15, Issue:7

    Topics: Adult; Aorta; Atherosclerosis; Atrial Fibrillation; Biomarkers; Cross-Sectional Studies; Echocardiography; Female; Heart Ventricles; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Regression Analysis; Risk Factors; Vascular Stiffness

2020
N-Acetylcysteine Inhibits Kynurenine Aminotransferase II.
    Neuroscience, 2020, 09-15, Volume: 444

    Topics: Acetylcysteine; Animals; Kynurenic Acid; Kynurenine; Rats; Transaminases

2020
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans.
    Journal of internal medicine, 2021, Volume: 289, Issue:1

    Topics: Carotid Artery Diseases; Down-Regulation; Humans; Inflammation; Kynurenic Acid; Kynurenine; Macrophages; Plaque, Atherosclerotic; Tryptophan; Up-Regulation

2021
Serum Kynurenines Correlate With Depressive Symptoms and Disability in Poststroke Patients: A Cross-sectional Study.
    Neurorehabilitation and neural repair, 2020, Volume: 34, Issue:10

    Topics: Adult; Aged; Case-Control Studies; Cross-Sectional Studies; Depression; Female; Functional Status; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Psychiatric Status Rating Scales; Severity of Illness Index; Stroke

2020
The role of the kynurenine pathway and quinolinic acid in adolescent major depressive disorder.
    International journal of clinical practice, 2021, Volume: 75, Issue:4

    Topics: Adolescent; Cross-Sectional Studies; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid

2021
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder.
    The International journal of neuroscience, 2022, Volume: 132, Issue:8

    Topics: Autism Spectrum Disorder; Child, Preschool; Humans; Infant; Kynurenic Acid; Kynurenine; Tandem Mass Spectrometry; Tryptophan

2022
Alterations in plasma kynurenine pathway metabolites in children and adolescents with bipolar disorder and unaffected offspring of bipolar parents: A preliminary study.
    Bipolar disorders, 2021, Volume: 23, Issue:7

    Topics: Adolescent; Adult; Bipolar Disorder; Child; Humans; Kynurenic Acid; Kynurenine; Parents; Tryptophan

2021
Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells-In Vitro Studies.
    International journal of molecular sciences, 2020, Oct-26, Volume: 21, Issue:21

    Topics: Basic Helix-Loop-Helix Transcription Factors; Carbazoles; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase 4; Gene Expression Regulation, Neoplastic; Humans; Kynurenic Acid; Kynurenine; Melanocytes; Melanoma; Phosphorylation; Receptors, Aryl Hydrocarbon; Retinoblastoma Protein

2020
Central levels of tryptophan metabolites in subjects with bipolar disorder.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2021, Volume: 43

    Topics: Bipolar Disorder; Chromatography, Liquid; Humans; Kynurenic Acid; Kynurenine; Tandem Mass Spectrometry; Tryptophan

2021
Kynurenic Acid Protects Against Reactive Glial-associated Reductions in the Complexity of Primary Cortical Neurons.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2021, Volume: 16, Issue:3

    Topics: Animals; Kynurenic Acid; Kynurenine; Neuroglia; Neurons; Quinolinic Acid; Rats

2021
The role of anthranilic acid in the increase of depressive symptoms and major depressive disorder during treatment for hepatitis C with pegylated interferon-α2a and oral ribavirin.
    Journal of psychiatry & neuroscience : JPN, 2021, 01-18, Volume: 46, Issue:1

    Topics: Adult; Antiviral Agents; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Hepatitis C, Chronic; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; ortho-Aminobenzoates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Tryptophan

2021
Tryptophan Derivatives by
    International journal of molecular sciences, 2021, Jan-05, Volume: 22, Issue:1

    Topics: Chromatography, Liquid; Culture Media; Fermentation; Glycine max; Humans; Kynurenic Acid; Kynurenine; Melatonin; Neurotransmitter Agents; Saccharomyces cerevisiae; Signal Transduction; Tandem Mass Spectrometry; Tryptophan

2021
Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma.
    International journal of molecular sciences, 2021, Jan-21, Volume: 22, Issue:3

    Topics: Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Genetic Diseases, Inborn; Glaucoma; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Metabolic Networks and Pathways; Mice; Retina; Species Specificity; Tryptophan

2021
Association of the kynurenine pathway metabolites with clinical, cognitive features and IL-1β levels in patients with schizophrenia spectrum disorder and their siblings.
    Schizophrenia research, 2021, Volume: 229

    Topics: Cognition; Humans; Kynurenic Acid; Kynurenine; Schizophrenia; Siblings

2021
Chronic restraint stress induced changes in colonic homeostasis-related indexes and tryptophan-kynurenine metabolism in rats.
    Journal of proteomics, 2021, 05-30, Volume: 240

    Topics: Animals; Colon; Homeostasis; Humans; Kynurenic Acid; Kynurenine; Rats; Tryptophan

2021
Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia.
    Translational psychiatry, 2021, 04-01, Volume: 11, Issue:1

    Topics: Humans; Kynurenic Acid; Kynurenine; Memory, Short-Term; Quinolinic Acid; Schizophrenia; Tryptophan

2021
Sex-specific alterations in NAD+ metabolism in 3xTg Alzheimer's disease mouse brain assessed by quantitative targeted LC-MS.
    Journal of neurochemistry, 2021, Volume: 159, Issue:2

    Topics: Alzheimer Disease; Animals; Chromatography, High Pressure Liquid; Encephalitis; Female; Humans; Kynurenic Acid; Kynurenine; Male; Metabolome; Mice; Mice, Transgenic; NAD; Neuroprotection; Nicotinamide Mononucleotide; Sex Characteristics; Tandem Mass Spectrometry

2021
Autoimmune Concept of Schizophrenia: Historical Roots and Current Facets.
    Psychiatria Danubina, 2021,Spring, Volume: 33, Issue:1

    Topics: Antipsychotic Agents; Humans; Kynurenic Acid; Kynurenine; Psychotic Disorders; Schizophrenia

2021
The kynurenine pathway in schizophrenia and other mental disorders: Insight from meta-analyses on the peripheral blood levels of tryptophan and related metabolites.
    Schizophrenia research, 2021, Volume: 232

    Topics: Bipolar Disorder; Humans; Kynurenic Acid; Kynurenine; Schizophrenia; Tryptophan

2021
Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat.
    Scientific reports, 2021, 05-27, Volume: 11, Issue:1

    Topics: Adult; Aged; Chromatography, High Pressure Liquid; Exercise; Female; Humans; Kynurenic Acid; Kynurenine; Male; Mass Spectrometry; Middle Aged; Sweat; Tryptophan

2021
Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period.
    The journal of headache and pain, 2021, Jun-25, Volume: 22, Issue:1

    Topics: Adult; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Pituitary Adenylate Cyclase-Activating Polypeptide; Prognosis; Tandem Mass Spectrometry

2021
Methylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children.
    Psychiatry research, 2021, Volume: 303

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Humans; Kynurenic Acid; Kynurenine; Methylphenidate; Tryptophan

2021
A Role for Xanthurenic Acid in the Control of Brain Dopaminergic Activity.
    International journal of molecular sciences, 2021, Jun-28, Volume: 22, Issue:13

    Topics: Animals; Brain; Dopamine; Kynurenic Acid; Kynurenine; Male; Rats; Rats, Wistar; Xanthurenates

2021
The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation.
    Brain, behavior, and immunity, 2021, Volume: 97

    Topics: Depression; Depressive Disorder, Major; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan

2021
UVB Radiation and Selected Tryptophan-Derived AhR Ligands-Potential Biological Interactions in Melanoma Cells.
    International journal of molecular sciences, 2021, Jul-13, Volume: 22, Issue:14

    Topics: Basic Helix-Loop-Helix Transcription Factors; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Ligands; Melanoma; Receptors, Aryl Hydrocarbon; Tumor Cells, Cultured; Ultraviolet Rays

2021
A single prenatal lipopolysaccharide injection has acute, but not long-lasting, effects on cerebral kynurenine pathway metabolism in mice.
    The European journal of neuroscience, 2021, Volume: 54, Issue:6

    Topics: Animals; Female; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Mice; Placenta; Pregnancy; Quinolinic Acid

2021
Kynurenine pathway in post-mortem prefrontal cortex and cerebellum in schizophrenia: relationship with monoamines and symptomatology.
    Journal of neuroinflammation, 2021, Sep-12, Volume: 18, Issue:1

    Topics: Cerebellum; Humans; Kynurenic Acid; Kynurenine; Prefrontal Cortex; Schizophrenia

2021
Increase of Kynurenic Acid after Encephalomyocarditis Virus Infection and Its Significances.
    Neuro-Signals, 2021, 09-30, Volume: 29, Issue:1

    Topics: Animals; Biomarkers; Encephalomyocarditis virus; Kynurenic Acid; Kynurenine; Neopterin; Swine

2021
Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms.
    Translational psychiatry, 2021, 10-01, Volume: 11, Issue:1

    Topics: Alcoholism; Gastrointestinal Microbiome; Humans; Inflammation; Kynurenic Acid; Kynurenine; Quinolinic Acid

2021
Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease.
    Cell reports. Medicine, 2021, 10-19, Volume: 2, Issue:10

    Topics: Adolescent; Adult; Aged; Chemokine CXCL9; Female; Fibrosis; Gene Expression Regulation; Graft vs Host Disease; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-18; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Leukemia; Lymphoma; Male; Metabolic Networks and Pathways; Middle Aged; ortho-Aminobenzoates; Retrospective Studies; Riboflavin; Severity of Illness Index; Signal Transduction; Stem Cell Transplantation; Transplantation, Homologous; Tryptophan; Vitamin B 6

2021
Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition.
    Behavioural brain research, 2022, 02-10, Volume: 418

    Topics: Adult; Anxiety; Bile Acids and Salts; Chromatography, Liquid; Depression; Dietary Fiber; Fatty Acids, Volatile; Feasibility Studies; Feces; Female; Gastrointestinal Microbiome; Humans; Kynurenic Acid; Kynurenine; Mental Health; Perinatal Care; Pilot Projects; Pregnancy; Tandem Mass Spectrometry; Tryptophan

2022
The immune-kynurenine pathway in social anxiety disorder.
    Brain, behavior, and immunity, 2022, Volume: 99

    Topics: Female; Humans; Kynurenic Acid; Kynurenine; Male; Phobia, Social; Schizophrenia; Tryptophan

2022
Serum kynurenine metabolites might not be associated with risk factors of treatment-resistant schizophrenia.
    Journal of psychiatric research, 2022, Volume: 145

    Topics: Diffusion Tensor Imaging; Humans; Kynurenic Acid; Kynurenine; Risk Factors; Schizophrenia; Schizophrenia, Treatment-Resistant

2022
The Role of Kynurenines in Cognitive Dysfunction in Bipolar Disorder.
    Neuropsychobiology, 2022, Volume: 81, Issue:3

    Topics: Bipolar Disorder; Cognitive Dysfunction; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan

2022
Peripheral and central kynurenine pathway abnormalities in major depression.
    Brain, behavior, and immunity, 2022, Volume: 101

    Topics: Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid

2022
Alterations in the kynurenine pathway and excitatory amino acid transporter-2 in depression with and without psychosis: Evidence of a potential astrocyte pathology.
    Journal of psychiatric research, 2022, Volume: 147

    Topics: Astrocytes; Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Psychotic Disorders

2022
Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis.
    Journal of clinical laboratory analysis, 2022, Volume: 36, Issue:3

    Topics: Adult; Aged; COVID-19; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Picolinic Acids; Prognosis; Quinolinic Acid; SARS-CoV-2; Tryptophan

2022
Kynurenine and kynurenic acid: Two human neuromodulators found in Cannabis sativa L.
    Journal of pharmaceutical and biomedical analysis, 2022, Mar-20, Volume: 211

    Topics: Animals; Cannabis; Humans; Kynurenic Acid; Kynurenine; Neurotransmitter Agents; Tryptophan

2022
The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity.
    The Journal of clinical endocrinology and metabolism, 2022, 05-17, Volume: 107, Issue:6

    Topics: Adiposity; Adult; Birth Weight; Cesarean Section; Child; Child, Preschool; Female; Fetal Blood; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; Longitudinal Studies; Pediatric Obesity; Pregnancy; Prospective Studies; Quinolinic Acid

2022
Disturbance of neurotransmitter metabolism in drug-naïve, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts.
    European archives of psychiatry and clinical neuroscience, 2022, Volume: 272, Issue:7

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Adult; Biomarkers; Depressive Disorder, Major; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Methoxyhydroxyphenylglycol; Neurotransmitter Agents; Norepinephrine; Serotonin; Tryptophan; Vanilmandelic Acid

2022
Curcumin Facilitates Aryl Hydrocarbon Receptor Activation to Ameliorate Inflammatory Astrogliosis.
    Molecules (Basel, Switzerland), 2022, Apr-13, Volume: 27, Issue:8

    Topics: Animals; Curcumin; Gliosis; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenic Acid; Kynurenine; Ligands; Lipopolysaccharides; Molecular Docking Simulation; Rats; Receptors, Aryl Hydrocarbon; Tumor Necrosis Factor-alpha

2022
Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study.
    Clinical oral investigations, 2022, Volume: 26, Issue:9

    Topics: Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2022
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease.
    Amino acids, 2022, Volume: 54, Issue:6

    Topics: Behcet Syndrome; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2022
Kynurenine pathway and autism spectrum phenotypes: an investigation among adults with autism spectrum disorder and their first-degree relatives.
    CNS spectrums, 2023, Volume: 28, Issue:3

    Topics: Autism Spectrum Disorder; Autistic Disorder; Humans; Kynurenic Acid; Kynurenine; Phenotype; Tryptophan

2023
Perivascular brown adipocytes-derived kynurenic acid relaxes blood vessel via endothelium PI3K-Akt-eNOS pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 150

    Topics: Adipocytes, Brown; Animals; Endothelial Cells; Endothelium; Kynurenic Acid; Kynurenine; Mice; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt

2022
Analog of kynurenic acid decreases tau pathology by modulating astrogliosis in rat model for tauopathy.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 152

    Topics: Animals; Gliosis; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Neuroprotective Agents; Rats; Rats, Inbred SHR; Tauopathies

2022
Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Cross-Sectional Studies; Female; Humans; Kynurenic Acid; Kynurenine; Polycystic Ovary Syndrome; Quinolinic Acid; Serotonin; Tryptophan

2022
Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress.
    Journal of neural transmission (Vienna, Austria : 1996), 2022, Volume: 129, Issue:8

    Topics: Anxiety; Biomarkers; COVID-19; Depression; Humans; Kynurenic Acid; Kynurenine; Survivors; Tryptophan

2022
C-Reactive protein and the kynurenic acid to quinolinic acid ratio are independently associated with white matter integrity in major depressive disorder.
    Brain, behavior, and immunity, 2022, Volume: 105

    Topics: C-Reactive Protein; Depressive Disorder, Major; Diffusion Tensor Imaging; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Sexually Transmitted Diseases; White Matter

2022
Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα.
    Scientific reports, 2022, 07-19, Volume: 12, Issue:1

    Topics: Animals; Endothelial Cells; Humans; Hypoxia; Interleukin-6; Kynurenic Acid; Kynurenine; Monocrotaline; Pulmonary Arterial Hypertension; Quinolinic Acid; Rats; Receptors, Interleukin-6

2022
Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study.
    European journal of nutrition, 2022, Volume: 61, Issue:8

    Topics: Calcium; Child; Child Health; Cross-Sectional Studies; Depression; Docosahexaenoic Acids; Eicosapentaenoic Acid; Female; Humans; Isoflavones; Japan; Kynurenic Acid; Kynurenine; Pregnancy; Pregnancy Complications; Prevalence; Quinolinic Acids; Serotonin; Surveys and Questionnaires; Tobacco Smoke Pollution; Tryptophan; Vitamin D

2022
Kynurenine metabolism is altered in mdx mice: a potential muscle to brain connection.
    Experimental physiology, 2022, Volume: 107, Issue:9

    Topics: Animals; Brain; Disease Models, Animal; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Peroxisome Proliferator-Activated Receptors; Tumor Necrosis Factor-alpha

2022
A sensitive UPLC-MS/MS method for the simultaneous determination of the metabolites in the tryptophan pathway in rat plasma.
    Journal of pharmaceutical and biomedical analysis, 2022, Sep-20, Volume: 219

    Topics: Acute Kidney Injury; Animals; Biomarkers; Chromatography, High Pressure Liquid; Chromatography, Liquid; Hydroxyindoleacetic Acid; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Rats; Tandem Mass Spectrometry; TRPM Cation Channels; Tryptophan

2022
Tryptophan-kynurenine metabolism during acute alcohol withdrawal in patients with alcohol use disorder: The role of immune activation.
    Alcoholism, clinical and experimental research, 2022, Volume: 46, Issue:9

    Topics: Alcohol Drinking; Alcoholism; Biomarkers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Neopterin; Quinolinic Acid; Substance Withdrawal Syndrome; Tryptophan

2022
Elevated salivary kynurenic acid levels related to enlarged choroid plexus and severity of clinical phenotypes in treatment-resistant schizophrenia.
    Brain, behavior, and immunity, 2022, Volume: 106

    Topics: Antipsychotic Agents; Choroid Plexus; Humans; Kynurenic Acid; Kynurenine; Phenotype; Schizophrenia; Schizophrenia, Treatment-Resistant

2022
Altered Tryptophan Metabolism on the Kynurenine Pathway in Depressive Patients with Small Intestinal Bacterial Overgrowth.
    Nutrients, 2022, Aug-06, Volume: 14, Issue:15

    Topics: Chromatography, Liquid; Humans; Kynurenic Acid; Kynurenine; Rifaximin; Tandem Mass Spectrometry; Tryptophan

2022
Binge-like mephedrone treatment induces memory impairment concomitant with brain kynurenic acid reduction in mice.
    Toxicology and applied pharmacology, 2022, 11-01, Volume: 454

    Topics: Adolescent; Animals; Humans; Kynurenic Acid; Kynurenine; Methamphetamine; Mice; Transaminases; Tryptophan

2022
Simultaneous determination of serum tryptophan metabolites in an older Chinese population.
    Biomedical chromatography : BMC, 2023, Volume: 37, Issue:1

    Topics: Chromatography, High Pressure Liquid; East Asian People; Humans; Kynurenic Acid; Kynurenine; Serotonin; Tandem Mass Spectrometry; Tryptophan

2023
Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis.
    Scientific reports, 2022, 09-16, Volume: 12, Issue:1

    Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Lymnaea; Quinolinic Acid; Tryptophan

2022
Deficiency of kynurenine 3-monooxygenase exacerbates impairment of prepulse inhibition induced by phencyclidine.
    Biochemical and biophysical research communications, 2022, 11-12, Volume: 629

    Topics: Animals; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Inbred C57BL; Phencyclidine; Prepulse Inhibition; Quinolinic Acid; RNA, Messenger

2022
2-month ketogenic diet preferentially alters skeletal muscle and augments cognitive function in middle aged female mice.
    Aging cell, 2022, Volume: 21, Issue:10

    Topics: Animals; Cognition; Diet, Ketogenic; Female; Kynurenic Acid; Kynurenine; Male; Mice; Muscle, Skeletal; Neurotoxins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Quinolinic Acid

2022
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
    EBioMedicine, 2022, Volume: 84

    Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epilepsy; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Spasm; Tandem Mass Spectrometry; Tryptophan

2022
Direct Fluorescence Evaluation of d-Amino Acid Oxidase Activity Using a Synthetic d-Kynurenine Derivative.
    Analytical chemistry, 2022, 10-25, Volume: 94, Issue:42

    Topics: Animals; D-Amino-Acid Oxidase; Fluorometry; Kynurenic Acid; Kynurenine; Schizophrenia; Swine

2022
Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder.
    Journal of psychosomatic research, 2022, Volume: 163

    Topics: Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Pain; Quinolinic Acid; Serotonin; Tandem Mass Spectrometry; Tryptophan

2022
Associations between circulating interferon and kynurenine/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE.
    Lupus science & medicine, 2022, Volume: 9, Issue:1

    Topics: Cognitive Dysfunction; Humans; Interferons; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; Quinolinic Acid; Tryptophan

2022
Dysregulation of tryptophan metabolism and distortion of cell signaling after oral exposure to ethanol and Kynurenic acid.
    Gene, 2023, Feb-05, Volume: 852

    Topics: Adult; Animals; Ethanol; Humans; Kynurenic Acid; Kynurenine; Mice; Signal Transduction; Tryptophan

2023
Differential Levels of Tryptophan-Kynurenine Pathway Metabolites in the Hippocampus, Anterior Temporal Lobe, and Neocortex in an Animal Model of Temporal Lobe Epilepsy.
    Cells, 2022, 11-10, Volume: 11, Issue:22

    Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kynurenic Acid; Kynurenine; Neocortex; Rats; Temporal Lobe; Tryptophan

2022
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease.
    Kardiologiia, 2022, Nov-30, Volume: 62, Issue:11

    Topics: Atherosclerosis; Coronary Artery Disease; Humans; Hydroxyindoleacetic Acid; Hypertension; Kynurenic Acid; Kynurenine; Quinolinic Acid; Serotonin; Tryptophan

2022
Obesity-Induced Memory Deficits in Female Rats Are Oestrous Cycle Dependent and Linked to Impaired Brain Kynurenine Pathway Metabolism.
    Neuroendocrinology, 2023, Volume: 113, Issue:5

    Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Memory Disorders; NAD; Obesity; Rats; Tryptophan

2023
Tryptophan catabolites and depression in the general population: results from the Gutenberg Health Study.
    BMC psychiatry, 2023, 01-11, Volume: 23, Issue:1

    Topics: Biomarkers; C-Reactive Protein; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Tryptophan

2023
The influence of cyclooxygenase inhibitors on kynurenic acid production in rat kidney: a novel path for kidney protection?
    Pharmacological reports : PR, 2023, Volume: 75, Issue:2

    Topics: Acetaminophen; Animals; Cyclooxygenase Inhibitors; Kidney; Kynurenic Acid; Kynurenine; Rats; Transaminases

2023
Simultaneous measurement of kynurenine metabolites and explorative metabolomics using liquid chromatography-mass spectrometry: A novel accurate method applied to serum and plasma samples from a large healthy cohort.
    Journal of pharmaceutical and biomedical analysis, 2023, Apr-01, Volume: 227

    Topics: Chromatography, Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; Tandem Mass Spectrometry; Tryptophan; Young Adult

2023
Beneficial Effect of Increased Tryptophan Intake on Its Metabolism and Mental State of the Elderly.
    Nutrients, 2023, Feb-07, Volume: 15, Issue:4

    Topics: Aged; Chromatography, Liquid; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Tryptophan

2023
Changes in Tryptophan Metabolism on Serotonin and Kynurenine Pathways in Patients with Irritable Bowel Syndrome.
    Nutrients, 2023, Mar-03, Volume: 15, Issue:5

    Topics: Chromatography, Liquid; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Kynurenic Acid; Kynurenine; Serotonin; Tandem Mass Spectrometry; Tryptophan

2023
Modulating the Kynurenine pathway or sequestering toxic 3-hydroxykynurenine protects the retina from light-induced damage in Drosophila.
    PLoS genetics, 2023, Volume: 19, Issue:3

    Topics: Animals; Drosophila; Drosophila melanogaster; Kynurenic Acid; Kynurenine; Retina

2023
Cluster headache and kynurenines.
    The journal of headache and pain, 2023, Apr-05, Volume: 24, Issue:1

    Topics: Cluster Headache; Humans; Kynurenic Acid; Kynurenine; Neuroinflammatory Diseases; Tryptophan

2023
The association between inflammation and kynurenine pathway metabolites in electroconvulsive therapy for schizophrenia: Implications for clinical efficacy.
    Brain, behavior, and immunity, 2023, Volume: 113

    Topics: Electroconvulsive Therapy; Humans; Interleukin-18; Kynurenic Acid; Kynurenine; RNA, Messenger; Schizophrenia; Treatment Outcome; Tryptophan

2023
Relationship of tryptophan metabolites with the type and severity of multiple sclerosis.
    Multiple sclerosis and related disorders, 2023, Volume: 77

    Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Mammals; Multiple Sclerosis; Quinolinic Acid; Tryptophan

2023
LC-MS/MS-based quantification of tryptophan, kynurenine, and kynurenic acid in human placental, fetal membranes, and umbilical cord samples.
    Scientific reports, 2023, 08-02, Volume: 13, Issue:1

    Topics: Chromatography, Liquid; Extraembryonic Membranes; Female; Humans; Kynurenic Acid; Kynurenine; Placenta; Pregnancy; Reproducibility of Results; Tandem Mass Spectrometry; Tryptophan; Umbilical Cord

2023
Kynurenic Acid Levels and Kynurenine Aminotransferase I, II and III Activities in Ganglia, Heart and Liver of Snail Helix Pomatia.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2023, Aug-18, Volume: 57, Issue:4

    Topics: Animals; Biotin; Ganglia; Glutamic Acid; Kynurenic Acid; Kynurenine; Liver; Mammals; Rats; Transaminases

2023
Lower levels of the neuroprotective tryptophan metabolite, kynurenic acid, in users of estrogen contraceptives.
    Scientific reports, 2023, 09-29, Volume: 13, Issue:1

    Topics: Contraceptives, Oral, Hormonal; Estrogens; Female; Humans; Kynurenic Acid; Kynurenine; Pregnancy; Pyridoxine; Tryptophan; Vitamin B 6

2023
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.
    Diabetes care, 2023, Dec-01, Volume: 46, Issue:12

    Topics: Diabetes Mellitus, Type 2; Disease Progression; Humans; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Tryptophan

2023
Differential Effects of Hypothermia and SZR72 on Cerebral Kynurenine and Kynurenic Acid in a Piglet Model of Hypoxic-Ischemic Encephalopathy.
    International journal of molecular sciences, 2023, Sep-25, Volume: 24, Issue:19

    Topics: Animals; Asphyxia; Hypothermia; Hypoxia-Ischemia, Brain; Kynurenic Acid; Kynurenine; Swine; Tryptophan

2023
The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study.
    Journal of the neurological sciences, 2023, Nov-15, Volume: 454

    Topics: Biomarkers; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Male; Prospective Studies; Stroke

2023
Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia.
    Biomolecules, 2023, 09-26, Volume: 13, Issue:10

    Topics: Case-Control Studies; Female; Humans; Insulin Resistance; Kynurenic Acid; Kynurenine; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Tryptophan

2023
Longitudinal associations of macronutrient and micronutrient intake with plasma kynurenines in colorectal cancer survivors up to 12 months posttreatment.
    The American journal of clinical nutrition, 2023, Volume: 118, Issue:5

    Topics: Eating; Humans; Kynurenic Acid; Kynurenine; Micronutrients; Neoplasms; Nutrients; Prospective Studies; Quality of Life; Survivors; Tryptophan

2023
Kynurenine, Kynurenic Acid, Quinolinic Acid and Interleukin-6 Levels in the Serum of Patients with Autism Spectrum Disorder.
    Medicina (Kaunas, Lithuania), 2023, Oct-27, Volume: 59, Issue:11

    Topics: Autism Spectrum Disorder; Child; Child, Preschool; Humans; Infant; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic Acid

2023