kynurenine has been researched along with glutamic acid in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.33) | 18.7374 |
| 1990's | 8 (13.33) | 18.2507 |
| 2000's | 9 (15.00) | 29.6817 |
| 2010's | 32 (53.33) | 24.3611 |
| 2020's | 9 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jacobs, BL; Levine, ES | 1 |
| Du, F; Schwarcz, R | 1 |
| Rios, C; Santamaria, A | 1 |
| Connick, JH; Stone, TW | 1 |
| Aleksandrov, VG; Lapin, IP; Mandel'shtam, IuE; Ryzhov, IV; Slepokurov, MV | 1 |
| Reis, DJ; Sun, MK | 1 |
| Brookes, N | 1 |
| Chaudhri, G; Hunt, NH; Moore, DE; Sanni, LA; Stocker, R; Tattam, BN; Thomas, SR | 1 |
| Acuña-Castroviejo, D; Camacho, E; Escames, G; Espinosa, A; Gallo, MA; Gómez, I; León, J; Vives, F | 1 |
| Acuña-Castroviejo, D; Camacho, E; Crespo, E; Escames, G; Espinosa, A; Gallo, MA; León, J; Vives, F | 1 |
| Chmielewski, M; Kocki, T; Turski, WA; Urbańska, EM | 1 |
| Baran, H; Gille, L; Kepplinger, B; Nohl, H; Staniek, K; Stolze, K | 1 |
| Baraldi, M; Cannazza, G; Zanoli, P | 1 |
| Albrecht, J; Dolińska, M; Dybel, A; Kocki, T; Turski, WA; Urbańska, EM | 1 |
| Carpenedo, R; Chiarugi, A; Cozzi, A; Meli, E; Moroni, F; Pellegrini-Giampietro, DE | 1 |
| Albuquerque, EX; Rassoulpour, A; Schwarcz, R; Wu, HQ | 1 |
| Brown, JF; Cezar, GG; Gage, FH; Muotri, AR; Piekarczyk, MS; Quam, JA; Rosa, GJ; Smith, AM | 1 |
| Bhagwagar, Z; Hannestad, J; McNally, L | 1 |
| Alexander, K; Bruno, JP; Gash, CR; Gerhardt, GA; Huettl, P; Konradsson-Geuken, A; Pomerleau, F | 1 |
| Albuquerque, EX; Bruno, JP; Pellicciari, R; Pereira, EF; Schwarcz, R; Wu, HQ | 1 |
| Babu, GN; Kumar, A | 1 |
| Müller, N | 1 |
| Sas, K | 1 |
| Bernstein, HG; Bogerts, B; Gos, T; Myint, AM; Sarnyai, Z; Steiner, J; Walter, M | 1 |
| Alexander, KS; Bruno, JP; Schwarcz, R; Wu, HQ | 1 |
| Acher, F; Battaglia, G; Bertrand, HO; Bruno, V; Curini, M; Di Marco, R; Fazio, F; Goudet, C; Lionetto, L; Molinaro, G; Ngomba, RT; Nicoletti, F; Notartomaso, S; Pin, JP; Rosati, O; Scarselli, P; Simmaco, M | 1 |
| Bruno, JP; Elmer, GI; Pocivavsek, A; Schwarcz, R; Wu, HQ | 1 |
| D'Angelo, JA; Dickinson, BL; Fiebiger, E; Mattox, ML | 1 |
| Alexander, KS; Bruno, JP; Pershing, ML; Pocivavsek, A; Schwarcz, R; Wu, HQ | 1 |
| Barboni, L; Graham, D; Liao, Z; Nzowa, LK; Tapondjou, LA; Teponno, RB; Verotta, L; Zink, MC | 1 |
| Majláth, Z; Toldi, J; Vécsei, L | 1 |
| Majláth, Z; Obál, I; Toldi, J; Vécsei, L | 1 |
| Dantzer, R; Walker, AK | 1 |
| Gritton, H; Johnson, DE; Koshy Cherian, A; Kozak, R; Sarter, M; Young, D | 1 |
| Albrecht, J; Hilgier, W; Kocki, T; Obara-Michlewska, M; Oja, SS; Saransaari, P; Turski, WA | 1 |
| Anderson, C; Clifford, D; Cohen, B; Drewes, JL; Evans, S; Graham, D; Haughey, N; Hosey, L; McCarthy, S; Miyahara, S; Nath, A; Pardo, CA; Sacktor, N; Schifitto, G; Zink, MC | 1 |
| Bortz, DM; Bruno, JP; Fredericks, PJ; Jørgensen, CV; Leuner, B; Pershing, ML; Pocivavsek, A; Schwarcz, R; Vunck, SA | 1 |
| Balog, A; Majláth, Z; Tajti, J; Vécsei, L | 1 |
| Dezsi, L; Martos, D; Tuka, B; Vecsei, L | 1 |
| Al-Farsi, YM; Al-Shaffae, MA; Al-Sharbati, M; Bilgin, AA; de Paula Martins, R; Essa, MM; Guillemin, GJ; Lim, CK; Lovejoy, DB; Waly, MI | 1 |
| De Picker, L; Dedeurwaerdere, S; Kosten, L; Staelens, S; Stroobants, S; Thomae, D; Van Eetveldt, A; Verhaeghe, J; Verkerk, R; Wyffels, L | 1 |
| Can, A; Chiappelli, J; Du, X; Fuchs, D; Hong, LE; Kochunov, P; Lowry, CA; Postolache, TT; Rowland, LM; Savransky, A; Shukla, DK; Tagamets, M; Wijtenburg, SA | 1 |
| Schwarcz, R | 1 |
| Nagy-Grocz, G; Petrovics-Balog, A; Szok, D; Tajti, J; Toldi, J; Tuka, B; Vecsei, L | 1 |
| Bortz, DM; Bruno, JP; Schwarcz, R; Wu, HQ | 1 |
| Parasram, K | 1 |
| Klivényi, P; Szalárdy, L; Vécsei, L; Veres, G; Zádori, D | 1 |
| Caso, JR; García-Bueno, B; Leza, JC; Madrigal, JLM; Martín-Hernández, D; Tendilla-Beltrán, H | 1 |
| Guadagno, E; Li, C; Ramamurthy, J; Trakadis, Y; Wang, A; Wang, C; Zhang, E | 1 |
| Han, XM; Lu, YN; Qin, YJ; Rang, Y; Wang, NX; Zhai, XJ; Zhang, XL; Zhu, Y | 1 |
| Brimble, MA; Harris, PWR; Hermant, Y; Xu, B; Yang, SH | 1 |
| Bevilacqua, M; Bove, M; Colia, AL; Dimonte, S; Francavilla, M; Morgese, MG; Schiavone, S; Trabace, L; Tucci, P | 1 |
| Antunes Soares, FA; Aschner, M; Bicca Obetine Baptista, F; Duarte Hartmann, D; Farina Gonçalves, D; Franzen da Silva, A; Lenz Dalla Corte, C; Limana da Silveira, T; Lopes Machado, M; Marafiga Cordeiro, L | 1 |
| Alvarenga, AC; Appel, RM; Arima, EC; Ayache, R; Budib, MA; D'Amora, P; Diaz, RS; Evans, SS; Júnior, SS; Martins, WG; Nagourney, RA; Palma, AM; Pontes, HBD; Salzgeber, MB; Silva, FC; Silva, IDCG; Silva, NLF; Silva, RMS | 1 |
| Cai, H; Cao, T; Chen, Q; Jiao, S; Wang, L; Wu, X; Yang, C; Yang, D; Yang, P; Zeng, C; Zhang, S; Zhu, Z | 1 |
| Chen, Q; Chen, W; Kong, Q; Mao, X; Wang, G; Zhang, H; Zhao, J | 1 |
| Chai, X; Li, Z; Liu, F; Sun, P; Wang, M; Wei, J; Zhao, S; Zheng, W; Zhu, X | 1 |
| Chen, B; Di, Z; Guo, Q; Hu, R; Jiang, S; Liu, J; Ma, R; Shi, M; Song, Z; Sun, S; Wu, X; Xu, H | 1 |
| Liu, Z; Mu, C; Zhu, W | 1 |
| Baran, H; Kepplinger, B; Kronsteiner, C | 1 |
16 review(s) available for kynurenine and glutamic acid
| Article | Year |
|---|---|
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Brain Diseases; Dioxygenases; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans; Kynurenic Acid; Kynurenine; Lyases; Nerve Degeneration; Oxygenases; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Neurotransmitter; Transaminases | 1991 |
Quinolinic acid and other kynurenines in the central nervous system.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Convulsants; Glutamates; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Kynurenine; Neurotransmitter Agents; Pipecolic Acids; Quinolinic Acid; Quinolinic Acids; Rats; Retina; Synapses; Synaptic Transmission; Tryptophan Oxygenase | 1985 |
Identification of small molecules from human embryonic stem cells using metabolomics.
Topics: Biomarkers; Cell Culture Techniques; Cell Differentiation; DNA Primers; Embryonic Stem Cells; Folic Acid; Glutamic Acid; Humans; Kynurenine; Metabolism; Pyrrolidonecarboxylic Acid; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid | 2007 |
Inflammation, glutamate, and glia in depression: a literature review.
Topics: Animals; Astrocytes; Brain; Depressive Disorder; Disease Models, Animal; Glutamic Acid; Humans; Inflammation Mediators; Kynurenine; Microglia; Neuroglia; Neuronal Plasticity; Rats; Receptors, Glutamate; Serotonin | 2008 |
COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Cyclooxygenase 2 Inhibitors; Cytokines; Depressive Disorder; Glutamic Acid; Humans; Inflammation; Kynurenine; Prostaglandins; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate | 2010 |
Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity.
Topics: Blood-Brain Barrier; Depressive Disorder, Major; Glutamic Acid; Humans; Inflammation; Kynurenine; Neuroglia; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission | 2012 |
The potential role of kynurenines in Alzheimer's disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors.
Topics: Alzheimer Disease; Animals; Glutamic Acid; Humans; Kynurenine; Neuroprotective Agents; Receptors, Glutamate; Signal Transduction | 2014 |
Mental disturbances in Parkinson's disease and related disorders: the role of excitotoxins.
Topics: Dopamine; Glutamic Acid; Humans; Kynurenine; Mental Disorders; Neuroprotective Agents; Neurotoxins; Parkinson Disease | 2014 |
Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?
Topics: Animals; Blood-Brain Barrier; Depressive Disorder; Glutamic Acid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Neuroimmunomodulation; Quinolinic Acid | 2014 |
Drug targets of migraine and neuropathy: treatment of hyperexcitability.
Topics: Animals; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Hyperalgesia; Kynurenine; Migraine Disorders; Neuralgia | 2015 |
Alzheimer's disease, astrocytes and kynurenines.
Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Glutamic Acid; Humans; Kynurenine | 2015 |
Kynurenines and Glutamate: Multiple Links and Therapeutic Implications.
Topics: Animals; Brain; Glutamic Acid; Humans; Kynurenine; Tryptophan | 2016 |
Kynurenines and PACAP in Migraine: Medicinal Chemistry and Pathogenetic Aspects.
Topics: Animals; Chemistry, Pharmaceutical; Glutamic Acid; Humans; Kynurenine; Migraine Disorders; Neurons; Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, N-Methyl-D-Aspartate | 2017 |
Phytochemical treatments target kynurenine pathway induced oxidative stress.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Kynurenine; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Phytochemicals; Plant Extracts; Quinolinic Acid; Tryptophan | 2018 |
Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines.
Topics: Alzheimer Disease; Animals; Central Nervous System; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Humans; Immunity, Innate; Inflammation; Kynurenine; Mitochondria; Quinolinic Acid; Reactive Oxygen Species; Receptors, Glutamate; Signal Transduction | 2018 |
Metabolomics in patients with psychosis: A systematic review.
Topics: 3-Hydroxybutyric Acid; Aspartic Acid; Biomarkers; Bipolar Disorder; Creatine; Female; Glutamic Acid; Glutathione; Humans; Kynurenine; Lactic Acid; Linoleic Acid; Male; Metabolome; Metabolomics; Psychotic Disorders; Schizophrenia; Serine; Tryptophan | 2018 |
1 trial(s) available for kynurenine and glutamic acid
| Article | Year |
|---|---|
Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Ceramides; Cytokines; Double-Blind Method; Female; Glutamic Acid; HIV-1; Humans; Kynurenine; Male; Middle Aged; Minocycline; Neurofilament Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type II; Oxidative Stress | 2014 |
43 other study(ies) available for kynurenine and glutamic acid
| Article | Year |
|---|---|
Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat.
Topics: Acoustic Stimulation; Afferent Pathways; Animals; Bicuculline; Cats; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Iontophoresis; Kynurenine; Neurons; Raphe Nuclei; Serotonin; Wakefulness | 1992 |
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Malondialdehyde; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Thiobarbiturates | 1991 |
[Effect of excitant amino acid antagonists on glutamate receptors in the locust and on convulsions induced by glutamate, aspartate, kynurenine and quinolinic acid in mice].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glutamates; Glutamic Acid; Grasshoppers; Kynurenine; Male; Membrane Potentials; Mice; Muscles; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, Glutamate; Receptors, Neurotransmitter; Seizures | 1986 |
Hypoxic excitation of medullary vasomotor neurons in rats are not mediated by glutamate or nitric oxide.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Oxidoreductases; Animals; Glutamates; Glutamic Acid; Hypoxia, Brain; Injections, Spinal; Kynurenine; Male; Medulla Oblongata; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sodium Cyanide; Sympathectomy, Chemical; Tetrodotoxin; Vasomotor System | 1993 |
Interaction between the glutamine cycle and the uptake of large neutral amino acids in astrocytes.
Topics: Amino Acids; Ammonia; Animals; Astrocytes; Glutamates; Glutamic Acid; Glutamine; Kynurenine; Methionine Sulfoximine; Mice; Phenylalanine | 1993 |
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Female; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Osmolar Concentration; Oxidation-Reduction; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1998 |
Modulation of rat striatal glutamatergic response in search for new neuroprotective agents: evaluation of melatonin and some kynurenine derivatives.
Topics: Animals; Corpus Striatum; Electric Stimulation; Electrophysiology; Evoked Potentials; Glutamic Acid; Iontophoresis; Kynurenic Acid; Kynurenine; Male; Melatonin; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Reaction Time; Structure-Activity Relationship | 1998 |
Modification of nitric oxide synthase activity and neuronal response in rat striatum by melatonin and kynurenine derivatives.
Topics: Animals; Corpus Striatum; Electric Stimulation; Glutamic Acid; Kynurenine; Melatonin; Neurons; Nitric Oxide Synthase; Rats; Somatosensory Cortex | 1998 |
Formation of endogenous glutamatergic receptors antagonist kynurenic acid--differences between cortical and spinal cord slices.
Topics: Aminooxyacetic Acid; Animals; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Kynurenine; Male; Rats; Rats, Wistar; Receptors, Glutamate; Spinal Cord; Transaminases | 2000 |
Kynurenic acid influences the respiratory parameters of rat heart mitochondria.
Topics: Animals; Cell Respiration; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Kynurenine; Malates; Male; Mitochondria, Heart; Oxygen Consumption; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2001 |
Prenatal exposure to methyl mercury in rats: focus on changes in kynurenine pathway.
Topics: Animals; Aspartic Acid; Female; Fetus; Glutamic Acid; Hippocampus; Kynurenine; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neurons; ortho-Aminobenzoates; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 2001 |
Regulation of kynurenic acid synthesis in C6 glioma cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Buffers; Calcium; Glioma; Glutamic Acid; Guanosine Diphosphate; Kynurenic Acid; Kynurenine; Leucine; Magnesium; Potassium; Rats; Receptors, Metabotropic Glutamate; Sodium; Thionucleotides; Tumor Cells, Cultured; Veratridine | 2002 |
Studies on the neuroprotective action of kynurenine mono-oxygenase inhibitors in post-ischemic brain damage.
Topics: Animals; Brain Ischemia; Cell Death; Enzyme Inhibitors; Glutamic Acid; Hippocampus; In Vitro Techniques; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neurons; Neuroprotective Agents; Rats | 2003 |
Prolonged nicotine administration results in biphasic, brain-specific changes in kynurenate levels in the rat.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Extracellular Fluid; Glutamic Acid; Hippocampus; Kynurenic Acid; Kynurenine; Male; Nicotine; Rats; Rats, Sprague-Dawley; Smoking; Tobacco Use Disorder; Up-Regulation | 2005 |
Second-by-second analysis of alpha 7 nicotine receptor regulation of glutamate release in the prefrontal cortex of awake rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Calibration; Catheterization; Choline; Electrodes, Implanted; Glutamic Acid; Kynurenine; Male; Microelectrodes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Nicotinic; Time Factors | 2009 |
The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Cholinesterase Inhibitors; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Fluid; Galantamine; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Microdialysis; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Schizophrenia | 2010 |
In vivo neuroprotective effects of peripheral kynurenine on acute neurotoxicity induced by glutamate in rat cerebral cortex.
Topics: Animals; Catalase; Cerebral Cortex; Flow Cytometry; Glutamic Acid; Glutathione; Glutathione Reductase; Kynurenine; Lipid Peroxidation; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 2010 |
Potential role of glutamate neurotransmission in the pathogenesis of ischemic brain damage and of depression. Effects of L-kynurenine on the survival of the hippocampal neurons and on the corticocerebral blood flow in ischemic animal models.
Topics: Animals; Brain Ischemia; Cell Survival; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Citalopram; Depression; Disease Models, Animal; Electrophysiology; Fluoxetine; Glutamic Acid; Hippocampus; Kynurenine; Male; Rabbits; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission; Wakefulness | 2010 |
Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cognition; Cognition Disorders; Disease Models, Animal; Galantamine; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Nootropic Agents; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Nicotinic; Schizophrenia | 2012 |
Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.
Topics: Animals; Cells, Cultured; Cyclic AMP; Glutamic Acid; Humans; Kynurenine; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Oxazines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 2012 |
Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Chromatography, High Pressure Liquid; Cognition Disorders; Electrochemical Techniques; Female; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Maze Learning; Memory; Microdialysis; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Spatial Behavior | 2012 |
The cystine/glutamate antiporter regulates the functional expression of indoleamine 2,3-dioxygenase in human dendritic cells.
Topics: Amino Acid Transport System y+; Cell Differentiation; Cells, Cultured; Cystine; Dendritic Cells; Gene Expression; Glutamic Acid; Glutathione; Homocysteine; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; RNA, Messenger | 2012 |
Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine.
Topics: Animals; Attention; Brain; Cognition; Female; Galantamine; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Nootropic Agents; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Set, Psychology | 2013 |
Two new tryptophan derivatives from the seed kernels of Entada rheedei: effects on cell viability and HIV infectivity.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cell Line; Cell Survival; Dopamine; Fabaceae; Glutamic Acid; HIV; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukocytes, Mononuclear; Melatonin; Molecular Structure; Plant Extracts; Psychotropic Drugs; Seeds; Serotonin; Tryptophan; Virus Replication | 2013 |
A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats.
Topics: Animals; Central Nervous System Agents; Enzyme Inhibitors; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Membrane Potentials; Microdialysis; Microelectrodes; Nicotine; Nicotinic Agonists; Potassium Chloride; Prefrontal Cortex; Pyrazoles; Rats, Sprague-Dawley; Rats, Wistar; Transaminases | 2014 |
Modulation by kynurenine of extracellular kynurenate and glutamate in cerebral cortex of rats with acute liver failure.
Topics: Animals; Cerebral Cortex; Glutamic Acid; Kynurenic Acid; Kynurenine; Liver Failure, Acute; Male; Rats; Rats, Sprague-Dawley; Transaminases | 2014 |
Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Brain; Cognition; Dendritic Spines; Diet; Female; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Receptors, Metabotropic Glutamate; Reversal Learning; RNA, Messenger; Schizophrenia | 2015 |
Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity.
Topics: Adolescent; Animals; Autistic Disorder; Child; Child, Preschool; Cross-Sectional Studies; Female; Glutamic Acid; Humans; Kynurenine; Male; Oman; Siblings | 2016 |
Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction.
Topics: Animals; Brain; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenine; Male; Molecular Imaging; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tryptophan | 2016 |
Tryptophan Metabolism and White Matter Integrity in Schizophrenia.
Topics: Adult; Analysis of Variance; Anisotropy; Diffusion Tensor Imaging; Female; Glutamic Acid; Humans; Kynurenine; Magnetic Resonance Spectroscopy; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Tryptophan; White Matter; Young Adult | 2016 |
Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex.
Topics: Administration, Oral; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Electrodes; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Heterocyclic Compounds, 3-Ring; Kynurenic Acid; Kynurenine; Male; Microdialysis; N-Methylaspartate; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Thiazolidinediones; Transaminases | 2017 |
Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.
Topics: Animals; Antidepressive Agents; Chronic Disease; Cytokines; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenic Acid; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stress, Psychological; Synaptic Transmission; Tryptophan | 2019 |
Development of an underivatized LC-MS/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats.
Topics: Animals; Blood Chemical Analysis; Chromatography, Liquid; Depression; Disease Models, Animal; Glutamic Acid; Hippocampus; Kynurenic Acid; Kynurenine; Limit of Detection; Linear Models; Male; Neurotransmitter Agents; Phenylalanine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Tryptophan; Urinalysis | 2019 |
A Versatile Boc Solid Phase Synthesis of Daptomycin and Analogues Using Site Specific, On-Resin Ozonolysis to Install the Kynurenine Residue.
Topics: Anti-Infective Agents; Daptomycin; Drug Evaluation, Preclinical; Glutamates; Glutamic Acid; Kynurenine; Ozone; Solid-Phase Synthesis Techniques; Staphylococcus aureus; Threonine | 2019 |
Sublingual AKBA Exerts Antidepressant Effects in the Aβ-Treated Mouse Model.
Topics: Amyloid beta-Peptides; Animals; Antidepressive Agents; Biomarkers; Depression; Disease Models, Animal; Glial Fibrillary Acidic Protein; Glutamic Acid; Kynurenine; Male; Mice; Treatment Outcome; Triterpenes | 2021 |
Caenorhabditis elegans as a model for studies on quinolinic acid-induced NMDAR-dependent glutamatergic disorders.
Topics: 1-Octanol; Adenosine Triphosphate; Amino Acid Metabolism, Inborn Errors; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Citrate (si)-Synthase; Disease Models, Animal; Glutamic Acid; Humans; Kynurenine; Motor Activity; Neurodegenerative Diseases; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission | 2021 |
Towards risk stratification and prediction of disease severity and mortality in COVID-19: Next generation metabolomics for the measurement of host response to COVID-19 infection.
Topics: Adult; Aged; Area Under Curve; Carnitine; Citrulline; COVID-19; Female; Glutamic Acid; Humans; Kynurenine; Male; Metabolome; Metabolomics; Middle Aged; Ornithine; Risk Factors; ROC Curve; SARS-CoV-2; Severity of Illness Index; Tryptophan | 2021 |
Disturbance of neurotransmitter metabolism in drug-naïve, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Adult; Biomarkers; Depressive Disorder, Major; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Methoxyhydroxyphenylglycol; Neurotransmitter Agents; Norepinephrine; Serotonin; Tryptophan; Vanilmandelic Acid | 2022 |
Topics: Animals; Autistic Disorder; Bifidobacterium longum; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Kynurenine; Neuroinflammatory Diseases; Neurotransmitter Agents; Quinolinic Acid; Rats | 2022 |
Topics: Animals; Cognition; Diet; Dysbiosis; Gastrointestinal Microbiome; Glutamic Acid; Kynurenine; Lipopolysaccharides; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; Tryptophan | 2022 |
Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model.
Topics: Animals; Depression; Disease Models, Animal; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Tryptophan | 2022 |
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon.
Topics: Amino Acids; Animals; Anti-Bacterial Agents; Colon; gamma-Aminobutyric Acid; Glutamic Acid; Kynurenine; Putrescine; Swine; Transaminases; Tryptophan | 2023 |
Kynurenic Acid Levels and Kynurenine Aminotransferase I, II and III Activities in Ganglia, Heart and Liver of Snail Helix Pomatia.
Topics: Animals; Biotin; Ganglia; Glutamic Acid; Kynurenic Acid; Kynurenine; Liver; Mammals; Rats; Transaminases | 2023 |